利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

102 条记录 (耗时 0.033 秒)

    3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES
    64.
    发明申请
    3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES 有权
    3- [1,4]氧杂环丁烷-4-吡啶酮衍生物

    公开(公告)号：US20120095216A1

    公开(公告)日：2012-04-19

    申请号：US13262396

    申请日：2010-04-01

    申请人： Kazutoshi Watanabe ,  Kazuki Nakayama ,  Daiki Sakai

    发明人： Kazutoshi Watanabe ,  Kazuki Nakayama ,  Daiki Sakai

    IPC分类号： C07D413/14

    CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/14

    摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C—F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N—R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

    摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐：其中Z表示氮原子，C-F等; R1表示C1-C3烷基; Y表示氧原子或N-R7; R2，R3，R4，R5，R6和R7各自独立地表示氢原子，C1-C6烷基或由式（II）表示的基团：其用于预防和/或治疗由 tau蛋白激酶1多动症如神经变性疾病（如阿兹海默症）。

    Optical displacement detection mechanism and surface information measurement device using the same
    66.
    发明授权
    Optical displacement detection mechanism and surface information measurement device using the same 有权
    光学位移检测机构和表面信息测量装置使用相同

    公开(公告)号：US07973942B2

    公开(公告)日：2011-07-05

    申请号：US11841445

    申请日：2007-08-20

    申请人： Masato Iyoki ,  Hiroyoshi Yamamoto ,  Kazutoshi Watanabe ,  Masatsugu Shigeno

    发明人： Masato Iyoki ,  Hiroyoshi Yamamoto ,  Kazutoshi Watanabe ,  Masatsugu Shigeno

    IPC分类号： G01B11/14 ,  G01B11/30 ,  G01N21/55 ,  G01N23/00 ,  G01N21/86 ,  G21K7/00 ,  G01V8/00 ,  G01Q20/02

    CPC分类号： G01B11/024 ,  G01Q20/02

    摘要： There is provided an optical displacement detection mechanism in which, even if a measurement object changes, a detection sensitivity and a ratio of a noise are adjustable without depending on optical characteristics such as reflectivity, or a shape and mechanical characteristics of a measurement object, an influence of a thermal deformation of the measurement object by an irradiated light to the measurement object can be made small, and a measurement accuracy can be ensured under optimum conditions. In an optical displacement detection mechanism comprising a light source irradiating a light to a cantilever becoming the measurement object, a light source drive circuit driving the light source, a photodetector receiving the light after irradiated to the cantilever from the light source to thereby detect an intensity of the light, and an amplifier amplifying a detection signal of the photodetector at a predetermined amplification rate, there is made such that, by providing a light intensity regulator and an amplification rate regulator, an irradiated light intensity to the cantilever and an amplification rate of the photodetector can be made variable.

    摘要翻译： 提供了一种光学位移检测机构，其中即使测量对象改变，检测灵敏度和噪声比可以调节，而不依赖于诸如反射率的光学特性或测量对象的形状和机械特性， 可以使通过照射光将测量对象的热变形对测量对象的影响减小，并且可以在最佳条件下确保测量精度。 在包括将光照射到作为测量对象的悬臂的光源的光学位移检测机构中，驱动光源的光源驱动电路，从光源照射到悬臂的光接收器，其接收光，从而检测强度 以及以预定的放大率放大光检测器的检测信号的放大器，通过提供光强度调节器和放大率调节器，对悬臂的照射光强度和放大率 可以使光电检测器变得可变。

    2-SUBSTITUTED-6-HETEROCYCLIC PYRIMIDONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS
    69.
    发明申请
    2-SUBSTITUTED-6-HETEROCYCLIC PYRIMIDONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS 失效
    2-取代的6-杂环基吡啶酮衍生物作为TAU蛋白激酶1抑制剂

    公开(公告)号：US20100113775A1

    公开(公告)日：2010-05-06

    申请号：US12518997

    申请日：2007-12-26

    申请人： Kazutoshi Watanabe ,  Toshiyuki Kohara ,  Kenji Fukunaga ,  Fumiaki Uehara

    发明人： Kazutoshi Watanabe ,  Toshiyuki Kohara ,  Kenji Fukunaga ,  Fumiaki Uehara

    IPC分类号： C07D413/14

    CPC分类号： C07D413/14

    摘要： A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein each R1 represents hydrogen atom or the like; X represents oxygen atom or the like; A represents a C3-C7 cycloalkyl group, a C6-C10 aryl group or a heterocyclic group; R6 represents a halogen atom or the like; s represents 0 or an integer of 1 to 5; Q represents a pyridine ring which may be substituted or pyrimidine ring; and R2 represents hydrogen atom or the like, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).

    摘要翻译： 由式（I）表示的化合物或其光学活性异构体或其药学上可接受的盐：其中每个R 1表示氢原子等; X表示氧原子等; A表示C 3 -C 7环烷基，C 6 -C 10芳基或杂环基; R6表示卤素原子等; s表示0或1〜5的整数， Q表示可以被取代或嘧啶环的吡啶环; R2代表氢原子等，其用于预防和/或治疗由tau蛋白激酶1的异常活性引起的疾病，例如神经变性疾病（例如阿尔茨海默病）。