公开(公告)号：US06790935B1

公开(公告)日：2004-09-14

申请号：US09890636

申请日：2001-08-03

申请人： Manfred Mutter ,  Roland Wenger ,  Jean-François Guichou ,  Michael Keller ,  Thomas Ruckle ,  Torsten Woehr

发明人： Manfred Mutter ,  Roland Wenger ,  Jean-François Guichou ,  Michael Keller ,  Thomas Ruckle ,  Torsten Woehr

IPC分类号： C07K750

CPC分类号： C07K7/645

摘要： The invention relates to cyclosporin derivatives, whereby the peptide chain thereof comprises at least one pseudo-proline type non-natural amino acid radical. The invention also relates to a method for the production of said derivatives.

摘要翻译： 本发明涉及环孢菌素衍生物，其中肽链包含至少一个假脯氨酸型非天然氨基酸基团。 本发明还涉及生产所述衍生物的方法。

公开(公告)号：US09842025B2

公开(公告)日：2017-12-12

申请号：US13351132

申请日：2012-01-16

申请人： Michael Keller

发明人： Michael Keller

IPC分类号： G06F15/167 ,  G06F11/14

CPC分类号： G06F11/1438 ,  G06F2201/84

摘要： Exemplary system and computer program product embodiments for efficient state tracking for clusters are provided. In one embodiment, by way of example only, in a distributed shared memory architecture, an asynchronous calculation of deltas and the views is performed while concurrently receiving client requests and concurrently tracking the client requests times. The results of the asynchronous calculation may be applied to each of the client requests that are competing for data of the same concurrency during a certain period with currently executing client requests. Additional system and computer program product embodiments are disclosed and provide related advantages.

公开(公告)号：US09105882B2

公开(公告)日：2015-08-11

申请号：US13643557

申请日：2011-04-13

申请人： Peter Birke ,  Michael Schiemann ,  Olaf Böse ,  Hans-Georg Schweiger ,  Michael Keller

发明人： Peter Birke ,  Michael Schiemann ,  Olaf Böse ,  Hans-Georg Schweiger ,  Michael Keller

IPC分类号： H01M2/02 ,  H01M10/04 ,  H01M10/613 ,  H01M10/625 ,  H01M10/647 ,  H01M10/651 ,  H01G9/04 ,  H01G11/74 ,  H01G11/82 ,  H01M10/0525 ,  H01M10/058

CPC分类号： H01M2/0237 ,  H01G9/058 ,  H01G11/74 ,  H01G11/82 ,  H01M2/021 ,  H01M2/0212 ,  H01M2/024 ,  H01M10/04 ,  H01M10/0525 ,  H01M10/058 ,  H01M10/613 ,  H01M10/625 ,  H01M10/647 ,  H01M10/651 ,  Y02E60/13 ,  Y02T10/7011 ,  Y02T10/7022

摘要： An energy storage cell has a cell body with an areal expansion in an extension plane, with four side faces bounding a circumference of the area of extent and having each two of the side faces parallel to one another. A conductor electrode and a second electrode are disposed on one of the side faces symmetrically in the direction of the circumference of the extension plane relative to a center of the corresponding side face. A line from a contact point between an inward facing edge of the electrodes to a center point of the extension plane encloses an angle λ of 10°

摘要翻译： 储能单元具有在延伸平面中具有面扩张的单体体，其四个侧面限定该范围的区域的圆周，并且每两个侧面彼此平行。 导体电极和第二电极相对于相应侧面的中心在延伸面的圆周方向上对称地设置在一个侧面上。 从电极的朝内的边缘到延伸平面的中心点之间的接触点的线与对应的侧面包围10°<λ<36°的角度λ。 侧面的中心和/或电极的向外的边缘的接触点形成角度＆bgr; 约8°<＆bgr <45°的延伸平面的中心点与所述中心的相应侧面。

公开(公告)号：US20140134926A1

公开(公告)日：2014-05-15

申请号：US14073942

申请日：2013-11-07

申请人： Rolf Groppe ,  Michael Keller ,  Uwe Kirchhübel ,  Rolf-Dieter Woitscheck

发明人： Rolf Groppe ,  Michael Keller ,  Uwe Kirchhübel ,  Rolf-Dieter Woitscheck

IPC分类号： B24B55/06 ,  B24B19/14

CPC分类号： B24B55/06 ,  B24B19/14 ,  F01D5/005 ,  F01D5/20 ,  F01D25/26

摘要： A method and device for setting a predetermined radial gap width for rotor blades arranged in a housing of a turbomachine is provided. The method includes removing a housing part and at least partially exposing the rotor blades which are to be machined, arranging a grinding device in the region of a rotor blade which is to be machined such that the tip of the rotor blade is machined using a grinding disk of the grinding device, screening off the machining region by arranging a screening device which is formed so as to counter a release of grinding dust from the screen off machining region, providing a suction extraction such that it extracts grinding dust from the screened-off machining region and grinding the tip of the rotor blade in situ producing the radial gap width.

摘要翻译： 提供了一种用于设置设置在涡轮机的壳体中的转子叶片的预定径向间隙宽度的方法和装置。 该方法包括移除壳体部分并且至少部分地暴露待加工的转子叶片，将磨削装置设置在待加工的转子叶片的区域中，使得转子叶片的尖端使用研磨 研磨装置的盘，通过布置筛分装置来筛选加工区域，所述筛分装置形成为抵抗来自筛分的加工区域的研磨粉尘的释放，提供抽吸提取，使得其从筛选中提取研磨粉尘 加工区域并原位研磨转子叶片的尖端产生径向间隙宽度。

公开(公告)号：US08537961B2

公开(公告)日：2013-09-17

申请号：US13099941

申请日：2011-05-03

申请人： Michael Keller

发明人： Michael Keller

IPC分类号： G21C23/00 ,  F01K3/18 ,  G21D5/02 ,  G21D7/00 ,  G21G1/02 ,  G21C9/00 ,  G21C19/28 ,  G21C15/00 ,  G21C3/56 ,  F02C1/00 ,  F02C1/04 ,  F01K25/02 ,  F01K25/08 ,  F01K3/00 ,  F01K19/00 ,  F01K23/04 ,  F01K17/00 ,  F02G1/00

CPC分类号： F02C6/18 ,  F01K3/181 ,  F01K13/00 ,  F01K21/04 ,  F01K23/16 ,  Y02E20/16 ,  Y02E20/18

摘要： Disclosed is an advanced process that relates to the enhanced production of energy using the integration of multiple thermal cycles (Brayton and Rankine) that employ multiple fuels, multiple working fluids, turbines and equipment. The method includes providing a nuclear reactor, reactor working fluid, heat exchangers, compressors, and multiple turbines to drive compressors that pressurize a humidified working fluid that is combusted with fuel fired in at least one gas turbine. The turbine(s) provide for electrical energy, processes or other mechanical loads.

摘要翻译： 公开了一种先进的方法，其涉及使用多个燃料，多种工作流体，涡轮机和设备的多个热循环（Brayton和Rankine）的集成来增强能量生产。 该方法包括提供核反应堆，反应堆工作流体，热交换器，压缩机和多个涡轮机，以驱动对在至少一个燃气轮机中燃烧的燃料燃烧的加湿工作流体加压的压缩机。 涡轮机提供电能，过程或其他机械负载。

公开(公告)号：US20130196198A1

公开(公告)日：2013-08-01

申请号：US12097079

申请日：2006-08-23

申请人： Nevzat Güner ,  Swen Wiethoff ,  Knut Welke ,  Sönke Gürtler ,  Rogelio Víllarroel ,  Martin Voss ,  Reinhard Kassen ,  Reinhard Ganghofner ,  Michael Keller ,  Peter Birke ,  Axel Rudorff

发明人： Nevzat Güner ,  Swen Wiethoff ,  Knut Welke ,  Sönke Gürtler ,  Rogelio Víllarroel ,  Martin Voss ,  Reinhard Kassen ,  Reinhard Ganghofner ,  Michael Keller ,  Peter Birke ,  Axel Rudorff

IPC分类号： H01M10/50

CPC分类号： H01M10/613 ,  H01M2/1016 ,  H01M10/625 ,  H01M10/643 ,  H01M10/6555 ,  H01M10/6557 ,  H01M10/6567

摘要： The invention relates to a battery holder (1) for galvanic cells, in which a first honey-comb structure (2.1 to 2.n), comprising a lower and an upper basic cooling body (3.1, 3.2) and at least one intermediate cooling body (4), is provided, wherein in each case, galvanic cells can be arranged on a cell level (5.1 to 5.n) in each case between one of the basic cooling bodies (3.1, 3.2) and one of the intermediate cooling bodies (4) and/or between two of the intermediate cooling bodies (4), wherein the galvanic cells of one of the cell levels (5.1 to 5.n) are displaced to the side to the galvanic cells of at least one adjacent cell level (5.1 to 5.n) by half the width of a galvanic cell, and wherein the intermediate cooling body (4) and the basic cooling bodies (3.1, 3.2) are formed in an area between the galvanic cells according to the outer contours of the galvanic cells, and wherein each of the cooling bodies (3.1, 3.2, 4) comprises at least on one end which lies in an axial direction to the galvanic cells a cooling chamber (8), through which a cooling medium (K) can flow, into which the cooling medium (K) can flow from at least one cooling chamber (K) of at least one adjacent cooling body (3.1, 3.2, 4) and/or from which the cooling medium (K) can flow out into at least one cooling chamber (8) of at least one of the adjacent cooling bodies (3.1, 3.2, 4), wherein at least one cooling chamber (8) of at least one of the cooling bodies (3.1, 3.2, 4) comprises a cooling agent inflow (6) and/or a cooling agent outflow (7).

摘要翻译： 本发明涉及一种用于电池的电池座（1），其中包括下和上基本冷却体（3.1,3.2）的第一蜂巢结构（2.1至2.n）和至少一个中间冷却 主体（4），其中在每种情况下，每个情况下，电池单元可以布置在电池级（5.1至5.n）之间，在每种情况下在一个基本冷却体（3.1,3.2）之间和中间冷却 主体（4）和/或两个中间冷却体（4）之间，并且其中一个电池电平（5.1至5.n）的电池单元位于至少一个相邻电池的电池单元的一侧 （5.1〜5.n）电流单元的宽度的一半，并且其中中间冷却体（4）和基本冷却体（3.1,3.2）根据外部轮廓形成在原电池之间的区域中 的电池，并且其中每个冷却体（3.1,3.2,4）包括至少一个位于轴向方向上的一端 向所述原电池提供冷却介质（K）能够流过的冷却室（8），所述冷却介质（K）可以从至少一个相邻冷却体（3.1）的至少一个冷却室（K）流入所述冷却室 ，3.2,4）和/或冷却介质（K）可从该冷却介质（K）流出到至少一个相邻的冷却体（3.1,3.2,4）的至少一个冷却室（8）中，其中至少一个冷却 至少一个冷却体（3.1,3.2,4）的室（8）包括冷却剂流入物（6）和/或冷却剂流出物（7）。

公开(公告)号：US20120015026A1

公开(公告)日：2012-01-19

申请号：US13258919

申请日：2010-03-24

申请人： Giancarlo Francese ,  Michael Keller

发明人： Giancarlo Francese ,  Michael Keller

IPC分类号： A61K9/127 ,  A61K33/24 ,  A61K38/12 ,  A61P35/00 ,  A61K38/14 ,  A61K38/13 ,  A61K38/17 ,  A61K38/06 ,  A61K31/7088 ,  A61K31/704

CPC分类号： A61K31/713 ,  A61K9/127

摘要： The present invention relates generally to the fields of molecular biology, medicine, oncology, and delivery of therapeutic compounds. In particular, the present invention relates to pharmaceutical compositions containing a hydrophobic drug substance and an inhibitory nucleic acid molecule, such as short interfering RNA (siRNA), in a single drug delivery system, as well as a process for making and a process for administering the same.

摘要翻译： 本发明一般涉及分子生物学，药物，肿瘤学和治疗化合物的递送领域。 特别地，本发明涉及在单一药物递送系统中含有疏水性药物物质和抑制性核酸分子如短干扰RNA（siRNA）的药物组合物，以及制备方法和给药方法 一样。

公开(公告)号：US20100230191A1

公开(公告)日：2010-09-16

申请号：US12597323

申请日：2008-04-23

申请人： Peter Birke ,  Michael Keller ,  Kazuhiro Takahashi ,  Hideo Yabe ,  Kiyoko Abe ,  Kazunori Ozawa

发明人： Peter Birke ,  Michael Keller ,  Kazuhiro Takahashi ,  Hideo Yabe ,  Kiyoko Abe ,  Kazunori Ozawa

IPC分类号： B60K6/20 ,  H01M4/58

CPC分类号： H01M10/0525 ,  H01M4/131 ,  H01M4/133 ,  H01M4/136 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M10/0585 ,  Y02T10/7011

摘要： An electrochemical cell with a cathode electrode and an anode electrode separated by a separator, whereby: the cathode electrode includes at least a two-phase active material based on a lithium-transition metal oxide, and the anode electrode includes at least such a material that the anode electrode has an open circuit voltage curve with a total travel of at least 0.7 V and a steep voltage discharge curve without a saddle point.

摘要翻译： 一种具有由隔膜隔开的阴极电极和阳极电极的电化学电池，由此：所述阴极电极至少包含基于锂 - 过渡金属氧化物的两相活性材料，并且所述阳极电极至少包括这样的材料： 阳极电极具有总行程至少为0.7V的开路电压曲线和没有鞍点的陡峭的电压放电曲线。

公开(公告)号：US20100200314A1

公开(公告)日：2010-08-12

申请号：US12597297

申请日：2008-04-23

申请人： Peter Birke ,  Swen Wiethoff ,  Michael Keller ,  Frank Czogalla ,  Kazuhiro Takahashi ,  Hideo Yabe ,  Kiyoko Abe ,  Kazunori Ozawa

发明人： Peter Birke ,  Swen Wiethoff ,  Michael Keller ,  Frank Czogalla ,  Kazuhiro Takahashi ,  Hideo Yabe ,  Kiyoko Abe ,  Kazunori Ozawa

IPC分类号： B60K6/28 ,  H01M2/26 ,  H01M6/46

CPC分类号： H01M2/266 ,  H01M8/0247 ,  H01M8/2465

摘要： An energy storage assembly with a plurality of flat electrochemical cells, each of them includes a pair of electrodes which electrically connect the electrochemical cells with each other through outward electrode terminals, wherein each electrochemical cell includes as a pair of outward electrode terminals a straight outward terminal and a curved outward terminal, the electrochemical cells are connected with each other that a straight outward terminal of one of the electrochemical cell is connected with a curved outward terminal of an adjacent electrochemical cell.

摘要翻译： 一种具有多个平坦电化学电池的能量存储组件，每个电池单元包括一对通过外部电极端子将电化学电池彼此电连接的电极，其中每个电化学电池包括一对向外的电极端子， 和弯曲的外部端子，所述电化学电池彼此连接，所述电化学电池中的一个的直的外部端子与相邻的电化学电池的弯曲的外部端子连接。

公开(公告)号：US20100055344A1

公开(公告)日：2010-03-04

申请号：US12300966

申请日：2006-05-15

申请人： Carmen Ostwald ,  Manfred Meurer ,  Oliver Bendick ,  Michael Keller ,  Erich Nabbefeld-Arnold

发明人： Carmen Ostwald ,  Manfred Meurer ,  Oliver Bendick ,  Michael Keller ,  Erich Nabbefeld-Arnold

IPC分类号： B05D3/06 ,  B05D3/02 ,  B05D1/18 ,  B05D1/36

CPC分类号： C23C2/02 ,  C23C2/06 ,  C23C2/26 ,  C23G1/20

摘要： Economic production of highly corrosion-resistant flat steel products with a corrosion protection system, which are at the same time easy to process further, is described. The following work steps are applied: preheating the steel substrate to a strip temperature under inert gas atmosphere; cooling the steel substrate to the strip inlet temperature; hot dip coating of the steel substrate in a zinc bath so that a metallic corrosion protection coating is formed on the steel substrate which has an Al content of max 0.5 wt. % in an intermediate layer; adjusting the thickness of the metallic corrosion protection coating applied to the steel substrate in the melt bath to values of 3 to 20 μm per side by scraping away excess coating material; cooling the steel substrate with the metallic corrosion protection coating; and applying the organic coating to the metallic corrosion protection coating of the steel substrate.

摘要翻译： 描述了具有同时易于进一步处理的具有防腐蚀系统的高耐腐蚀扁钢产品的经济生产。 应用以下工作步骤：在惰性气体气氛下将钢基材预热至带材温度; 将钢基材冷却至带材入口温度; 在锌浴中对钢基材进行热浸涂层，使得在Al基质含量最多为0.5wt。％的钢基材上形成金属防腐蚀涂层。 ％在中间层; 通过刮掉多余的涂层材料来调节在熔融浴中施加到钢基底上的金属防腐蚀涂层的厚度，使其每侧的厚度为3至20μm; 用金属防腐涂层冷却钢基材; 并将有机涂层施加到钢基材的金属防腐蚀涂层上。