公开(公告)号：US06383175B1

公开(公告)日：2002-05-07

申请号：US09406734

申请日：1999-09-28

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61B1822

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

摘要翻译： 在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。 此外，使用单个光源实现诊断和治疗。 治疗期间同时诊断也得到实现。 半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。 光传输线引导照射的激光附近的焦点，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像 提取/分析装置拾取并分析所提取的荧光的图像，并且图像显示装置显示分析结果。

公开(公告)号：US06514277B1

公开(公告)日：2003-02-04

申请号：US09329998

申请日：1999-06-11

申请人： Lothar Lilge ,  David Walsh

发明人： Lothar Lilge ,  David Walsh

IPC分类号： A61B1822

CPC分类号： G01N21/7703 ,  A61N5/0601 ,  A61N5/062 ,  G01N21/6428 ,  G01N2201/0846 ,  G01N2201/088

摘要： A multitasking optical fiber probe for collecting dosimeter information from more than one position in a sample. The basic principle of the present invention involves using one or more different sensor zones along the length of the fiber each with a different photoactive constituent having a sufficiently unique emission spectra (spectral or temporal) to enable deconvolution of the emission spectra by the computer and therefore correlation of the detected parameter with the position of the sensor zone along the length of the optical fiber. In the broadest form of the invention the probe is embodied by only one sensor zone located at some point along the length of the fiber spaced away from the end face of the fiber. Probes are provided in which multiple sensor zones are disposed along the length of the fiber and photoactive constituents with sufficiently unique emission spectra (intensity and/or spectral shape which convey the optical information) are used in the different sensor zones so that the different spectra can be deconvoluted so that the contributions from the various etch zones can be distinguished. More than one different photoactive constituent could be incorporated into a single sensor zone for measuring several factors in the vicinity of the sensor zone. In photodynamic therapy applications the probe is isotropic in response and can be employed for all light (300 to 900nm) based medical diagnostics and therapeutics. As an extension the probe can include photosensitiser and molecular oxygen concentrations dosimetry to be used for photodynamic therapy (PDT) treatment monitoring, dosimetry and planning utilizing a mathematical model describing tissue response to PDT.

摘要翻译： 一种用于从样品中多于一个位置收集剂量计信息的多任务光纤探针。 本发明的基本原理涉及沿着纤维的长度使用一个或多个不同的传感器区域，每个具有不同的光活性组分具有足够独特的发射光谱（光谱或时间），以使计算机能够对发射光谱进行去卷积，因此 检测参数与传感器区域沿着光纤长度的位置的相关性。 在本发明的最广泛形式中，探针仅通过位于沿纤维长度的某一点处的一个传感器区域，该距离与纤维的端面间隔开。 提供探针，其中多个传感器区域沿着纤维的长度设置，并且光​​活性组分具有足够独特的发射光谱（传递光学信息的强度和/或光谱形状）被用于不同的传感器区域，使得不同的光谱可以 被去卷积，从而可以区分来自各种蚀刻区域的贡献。 可以将多于一种不同的光活性成分结合到单个传感器区域中，以测量传感器区域附近的几个因素。 在光动力学治疗应用中，探针是各向同性的响应，可用于所有基于光（300至900nm）的医疗诊断和治疗。 作为延伸，探针可以包括用于光动力治疗（PDT）治疗监测，剂量测定和计划的光敏剂和分子氧浓度剂量学，其使用描述对PDT的组织反应的数学模型。

公开(公告)号：US06454762B1

公开(公告)日：2002-09-24

申请号：US09626330

申请日：2000-07-26

申请人： Peter Rösler ,  Ronald Sroka ,  Andreas Leunig

发明人： Peter Rösler ,  Ronald Sroka ,  Andreas Leunig

IPC分类号： A61B1822

CPC分类号： A61B18/24 ,  A61B17/24 ,  A61B18/201 ,  A61B18/22 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2017/3445 ,  A61B2018/2238 ,  A61B2090/035 ,  A61B2218/008

摘要： An instrument is provided for applying light, particularly laser light, to the human or animal body. A tubular shaft is provided into which a flexible light waveguide may be inserted, where a light-emitting end of the waveguide comes to rest at a distal end portion of the tubular shaft. The distal end portion of the tubular shaft is pivotally connected with the remaining portion of the tubular shaft, so that the distal end portion may be pivoted away from the longitudinal axis of the tubular shaft. Manipulating devices are provided at the proximal end of the tubular shaft for pivoting the distal end portion. The manipulating devices include at least one movable operating element, which is directly connected to the distal end portion by means of an actuator element.

摘要翻译： 提供了一种用于将光，特别是激光照射到人或动物体上的仪器。 提供管状轴，其中可以插入柔性光波导，其中波导的发光端在管状轴的远端部处停止。 管状轴的远端部分与管状轴的剩余部分枢转地连接，使得远端部分可以远离管状轴的纵向轴线枢转。 操纵装置设置在管状轴的近端处，用于枢转远端部分。 操纵装置包括至少一个可移动操作元件，其通过致动器元件直接连接到远端部分。

公开(公告)号：US06775315B1

公开(公告)日：2004-08-10

申请号：US09877283

申请日：2001-06-08

申请人： Scott Allen Nield ,  Robert M. Trusty ,  William Conrad Stenton ,  A. James Gabura ,  Edward Malcolm Benneyworth

发明人： Scott Allen Nield ,  Robert M. Trusty ,  William Conrad Stenton ,  A. James Gabura ,  Edward Malcolm Benneyworth

IPC分类号： A61B1822

CPC分类号： H01S5/4025 ,  H01S5/02 ,  H01S5/06825

摘要： An optical bench for processing laser light in a laser system, including an optical bench housing, a beam dump mounted to the optical bench housing so as to be in optical communication therewith, steering optics mounted within the optical bench housing for directing the laser light in a path from a laser light input to an output, and a mechanism for causing the laser light to deviate from the path and be directed into the beam dump upon recognition of a specified condition in the laser system, wherein the laser light is thermally isolated from the steering optics. The mechanism can either cause at least one optically reflective element to be inserted into the path, cause at least one optical element of the steering optics to have a change in position with respect to the path, and/or causes at least one optical element of the steering optics to be removed from the path.

摘要翻译： 一种用于在激光系统中处理激光的光学台，包括光学工作台外壳，安装到光学工作台外壳上以便与其进行光学连通的光束转台，安装在光学工作台外壳内的转向光学元件，用于将激光引导 从激光输入到输出的路径，以及用于使得激光偏离路径并且在识别到激光系统中的指定条件时被引导到光束转台中的机构，其中激光与 转向光学元件。 该机构可以使至少一个光学反射元件插入到路径中，使得转向光学元件的至少一个光学元件相对于路径具有位置变化，和/或使至少一个光学元件 要从路径移除的转向光学元件。

公开(公告)号：US06699239B1

公开(公告)日：2004-03-02

申请号：US09700948

申请日：2002-02-28

申请人： Hans-Peter Stiller ,  Robert Ibler ,  Thomas Hurland

发明人： Hans-Peter Stiller ,  Robert Ibler ,  Thomas Hurland

IPC分类号： A61B1822

CPC分类号： A61B18/22 ,  A61B2018/2255 ,  A61B2018/2288

摘要： A laser instrument that can perform effective vaporization of biological tissue and stabilization of the application cap during tissue removal is provided. The laser instrument includes an optical waveguide with a light guide portion that emits light and an application cap coupled to the optical waveguide that transmits light. The laser instrument can be inserted into an endoscope and extended or retracted to position the application cap for vaporization and removal of biological tissue.

摘要翻译： 提供了可以在组织去除期间执行生物组织的有效蒸发和应用盖的稳定的激光仪器。 激光仪器包括具有发光的导光部分的光波导和耦合到透射光的光波导的应用帽。 激光仪器可以插入到内窥镜中并且延伸或缩回以定位应用帽，以便蒸发和去除生物组织。

公开(公告)号：US06740107B2

公开(公告)日：2004-05-25

申请号：US10024798

申请日：2001-12-19

申请人： Marvin P. Loeb ,  L. Dean Crawford ,  Randy P. Graham

发明人： Marvin P. Loeb ,  L. Dean Crawford ,  Randy P. Graham

IPC分类号： A61B1822

CPC分类号： A61B18/24 ,  A61B18/1492 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/22059 ,  A61B2017/22069 ,  A61B2018/00196 ,  A61B2018/2211 ,  A61B2018/2277

摘要： A catheter device suitable for shrinking chordae tendineae of the human heart is provided having an energy conduit and a positioning device that facilitates the delivery of thermal energy, including coherent (laser) or non-coherent light, RF, microwave or ultrasound energy, to a predetermined region of the chordae tendineae or other collagen-containing tissue, such as the female urethra or the esophagus near the sphincter. The device comprises a tubular catheter containing an energy conduit, such as a fiber optic cable, adapted for delivering thermal energy to the tissue. The tubular catheter also contain a stabilizing device, disposed at its distal end, such as an asymmetrically shaped balloon or a retractable flexible metal hook. With the distal end of the catheter device positioned within a human heart, application of thermal energy to the chordae tendineae results in a shrinkage of the chordae, providing a treatment for primary mitral valve regurgitation.

摘要翻译： 提供了适合于收缩人心脏腱索的导管装置，其具有能量导管和定位装置，该能量导管和定位装置有助于将包括相干（激光）或非相干光，RF，微波或超声能量的热能传递到 腱索或其他含胶原的组织的预定区域，例如在括约肌附近的女性尿道或食管。 该装置包括管状导管，其包含适于将热能输送到组织的能量导管，例如光纤电缆。 管状导管还包含设置在其远端的稳定装置，例如不对称形状的气囊或可伸缩的柔性金属钩。 随着导管装置的远端定位在人的心脏内，向腱索的腱索施加热能导致腱索的收缩，从而提供主要的二尖瓣关闭不全的治疗。

公开(公告)号：US06605082B2

公开(公告)日：2003-08-12

申请号：US09895408

申请日：2001-07-02

申请人： Norihiko Hareyama ,  Toru Nagase ,  Makoto Inaba ,  Takefumi Uesugi ,  Satoshi Mizukawa ,  Shin Maki ,  Shigeki Ariura

发明人： Norihiko Hareyama ,  Toru Nagase ,  Makoto Inaba ,  Takefumi Uesugi ,  Satoshi Mizukawa ,  Shin Maki ,  Shigeki Ariura

IPC分类号： A61B1822

CPC分类号： A61B18/20 ,  A61B90/37 ,  A61B2017/00084 ,  A61B2017/00199 ,  A61B2017/00274 ,  A61B2018/00023 ,  A61B2018/00547 ,  A61B2018/00636 ,  A61B2018/00982 ,  A61B2018/2272

摘要： The invention relates to a thermal treatment apparatus capable of irradiating targeted lesions with energy to obtain good treatment results. The invention displays the diagnostic images 2201 of the lesion overlaid upon the laser irradiation areas a, b, c, and d and is capable of setting up the laser emission angle, output and time using the graphical user interface displayed on the touch panel.

摘要翻译： 本发明涉及能够用能量照射目标病变以获得良好治疗结果的热处理装置。本发明显示覆盖在激光照射区域a，b，c和d上的病变的诊断图像2201，并且能够设定 使用触摸面板上显示的图形用户界面来提高激光发射角度，输出和时间。

公开(公告)号：US06758844B2

公开(公告)日：2004-07-06

申请号：US10056130

申请日：2002-01-24

申请人： Wolfgang Neuberger

发明人： Wolfgang Neuberger

IPC分类号： A61B1822

CPC分类号： A61B18/20 ,  A61B2018/00029

摘要： A system and method is disclosed for improved treatment of oral tissues using 980 nm laser radiation and a handpiece with means for concurrently delivering the laser radiation and a liquid/gas spray onto the treatment area to improve the treatment effects. Unwanted heating and carbonization of surrounding tissues is reduced. The liquid/gas spray may be mixed inside the handpiece or in a separate device. The combination of cooling sprays with radiation wavelengths having high absorption in water has previously been avoided due to the thought that energy absorption by the cooling fluid would render the energy delivered to the tissue uncontrollable and of minimal benefit. Preferably, pulsed laser light provides a localized energy deposition and heating to avoid unwanted heating of underlying tissue. The liquid spray flushes away tissue debris in addition to cooling the treated tissue.

摘要翻译： 公开了一种用于使用980nm激光辐射改善口腔组织治疗的系统和方法，以及具有用于同时递送激光辐射和液体/气体喷雾到处理区域以提高治疗效果的手段的手持件。 周围组织的不需要的加热和碳化减少。 液体/气体喷雾可以在机头内部或在单独的装置中混合。 由于认为冷却流体的能量吸收将使能量传递给组织的能量不受控制并且具有最小的益处，所以先前已经避免了冷却喷雾与具有在水中的高吸收的辐射波长的组合。 优选地，脉冲激光提供局部能量沉积和加热以避免下层组织的不期望的加热。 除了冷却经处理的组织之外，液体喷雾还冲掉组织碎片。

公开(公告)号：US06575965B1

公开(公告)日：2003-06-10

申请号：US09713988

申请日：2000-11-16

申请人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

发明人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

IPC分类号： A61B1822

CPC分类号： A61B17/12022 ,  A61B5/0084 ,  A61B17/1214 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/12072 ,  A61B2017/12077 ,  A61B2017/2926

摘要： A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof. A mechanical sensor is attached to the distal end of the fiberoptic cable and connected to provide light signal information about a particular physical environment and communicated externally through the fiberoptic cable.

摘要翻译： 医疗装置构造成具有导管的基本形式，其具有用于插入体内和在体内操作的远端，并且近端为使用者提供控制体内远端的操作。 光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。 连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的光，并且可以包括光电池和机电马达或热敏光热材料。 电子传感器被连接以从光纤电缆的所述远端接收电力，并且被连接以提供关于特定物理环境的信号信息，并且通过光纤电缆向外传播到其近端。 机械传感器连接到光纤电缆的远端并被连接以提供关于特定物理环境的光信号信息，并通过光纤电缆在外部通信。

公开(公告)号：US06451010B1

公开(公告)日：2002-09-17

申请号：US09550096

申请日：2000-04-14

申请人： David Angeley

发明人： David Angeley

IPC分类号： A61B1822

CPC分类号： A61B18/201 ,  A61B18/20 ,  A61B2018/00636 ,  A61B2018/2035 ,  G02B15/173

摘要： A handpiece for projecting laser radiation from a solid-state laser via an articulated arm to biological tissue being treated is disclosed. An optical system in the handpiece provides that the laser radiation is projected in a spot of selectively variable size at a fixed distance from the handpiece. The projected spot can be defined as an image of a characteristic invariant cross-section of the laser beam delivered to the handpiece which has about the same width at a wide range of M2 values of the laser beam. This provides that at any mechanically selected size, the size of the projected spot remains substantially constant over the range of M2 values between about 1 and 15. In one example the handpiece projects 2.94 &mgr;m radiation in a range of spot sizes between about 0.5 mm and 1.5 mm. Spot size remains substantially constant over a range of M2 values between about 1 and 15.

摘要翻译： 公开了一种用于将来自固体激光器的激光辐射经由铰接臂投射到被处理的生物组织的手持件。 手持件中的光学系统提供了激光辐射以与手持件相距一定距离的可选择尺寸的投影点。 投影点可以被定义为传递到手持件的激光束的特征不变横截面的图像，该激光束在激光束的M2值的宽范围内具有大致相同的宽度。 这提供了在任何机械选择的尺寸上，投影光斑的尺寸在约1至15之间的M2值的范围内保持基本上恒定。在一个示例中，手持件在约0.5mm和 1.5毫米。 斑点尺寸在约1至15之间的M2值范围内保持基本恒定。