公开(公告)号：US20120309194A1

公开(公告)日：2012-12-06

申请号：US13188174

申请日：2011-07-21

申请人： Qing Xu ,  Camelia Rusu ,  Jaroslaw W. Winniczek ,  Frank Y. Lin ,  Alan J. Miller

发明人： Qing Xu ,  Camelia Rusu ,  Jaroslaw W. Winniczek ,  Frank Y. Lin ,  Alan J. Miller

IPC分类号： H01L21/3065

CPC分类号： H01L21/30655 ,  H01J37/32082 ,  H01J37/32449 ,  H01L21/76802 ,  H01L21/76898

摘要： A method for etching features into an etch layer in a plasma processing chamber, comprising a plurality of cycles is provided. Each cycle comprises a deposition phase and an etching phase. The deposition phase comprises providing a flow of deposition gas, forming a plasma from the deposition gas in the plasma processing chamber, providing a first bias during the deposition phase to provide an anisotropic deposition, and stopping the flow of the deposition gas into the plasma processing chamber. The etching phase, comprises providing a flow of an etch gas, forming a plasma from the etch gas in the plasma processing chamber, providing a second bias during the etch phase, wherein the first bias is greater than the second bias, and stopping the flow of the etch gas into the plasma processing chamber.

摘要翻译： 提供了一种用于将特征蚀刻到等离子体处理室中的蚀刻层的方法，其包括多个循环。 每个循环包括沉积阶段和蚀刻阶段。 沉积阶段包括提供沉积气体流，从等离子体处理室中的沉积气体形成等离子体，在沉积阶段提供第一偏压以提供各向异性沉积，并停止沉积气体流入等离子体处理 房间。 蚀刻阶段包括提供蚀刻气体流，从等离子体处理室中的蚀刻气体形成等离子体，在蚀刻阶段期间提供第二偏压，其中第一偏压大于第二偏压，并停止流动 的蚀刻气体进入等离子体处理室。

公开(公告)号：US08190232B2

公开(公告)日：2012-05-29

申请号：US12165830

申请日：2008-07-01

申请人： Li Zhang ,  Carol L. Novak ,  Qing Xu ,  Chong Chen

发明人： Li Zhang ,  Carol L. Novak ,  Qing Xu ,  Chong Chen

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/417 ,  A61B5/4504

摘要： A method to automatically align magnetic resonance (MR) brain scans for diagnostic scan planning, including: acquiring a three-dimensional (3D) localizer image of a patient; selecting a two-dimensional (2D) coronal view and a 2D transverse view from the localizer image; identifying a mid-sagittal plane (MSP) line in each of the coronal and transverse views and calculating a 3D MSP based on the MSP lines; reconstructing the localizer image based on an equation for the 3D MSP to obtain an image of the MSP of the patient's brain; identifying crista galli (CG) and tip of the occipital bone (TOB) in the image of the MSP of the patient's brain; calculating a transformation matrix based on the MSP, CG and TOB in the image and using the transformation matrix to obtain a scan plan for the patient; and outputting the scan plan for the patient.

摘要翻译： 一种用于自动对准用于诊断扫描计划的磁共振（MR）脑扫描的方法，包括：获取患者的三维（3D）定位器图像; 从定位器图像中选择二维（2D）冠状视图和2D横向视图; 识别每个冠状和横向视图中的中矢状面（MSP）线，并基于MSP线计算3D MSP; 基于3D MSP的等式重建定位器图像以获得患者脑的MSP的图像; 在患者大脑的MSP图像中识别嵴（CG）和枕骨顶端（TOB）; 基于图像中的MSP，CG和TOB计算变换矩阵，并使用变换矩阵获得患者的扫描方案; 并输出病人的扫描方案。

公开(公告)号：US20120130073A1

公开(公告)日：2012-05-24

申请号：US13269523

申请日：2011-10-07

申请人： Zhaozhong Jia ,  Chandrasekar Venkataramani ,  Wolin Huang ,  Mukund Mehrotra ,  Yonghong Song ,  Qing Xu ,  Shawn M. Bauer ,  Jack W. Rose ,  Brian Kane ,  Anjali Pandey

发明人： Zhaozhong Jia ,  Chandrasekar Venkataramani ,  Wolin Huang ,  Mukund Mehrotra ,  Yonghong Song ,  Qing Xu ,  Shawn M. Bauer ,  Jack W. Rose ,  Brian Kane ,  Anjali Pandey

IPC分类号： C07D403/12

CPC分类号： A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

公开(公告)号：US20120129867A1

公开(公告)日：2012-05-24

申请号：US13360862

申请日：2012-01-30

申请人： Shawn M. Bauer ,  Zhaozhong J. Jia ,  Yonghong Song ,  Qing Xu ,  Mukund Mehrotra ,  Jack W. Rose ,  Wolin Huang ,  Chandrasekar Venkataramani ,  Anjali Pandey

发明人： Shawn M. Bauer ,  Zhaozhong J. Jia ,  Yonghong Song ,  Qing Xu ,  Mukund Mehrotra ,  Jack W. Rose ,  Wolin Huang ,  Chandrasekar Venkataramani ,  Anjali Pandey

IPC分类号： A61K31/506 ,  C12N9/99 ,  A61P9/00 ,  A61P9/10 ,  A61P37/08 ,  A61P37/06 ,  A61P29/00 ,  A61P17/06 ,  A61P13/12 ,  A61P35/00 ,  A61P7/06 ,  C07D403/12 ,  A61P11/06

CPC分类号： C07D417/12 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/551 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

摘要： The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

摘要翻译： 本发明涉及式I-II化合物及其药学上可接受的互变异构体，其盐或其立体异构体，其是syk和/或JAK激酶的抑制剂。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制性syk和/或JAK激酶活性的方法，抑制血小板聚集的方法以及预防方法 或治疗至少部分通过syk和/或JAK激酶活性介导的许多病症，例如不期望的血栓形成和非霍奇金淋巴瘤。

公开(公告)号：US08175352B2

公开(公告)日：2012-05-08

申请号：US12231636

申请日：2008-09-04

申请人： Qing Xu ,  Li Zhang ,  Chong Chen

发明人： Qing Xu ,  Li Zhang ,  Chong Chen

IPC分类号： G06K9/00

CPC分类号： A61B5/055 ,  A61B5/0037 ,  G01R33/543 ,  G01R33/546 ,  G01R33/5608 ,  G06T7/74 ,  G06T2207/10088 ,  G06T2207/30041

摘要： A method and system for automated magnetic resonance (MR) scan prescription is disclosed. A 3D MR scout image is obtained by an initial MR scan. The location of an optic nerve in the scout image is determined by registering a template image to the scout image using a hierarchical series of rigid registrations. The hierarchical series of rigid registrations utilizes a coarse to fine scheme to register regions in the template image to the scout image, starting with the whole template image and finishing with the optic nerve. A diagnostic MR scan is then aligned based on the location of the optic nerve in the scout image, and the diagnostic scan is performed resulting in a high quality diagnostic 3D MR image.

摘要翻译： 公开了一种用于自动磁共振（MR）扫描处方的方法和系统。 通过初始MR扫描获得3D MR侦察图像。 通过使用一系列刚性注册将模板图像注册到侦察图像来确定侦察图像中的视神经的位置。 刚性注册的分级系列利用粗略到精细的方案将模板图像中的区域注册到侦察图像，从整个模板图像开始并用视神经完成。 然后基于视觉神经在侦察图像中的位置对准诊断MR扫描，并执行诊断扫描，导致高质量诊断3D MR图像。

公开(公告)号：US08138339B2

公开(公告)日：2012-03-20

申请号：US12386509

申请日：2009-04-16

申请人： Shawn M. Bauer ,  Zhaozhong J. Jia ,  Yonghong Song ,  Qing Xu ,  Mukund Mehrotra ,  Jack W. Rose ,  Wolin Huang ,  Chandrasekar Venkataramani ,  Anjali Pandey

发明人： Shawn M. Bauer ,  Zhaozhong J. Jia ,  Yonghong Song ,  Qing Xu ,  Mukund Mehrotra ,  Jack W. Rose ,  Wolin Huang ,  Chandrasekar Venkataramani ,  Anjali Pandey

IPC分类号： C07D239/28 ,  C07D403/02 ,  C07D413/02 ,  C07D279/12 ,  A61K31/506 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/541

CPC分类号： C07D417/12 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/551 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

摘要： The present invention is directed to 2-cycloalkylamino-4-arylamino-benzamide compounds of formula I pharmaceutically acceptable salts thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder.

摘要翻译： 本发明涉及作为syk和/或JAK激酶抑制剂的式I的药学上可接受的盐的2-环烷基氨基-4-芳基氨基 - 苯甲酰胺化合物。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制性syk和/或JAK激酶活性的方法，以及预防或治疗多种病症介导的方法 至少部分地由syk和/或JAK激酶活性，例如心血管疾病，炎性疾病，自身免疫疾病和细胞增殖性疾病。

公开(公告)号：US20120001565A1

公开(公告)日：2012-01-05

申请号：US13088251

申请日：2011-04-15

申请人： Jin Hu ,  Qing Xu ,  Quansong Wu

发明人： Jin Hu ,  Qing Xu ,  Quansong Wu

IPC分类号： H05B41/16

CPC分类号： H05B41/2887 ,  H05B41/2882 ,  H05B41/388

摘要： The present invention is generally related to an electronic ballast, an ignition control apparatus used therein and associated method of operation. In one embodiment, an electronic ballast comprising an inverter and an ignition control apparatus which comprises a stability monitoring circuit and a controlled ignition circuit. The inverter converts a DC input voltage into an AC voltage to drive a gas discharge lamp. The stability monitoring circuit monitors whether the DC input voltage is stable. The controlled ignition circuit is electrically coupled to the stability monitoring circuit and the lamp, ignites the lamp based on the monitoring result. The controlled ignition circuit does not ignite the gas discharge lamp until the DC input voltage becomes stable.

摘要翻译： 本发明通常涉及电子镇流器，其中使用的点火控制装置和相关的操作方法。 在一个实施例中，一种电子镇流器包括逆变器和点火控制装置，其包括稳定性监视电路和受控点火电路。 逆变器将直流输入电压转换为交流电压以驱动气体放电灯。 稳定监视电路监视直流输入电压是否稳定。 受控点火电路电耦合到稳定性监测电路和灯，基于监测结果点燃灯。 直流输入电压稳定后，控制点火电​​路不会点燃气体放电灯。

公开(公告)号：US20090298823A1

公开(公告)日：2009-12-03

申请号：US12386848

申请日：2009-04-22

申请人： Yonghong Song ,  Qing Xu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Mukund Mehrotra ,  Anjali Pandey

发明人： Yonghong Song ,  Qing Xu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Mukund Mehrotra ,  Anjali Pandey

IPC分类号： A61K31/5377 ,  C07D487/04 ,  C07D239/28 ,  C07D413/14 ,  A61K31/497 ,  A61K31/506 ,  A61P7/02

CPC分类号： C07D471/04 ,  C07D239/48 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D473/16

摘要： The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

摘要翻译： 本发明涉及式I-II化合物及其药学上可接受的盐，酯和前体药物，它们是syk和/或JAK激酶的抑制剂。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制性syk和/或JAK激酶活性的方法，抑制血小板聚集的方法以及预防方法 或治疗至少部分通过syk和/或JAK激酶活性介导的许多病症，例如不期望的血栓形成和非霍奇金淋巴瘤。

公开(公告)号：US20080071163A1

公开(公告)日：2008-03-20

申请号：US11856104

申请日：2007-09-17

申请人： Li Zhang ,  Carol Novax ,  Hong Chen ,  Qing Xu

发明人： Li Zhang ,  Carol Novax ,  Hong Chen ,  Qing Xu

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0037 ,  A61B5/6814 ,  G01R33/4833

摘要： A method and system for automatic MR brain scan planning is disclosed. The method utilizes a set of 2D orthogonal localizer images to determine scanning planes for 3D diagnostic MR scans. A location of the mid-sagittal plane (MSP) is detected in each of a transversal localizer image and a coronal localizer image. A sagittal scanning plane is determined based on the location of the MSP in the transversal and coronal localizer images. A diagnostic sagittal MR scan is then acquired based on the sagittal scanning plane. The corpus callosum CC is segmented in a sagittal MR image slice resulting from the diagnostic sagittal MR scan. A transversal scanning plane can be determined based on a location of the CC in the sagittal MR image slice and the location of the MSP in the coronal localizer image, and a coronal scanning plane can be determined based on the location of the CC in the sagittal MR image slice and the location of the MSP in the transversal localizer image.

摘要翻译： 公开了用于自动MR脑扫描计划的方法和系统。 该方法利用一组2D正交定位图像来确定3D诊断MR扫描的扫描平面。 在横向定位器图像和冠状定位器图像中的每一个中检测到中间矢状面（MSP）的位置。 基于MSP在横向和冠状定位器图像中的位置来确定矢状扫描平面。 然后基于矢状扫描平面获取诊断矢状MR扫描。 胼um体CC被分割成由诊断矢状MR扫描得到的矢状MR图像切片。 可以基于矢状位MR图像切片中的CC的位置和冠状位置定位器图像中的MSP的位置来确定横向扫描平面，并且可以基于CC在矢状位置中的位置来确定冠状扫描平面 MR图像切片和MSP在横向定位器图像中的位置。

公开(公告)号：US20060281817A1

公开(公告)日：2006-12-14

申请号：US11448260

申请日：2006-06-07

申请人： Carol Colton ,  Michael Vitek ,  Warren Strittmatter ,  Qing Xu ,  James Burke

发明人： Carol Colton ,  Michael Vitek ,  Warren Strittmatter ,  Qing Xu ,  James Burke

IPC分类号： A61K31/198 ,  A61K31/13

CPC分类号： A61K45/06 ,  A61K31/13 ,  A61K31/198 ,  A61K2300/00

摘要： A method of treating a neurodegenerative disease in a subject in need thereof comprises: (a) administering the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to treat the disease; and concurrently (b) administering the subject a polyamine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to reduce damage to the gastroinestinal tract of the subject by the ornithine decarboxylase inhibitor.

摘要翻译： 在有需要的受试者中治疗神经变性疾病的方法包括：（a）给予受试者具有有效治疗疾病的量的鸟氨酸脱羧酶抑制剂，例如α-二氟甲基鸟氨酸或其药学上可接受的盐或前药; 并且同时（b）以有效减少鸟氨酸脱羧酶抑制剂对受试者的胃肠道损伤的量给予受试者多胺或其药学上可接受的盐或前药。