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公开(公告)号：US20080009056A1
公开(公告)日：2008-01-10
申请号：US11703200
申请日：2007-02-07
摘要： A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译： 通过SST方法从人类文库制备的新多肽及其制备方法; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。
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公开(公告)号：US20070155713A1
公开(公告)日：2007-07-05
申请号：US10554096
申请日：2004-04-20
IPC分类号： A61K31/55 , A61K31/498 , C07D487/10
CPC分类号： C07D471/10 , A61K31/499
摘要： A pharmaceutical composition comprising, as an active ingredient, the compounds represented by formula (I) (wherein all of the symbols have the same meanings as defined in specification.), salts thereof, solvates thereof, or prodrugs thereof. The compounds represented by formula (I) are used for prevention and/or treatment of various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, chronic rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis and the like), immunologic diseases (treatment of autoimmune diseases, transplant rejection, immunosuppression, psoriasis, multiple sclerosis and the like), human immunodeficiency virus infection (acquired immunodeficiency syndrome and the like), allergic diseases (atopic dermatitis, nettle rash, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis and the like), suppression of ischemia-reperfusion injury, acute respiratory distress syndrome, shock accompanied by bacterial infection, diabetes mellitus, or metastasis and the like.
摘要翻译： 一种药物组合物，其包含作为活性成分的由式（I）表示的化合物（其中所有符号具有与说明书中定义相同的含义），其盐，溶剂化物或其前药。 由式（I）表示的化合物用于预防和/或治疗各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，慢性类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），免疫疾病 自身免疫性疾病，移植排斥反应，免疫抑制，牛皮癣，多发性硬化等），人类免疫缺陷病毒感染（获得性免疫缺陷综合征等），过敏性疾病（特应性皮炎，荨麻疹，过敏性支气管肺曲霉病，过敏嗜酸性胃肠炎等） ），抑制缺血再灌注损伤，急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病或转移等。
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公开(公告)号：US06664383B1
公开(公告)日：2003-12-16
申请号：US09700397
申请日：2000-11-14
IPC分类号： C12Q168
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C12N9/6421
摘要： A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopoiesis regulating activity, tissue generation/regeneration activity, activin/inhibin activity, chemotactic/chemokinetic activity, hemostatic and thrombolytic activity, and receptor/ligand activity, therefore, they are expected to be useful for prevention and/or treatment of various diseases.
摘要翻译： 新的人多肽，编码它的cDNA及其药学用途。本发明的多肽具有造血调节活性，组织产生/再生活性，激活素/抑制素活性，趋化性/动力学活性，止血和溶栓活性，以及 受体/配体活性，因此预期它们可用于预防和/或治疗各种疾病。
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公开(公告)号：US08614323B2
公开(公告)日：2013-12-24
申请号：US13596780
申请日：2012-08-28
IPC分类号： C07D471/10
CPC分类号： A61K31/695 , A61K31/4178 , A61K31/435 , A61K31/5377 , A61K45/06 , C07D233/64 , C07D471/10 , C07F7/1804
摘要： The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。 本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化 ，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如， 癌症，癌症转移等）或再生治疗剂。
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65.发明授权Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient 失效含氮杂环衍生物和含有与活性成分相同的药物公开(公告)号：US08410276B2
公开(公告)日：2013-04-02
申请号：US13016849
申请日：2011-01-28
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D413/12 , A61K31/00 , C07D211/58 , C07D231/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/14
摘要： A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: (wherein each symbol is as defined in the description.) The compounds represented by formula (I) has the antagonistic activity against CCR5, so they are useful in preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, inflammatory bowel disease such as ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation (rejection of graft of solid organ, rejection of graft of pancreatic islet cells in therapy for diabetes, graft-versus-host disease, etc.), immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, infection with RSV, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), cardiovascular diseases (arteriosclerosis, ischemic reperfusion injury, etc.), acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.
摘要翻译： 由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药：（其中各符号如说明书中所定义）。式（I）表示的化合物具有拮抗作用 因此它们可用于预防和/或治疗CCR5相关疾病，例如各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿关节炎，鼻炎，结膜炎，炎性肠病如溃疡性结肠炎） 等等），免疫疾病（自身免疫性疾病，器官移植排斥反应（实体器官移植排斥反应，胰岛细胞移植对糖尿病的治疗排斥反应，移植物抗宿主病等），免疫抑制，牛皮癣， 多发性硬化症等），感染性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，RSV感染等），过敏性疾病（特应性皮炎，荨麻疹，过敏性 急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病，癌症转移等），心血管疾病（动脉硬化，缺血再灌注损伤等）。
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公开(公告)号：US08246955B2
公开(公告)日：2012-08-21
申请号：US13169278
申请日：2011-06-27
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译： 本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。 由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或 预防免疫病引起的疾病。
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公开(公告)号：US20120101280A1
公开(公告)日：2012-04-26
申请号：US13378799
申请日：2010-06-15
申请人： Koji Yoshida , Hiroshi Ochiai , Kousuke Tani , Shiro Shibayama , Miki Kasano
发明人： Koji Yoshida , Hiroshi Ochiai , Kousuke Tani , Shiro Shibayama , Miki Kasano
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The invention relates to a compound represented by formula (I): a salt thereof, an N-oxide thereof, or a solvate thereof (symbols in the formula are as described in the specification).The compound of the present invention exhibits very low risk of side effects and also has persistent and strong antagonistic activity against CXCR4, and is therefore useful as pharmaceuticals, for example, preventive and/or therapeutic agent for inflammatory and immune diseases, infections (for example, HIV infection), diseases associated with HIV infection (for example, acquired immunodeficiency syndrome (AIDS)), cancer, cancer metastasis, psychoneurotic diseases and cardiovascular diseases (for example, retinopathy), metabolic diseases, cancerous diseases, or an agent for regeneration therapy.
摘要翻译： 本发明涉及由式（I）表示的化合物：其盐，其N-氧化物或其溶剂化物（式中的符号如说明书中所述）。 本发明的化合物显示出非常低的副作用风险，并且对CXCR4具有持久和强烈的拮抗活性，因此可用作药物，例如用于炎症和免疫疾病，感染的预防和/或治疗剂（例如 ，艾滋病毒感染），与艾滋病毒感染有关的疾病（例如，获得性免疫缺陷综合征（AIDS）），癌症，癌症转移，精神神经病和心血管疾病（例如视网膜病变），代谢疾病，癌性疾病或再生药剂 治疗。
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68.发明授权公开(公告)号：US08003642B2
公开(公告)日：2011-08-23
申请号：US12282464
申请日：2007-03-09
IPC分类号： A61K31/5377 , A61K31/4545 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14 , C07D419/14
摘要： The compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof specifically binds CCR5, so it is useful for preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection diabetes cancer metastasis and so on Wherein all symbols in formula are as defined in the specification.
摘要翻译： 由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药特异性结合CCR5，因此其可用于预防和/或治疗CCR5相关疾病，例如各种 炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），免疫疾病（器官移植中的自身免疫性疾病，排斥反应，免疫抑制，牛皮癣，多发性硬化症等），感染性 疾病（人体免疫缺陷病毒感染，获得性免疫缺陷综合征等），过敏性疾病（特应性皮炎，荨麻疹，过敏性支气管肺曲霉病，过敏嗜酸性胃肠炎等），缺血再灌注损伤，急性呼吸窘迫综合征，伴随细菌感染糖尿病的休克 癌症转移等等，其中公式中的所有符号如说明书中所定义。
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公开(公告)号：US20100285527A1
公开(公告)日：2010-11-11
申请号：US12772617
申请日：2010-05-03
CPC分类号： C07K14/705 , A61K38/00 , C07K14/4703
摘要： Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or expression plasmids having the cDNAs integrated thereinto; host cells transformed by the plasmids; antibodies against the above polypeptides; and medicinal compositions containing the peptides or the antibodies.
摘要翻译： 由人成人脑组织产生的新型多肽，源自其的细胞系，源自人骨髓的细胞系和人脐带静脉内皮细胞系; 一种生产这些多肽的方法; 编码多肽的cDNA; 片段可与cDNA序列选择性杂交; 具有整合cDNA的复制或表达质粒; 由质粒转化的宿主细胞; 针对上述多肽的抗体; 以及含有肽或抗体的药物组合物。
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公开(公告)号：US07759336B2
公开(公告)日：2010-07-20
申请号：US10538758
申请日：2003-12-09
IPC分类号： A01N43/00 , A61K31/55 , C07D223/00
CPC分类号： C07D221/22 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D493/10
摘要： The compound represented by formulae (I) and (II), the salt thereof, the N-oxide thereof or the solvate thereof, or the prodrug thereof and the pharmaceutical composition comprising thereof have a CXCR4-regulating effect, and they are effective in treatment and prevention of various inflammatory disease, various allergic disease, acquired immunodeficiency syndrome infection with human immunodeficiency virus, or agents for regeneration therapy. (wherein ring A represents a nitrogen-containing heterocyclic group which may have a substituent(s); ring B represents a homocyclic group which may have a substituent(s) or a heterocyclic group which may have a substituent(s); and Y represents a hydrocarbon group which may have a substituent(s), a heterocyclic group which may have a substituent(s), an amino group which may be protected, a hydroxyl group which may be protected or a mercapto group which may be protected; T represents ring A or an amino group which may be protected.)
摘要翻译： 由式（I）和（II）表示的化合物，其盐，其N-氧化物或其溶剂合物或其前药及其药物组合物具有CXCR4调节作用，并且它们在治疗中有效 预防各种炎症性疾病，各种过敏性疾病，人类免疫缺陷病毒的获得性免疫缺陷综合征感染或再生治疗药物。 （其中环A表示可以具有取代基的含氮杂环基;环B表示可以具有取代基的杂环基或可以具有取代基的杂环基; Y表示 可以具有取代基的烃基，可以具有取代基的杂环基，可被保护的氨基，可被保护的羟基或可被保护的巯基; T代表 环A或可被保护的氨基。）
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