公开(公告)号：US20050273075A1

公开(公告)日：2005-12-08

申请号：US10863043

申请日：2004-06-08

申请人： Peter Krulevitch ,  Mariam Maghribi

发明人： Peter Krulevitch ,  Mariam Maghribi

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61M25/10 ,  A61M2025/0093 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2037/0023 ,  A61M2037/0046

摘要： A method for delivering a therapeutic agent into tissue includes providing a device for delivering a therapeutic agent into tissue. The device has an elongated body; a first balloon in the body expandable from a collapsed position to an expanded position; a second balloon in the body expandable from a collapsed position to an expanded position. The second balloon has a plurality of apertures therein; and a therapeutic agent is located in the second balloon. A plurality of microprojections are located on a surface of the second balloon for penetrating tissue. Upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures. The device is placed adjacent a site in the tissue; and the therapeutic agent is delivered into the tissue at the site by expanding the first balloon from the collapsed position to the expanded position.

摘要翻译： 将治疗剂递送到组织中的方法包括提供用于将治疗剂递送到组织中的装置。 该装置具有细长的主体; 主体中的第一气球从折叠位置伸展到展开位置; 主体中的第二气球从折叠位置伸展至展开位置。 第二气球在其中具有多个孔; 并且治疗剂位于第二气囊中。 多个微突出物位于第二球囊的用于穿透组织的表面上。 当第一气囊从折叠位置膨胀到扩张位置时，第二气囊从折叠位置膨胀到扩张位置，用于将多个微突出物展开到组织中，并且用于将治疗剂从第二气囊分配到组织中 多个孔。 该装置放置在组织中的一个位置附近; 并且通过将第一气囊从折叠位置膨胀到扩张位置，将治疗剂递送到该部位的组织中。

公开(公告)号：US20050029308A1

公开(公告)日：2005-02-10

申请号：US10621657

申请日：2003-07-16

申请人： William Benett ,  Peter Krulevitch ,  Steven Visuri ,  John Dzenitis ,  Kevin Ness

发明人： William Benett ,  Peter Krulevitch ,  Steven Visuri ,  John Dzenitis ,  Kevin Ness

IPC分类号： B01L3/02 ,  G01N1/00 ,  G01N35/10 ,  B67D5/42

CPC分类号： B01L3/0217 ,  B01L2400/0487 ,  G01N35/1016 ,  G01N35/1065 ,  G01N2035/1034

摘要： A dispensing system delivers a precise amount of fluid for biological or chemical processing and/or analysis. Dispensing means moves the fluid. The dispensing means is operated by a pneumatic force. Connection means delivers the fluid to the desired location. An actuator means provides the pneumatic force to the dispensing means. Valving means transmits the pneumatic force from the actuator means to the dispensing means.

摘要翻译： 分配系统提供精确量的用于生物或化学处理和/或分析的流体。 分液装置移动流体。 分配装置通过气动力操作。 连接装置将流体输送到所需位置。 致动器装置向分配装置提供气动力。 阀装置将气动力从致动器装置传递到分配装置。

公开(公告)号：US06575965B1

公开(公告)日：2003-06-10

申请号：US09713988

申请日：2000-11-16

申请人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

发明人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

IPC分类号： A61B1822

CPC分类号： A61B17/12022 ,  A61B5/0084 ,  A61B17/1214 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/12072 ,  A61B2017/12077 ,  A61B2017/2926

摘要： A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof. A mechanical sensor is attached to the distal end of the fiberoptic cable and connected to provide light signal information about a particular physical environment and communicated externally through the fiberoptic cable.

摘要翻译： 医疗装置构造成具有导管的基本形式，其具有用于插入体内和在体内操作的远端，并且近端为使用者提供控制体内远端的操作。 光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。 连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的光，并且可以包括光电池和机电马达或热敏光热材料。 电子传感器被连接以从光纤电缆的所述远端接收电力，并且被连接以提供关于特定物理环境的信号信息，并且通过光纤电缆向外传播到其近端。 机械传感器连接到光纤电缆的远端并被连接以提供关于特定物理环境的光信号信息，并通过光纤电缆在外部通信。

公开(公告)号：US06491685B2

公开(公告)日：2002-12-10

申请号：US09516999

申请日：2000-03-01

申请人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

发明人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

IPC分类号： A61B1722

CPC分类号： A61B18/26 ,  A61B2018/263

摘要： An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.

摘要翻译： 声波聚焦装置，其声波通过激光辐射通过光纤产生。 声能能够有效地破坏肾脏和胆汁结石，并可通过内窥镜手术递送至结石部位。 该装置包括附接到光纤的远端的换能器尖端，通过激光能量被引导。 换能器尖端封装外源吸收染料。 在适当的照射条件（高吸收能量密度，短脉冲持续时间）下，通过吸收器的热弹性膨胀产生应力波，以破坏结石。 换能器尖端可以被配置成声透镜，使得发射的声波成形或聚焦。 此外，压应力波可以从高密度/低密度界面反射，以将压缩波反转成拉伸应力波，并且拉伸应力在某些情况下在破坏材料中可能更有效，因为大多数材料的张力比压缩弱。 估计表明，该装置提供的应力幅度可以放大100倍以上，大大提高了光能量对目标材料的破坏效率。

公开(公告)号：US06437551B1

公开(公告)日：2002-08-20

申请号：US09704355

申请日：2000-11-01

申请人： Peter Krulevitch ,  Harold D. Ackler ,  Frederick Becker ,  Bernhard E. Boser ,  Adam B. Eldredge ,  Christopher K. Fuller ,  Peter R. C. Gascoyne ,  Julie K. Hamilton ,  Stefan P. Swierkowski ,  Xiao-Bo Wang

发明人： Peter Krulevitch ,  Harold D. Ackler ,  Frederick Becker ,  Bernhard E. Boser ,  Adam B. Eldredge ,  Christopher K. Fuller ,  Peter R. C. Gascoyne ,  Julie K. Hamilton ,  Stefan P. Swierkowski ,  Xiao-Bo Wang

IPC分类号： G01N2700

CPC分类号： G01N33/5438 ,  B01L3/5027 ,  G01N27/026 ,  G01N2015/129

摘要： A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.

摘要翻译： 一种用于基于交流（AC）阻抗测量来检测和识别电池和其他颗粒的微加工仪器。 微制造的AC阻抗传感器包括两个关键元件：1）优选玻璃基板的微流体芯片，其中至少有一个微通道，并且在两个基板上图案化电极，以及2）连接到微流体芯片上的电极的电路，以及 检测与微通道下游的颗粒相关联的信号。 这些电路可以以高吞吐量进行多个交流阻抗测量，具有足够的分辨率，以识别适用于环境检测和临床诊断应用的不同粒子和细胞类型。