公开(公告)号：US09086445B2

公开(公告)日：2015-07-21

申请号：US14079195

申请日：2013-11-13

申请人： Ryoko Sugano ,  Masahiko Ichimura ,  Akihiko Kandori

发明人： Ryoko Sugano ,  Masahiko Ichimura ,  Akihiko Kandori

IPC分类号： B82Y25/00 ,  G01R33/09

CPC分类号： G01R33/093

摘要： To increase an output from a magnetoresistive element without using a special magnetic material, provided is a magnetic detection device including a magnetoresistive element including a ferromagnetic reference layer having a fixed magnetization direction, to which a spin wave induction layer is connected, so that the spin wave induction layer injects, into the ferromagnetic reference layer, electrons having spins in a specific direction by a spin electromotive force internally generated.

摘要翻译： 为了增加来自磁阻元件的输出而不使用特殊的磁性材料，提供了一种磁检测装置，其包括磁阻元件，磁阻元件包括具有固定磁化方向的铁磁参考层，自旋波感应层连接到该铁磁参考层，使得旋转 波感应层通过内部产生的自旋电动势向铁磁参考层中注入具有沿特定方向旋转的电子。

公开(公告)号：US08374672B2

公开(公告)日：2013-02-12

申请号：US11905706

申请日：2007-10-03

申请人： Yusuke Seki ,  Akihiko Kandori ,  Mitsuru Oonuma

发明人： Yusuke Seki ,  Akihiko Kandori ,  Mitsuru Oonuma

IPC分类号： A61B5/05

CPC分类号： A61B5/04007 ,  G01R33/0354

摘要： There is provided a biomagnetic field measurement apparatus capable of carrying out exact positioning work and highly sensitive signal detection. To bring a sensor surface close to a body surface while the sensor surface and the body surface are kept parallel, a cryostat is constructed so as to be capable of oscillating and expanding and contracting. A gantry is formed by three supports. A first support is a portal support that supports the whole of the gantry. A second support is supported on the first support, and is rotatable with a first direction being the axis. A third support is supported on the second support, and is movable in the axial direction of the cryostat as viewed from the second support. The cryostat is supported on the third support, and moves integrally with the third support.

摘要翻译： 提供了能够进行精确定位工作和高灵敏度信号检测的生物磁场测量装置。 为了使传感器表面靠近身体表面，同时传感器表面和身体表面保持平行，构造低温恒温器以便能够振荡和膨胀和收缩。 龙门架由三个支架组成。 第一个支持是支持整个龙门架的门户支持。 第二支撑件支撑在第一支撑件上，并且可以第一方向作为轴线旋转。 第三支撑件支撑在第二支撑件上，并且从第二支撑件观察时可以在低温恒温器的轴向方向上移动。 低温恒温器支撑在第三支架上，与第三支架一体地移动。

公开(公告)号：US08193003B2

公开(公告)日：2012-06-05

申请号：US12149990

申请日：2008-05-12

申请人： Akira Tsukamoto ,  Daisuke Suzuki ,  Akihiko Kandori

发明人： Akira Tsukamoto ,  Daisuke Suzuki ,  Akihiko Kandori

IPC分类号： G01N33/553 ,  G01N33/53

CPC分类号： G01N33/54333

摘要： Accurate measurement cannot be performed due to magnetic signals from magnetic impurities included in a specimen container. By finding a difference between two measurement signals obtained by applying an external magnetic field for orientation to respective normal and reverse directions, the magnetic signals from the magnetic impurities included in the specimen container which are not dependent on the external magnetic field for orientation can be cancelled. The influence of the magnetic impurities included in the specimen container is reduced, and the signal of the intended bound magnetic marker can be measured with high sensitivity.

摘要翻译： 由于样品容器中包含的磁性杂质的磁信号，无法进行准确的测量。 通过在相应的正反方向上施加用于取向的外部磁场获得的两个测量信号之间的差异，可以取消不依赖于用于取向的外部磁场的样本容器中包含的磁性杂质的磁信号 。 包含在标本容器中的磁性杂质的影响减小，可以高灵敏度地测量预期的结合磁性标记的信号。

公开(公告)号：US07528602B2

公开(公告)日：2009-05-05

申请号：US11446110

申请日：2006-06-05

申请人： Yusuke Seki ,  Mitsuru Onuma ,  Akihiko Kandori

发明人： Yusuke Seki ,  Mitsuru Onuma ,  Akihiko Kandori

IPC分类号： G01V3/00

CPC分类号： G01R33/025 ,  A61B5/04005

摘要： A magnetic shielding apparatus having a high shielding effect. With the magnetic shielding apparatus having an opening (for example, a cylindrical magnetic shielding apparatus provided with a door), the door covering the opening is electrically and/or magnetically connected to a main body by means of electrically and/or magnetically connecting members. The magnetic shielding apparatus is higher in magnetic shielding factor than the conventional magnetic shielding apparatus, and a magnetic field measuring apparatus using the magnetic shielding apparatus, capable of measuring biomagnetism generated from an inspection target (a living body), with higher sensibility than before.

摘要翻译： 一种屏蔽效果好的磁屏蔽装置。 利用具有开口的磁屏蔽装置（例如设置有门的圆柱形磁屏蔽装置），通过电和/或磁性连接构件将覆盖开口的门电和/或磁性地连接到主体。 磁屏蔽装置的磁屏蔽系数高于常规磁屏蔽装置，并且使用能够测量从检查对象（活体）产生的生物磁性的磁屏蔽装置的磁场测量装置，其灵敏度比以前更高。

公开(公告)号：US20070085534A1

公开(公告)日：2007-04-19

申请号：US11545461

申请日：2006-10-11

申请人： Yusuke Seki ,  Akihiko Kandori

发明人： Yusuke Seki ,  Akihiko Kandori

IPC分类号： G01R33/02

CPC分类号： G01R33/02 ,  G01R33/0358

摘要： A magnetic detection coil is provided, which includes a plurality of differential coils. Each differential coil is made of one of superconductors and metallic materials. The differential coils having mutually different loop directions are arranged in parallel at a spatially predetermined distance apart and mutually electrically connected in series. Each differential coil is one of a first-order differential coil and a second-order differential coil.

摘要翻译： 提供磁检测线圈，其包括多个差动线圈。 每个差分线圈由超导体和金属材料之一制成。 具有相互不同的环路方向的差分线圈在空间预定的距离处并排布置并且彼此串联电连接。 每个差分线圈是一阶差分线圈和二阶差分线圈之一。

公开(公告)号：US07993581B2

公开(公告)日：2011-08-09

申请号：US11006757

申请日：2004-12-08

申请人： Yusuke Seki ,  Akira Tsukamoto ,  Daisuke Suzuki ,  Masahiro Yamaoka ,  Nami Sugita ,  Akihiko Kandori ,  Kazuo Saitoh

发明人： Yusuke Seki ,  Akira Tsukamoto ,  Daisuke Suzuki ,  Masahiro Yamaoka ,  Nami Sugita ,  Akihiko Kandori ,  Kazuo Saitoh

IPC分类号： G01N1/36 ,  G01N33/553

CPC分类号： G01N33/54373 ,  G01N27/745

摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.

摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。

公开(公告)号：US07912530B2

公开(公告)日：2011-03-22

申请号：US11545461

申请日：2006-10-11

申请人： Yusuke Seki ,  Akihiko Kandori

发明人： Yusuke Seki ,  Akihiko Kandori

IPC分类号： A61B5/00

CPC分类号： G01R33/02 ,  G01R33/0358

摘要： A magnetic detection coil is provided, which includes a plurality of differential coils. Each differential coil is made of one of superconductors and metallic materials. The differential coils having mutually different loop directions are arranged in parallel at a spatially predetermined distance apart and mutually electrically connected in series. Each differential coil is one of a first-order differential coil and a second-order differential coil.

摘要翻译： 提供磁检测线圈，其包括多个差动线圈。 每个差分线圈由超导体和金属材料之一制成。 具有相互不同的环路方向的差分线圈在空间预定的距离处并排布置并且彼此串联电连接。 每个差分线圈是一阶差分线圈和二阶差分线圈之一。

公开(公告)号：US20090143665A1

公开(公告)日：2009-06-04

申请号：US12277692

申请日：2008-11-25

申请人： Yusuke Seki ,  Akihiko Kandori

发明人： Yusuke Seki ,  Akihiko Kandori

IPC分类号： G01R33/035 ,  A61B5/05

CPC分类号： G01R33/0354 ,  G01R33/04

摘要： It is an aspect of the present invention to provide a magnetic detection coil 1b made of a single wire of one of superconducting and metallic materials. Four second-order differential coils 21 to 24 are arranged so that a geometric figure obtained by connecting the respective centers of said four differential coils can form a parallelogram. By providing intersections 25 to 27 between said four second-order differential coils 21 to 24, the values of magnetic flux respectively penetrating said differential coils 21 to 24 are differentiated in three different directions.The present invention is able to detect magnetic signals stably, despite a current direction of the signal source.

摘要翻译： 本发明的一个方面是提供一种由超导和金属材料之一的单线制成的磁检测线圈1b。 四个二阶差分线圈21至24被布置成使得通过连接所述四个差分线圈的各个中心而获得的几何图形可以形成平行四边形。 通过在所述四个二阶差分线圈21至24之间设置交叉点25至27，分别穿过所述差动线圈21至24的磁通量的值在三个不同方向上是不同的。 尽管信号源的电流方向，本发明能够稳定地检测磁信号。

公开(公告)号：US20050261578A1

公开(公告)日：2005-11-24

申请号：US11130215

申请日：2005-05-17

申请人： Tsuyoshi Yamamoto ,  Akihiko Kandori

发明人： Tsuyoshi Yamamoto ,  Akihiko Kandori

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B5/11 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  A61B5/02 ,  A61B5/05

CPC分类号： A61B5/0073 ,  A61B5/14553

摘要： A method is provided which permits a reproduction time to verify a measurement image in a living body light measurement to be shortened, an effective performance check to be made, and periods containing noise and periods where tasks are not performed correctly to be eliminated in a short time. A moving image of a subject is photographed in a first trial period (rest period when the subject is at rest and task period when a task is given to the subject) and a second trial period (rest period when the subject is at rest and task period when a task is given to the subject), and a moving image in the first trial period and a moving image in the second trial period are displayed effectively simultaneously. The performance check in each trial period can be performed efficiently, and the moving image reproduction time can be shortened. Further, periods containing noise and periods where tasks are not performed correctly can be eliminated in a shorter time than in the prior art.

摘要翻译： 提供了一种方法，其允许缩短生物体光测量中的测量图像的再现时间，进行有效的性能检查，以及包含噪声的周期和不正确执行任务的周期在短时间内被消除的方法 时间。 拍摄对象的运动图像在第一试验期间（休息期间，当对象被放置于受试者的任务时的任务期间）和第二试验期间（休息期间 显示有效地同时显示第一试用期间的运动图像和第二试用期间的运动图像。 可以有效地执行每个试用期的性能检查，并且可以缩短运动图像再现时间。 此外，与现有技术相比，可以在更短的时间内消除包含噪声和任务不正确执行的周期的周期。

公开(公告)号：US20050202572A1

公开(公告)日：2005-09-15

申请号：US11006757

申请日：2004-12-08

申请人： Yasuke Seki ,  Akira Tsukamoto ,  Daisuke Suzuki ,  Masahiro Yamaoka ,  Nami Sugita ,  Akihiko Kandori ,  Kazuo Saitoh

发明人： Yasuke Seki ,  Akira Tsukamoto ,  Daisuke Suzuki ,  Masahiro Yamaoka ,  Nami Sugita ,  Akihiko Kandori ,  Kazuo Saitoh

IPC分类号： G01N33/53 ,  G01N27/72 ,  G01N33/542 ,  G01N33/553

CPC分类号： G01N33/54373 ,  G01N27/745

摘要： The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized. By rotation of the holder, areas fixing and holding different ones of the sample containers are successively inserted into the magnetic shield, and the magnetization of the marked samples accommodated in first ones of the sample containers and the detection of magnetic fields generated from the marked samples accommodated in second ones of the sample containers are executed in parallel.

摘要翻译： 本发明提供了一种免疫测定技术，其能够通过使用磁性颗粒和SQUID磁性传感器的磁性方法高灵敏度地高效检测抗原 - 抗体反应。 基于该技术的系统包括：盘形样品保持器，其保持圆圈上的多个样品容器，用于容纳标记的样品，通过抗原 - 抗体反应用磁性颗粒标记样品; 用于使支架围绕其中心轴旋转的旋转装置; 用于将标记样品磁化在磁屏蔽外的磁化装置; 以及磁传感器，用于在磁屏蔽内检测从已经被磁化的标记样品产生的磁场。 通过保持器的旋转，将固定和保持不同样本容器的区域依次插入到磁屏蔽中，并且标记的样品的磁化容纳在第一个样品容器中，并且检测从标记的样品产生的磁场 容纳在第二个样品容器中并行执行。