公开(公告)号：US20160108030A1

公开(公告)日：2016-04-21

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D401/14 ,  A61K31/517 ,  A61K31/4439 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/496 ,  A61K31/5377 ,  C07D491/052 ,  A61K31/444 ,  C07D401/12

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式（I）化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US20250049780A1

公开(公告)日：2025-02-13

申请号：US18771751

申请日：2024-07-12

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore

IPC: A61K31/4545 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US12070455B2

公开(公告)日：2024-08-27

申请号：US17930538

申请日：2022-09-08

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

CPC classification number: A61K31/4545 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20230312567A1

公开(公告)日：2023-10-05

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US11753399B2

公开(公告)日：2023-09-12

申请号：US17584643

申请日：2022-01-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I):




or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20230270734A1

公开(公告)日：2023-08-31

申请号：US17930538

申请日：2022-09-08

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore

IPC: A61K31/4545 ,  A61K45/06 ,  A61K31/4706 ,  C07D519/00 ,  A61K31/439 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377

CPC classification number: A61K31/4545 ,  A61K45/06 ,  A61K31/4706 ,  C07D519/00 ,  A61K31/439 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20230002407A1

公开(公告)日：2023-01-05

申请号：US17317041

申请日：2021-05-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07B59/00

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20220389034A1

公开(公告)日：2022-12-08

申请号：US17721636

申请日：2022-04-15

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore ,  Christopher J. Swank

IPC: C07D519/00 ,  C07D495/04

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20180237455A1

公开(公告)日：2018-08-23

申请号：US15891163

申请日：2018-02-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/14 ,  C07D409/14 ,  C07D401/12 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180051005A1

公开(公告)日：2018-02-22

申请号：US15680041

申请日：2017-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/675 ,  A61K31/537 ,  A61K31/7076 ,  C07F5/02 ,  C07D231/54 ,  C07C317/08

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/025

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.