公开(公告)号：US08050423B2

公开(公告)日：2011-11-01

申请号：US12165716

申请日：2008-07-01

申请人： Akira Yamauchi ,  Hiroyuki Tsurumi

发明人： Akira Yamauchi ,  Hiroyuki Tsurumi

IPC分类号： H04B15/00

CPC分类号： H03F3/68 ,  H03F2200/03

摘要： An n-channel integrated circuit device (n is an integer of 1 or greater) for muting an audio signal includes a control circuit configured to generate a control signal and a delayed control signal, a charging and discharging circuit configured to charge and discharge a time constant control terminal according to the control signal and the delayed control signal, an N-th voltage-to-current converting circuit (N is an integer from 1 to n) configured to generate a (2N−1)-th current corresponding to a voltage on the time constant control terminal and a (2N)-th current corresponding to an intermediate voltage, a (2N−1)-th mirror circuit configured to copy the (2N−1)-th current to generate (4N−3)-th and (4N−2)-th intermediate currents, a (2N)-th mirror circuit configured to copy the (2N)-th current to generate (4N−1)-th and (4N)-th intermediate currents, a (2N−1)-th selecting and combining circuit configured to combine a (2N−1)-th mute control current using the (4N−3)-th intermediate current and the (4N−1)-th intermediate current, and a (2N)-th selecting and combining circuit configured to combine a (2N)-th mute control current using the (4N−2)-th intermediate current and the (4N)-th intermediate current.

摘要翻译： 用于使音频信号静音的n沟道集成电路器件（n为1或更大的整数）包括被配置为产生控制信号和延迟的控制信号的控制电路，被配置为对时间进行充放电的充电和放电电路 恒定控制端子，根据控制信号和延迟的控制信号，配置为产生与第一电压对应的第（2N-1）电流的第N电压 - 电流转换电路（N为1至n的整数） 时间常数控制端子上的电压和与中间电压对应的第（2N）电流，配置成复制第（2N-1）个电流以产生（4N-3）电流的第（2N-1） 和第（4N-2）中间电流，第（2N）个第二镜电路，被配置为复制第（2N）个电流以产生（4N-1）和（4N）中间电流， （2N-1）个选择和组合电路，被配置为使用第（4N-3）个int（第2N-1）个int （4N-1）中间电流和第（2Nn）中间电流以及第（2N）个选择和组合电路，其被配置为使用（4N-2）中间电流和（4N-2）中间电流组合第（2N）个静音控制电流 （4N）中间电流。

公开(公告)号：US20100009908A1

公开(公告)日：2010-01-14

申请号：US12309583

申请日：2007-07-18

申请人： Nozomu Nishi ,  Mitsuomi Hirashima ,  Akira Yamauchi

发明人： Nozomu Nishi ,  Mitsuomi Hirashima ,  Akira Yamauchi

IPC分类号： A61K47/48

CPC分类号： C07K14/4726 ,  A61K38/00

摘要： Galectin 9, which is an immune function-controlling factor belonging to a new class that is different from known cytokines and is expected to be used as a therapeutic drug for various immune-related diseases such as an autoimmune disease, has disadvantages (such as high sensitivity to protease and poor solubility) to be solved in developing therapeutic drugs. Therefore, there is a need to overcome these disadvantages. Chemically modified galectin 9, prepared by conjugating a polymer (for example, poly(ethylene glycol: PEG) to galectin 9, in particular, stabilized galectin 9, is verified to exert higher solubility with improvements in pharmacodynamics and pharmacokinetics (for example, prolongation of action potential duration, such as prolongation of blood half-life and others) and in suppression of hemagglutination and thus has excellent characteristics as a drug.

摘要翻译： 作为属于与已知细胞因子不同的新类别的免疫功能调节因子的半乳凝素9预期被用作各种免疫相关疾病如自身免疫性疾病的治疗药物，具有缺点（例如高 对蛋白酶的敏感性和溶解性差）在开发治疗药物中得到解决。 因此，需要克服这些缺点。 验证通过将聚合物（例如，聚乙二醇：PEG）与半乳聚糖9（特别是稳定的半乳聚糖9）结合而制备的化学修饰的半乳凝素9，其药效学和药代动力学的改善（例如， 动作电位持续时间，如血液半衰期延长等），抑制血细胞凝集，作为药物具有优异的特性。

公开(公告)号：US20090023143A1

公开(公告)日：2009-01-22

申请号：US11905296

申请日：2007-09-28

申请人： Mitsuomi Hirashima ,  Akira Yamauchi ,  Toshiro Kageshita ,  Takanori Nakamura ,  Nozomu Nishi

发明人： Mitsuomi Hirashima ,  Akira Yamauchi ,  Toshiro Kageshita ,  Takanori Nakamura ,  Nozomu Nishi

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C07K16/18 ,  C07K16/26 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/4724

摘要： By disclosing part of metastasis mechanisms in cancer cells, the metastatic potential of cancer cells will be determinable. Anti-galectin-9 Ab against galectin-9 is contained as an effective component with or without others, thereby enabling the evaluation or detection of galectin-9 expression levels in cancer cells wherein the metastatic potential of the cancer cells can be assessed or detected.

摘要翻译： 通过揭示癌细胞中转移机制的一部分，癌细胞的转移潜力是可以确定的。 含有半乳凝素-9抗体的抗半乳凝素-9抗体作为有或无其他成分的有效成分被含有，从而能够评价或检测癌细胞中的半乳凝素-9表达水平，其中可以评估或检测癌细胞的转移潜力。

公开(公告)号：US20090004730A1

公开(公告)日：2009-01-01

申请号：US11908980

申请日：2006-03-17

申请人： Nao Nitta ,  Shiro Kanegasaki ,  Akira Yamauchi

发明人： Nao Nitta ,  Shiro Kanegasaki ,  Akira Yamauchi

IPC分类号： C12M1/34

CPC分类号： G02B21/34 ,  C12N9/93

摘要： A cell observation support instrument having opposed first and second surface members 115 and 117 and stoppers that are positioned between the first and second surface members 115 and 117 in order to prevent movement of cells. The first and second surface members 115 and 117 form a cell-containing space 110 between opposed surfaces of the members 115 and 117, in order to contain a plurality of cells while allowing movement of the cells. At least one of the first and second surface members 115 and 117 is a member through which an inner side of the cell-containing space 110 can be optically observed from the outside. The stoppers are arranged in the cell-containing space 110, and the number of the stoppers is one or more.

摘要翻译： 电池观察支撑器具具有相对的第一和第二表面构件115和117以及位于第一和第二表面构件115和117之间的止动件，以防止电池移动。 第一和第二表面构件115和117在构件115和117的相对表面之间形成包含细胞的空间110，以便容纳多个单元，同时允许单元的移动。 第一和第二表面构件115和117中的至少一个是可以从外部光学观察细胞容纳空间110的内侧的构件。 止动件布置在容纳细胞的空间110中，止动件的数量为一个或多个。

公开(公告)号：US20080073027A1

公开(公告)日：2008-03-27

申请号：US11979595

申请日：2007-11-06

申请人： Akira Yamauchi ,  Mikio Kawakami

发明人： Akira Yamauchi ,  Mikio Kawakami

IPC分类号： B29C65/00 ,  B32B38/00 ,  G01B11/00

CPC分类号： H05K13/0015 ,  H01L21/681 ,  H01L23/544 ,  H01L24/75 ,  H01L24/81 ,  H01L2223/54473 ,  H01L2924/15788 ,  H05K13/0812 ,  Y10T29/4913 ,  Y10T29/49131 ,  Y10T29/49133 ,  Y10T29/49137 ,  Y10T29/53091 ,  Y10T29/53174 ,  H01L2924/00

摘要： Positioning recognition marks are read by movable recognition device for positioning objects to be bonded to each other. An alignment method includes a step of reading the recognition marks during movement of the recognition device before its complete stop, and a step of identifying absolute positions of the recognition marks by correcting the mark recognition positions having been read based on a position feedback signal of the moving recognition device. A mounting method using the alignment method is also disclosed. It is possible to maintain a high alignment accuracy, eliminate necessity of assuring a settling time for complete stop of the movable recognition device, and significantly reduce the alignment time and mounting tact.

摘要翻译： 定位识别标记由可移动识别装置读取，用于定位要彼此粘合的对象。 对准方法包括在识别装置在其完全停止之前的移动期间读取识别标记的步骤，以及通过基于所述识别装置的位置反馈信号校正已经读取的标记识别位置来识别识别标记的绝对位置的步骤 移动识别装置。 还公开了使用对准方法的安装方法。 可以保持高的对准精度，消除确保可移动识别装置的完全停止的建立时间的必要性，并且显着地减少对准时间和安装节奏。

公开(公告)号：US07341877B2

公开(公告)日：2008-03-11

申请号：US11016720

申请日：2004-12-21

申请人： Akira Yamauchi ,  Yoshiyuki Arai

发明人： Akira Yamauchi ,  Yoshiyuki Arai

IPC分类号： H01L21/66

CPC分类号： H01L21/67294 ,  H01L21/67144 ,  H01L22/20 ,  H01L23/544 ,  H01L2223/54473 ,  H01L2924/0002 ,  H05K13/08 ,  H05K13/089 ,  Y10T29/53178 ,  H01L2924/00

摘要： A method of accurately calibrating a movement control system of mark recognition means in a chip mounting device, comprising the steps of: recognizing a first recognition mark put on a head (2) and a second recognition mark (13) put on a stage (26) with two-field recognition means (7) so as to calibrate and update the preceding control parameters inputted into the movement control system of the two-field recognition means (7); and, with the head (2) lowered to position the first recognition mark closely to the second recognition mark (13), recognizing both marks with third recognition means (20) when the two-field recognition means (7) is moved back so as to calibrate and update the preceding control parameters inputted into the movement control system of the two-field recognition means (7).

摘要翻译： 一种在芯片安装装置中精确校准标记识别装置的移动控制系统的方法，包括以下步骤：识别放置在平台（26）上的头部（2）和第二识别标记（13）上的第一识别标记 ），用于校准和更新输入到两场识别装置（7）的运动控制系统中的先前控制参数; 并且当头部（2）降低以将第一识别标记定位到第二识别标记（13）时，当两场识别装置（7）被移回时，用第三识别装置（20）识别两个标记，以便 校准和更新输入到两场识别装置（7）的运动控制系统中的先前控制参数。

公开(公告)号：US07299545B2

公开(公告)日：2007-11-27

申请号：US10509882

申请日：2003-03-27

申请人： Akira Yamauchi ,  Mikio Kawakami

发明人： Akira Yamauchi ,  Mikio Kawakami

IPC分类号： H05K13/04 ,  H05K13/00

CPC分类号： H05K13/0015 ,  H01L21/681 ,  H01L23/544 ,  H01L24/75 ,  H01L24/81 ,  H01L2223/54473 ,  H01L2924/15788 ,  H05K13/0812 ,  Y10T29/4913 ,  Y10T29/49131 ,  Y10T29/49133 ,  Y10T29/49137 ,  Y10T29/53091 ,  Y10T29/53174 ,  H01L2924/00

摘要： Positioning recognition marks are read by movable recognition device for positioning objects to be bonded to each other. An alignment method includes a step of reading the recognition marks during movement of the recognition device before its complete stop, and a step of identifying absolute positions of the recognition marks by correcting the mark recognition positions having been read based on a position feedback signal of the moving recognition device. A mounting method using the alignment method is also disclosed. It is possible to maintain a high alignment accuracy, eliminate necessity of assuring a settling time for complete stop of the movable recognition device, and significantly reduce the alignment time and mounting tact.

摘要翻译： 定位识别标记由可移动识别装置读取，用于定位要彼此粘合的对象。 对准方法包括在识别装置在其完全停止之前的移动期间读取识别标记的步骤，以及通过基于所述识别装置的位置反馈信号校正已经读取的标记识别位置来识别识别标记的绝对位置的步骤 移动识别装置。 还公开了使用对准方法的安装方法。 可以保持高的对准精度，消除确保可移动识别装置的完全停止的建立时间的必要性，并且显着地减少对准时间和安装节奏。

公开(公告)号：US20060085965A1

公开(公告)日：2006-04-27

申请号：US10528690

申请日：2003-09-22

申请人： Tadatomo Suga ,  Toshihiro Ito ,  Akira Yamauchi

发明人： Tadatomo Suga ,  Toshihiro Ito ,  Akira Yamauchi

IPC分类号： B23P11/00

CPC分类号： H01L24/81 ,  H01L2224/13144 ,  H01L2224/75 ,  H01L2224/7501 ,  H01L2224/751 ,  H01L2224/81801 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/01024 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/14 ,  Y10T29/49144 ,  Y10T29/49908 ,  Y10T29/49924 ,  Y10T29/5313 ,  Y10T29/53174 ,  H01L2224/0401

摘要： A device and method for bonding objects to be bonded each having a metal bonding portion on a substrate, comprising cleaning means for exposing the metal bonding portions to a plasma having an energy enough to etch the surfaces of the metal bonding portions at a depth of 1.6 nm or more over the entire surfaces of the metal bonding portions under a reduced pressure and bonding means for bonding the metal bonding portions of the objects taken out of the cleaning means in an atmospheric air. By using a specific scheme, metal bonding portions after the plasma cleaning can be bonded in the atmospheric air, thereby significantly simplifying the bonding process and the whole device and lowering the cost.

摘要翻译： 一种用于将每个具有金属接合部分的要被接合的物体接合在基板上的装置和方法，包括用于将金属接合部分暴露于等离子体的清洁装置，该等离子体具有足以在深度1.6刻蚀金属接合部分的表面的能量 在减压下的金属接合部的整个表面上的nm以上的粘合装置和用于将从清洁装置中取出的物体的金属接合部分接合在大气中的接合装置。 通过使用具体的方案，等离子体清洗后的金属接合部分可以粘结在大气中，从而大大简化了接合工艺和整个器件，降低了成本。

公开(公告)号：US20060016555A1

公开(公告)日：2006-01-26

申请号：US10511986

申请日：2003-04-22

申请人： Akira Yamauchi ,  Katsumi Terada ,  Satoru Naraba ,  Takashi Hare

发明人： Akira Yamauchi ,  Katsumi Terada ,  Satoru Naraba ,  Takashi Hare

IPC分类号： B29C65/00 ,  B32B37/00 ,  B32B38/00

CPC分类号： H01L24/81 ,  H01L21/67092 ,  H01L24/75 ,  H01L2224/0554 ,  H01L2224/05568 ,  H01L2224/05573 ,  H01L2224/056 ,  H01L2224/16 ,  H01L2224/75 ,  H01L2224/75743 ,  H01L2224/81203 ,  H01L2224/81801 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01006 ,  H01L2924/01033 ,  H01L2924/0105 ,  H01L2924/01057 ,  H01L2924/01078 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/07811 ,  H01L2924/14 ,  H01L2924/00 ,  H01L2224/05599 ,  H01L2224/0555 ,  H01L2224/0556

摘要： A mounting method and a mounting device, the mounting method comprising the steps of, after positioning objects being bonded relative to each other, moving a movable wall positioned therearound until coming into contact with one object holding means to form a local chamber having a local enclosed space, enclosing both objects in the chamber, reducing the pressure in the chamber, moving the object holding means in a direction for reducing the volume of the chamber and moving the movable wall following the movement of the object holding means, and bonding both objects to each other by pressing, whereby, since the part to be bonded and its vicinity can be locally and efficiently enclosed separably from surroundings, and the local chamber capable of properly varying the shape of the enclosed space can be formed interlockingly with the bonding operation while maintaining the enclosed state even at the time of bonding, a specified mounting can be easily performed by a small device.

摘要翻译： 一种安装方法和安装装置，所述安装方法包括以下步骤：在定位相对于彼此接合的物体之后，移动位于其周围的可移动壁，直到与一个物体保持装置接触以形成具有局部封闭 空间，将两个物体封闭在腔室中，减小腔室中的压力，使物体保持装置沿着减小腔室的体积的方向移动，并且随着物体保持装置的移动移动可移动壁，并且将两个物体粘合到 通过按压，由于可以将局部且有效地围绕周围环境部分地进行局部且有效地密封的部分，并且可以适当地改变封闭空间的形状的局部室与粘合操作互锁地形成，同时保持 封闭状态即使在接合时，也可以通过小型装置容易地进行规定的安装。

公开(公告)号：US20050274869A1

公开(公告)日：2005-12-15

申请号：US10509882

申请日：2003-03-27

申请人： Akira Yamauchi ,  Mikio Kawakami

发明人： Akira Yamauchi ,  Mikio Kawakami

IPC分类号： H01L21/68 ,  H01L23/544 ,  H05K13/00 ,  G02B7/04

CPC分类号： H05K13/0015 ,  H01L21/681 ,  H01L23/544 ,  H01L24/75 ,  H01L24/81 ,  H01L2223/54473 ,  H01L2924/15788 ,  H05K13/0812 ,  Y10T29/4913 ,  Y10T29/49131 ,  Y10T29/49133 ,  Y10T29/49137 ,  Y10T29/53091 ,  Y10T29/53174 ,  H01L2924/00

摘要： Positioning recognition marks (A, B, C, D) are read by movable recognition means (5) for positioning objects (2, 4) to be bonded to each other. An alignment method includes a step of reading the recognition marks (A, B, C, D) during movement of the recognition means (5) before its complete stop, and a step of identifying absolute positions of the recognition marks (A, B, C, D) by correcting the mark recognition positions having been read based on a position feedback signal of the moving recognition means (5). A mounting method using the alignment method is also disclosed. It is possible to maintain a high alignment accuracy, eliminate necessity of assuring a settling time for complete stop of the movable recognition means (5), and significantly reduce the alignment time and mounting tact.

摘要翻译： 定位识别标记（A，B，C，D）由可移动识别装置（5）读取，用于定位待彼此粘合的物体（2,4）。 对准方法包括在识别装置（5）完全停止之前移动期间读取识别标记（A，B，C，D）的步骤，以及识别识别标记（A，B， C），D）通过基于移动识别装置（5）的位置反馈信号校正已读取的标记识别位置。 还公开了使用对准方法的安装方法。 可以保持高的对准精度，消除了确保可移动识别装置（5）的完全停止的建立时间的必要性，并且显着减少对准时间和安装节奏。