公开(公告)号：US07754749B2

公开(公告)日：2010-07-13

申请号：US11915938

申请日：2006-05-30

申请人： Christopher Koradin ,  Wolfgang Von Deyn ,  Michael Rack ,  Thomas Zierke ,  David G. Kuhn ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi

发明人： Christopher Koradin ,  Wolfgang Von Deyn ,  Michael Rack ,  Thomas Zierke ,  David G. Kuhn ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi

IPC分类号： A01N43/653 ,  A61K31/4196 ,  A01P7/04 ,  C07D249/08

CPC分类号： C07D249/08

摘要： Compounds of formula (I) wherein X is chloro or bromo; Y is chloro or trifluoromethyl; and A and B are hydrogen or methyl with the proviso that one of A or B must be methyl; or the enantiomers or salts thereof, use of compounds of formula I for combating insects or acarids and for treating, controlling, preventing or protecting animals against infestation or infection by parasites, and compositions comprising compounds of formula I.

摘要翻译： 式（I）的化合物，其中X是氯或溴; Y是氯或三氟甲基; A和B为氢或甲基，条件是A或B之一必须为甲基; 或其对映异构体或其盐，使用式I化合物来防治昆虫或螨虫，以及治疗，控制，预防或保护动物免受寄生虫感染或感染，以及包含式I化合物的组合物。

公开(公告)号：US07655600B2

公开(公告)日：2010-02-02

申请号：US10583710

申请日：2004-12-22

申请人： Markus Kordes ,  Michael Hofmann ,  Michael Puhl ,  Norbert Götz ,  Michael Rack ,  Ernst Baumann ,  Wolfgang von Deyn ,  Thomas Schmidt ,  Livio Tedeschi ,  Michael F. Treacy ,  Deborah L. Culbertson ,  Toni Bucci ,  David G. Kuhn

发明人： Markus Kordes ,  Michael Hofmann ,  Michael Puhl ,  Norbert Götz ,  Michael Rack ,  Ernst Baumann ,  Wolfgang von Deyn ,  Thomas Schmidt ,  Livio Tedeschi ,  Michael F. Treacy ,  Deborah L. Culbertson ,  Toni Bucci ,  David G. Kuhn

IPC分类号： A01N43/76 ,  A01N43/78 ,  C07D277/04 ,  C07D277/08

CPC分类号： C07D263/28 ,  A01N43/76 ,  A01N43/78 ,  C07D277/18

摘要： The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula (I) wherein A is a radical of the formulae A′ or A2: NRA′A2 and wherein m is 0, 1, 2, 3, 4 or 5, n is 0, 1, 2, 3, 4 or 5, X is sulfur or oxygen, and wherein the variables R1, R2, R3, R4, R5a, R5b, R5c, R5d are as defined in the claims, and to the agriculturally acceptable salts thereof. The invention relates also to a method of combating animal pests, selected from insects, arachnids and nematodes and to a method for protecting crops from attack or infestation by insects, arachnids or nematodes, which comprises contacting a crop with a pesticidally effective amount of a 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula I and/or at least one salt thereof.

摘要翻译： 本发明涉及通式（I）的1-（唑啉-2-基）氨基-1,2-二苯基乙烷化合物，其中A为式A'或A2的基团：NRA'A2，其中m为0 ，1,2,3,4或5，n为0,1,2,3,4或5，X为硫或氧，其中R1，R2，R3，R4，R5a，R5b，R5c，R5d 如权利要求书中所定义，以及其农业上可接受的盐。 本发明还涉及一种对抗昆虫，蜘蛛和线虫的动物害虫的方法，还涉及一种保护作物免受昆虫，蜘蛛或线虫袭击或侵染的方法，其中包括使农作物与杀虫有效量的1 - （唑啉-2-基）氨基-1,2-二苯基乙烷化合物和/或其至少一种盐。

公开(公告)号：US20090280982A1

公开(公告)日：2009-11-12

申请号：US12440120

申请日：2007-09-11

申请人： Michael Puhl ,  Liliana Parra Rapado ,  Michael Rack ,  Jan Klaas Lohmann ,  Wassilios Grammenos ,  Wolfgang von Deyn ,  Jürgen Langewald ,  Ernst Baumann ,  Hassan Oloumi-Sadeghi ,  Douglas D. Anspaugh ,  Deborah L. Culbertson

发明人： Michael Puhl ,  Liliana Parra Rapado ,  Michael Rack ,  Jan Klaas Lohmann ,  Wassilios Grammenos ,  Wolfgang von Deyn ,  Jürgen Langewald ,  Ernst Baumann ,  Hassan Oloumi-Sadeghi ,  Douglas D. Anspaugh ,  Deborah L. Culbertson

IPC分类号： A01N25/26 ,  C07D215/36 ,  A01N43/42 ,  A01P7/00 ,  A01P7/04 ,  A01P7/02 ,  A01P5/00

CPC分类号： C07D215/12 ,  C07D215/18 ,  C07D215/20

摘要： The present invention relates to novel biphenyl-4-sulfonicacid (quinolin-4-ylmethyl)-amide compounds of formula (I) wherein R1 and R2 are halogen, OH, CN, NH2, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-alkyl-sulfinyl, C1-C6-alkylsulfonyl, etc.; R3, R4, R5, R6 are halogen, H, CN, NH2, NO2, OH, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkyl-sulfonyl, etc.; m is 0, 1, 2, 3, 4, or 5; and n is 1 or 2; and the N-oxides and salts thereof, and their use for combating arthropod pests and nematodes, and also to compositions comprising such compounds as active component. The present invention also relates to a method for controlling arthropod pests or nematode pests.

摘要翻译： 本发明涉及式（I）的新型联苯-4-磺酸（喹啉-4-基甲基） - 酰胺化合物，其中R 1和R 2是卤素，OH，CN，NH 2，NO 2，C 1 -C 6烷基，C 2 -C 6 - 烯基，C2-C6-炔基，C3-C7-环烷基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-卤代烷氧基，C1-C6-烷硫基，C1-C6烷基亚磺酰基，C1-C6 - 烷基磺酰基等; R3，R4，R5，R6是卤素，H，CN，NH2，NO2，OH，C1-C6-烷基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6-卤代烷氧基，C1-C6-烷硫基， C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基等; m为0,1,2,3,4或5; n为1或2; 及其N-氧化物及其盐，以及它们用于防治节肢动物害虫和线虫的用途，以及包含这些化合物作为活性成分的组合物。 本发明还涉及一种防治节肢动物害虫或线虫害虫的方法。

公开(公告)号：US07544637B2

公开(公告)日：2009-06-09

申请号：US11791398

申请日：2005-11-24

申请人： Wolfgang von Deyn ,  Henricus Maria Martinus Bastiaans ,  Matthias Pohlman ,  Michael Rack ,  Ernst Baumann ,  Michael Puhl ,  Michael Hofmann ,  Livio Tedeschi ,  Markus Kordes ,  Christopher Koradin ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Henry van Tuyl Cotter ,  Hassan Oloumi-Sadeghi

发明人： Wolfgang von Deyn ,  Henricus Maria Martinus Bastiaans ,  Matthias Pohlman ,  Michael Rack ,  Ernst Baumann ,  Michael Puhl ,  Michael Hofmann ,  Livio Tedeschi ,  Markus Kordes ,  Christopher Koradin ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Henry van Tuyl Cotter ,  Hassan Oloumi-Sadeghi

IPC分类号： C07C311/15 ,  A01N25/00 ,  A01N25/26 ,  A01P17/00 ,  A61K31/18

CPC分类号： C07C319/20 ,  A01N41/06 ,  C07C311/29 ,  C07C323/62

摘要： The invention relates to 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds I where the variables Alk and R1 to R5 are as defined in claim 1, and/or to their agriculturally useful salts. Moreover, the present invention relates to the use of compounds I and/or their salts for combating animal pests; agricultural compositions comprising such an amount of at least one compound of the general formula I and/or at least one agriculturally useful salt of I and at least one inert liquid and/or solid agronomically acceptable carrier that it has a pesticidal action and, if desired, at least one surfactant; and a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the formula I and/or at least one agriculturally acceptable salt thereof. a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a 2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the general formula I

摘要翻译： 本发明涉及2-氰基-3-（卤代）烷氧基 - 苯磺酰胺化合物I，其中变量Alk和R1至R5如权利要求1所定义，和/或其农业上有用的盐。 此外，本发明涉及化合物I和/或其盐对抗动物害虫的用途; 包含至少一种式I化合物和/或至少一种农业上可用的I盐和至少一种惰性液体和/或其农业上可接受的载体的农药组合物，其具有杀虫作用，如果需要 ，至少一种表面活性剂; 以及一种对抗动物害虫的方法，包括使动物有害生物，其习惯，繁殖地，食物供应，植物，种子，土壤，区域，动物害虫生长或可能生长的区域，材料或环境，或材料，植物 ，防止动物攻击或侵染的种子，土壤，表面或空间与杀虫有效量的式I的至少一个2-氰基-3-（卤代）烷氧基 - 苯磺酰胺化合物和/或至少一种农业上可接受的盐 其中。 包括从土壤和叶面昆虫中保护种子免受土壤昆虫和所得植物的根和芽的方法，包括在种子播种前和/或后发芽后将种子与2-氰基-3-（卤代）烷氧基 - 苯磺酰胺 通式I的化合物

公开(公告)号：US20080194404A1

公开(公告)日：2008-08-14

申请号：US11909452

申请日：2006-03-22

申请人： Wolfgang von Deyn ,  Florian Kaiser ,  Matthias Pohlman ,  Henricus Maria Martinus Bastiaans ,  Ernst Baumann ,  Michael Rack ,  Douglas D. Anspaugh ,  Henry Van Tuyl Cotter ,  Deborah L. Culbertson ,  Michael Hofmann ,  Carol Hicks

发明人： Wolfgang von Deyn ,  Florian Kaiser ,  Matthias Pohlman ,  Henricus Maria Martinus Bastiaans ,  Ernst Baumann ,  Michael Rack ,  Douglas D. Anspaugh ,  Henry Van Tuyl Cotter ,  Deborah L. Culbertson ,  Michael Hofmann ,  Carol Hicks

IPC分类号： A01N41/06 ,  A01P7/00

CPC分类号： A01N41/06 ,  A01N41/10

摘要： The present invention provides a method for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a sulphonyl compound of the general formula (I) where the variables R1 to R5 are as defined in claim 1.

摘要翻译： 本发明提供了一种保护种子免受土壤昆虫和幼苗根和土壤和叶面昆虫的芽的方法，其包括在播种前和/或在发芽前与种子接触之后，与通式（I）的磺酰基化合物接触，其中 变量R 1至R 5如权利要求1所定义。

公开(公告)号：US08598222B2

公开(公告)日：2013-12-03

申请号：US12990340

申请日：2009-05-04

申请人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Christopher Koradin ,  Michael Rack ,  Thomas Zierke ,  Martin Sukopp

发明人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Christopher Koradin ,  Michael Rack ,  Thomas Zierke ,  Martin Sukopp

IPC分类号： A61K31/415 ,  C07D231/14

CPC分类号： C07D409/12 ,  C07C251/76 ,  C07C251/84 ,  C07C251/86 ,  C07D231/14

摘要： The present invention relates to a process for preparing 1,3-substituted pyrazole compounds of the formula I in which X is especially a CX1X2X3 group in which X1, X2 and X3 are each independently especially hydrogen, fluorine or chlorine, R1 is C1-C4-alkyl or cyclopropyl, and R2 is hydrogen, CN or a CO2R2a group in which R2a is especially C1-C6-alkyl, comprising the following steps: i) reacting a compound of the formula II with a hydrazone of the formula III where the variables X and R2 in formula II are each as defined for formula I, Y is oxygen, an NRy1 group or an [NRy2Ry3]+Z− group, R3 is OR3a or an NR3bR3c group, and where the variable R1 in formula III is as defined for formula I, R4 and R5 are each independently hydrogen, C1-C6-alkyl, optionally substituted phenyl, where at least one of the R4 and R5 radicals is different from hydrogen, and where R4 and R5 together with the carbon atom to which they are bonded may also be a 5- to 10-membered saturated carbocycle; ii) treating the reaction product obtained with an acid in the presence of water.

摘要翻译： 本发明涉及一种制备式I的1,3-取代吡唑化合物的方法，其中X特别是X 1，X 2和X 3各自独立地是氢，氟或氯，R 1是C 1 -C 4 - 烷基或环丙基，并且R 2是氢，CN或其中R 2a特别是C 1 -C 6 - 烷基的CO 2 R 2 a基团，包括以下步骤：i）使式II化合物与式III的腙反应，其中变量 式II中的X和R 2各自如式I所定义，Y是氧，NRy1基或[NRy2Ry3] + Z-基，R3是OR3a或NR3bR3c基团，其中式III中的变量R1如所定义 对于式I，R 4和R 5各自独立地为氢，C 1 -C 6 - 烷基，任选取代的苯基，其中R 4和R 5基团中的至少一个不同于氢，并且其中R 4和R 5与它们的碳原子一起 键也可以是5至10元饱和碳环; ii）在水存在下用酸处理反应产物。

公开(公告)号：US08350046B2

公开(公告)日：2013-01-08

申请号：US12990892

申请日：2009-05-06

申请人： Wolfgang Reichert ,  Christopher Koradin ,  Sebastian Peer Smidt ,  Volker Maywald ,  Bernd Wolf ,  Michael Rack ,  Thomas Zierke ,  Michael Keil

发明人： Wolfgang Reichert ,  Christopher Koradin ,  Sebastian Peer Smidt ,  Volker Maywald ,  Bernd Wolf ,  Michael Rack ,  Thomas Zierke ,  Michael Keil

IPC分类号： C07D213/82 ,  C07D231/14

CPC分类号： C07C231/02 ,  C07C2601/14 ,  C07D213/82 ,  C07D231/14 ,  C07D231/16 ,  C07C233/65 ,  C07C233/75

摘要： A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.

摘要翻译： 制备式（I）的芳基羧酰胺的方法，其中Ar =单 - 三取代的苯基，吡啶基或吡唑基环，其中取代基选自卤素，C 1 -C 4 - 烷基和C 1 -C 4卤代烷基; M =噻吩基或苯基，其可以带有卤素取代基; Q =直接键合，亚环丙基，稠合双环[2.2.1]庚烷或双环[2.2.1]庚烯环; R1 =氢，卤素，C1-C6-烷基，C1-C4-烷氧基，C1-C4-卤代烷氧基，一至三取代的苯基，其中取代基选自卤素和三氟甲硫基，或环丙基; 通过使式（II）的酰氯与芳基胺（III）在合适的非水溶剂中反应，其中在没有辅助碱的情况下，a）最初加入酰氯（II），b） 建立0至700毫巴，c）芳基胺（III）以约化学计量的量计量，并且d）分离产物的值。

公开(公告)号：US20080214878A1

公开(公告)日：2008-09-04

申请号：US11911971

申请日：2006-04-21

申请人： Michael Rack ,  Sebastian Peer Smidt ,  Manuel Budich ,  Volker Maywald ,  Michael Keil ,  Bernd Wolf

发明人： Michael Rack ,  Sebastian Peer Smidt ,  Manuel Budich ,  Volker Maywald ,  Michael Keil ,  Bernd Wolf

IPC分类号： C07C17/12

CPC分类号： C07C25/13 ,  C07C17/12 ,  C07C17/208 ,  C07C17/23

摘要： Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X=fluorine of H, Z=nitro, bromo or chloro and n=0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced.

摘要翻译： 由氟代苯制备1,3,5-三氟-2,4,6-三氯苯的方法，包括步骤A）和B）：A）氯化式（II）的氟代苯衍生物，其中X = H的氟， Z =硝基，溴或氯，n = 0或1-4，B）氟化蒸馏残余物并通过蒸馏分离由此制得的1,3,5-三氟-2,4,6-三氯苯。

公开(公告)号：US08314233B2

公开(公告)日：2012-11-20

申请号：US12990359

申请日：2009-04-30

申请人： Thomas Zierke ,  Volker Maywald ,  Michael Rack ,  Sebastian Peer Smidt ,  Michael Keil ,  Bernd Wolf ,  Christopher Koradin

发明人： Thomas Zierke ,  Volker Maywald ,  Michael Rack ,  Sebastian Peer Smidt ,  Michael Keil ,  Bernd Wolf ,  Christopher Koradin

IPC分类号： C07D295/145 ,  C07D211/34 ,  C07D265/30

CPC分类号： C07D231/14 ,  C07C229/30 ,  C07D295/145

摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.

摘要翻译： 本发明涉及式（I）的二氟甲基取代的吡唑-4-基羧酸及其酯，2-（氨基亚甲基）-4,4-二氟-3-氧代苦味酯的方法，其中R 1，R 2和 R 3彼此独立地是C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基或NR 2 R 3是5-至10-元杂环基， 式（I）的化合物，其中适当的3-氨基丙烯酸酯与二氟乙酰氟反应，以及在制备二氟甲基取代的吡唑-4-基羧酸及其酯的方法中使用式（I）的化合物。

公开(公告)号：US20110054183A1

公开(公告)日：2011-03-03

申请号：US12990892

申请日：2009-05-06

申请人： Wolfgang Reichert ,  Christopher Koradin ,  Sebastian Peer Smidt ,  Volker Maywald ,  Bernd Wolf ,  Michael Rack ,  Thomas Zierke ,  Michael Keil

发明人： Wolfgang Reichert ,  Christopher Koradin ,  Sebastian Peer Smidt ,  Volker Maywald ,  Bernd Wolf ,  Michael Rack ,  Thomas Zierke ,  Michael Keil

IPC分类号： C07D213/82 ,  C07D231/14

CPC分类号： C07C231/02 ,  C07C2601/14 ,  C07D213/82 ,  C07D231/14 ,  C07D231/16 ,  C07C233/65 ,  C07C233/75

摘要： A process for preparing arylcarboxamides of the formula (I) whereAr =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, Ci-C4-alkyl and C1-C4-haloalkyl;M =thienyl or phenyl, which may bear a halogen substituent;Q =direct bond, cyclopropylene, fused bicycio[2.2.1]heptane or bicyclo[2.2.1]heptene ring;R1 =hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl;by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base,a) the acid chloride (II) is initially charged,b) a pressure of from 0 to 700 mbar is established,c) the arylamine (III) is metered in in an approximately stoichiometric amount andd) the product of value is isolated.

摘要翻译： 制备式（I）的芳基甲酰胺的方法，其中Ar =单 - 三取代的苯基，吡啶基或吡唑基环，其中取代基选自卤素，C 1 -C 4烷基和C 1 -C 4卤代烷基; M =噻吩基或苯基，其可以带有卤素取代基; Q =直接键合，亚环丙基，稠合二环[2.2.1]庚烷或双环[2.2.1]庚烯环; R1 =氢，卤素，C1-C6-烷基，C1-C4-烷氧基，C1-C4-卤代烷氧基，一至三取代的苯基，其中取代基选自卤素和三氟甲硫基，或环丙基; 通过使式（II）的酰氯与芳基胺（III）在合适的非水溶剂中反应，其中在没有辅助碱的情况下，a）最初加入酰氯（II），b） 建立0至700毫巴，c）芳基胺（III）以约化学计量的量计量，并且d）分离产物的值。