公开(公告)号：US09129387B2

公开(公告)日：2015-09-08

申请号：US11917937

申请日：2006-06-20

申请人： Olivier Ecabert ,  Peters Jochen ,  Juergen Weese

发明人： Olivier Ecabert ,  Peters Jochen ,  Juergen Weese

IPC分类号： G06F17/50 ,  G06T7/00

CPC分类号： G06T7/0089 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/30004 ,  G06T2207/30008

摘要： The invention relates to an adaptation system for adapting a deformable model comprising a plurality of model elements to an object of interest in an image data set, the adaptation system comprising a selector for selecting at least one image- driven model element from the plurality of model elements and an adapter for adapting the deformable model on the basis of optimizing a model energy of the deformable model, the model energy comprising an internal energy of the plurality of model elements and an external energy of the at least one image-driven model element, thereby adapting the deformable model. By enabling the adaptation system to selectively choose the image- driven model elements, the adaptation system of the current invention allows excluding a poorly adaptable model element from interacting with the image data set and thus from being pulled and/or pushed by the image data set into a wrong location.

摘要翻译： 本发明涉及一种用于将包括多个模型元素的可变形模型适配成图像数据集中的感兴趣对象的自适应系统，所述自适应系统包括用于从多个模型中选择至少一个图像驱动模型元素的选择器 元件和用于在优化可变形模型的模型能量的基础上适配可变形模型的适配器，模型能量包括多个模型元素的内部能量和至少一个图像驱动模型元素的外部能量， 从而适应可变形模型。 通过使自适应系统能够选择性地选择图像驱动的模型元素，本发明的自适应系统允许排除不良适应性模型元素与图像数据集的交互，从而被图像数据集拉拽和/或推动 进入错误的位置。

公开(公告)号：US20130231564A1

公开(公告)日：2013-09-05

申请号：US13818042

申请日：2011-08-24

申请人： Lyubomir Georgiev Zagorchev ,  Michael Daniel Cardinale ,  Scott Holland Settlemier ,  Kevin CamHong Quan ,  Sabine Mollus ,  Juergen Weese ,  Ivan Salgo

发明人： Lyubomir Georgiev Zagorchev ,  Michael Daniel Cardinale ,  Scott Holland Settlemier ,  Kevin CamHong Quan ,  Sabine Mollus ,  Juergen Weese ,  Ivan Salgo

IPC分类号： A61B8/08 ,  A61B8/14 ,  A61B8/00

CPC分类号： A61B8/0891 ,  A61B5/1075 ,  A61B8/0883 ,  A61B8/145 ,  A61B8/466 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/543 ,  A61B34/10 ,  A61B2034/105 ,  G06T7/12 ,  G06T7/149 ,  G06T7/62 ,  G06T7/66 ,  G06T2207/10136 ,  G06T2207/30101 ,  G06T2207/30172

摘要： An ultrasound system for planning a surgical implantation of a prosthetic aortic valve produces three dimensional images of the aortic root region of a patient. An electronic model of an aortic root is accessed and fitted to the aortic root in a three dimensional ultrasound image. Preferably the aortic root model exhibits closed contour cross-sections which are fitted to the endothelial lining of the aortic root in the ultrasound image. A medial axis of the fitted model is identified and radii measured from the medical axis to the border of the fitted model. The radii are joined to identify a surface forming a mesh model fitted to the aortic root anatomy of the patient. The shape and dimensions of the fitted model may be used to fabricate a custom prosthetic valve for aortic valve replacement.

摘要翻译： 用于规划假体主动脉瓣的手术植入的超声系统产生患者的主动脉根部区域的三维图像。 主动脉根部的电子模型在三维超声图像中被访问并适合于主动脉根部。 优选地，主动脉根部模型显示封闭的轮廓横截面，其被配合到超声图像中主动脉根部的内皮衬里。 识别拟合模型的中轴，并从医学轴线到拟合模型的边界测量半径。 连接半径以识别形成拟合到患者的主动脉根解剖结构的网格模型的表面。 拟合模型的形状和尺寸可用于制造用于主动脉瓣置换的定制假体瓣膜。

公开(公告)号：US08340744B2

公开(公告)日：2012-12-25

申请号：US12096995

申请日：2006-12-08

申请人： Joerg Bredno ,  Alexandra Groth ,  Juergen Weese ,  Antonius Johannes Cornelius Bruijns ,  Peter Maria Johannes Rongen ,  Ronaldus Petrus Johannes Hermans ,  Heidrun Steinhauser

发明人： Joerg Bredno ,  Alexandra Groth ,  Juergen Weese ,  Antonius Johannes Cornelius Bruijns ,  Peter Maria Johannes Rongen ,  Ronaldus Petrus Johannes Hermans ,  Heidrun Steinhauser

IPC分类号： A61B6/00 ,  G06K9/00 ,  G06G7/58

CPC分类号： G01R33/5635 ,  A61B5/0275 ,  A61B5/0456 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B8/06 ,  A61M5/007 ,  A61M5/1723 ,  A61M2230/04 ,  G01R33/281 ,  G01R33/5601 ,  G06T7/0012 ,  G06T7/20 ,  G06T2207/30101

摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.

摘要翻译： 提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。 一旦知道了心脏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而使准静态，常规流动获取传递到随后的可视化和分析过程。 还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达 因此在获取血流序列时控制主要不需要的变量之一。

公开(公告)号：US08160332B2

公开(公告)日：2012-04-17

申请号：US12443490

申请日：2007-09-28

申请人： Jens Von Berg ,  Bernd Hofmann ,  Cristian Lorenz ,  Olivier Ecabert ,  Jochen Peters ,  Juergen Weese

发明人： Jens Von Berg ,  Bernd Hofmann ,  Cristian Lorenz ,  Olivier Ecabert ,  Jochen Peters ,  Juergen Weese

IPC分类号： G06K9/00

CPC分类号： G06T7/30 ,  A61B5/055 ,  A61B6/504 ,  A61B6/5229 ,  A61B8/0891 ,  A61B8/5238 ,  G06F19/00 ,  G06T2207/20044 ,  G06T2207/30101 ,  Y10S128/922

摘要： The invention relates to a system (100) for registering a vessel model with an image data set based on a joined model comprising a reference object model and the vessel model, the system comprising: a placement unit (110) for placing the joined model in a space of the image data set, thereby creating a placed joined model comprising a placed reference object model and a placed vessel model; a computation unit (120) for computing a deformation field based on a landmark displacement field comprising displacements of landmarks of the placed reference object model relative to corresponding landmarks in the image data set; a transformation unit (130) for transforming the placed joined model using the deformation field, thereby creating a transformed joined model comprising a transformed reference object model and a transformed vessel model; and a registration unit (140) for registering the transformed vessel model with the image data set based on modifying the transformed vessel model and optimizing an objective function of the modified transformed vessel model, wherein the objective function comprises a location-prior term based on a localization of the modified transformed vessel model relative to the transformed joined model. Hence, the system is arranged to model a vessel taking into account the localization of a vessel model relative to a reference anatomical structure described by a reference model.

摘要翻译： 本发明涉及一种用于根据包括参考对象模型和血管模型的联合模型将具有图像数据集的血管模型登记的系统（100），所述系统包括：放置单元（110），用于将所连接的模型放置在 图像数据集合的空间，从而创建包括放置的参考对象模型和放置的容器模型的放置的连接模型; 计算单元（120），用于基于地标位移场计算变形场，所述地标位移场包括相对于所述图像数据组中的对应地标放置的所述参考对象模型的界标的位移; 变换单元（130），用于使用变形场来变换放置的接合模型，从而创建包括变换的参考对象模型和变换的容器模型的变换的连接模型; 以及注册单元（140），用于基于修改所述经变换的血管模型并优化所述经修改的转化的血管模型的目标函数，将经变换的血管模型与所述图像数据集进行登记，其中所述目标函数包括基于 修改的转化血管模型相对于转化的连接模型的定位。 因此，该系统被设置成考虑到血管模型相对于由参考模型描述的参考解剖结构的定位来建模血管。

公开(公告)号：US08150490B2

公开(公告)日：2012-04-03

申请号：US11815878

申请日：2006-02-13

申请人： Alexandra Groth ,  Juergen Weese ,  Joerg Bredno

发明人： Alexandra Groth ,  Juergen Weese ,  Joerg Bredno

IPC分类号： A61B6/00

CPC分类号： A61B6/507 ,  A61B5/4839 ,  A61B5/489 ,  A61B6/481 ,  A61B6/504 ,  A61M2005/14292 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/70 ,  G06T2207/20012 ,  G06T2207/30101

摘要： An apparatus determines an injection point for targeted drug delivery into a patient's body by injection of the drug into a vessel feeding a target area including a target. To provide the interventionalist with an objective and quantitative assessment of potential drug injection points instead of letting him rely on his subjective impression from the visual inspection of DSA sequences, a processor (4) includes an identification routine (41) for identification of a vessel tree topology of vessels feeding the target area, a flow determination routine (42) for determining the percentage of drug material delivered to said target after injection into different potential injection points in the vessel tree, a selection routine (43) for selecting as optimal injection point the potential injection point resulting in the highest percentage of drug delivery to the target.

摘要翻译： 装置通过将药物注射到进食包括靶的靶区域的血管中来确定靶向药物向患者体内输送的注射点。 为了向介入者提供对潜在药物注射点的客观和定量评估，而不是让他依赖于他对DSA序列的视觉检查的主观印象，处理器（4）包括用于识别血管树的识别程序（41） 供给目标区域的血管的拓扑结构，用于确定在注射到血管树中的不同潜在注射点之后输送到所述靶的药物材料的百分比的流量确定程序（42），用于选择最佳注射点的选择程序 潜在的注射点导致药物递送至目标的最高百分比。

公开(公告)号：US08144950B2

公开(公告)日：2012-03-27

申请号：US12097855

申请日：2006-12-14

申请人： Jochen Peters ,  Olivier Ecabert ,  Juergen Weese ,  Christian Lorenz ,  Jens Von Berg

发明人： Jochen Peters ,  Olivier Ecabert ,  Juergen Weese ,  Christian Lorenz ,  Jens Von Berg

IPC分类号： G06K9/00

CPC分类号： G06T9/001 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10081 ,  G06T2207/20081 ,  G06T2207/30101

摘要： Method and system for facilitating post-processing of images using deformable meshes in which a deformable mesh model of an object such as an organ is extended by attaching information thereon in order to simplify and/or facilitate a desired post-processing task so that the post-processing task effected when the mesh is applied to the same object in an additional image can expeditiously use this information. The information may be attached to the mesh after its creation, for example, upon segmentation of the same object in some training image. The post-processing task can therefore be performed automatically without user interaction upon segmentation of the object in the additional image. Information is encoded on the mesh by enumerating a list of triangles or vertices of the mesh which have to be considered in the subsequent, post-processing task and by optionally providing additional parameters defining the precise post-processing algorithm(s) to be used.

摘要翻译： 使用可变形网格促进图像后处理的方法和系统，其中通过在其上附加信息来扩展诸如器官的对象的可变形网格模型，以简化和/或促进期望的后处理任务，使得该帖子 当将网格应用于附加图像中的同一对象时，处理任务即可快速使用此信息。 信息可以在其创建之后附加到网格上，例如，在一些训练图像中对相同对象进行分割时。 因此，在附加图像中的对象的分割之后，可以自动执行后处理任务，而无需用户交互。 通过枚举在后续的后处理任务中必须考虑的网格的三角形或顶点列表以及可选地提供定义要使用的精确后处理算法的附加参数，将信息编码在网格上。

公开(公告)号：US20110124976A1

公开(公告)日：2011-05-26

申请号：US13055792

申请日：2009-07-22

申请人： Joerg Sabczynski ,  Steffen Renisch ,  Ingwer-Curt Carlsen ,  Sven Kabus ,  Roland Opfer ,  Michael Kaus ,  Karl Antonin Bzdusek ,  Juergen Weese ,  Vladimir Pekar

发明人： Joerg Sabczynski ,  Steffen Renisch ,  Ingwer-Curt Carlsen ,  Sven Kabus ,  Roland Opfer ,  Michael Kaus ,  Karl Antonin Bzdusek ,  Juergen Weese ,  Vladimir Pekar

IPC分类号： A61B5/00 ,  G06G7/60

CPC分类号： G06F19/3481 ,  A61B2034/105 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N5/103 ,  A61N7/02 ,  A61N2005/1041 ,  G06F19/321 ,  G06F19/324 ,  G16H10/60 ,  G16H50/20 ,  G16H50/50

摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.

摘要翻译： 治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204） 基于模型治疗和治疗方案。 在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否 基于患者的已知状态，候选参数组合适合于患者。

公开(公告)号：US20110002517A1

公开(公告)日：2011-01-06

申请号：US12920330

申请日：2009-03-02

申请人： Sabine Mollus ,  Joerg Bredno ,  Juergen Weese ,  Drazenko Babic

发明人： Sabine Mollus ,  Joerg Bredno ,  Juergen Weese ,  Drazenko Babic

IPC分类号： G06T7/00

CPC分类号： G06T17/00 ,  G16H50/50

摘要： A method of analyzing a tube system in particular by image processing of images of the tube system is provided by the present invention. In order to achieve a simulation of a medium flow through a calculated tube model, the present invention gathers a tube model from a specific tube data set. By defining the necessary parameters of a virtual injection of the medium by the user, the medium flows through the model. Using this displayed simulation for generating at least two images leads to an artificial image sequence that might support a person, which wants to examine a real structure, that corresponds to the calculated model. This might be seen in.

摘要翻译： 通过本发明提供了一种分析管系统的方法，特别是通过管系统的图像的图像处理来分析管系统。 为了通过计算的管模型实现介质流的模拟，本发明从特定的管数据集中收集管模型。 通过定义用户对介质的虚拟注入的必要参数，介质流经模型。 使用该显示的模拟来生成至少两个图像，导致可能支持想要检查与计算出的模型相对应的真实结构的人的人造图像序列。 这可能在。

公开(公告)号：US20100046815A1

公开(公告)日：2010-02-25

申请号：US12443490

申请日：2007-09-28

申请人： Jens Von Berg ,  Bernd Hofmann ,  Cristian Lorenz ,  Olivier Ecabert ,  Jochen Peters ,  Juergen Weese

发明人： Jens Von Berg ,  Bernd Hofmann ,  Cristian Lorenz ,  Olivier Ecabert ,  Jochen Peters ,  Juergen Weese

IPC分类号： G06K9/00

CPC分类号： G06T7/30 ,  A61B5/055 ,  A61B6/504 ,  A61B6/5229 ,  A61B8/0891 ,  A61B8/5238 ,  G06F19/00 ,  G06T2207/20044 ,  G06T2207/30101 ,  Y10S128/922

摘要： The invention relates to a system (100) for registering a vessel model with an image data set based on a joined model comprising a reference object model and the vessel model, the system comprising: a placement unit (110) for placing the joined model in a space of the image data set, thereby creating a placed joined model comprising a placed reference object model and a placed vessel model; a computation unit (120) for computing a deformation field based on a landmark displacement field comprising displacements of landmarks of the placed reference object model relative to corresponding landmarks in the image data set; a transformation unit (130) for transforming the placed joined model using the deformation field, thereby creating a transformed joined model comprising a transformed reference object model and a transformed vessel model; and a registration unit (140) for registering the transformed vessel model with the image data set based on modifying the transformed vessel model and optimizing an objective function of the modified transformed vessel model, wherein the objective function comprises a location-prior term based on a localization of the modified transformed vessel model relative to the transformed joined model. Hence, the system is arranged to model a vessel taking into account the localization of a vessel model relative to a reference anatomical structure described by a reference model.

摘要翻译： 本发明涉及一种用于根据包括参考对象模型和血管模型的联合模型将具有图像数据集的血管模型登记的系统（100），该系统包括：一个放置单元（110），用于将连接的模型放置在 图像数据集合的空间，从而创建包括放置的参考对象模型和放置的容器模型的放置的连接模型; 计算单元（120），用于基于地标位移场计算变形场，所述地标位移场包括相对于所述图像数据组中的对应地标放置的所述参考对象模型的界标的位移; 变换单元（130），用于使用变形场来变换放置的接合模型，从而创建包括变换的参考对象模型和变换的容器模型的变换的连接模型; 以及注册单元（140），用于基于修改所述经变换的血管模型并优化所述经修改的转化的血管模型的目标函数，将经变换的血管模型与所述图像数据集进行登记，其中所述目标函数包括基于 修改的转化血管模型相对于转化的连接模型的定位。 因此，该系统被设置成考虑到血管模型相对于由参考模型描述的参考解剖结构的定位来建模血管。

公开(公告)号：US20080319309A1

公开(公告)日：2008-12-25

申请号：US12096995

申请日：2006-12-08

申请人： Joerg Bredno ,  Alexandra Groth ,  Juergen Weese ,  Tom Bruijns ,  Peter M.J. Rongen ,  Roel Hermans ,  Heidrun Steinhauser

发明人： Joerg Bredno ,  Alexandra Groth ,  Juergen Weese ,  Tom Bruijns ,  Peter M.J. Rongen ,  Roel Hermans ,  Heidrun Steinhauser

IPC分类号： A61B5/055 ,  A61B6/00

CPC分类号： G01R33/5635 ,  A61B5/0275 ,  A61B5/0456 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B8/06 ,  A61M5/007 ,  A61M5/1723 ,  A61M2230/04 ,  G01R33/281 ,  G01R33/5601 ,  G06T7/0012 ,  G06T7/20 ,  G06T2207/30101

摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.

摘要翻译： 提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。 一旦知道心搏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而将“准静态”常规流量采集传递给随后的可视化和分析过程。 还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达 因此在获取血流序列时控制主要不需要的变量之一。