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公开(公告)号：US5807563A
公开(公告)日：1998-09-15
申请号：US912678
申请日：1997-08-18
CPC分类号： A61L31/16 , A61L15/24 , A61L26/0014 , A61L31/048 , A61B46/00 , A61B46/40 , A61L2300/202 , A61L2300/404
摘要： Disclosed are methods for draping a surgical incision site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape over the skin surface at the surgical incision site. An incision is then made through this surface and the surgery is then conducted through the incision.
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62.发明授权Methods for treating non-suturable, superficial wounds by use of cyanoacrylate ester compositions comprising an antimicrobial agent 失效通过使用包含抗微生物剂的氰基丙烯酸酯组合物来治疗不可缝合的浅表伤的方法
公开(公告)号：US5753699A
公开(公告)日：1998-05-19
申请号：US947792
申请日：1997-10-09
申请人： Richard J. Greff , Michael M. Byram
发明人： Richard J. Greff , Michael M. Byram
IPC分类号： A01N59/12 , A61K9/70 , A61K31/275 , A61K31/79 , A61L24/00 , A61L26/00 , C09D4/00 , A61K31/255 , C07C255/10
CPC分类号： A61L26/0014 , A01N59/12 , A61K31/275 , A61K31/79 , A61K9/7015 , A61L24/0015 , A61L26/0066 , C09D4/00 , A61L2300/202 , A61L2300/404
摘要： Antimicrobial cyanoacrylate compositions are applied to non-suturable, superficial wound surfaces. In situ polymerization of the cyanoacrylate ester provides for a polymeric film over the wound which promotes wound healing and retards infection of the wound.
摘要翻译： 抗微生物氰基丙烯酸酯组合物应用于不可缝合的表面伤口表面。 氰基丙烯酸酯的原位聚合提供了伤口上的聚合物膜，其促进伤口愈合并延缓伤口的感染。
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公开(公告)号：US5620441A
公开(公告)日：1997-04-15
申请号：US260084
申请日：1994-06-15
申请人： Richard J. Greff , David W. Tung
发明人： Richard J. Greff , David W. Tung
CPC分类号： A61B18/00 , A61B2218/008
摘要： A combination of electrical surgical apparatus includes a first electrical surgical apparatus having a first operative state and a second operative state. A conductor for conducting electrical energy to the first apparatus has first characteristics when the first apparatus is in the first operative state and has second characteristics when the first apparatus is in the second operative state. A sensor is coupled between the first apparatus and a second electrical surgical apparatus having a first operative state and a second operative state. The sensor is responsive to a change from one of the first and second characteristics of the conductor to the other of the first and second characteristics of the conductor to produce a transition signal. A switch coupled between the sensor and the second apparatus is responsive to the transition signal to change the state of the second apparatus from one of the first and second operative states of the second apparatus to the other of the first and second operative states of the second apparatus.
摘要翻译： 电手术装置的组合包括具有第一操作状态和第二操作状态的第一电手术装置。 当第一装置处于第一操作状态时，用于向第一装置传导电能的导体具有第一特性，并且当第一装置处于第二操作状态时具有第二特性。 传感器耦合在第一装置和具有第一操作状态和第二操作状态的第二电手术装置之间。 传感器响应于从导体的第一和第二特性之一到导体的第一和第二特性中的另一个的变化，以产生转变信号。 耦合在传感器和第二装置之间的开关响应于转换信号，以将第二装置的状态从第二装置的第一和第二操作状态中的一个改变为第二装置的第一和第二操作状态中的另一个 仪器。
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64.发明授权Use of cyanoacrylate adhesive compositions to inhibit acute radiation-induced skin damage 失效使用氰基丙烯酸酯粘合剂组合物抑制急性辐射诱导的皮肤损伤
公开(公告)号：US5554365A
公开(公告)日：1996-09-10
申请号：US435590
申请日：1995-05-05
IPC分类号： A61K47/30 , A61K31/00 , A61K31/74 , A61K31/78 , A61K31/785 , A61L26/00 , A61P17/00 , A61P39/00
CPC分类号： A61K31/785 , A61K31/78 , A61L26/0014
摘要： Disclosed are methods for inhibiting acute and/or late radiation/induced skin damage during treatment of a patient with ionizing radiation by application of a layer of cyanoacrylate adhesive to the skin surface prior to exposure of the surface to ionizing radiation.
摘要翻译： 公开的是在将表面暴露于电离辐射之前，通过将一层氰基丙烯酸酯粘合剂施加到皮肤表面来治疗患有电离辐射的患者期间的急性和/或晚期辐射/诱导的皮肤损伤的方法。
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公开(公告)号：US08524270B2
公开(公告)日：2013-09-03
申请号：US13477541
申请日：2012-05-22
申请人： Richard J. Greff
发明人： Richard J. Greff
CPC分类号： A61K47/34 , A61K38/00 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/32 , A61L26/0038 , A61L26/0085 , A61L26/009 , A61L2400/04
摘要： Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.
摘要翻译： 公开了一种生物相容性，止血的交联明胶组合物，其包含生物相容性材料，其包含交联明胶和足够量的润湿剂，以允许在水溶液存在下均匀地润湿海绵。
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公开(公告)号：US08187625B2
公开(公告)日：2012-05-29
申请号：US10068812
申请日：2002-02-04
申请人： Richard J. Greff
发明人： Richard J. Greff
CPC分类号： A61K47/34 , A61K38/00 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/32 , A61L26/0038 , A61L26/0085 , A61L26/009 , A61L2400/04
摘要： Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.
摘要翻译： 公开了一种生物相容性，止血的交联明胶组合物，其包含生物相容性材料，其包含交联明胶和足够量的润湿剂，以允许在水溶液存在下均匀地润湿海绵。
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公开(公告)号：US07459142B2
公开(公告)日：2008-12-02
申请号：US10162653
申请日：2002-06-06
申请人： Richard J. Greff
发明人： Richard J. Greff
CPC分类号： A61K47/32 , A61K9/0019 , A61K31/78 , A61K31/785 , A61K47/34 , A61K49/0409 , A61L24/001 , A61L2430/36
摘要： Disclosed are novel high viscosity compositions for embolizing blood vessels which comprise a biocompatible prepolymer and a contrast agent, and optionally a thickening agent and/or a biocompatible solvent. Also disclosed are methods for embolizing a vascular site by injecting high viscosity prepolymer compositions into said site. The disclosed compositions and methods are particularly well suited for the treatment of aneurysms.
摘要翻译： 公开了用于栓塞血管的新型高粘度组合物，其包含生物相容性预聚物和造影剂，以及任选的增稠剂和/或生物相容性溶剂。 还公开了通过将高粘度预聚物组合物注入所述部位栓塞血管部位的方法。 所公开的组合物和方法特别适用于治疗动脉瘤。
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68.发明授权公开(公告)号：US06492434B1
公开(公告)日：2002-12-10
申请号：US08393019
申请日：1995-02-27
IPC分类号： C08K608
CPC分类号： A61K31/74 , A61L24/06 , Y10S514/925 , Y10S514/928 , C08L35/04
摘要： A cyanoacrylate adhesive is applied onto intact surface skin areas prone to ulceration so as to inhibit formation of surface skin ulcers.
摘要翻译： 将氰基丙烯酸酯粘合剂施加到易于溃疡的完整表面皮肤区域上，以抑制表面皮肤溃疡的形成。
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69.发明授权Kits containing cyanoacrylate compositions comprising an antimicrobial agent 有权包含含有抗微生物剂的氰基丙烯酸酯组合物的试剂盒公开(公告)号：US06475502B1
公开(公告)日：2002-11-05
申请号：US09584473
申请日：2000-06-01
申请人： Connie C. Lee , Richard J. Greff , Ian N. Askill
发明人： Connie C. Lee , Richard J. Greff , Ian N. Askill
IPC分类号： A61L2600
CPC分类号： A61L31/16 , A61B17/00491 , A61K9/7015 , A61L15/24 , A61L15/46 , A61L26/0014 , A61L26/0066 , A61L31/048 , A61L2300/202 , A61L2300/404 , C08L35/04
摘要： Disclosed are kits of parts comprising a first container comprising a cyanoacrylate composition and a second container comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. Mixture of these compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.
摘要翻译： 公开的试剂盒包括包含氰基丙烯酸酯组合物的第一容器和包含相容的抗微生物剂，特别是相容的含碘抗微生物剂的第二容器。 这些组合物的混合物提供在哺乳动物皮肤上原位形成抗微生物聚合氰基丙烯酸酯膜。
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公开(公告)号：US06475466B1
公开(公告)日：2002-11-05
申请号：US09528656
申请日：2000-03-20
IPC分类号： A61K4904
CPC分类号： A61L24/06 , A61B17/00491 , A61B17/0057 , A61B2017/00575 , A61B2090/3933 , A61B2090/3937 , A61F2/06 , A61L24/001 , A61L24/08 , A61L2430/36 , Y10S524/916 , C08L29/04 , C08L33/04 , C08L1/12
摘要： Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of endoleaks is achieved by injection of either a biocompatible polymer or prepolymer fluid composition into the endoleak which composition in situ solidifies to seal the leak. Preferably, the biocompatible fluid composition comprises a contrast agent to allow the clinician to visualize the sealing process.
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