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86 条记录 (耗时 0.046 秒)

    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters
    62.
    发明授权
    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters 失效
    N-烷基1,4-二羟基吡啶二羧酸酯

    公开(公告)号：US5234935A

    公开(公告)日：1993-08-10

    申请号：US680454

    申请日：1991-04-04

    申请人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    发明人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    IPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/451 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90

    CPC分类号： C07D211/90

    摘要： Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl,R.sup.3 represents hydrogen or cyano, orR.sup.2 and R.sup.3 together form a fused benzo ring,R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, andR.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms.Many of the compounds are new.

    摘要翻译： 使用其中R 1表示氢，硝基，氰基，三氟甲基，三氟甲氧基，卤素或甲基的式（I）的N-烷基化1,4-二氢吡啶，改善循环，对血压影响最小，R 2表示氢， 卤素，硝基，羟基，三氟甲基或甲基，R 3表示氢或氰基，或R 2和R 3一起形成稠合的苯并环，R 4和R 5相同或不同，表示具有至多8个碳原子的直链或支链烷基， 任选被具有至多4个碳原子的烷氧基取代，R6代表具有至多10个碳原子的直链或支链烷基或代表具有3至7个碳原子的环烷基。 许多化合物是新的。

    Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics
    63.
    发明授权
    Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics 失效
    新的1-烷基取代的1,4-二氢吡啶内酯抗糖尿病药

    公开(公告)号：US5026714A

    公开(公告)日：1991-06-25

    申请号：US436157

    申请日：1989-11-13

    申请人： Siegfried Goldmann ,  Friedrich Bossert ,  Hilmar Bischoff ,  Dieter Petzinna ,  Walter Puls ,  Klaus Schlossmann

    发明人： Siegfried Goldmann ,  Friedrich Bossert ,  Hilmar Bischoff ,  Dieter Petzinna ,  Walter Puls ,  Klaus Schlossmann

    IPC分类号： A61K31/435 ,  A61P3/08 ,  A61P3/10 ,  C07D211/90 ,  C07D491/04 ,  C07D491/048

    CPC分类号： C07D491/04 ,  C07D211/90

    摘要： Novel blood sugar-lowering dihydropyridinelactones of the formula ##STR1## in which R represents halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, C.sub.1 -C.sub.10 -alkylsulphonyl, cyano, C.sub.1 -C.sub.6 - mono- or polyfluoroalkyl, C.sub.1 -C.sub.6 -mono- or polyfluoroalkoxy or nitro,R.sup.1 represents hydrogen, halogen or C.sub.1 -C.sub.10 -alkyl or C.sub.1 -C.sub.10 -alkoxy,R.sup.2 represents a C.sub.1 -C.sub.20 hydrocarbon radical which can optionally be interrupted or substituted,R.sup.3 represents hydrogen NH.sub.2, CHO, CN or a C.sub.1 -C.sub.6 hydrocarbon radical which can be interrupted in the chain, andR.sup.4 represents a C.sub.1 -C.sub.10 -alkyl or C.sub.2 -C.sub.10 -alkenyl radical which can optionally be interrupted or substituted with the proviso that R is not CF.sub.3 if R.sup.2 represents C.sub.2 H.sub.5.

    摘要翻译： 式中，R表示卤素，C 1 -C 10 - 烷基，C 1 -C 10 - 烷氧基，C 1 -C 10 - 烷硫基，C 1 -C 10 - 烷基亚磺酰基，C 1 -C 10 - 烷基磺酰基，氰基， C 1 -C 6 - 单 - 或多氟烷基，C 1 -C 6 - 单 - 或多氟烷氧基或硝基，R 1表示氢，卤素或C 1 -C 10 - 烷基或C 1 -C 10 - 烷氧基，R 2表示可任选地为 中间或取代的，R 3表示可在该链中中断的氢NH 2，CHO，CN或C 1 -C 6烃基，R 4表示可任选被中断或取代的C 1 -C 10 - 烷基或C 2 -C 10 - 烯基 条件是如果R2表示C2H5，R不为CF3。

    Bromo-phenyl substituted thiazolyl dihydropyrimidines
    64.
    发明授权
    Bromo-phenyl substituted thiazolyl dihydropyrimidines 有权
    溴 - 苯基取代的噻唑基二氢嘧啶

    公开(公告)号：US08236797B2

    公开(公告)日：2012-08-07

    申请号：US12664392

    申请日：2008-06-18

    申请人： Siegfried Goldmann ,  Jing Li ,  Yi Song Liu

    发明人： Siegfried Goldmann ,  Jing Li ,  Yi Song Liu

    IPC分类号： A61K31/535 ,  C07D413/14

    CPC分类号： C07D417/04 ,  C07D417/14

    摘要： This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.

    摘要翻译： 本发明涉及溴 - 苯基取代的噻唑基二氢嘧啶，其制备方法和用作治疗和预防乙型肝炎感染的药物。 本发明还涉及包含二氢嘧啶，一种或多种抗病毒剂和任选的用于治疗和预防HBV感染的免疫调节剂的组合物。