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公开(公告)号:US08841263B2
公开(公告)日:2014-09-23
申请号:US13525900
申请日:2012-06-18
申请人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译: 本发明提供可用作下式的治疗剂的大环化合物:或其药学上可接受的盐,酯,N-氧化物或前药,其中T,R 1,R 2,R 3,D,E,F和G如上所定义 这里。 更具体地,这些化合物可用作抗感染,抗增殖,抗炎和促动力剂。
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公开(公告)号:US08399660B2
公开(公告)日:2013-03-19
申请号:US11921838
申请日:2006-06-08
申请人: Shili Chen , Rongliang Lou , Yusheng Wu , Jiacheng Zhou , Roger Hanselmann
发明人: Shili Chen , Rongliang Lou , Yusheng Wu , Jiacheng Zhou , Roger Hanselmann
IPC分类号: A61K31/541 , A61P25/24 , C07D413/10
CPC分类号: C07D249/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07F7/0814
摘要: The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译: 本发明涉及制备三唑的方法。 这些化合物可用作抗感染,抗增殖,抗炎和促动力。
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公开(公告)号:US20130066076A1
公开(公告)日:2013-03-14
申请号:US13618091
申请日:2012-09-14
申请人: Yusheng Wu , Shili Chen , Yi Chen , Roger Hanselmann , Rongliang Lou , Jiacheng Zhou
发明人: Yusheng Wu , Shili Chen , Yi Chen , Roger Hanselmann , Rongliang Lou , Jiacheng Zhou
IPC分类号: C07D413/10 , C07D413/14 , C07D417/10 , C07D413/12 , C07D263/24
CPC分类号: C07D263/20 , C07D263/32 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
摘要: The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译: 本发明涉及制备联芳基恶唑烷酮的方法。 这些化合物可用作抗感染,抗增殖,抗炎和促动力。
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公开(公告)号:US20120252747A1
公开(公告)日:2012-10-04
申请号:US13525900
申请日:2012-06-18
申请人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号: A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译: 本发明提供可用作下式的治疗剂的大环化合物:或其药学上可接受的盐,酯,N-氧化物或前药,其中T,R 1,R 2,R 3,D,E,F和G如上所定义 这里。 更具体地,这些化合物可用作抗感染,抗增殖,抗炎和促动力剂。
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公开(公告)号:US08202843B2
公开(公告)日:2012-06-19
申请号:US10590782
申请日:2005-02-25
申请人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人: Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译: 本发明提供可用作下式的治疗剂的大环化合物:或其药学上可接受的盐,酯,N-氧化物或前药,其中T,R 1,R 2,R 3,D,E,F和G如上所定义 这里。 更具体地,这些化合物可用作抗感染,抗增殖,抗炎和促动力剂。
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公开(公告)号:US20080045585A1
公开(公告)日:2008-02-21
申请号:US10590782
申请日:2005-02-25
申请人: Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人: Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号: A61K31/335 , A61P43/00 , C07D269/00
摘要: The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译: 本发明提供可用作治疗剂的大环化合物。 更具体地,这些化合物可用作抗感染,抗增殖,抗炎和促动力剂。
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公开(公告)号:US06969726B2
公开(公告)日:2005-11-29
申请号:US10859476
申请日:2004-06-02
申请人: Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: A61K31/421 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D255/02 , C07D257/04 , C07D263/20 , C07D263/32 , C07D263/38 , C07D403/10 , C07D413/02 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D473/00 , C07D487/04
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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公开(公告)号:US09193731B2
公开(公告)日:2015-11-24
申请号:US13501825
申请日:2010-10-15
申请人: Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人: Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号: C07D487/04 , A61P31/04 , C07D491/048 , C07D519/00
CPC分类号: C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
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公开(公告)号:US20120220566A1
公开(公告)日:2012-08-30
申请号:US13501825
申请日:2010-10-15
申请人: Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人: Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号: A61K31/551 , A61K31/522 , A61P31/04 , A61K31/541 , A61K31/496 , A61P31/00 , C07D487/04 , A61K31/5377
CPC分类号: C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译: 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗,预防和降低人类和动物中微生物感染的风险。
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70.
公开(公告)号:US20100234591A1
公开(公告)日:2010-09-16
申请号:US12767380
申请日:2010-04-26
申请人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人: Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号: C07D417/10 , C07D413/10
CPC分类号: C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译: 本发明一般涉及抗感染,抗增殖,抗炎和促动力的领域。 更具体地,本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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