公开(公告)号：US07989164B2

公开(公告)日：2011-08-02

申请号：US11404181

申请日：2006-04-13

申请人： Ozgur Sahin ,  Calvin F. Quate ,  Olav Solgaard

发明人： Ozgur Sahin ,  Calvin F. Quate ,  Olav Solgaard

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

CPC分类号： G01Q60/34

摘要： Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA molecule attached to the surface with another DNA molecule. The complexed macromolecule is less flexible than an uncomplexed molecule. It will typically have more negative charge due to amino acids or DNA monomers. Both stiffness of the surface and the attractive capillary forces will change after binding and may be detected. By scanning the harmonic cantilever across a surface with macromolecules attached in tapping-mode and by recording the signals at the high frequency vibrations provided by harmonic cantilever, complexed molecules on a surface may be identified and quantified.

摘要翻译： 使用诸如用于原子力显微镜的谐波悬臂的方法和装置来检测由于大分子结合而导致的固体表面上的吸引力和排斥力的变化，例如附着在表面上的单链DNA分子的杂交 与另一个DNA分子。 络合的大分子比未复合的分子灵活性低。 由于氨基酸或DNA单体，它通常会具有更多的负电荷。 表面的刚度和吸引的毛细管力将在结合后改变并且可以被检测。 通过用分接模式连接的大分子扫描谐波悬臂，并通过在由谐波悬臂提供的高频振动下记录信号，可以识别和量化表面上的复合分子。

公开(公告)号：US20110160744A1

公开(公告)日：2011-06-30

申请号：US11444286

申请日：2006-05-31

申请人： Xiaojing Zhang ,  Olav Solgaard

发明人： Xiaojing Zhang ,  Olav Solgaard

IPC分类号： A61B19/00

CPC分类号： C12M35/04 ,  C12M35/00

摘要： According to an example embodiment of the present invention, a vibration-actuated microsurgical system includes an optical force detection arrangement having an optical encoding device configured to modulate an intensity of light in response to a displacement of a portion of the microsurgical system. Light sensing circuitry is configured to detect a force applied to the microsurgical system (e.g., and thereby to a sample) based on the intensity of light sensed from the optical encoding device. This detected force is used in controlling the application of the microsurgical system.

摘要翻译： 根据本发明的示例性实施例，振动致动的显微外科系统包括具有光学编码装置的光学力检测装置，所述光学编码装置被配置为响应于显微外科系统的一部分的位移来调制光的强度。 光感测电路被配置为基于从光学编码装置感测的光的强度来检测施加到显微外科系统（例如并且由此到样本）的力。 该检测力用于控制显微外科系统的应用。

公开(公告)号：US20100286674A1

公开(公告)日：2010-11-11

申请号：US12811888

申请日：2009-01-22

申请人： Adela Ben-Yakar ,  Christopher L. Hoy ,  Olav Solgaard

发明人： Adela Ben-Yakar ,  Christopher L. Hoy ,  Olav Solgaard

IPC分类号： A61B18/20 ,  H04N7/18 ,  A61B6/00

CPC分类号： G01B9/04 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/20 ,  A61B90/20 ,  A61B2018/20351 ,  G01N21/4795 ,  G01N21/6458

摘要： Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.

摘要翻译： 本文提供了用于生物组织成像的装置，系统和方法。 还提供了用于生物组织的外科手术操作的装置，系统和方法。 还提供了用于生物组织的组合成像和外科手术操作的装置，系统和方法。

公开(公告)号：US20100218288A1

公开(公告)日：2010-08-26

申请号：US12392811

申请日：2009-02-25

申请人： Ali Fatih Sarioglu ,  Olav Solgaard

发明人： Ali Fatih Sarioglu ,  Olav Solgaard

IPC分类号： G12B21/08

CPC分类号： G01Q20/02 ,  G01Q60/38

摘要： Various embodiments of the present invention are directed to microscopy cantilevers. Consistent with an example embodiment, aspects of the invention are directed to a cantilever having a body and a force sensor arrangement extending from an end of the body and including a tip near a free end of the force sensor arrangement. The force sensor arrangement exhibits a high temporal response to the tip's interaction with a sample, relative to the response of the cantilever. The force sensor arrangement's response is detected and used to characterize the sample.

摘要翻译： 本发明的各种实施方案涉及显微镜悬臂梁。 与示例性实施例一致，本发明的方面涉及一种具有主体和力传感器装置的悬臂，所述主体和力传感器装置从主体的端部延伸并且包括在力传感器装置的自由端附近的尖端。 相对于悬臂的响应，力传感器装置表现出对尖端与样品的相互作用的高时间响应。 检测力传感器装置的响应并用于表征样品。

公开(公告)号：US20090097811A1

公开(公告)日：2009-04-16

申请号：US12249550

申请日：2008-10-10

申请人： Sanja Hadzialic ,  Olav Solgaard

发明人： Sanja Hadzialic ,  Olav Solgaard

IPC分类号： G02B6/10

CPC分类号： G02B6/136 ,  G02B1/005

摘要： A method is disclosed for forming a photonic crystal in a homogeneous layer of material. The method enables the fabrication of 1D, 2D, or 3D photonic crystals. Photonic crystals in accordance with embodiments of the present invention exhibit low temperature sensitivity and low device curvature. In some embodiments, photonic crystals in accordance with embodiments of the present invention are integrated with mechanical elements, such as micromechanical, nanomechanical, microelectronic, and microfluidics devices and systems.

摘要翻译： 公开了一种在均质材料层中形成光子晶体的方法。 该方法能够制造1D，2D或3D光子晶体。 根据本发明的实施例的光子晶体显示出低的温度灵敏度和低的器件曲率。 在一些实施例中，根据本发明的实施例的光子晶体与诸如微机械，纳米机械，微电子和微流体装置和系统的机械元件集成。

公开(公告)号：US07509002B2

公开(公告)日：2009-03-24

申请号：US11940199

申请日：2007-11-14

申请人： Joseph M. Kahn ,  Mark A. Horowitz ,  Olav Solgaard ,  Shanhui Fan

发明人： Joseph M. Kahn ,  Mark A. Horowitz ,  Olav Solgaard ,  Shanhui Fan

IPC分类号： G02B6/26

CPC分类号： G02B6/4206 ,  G02B6/2861

摘要： Optical signals are passed in an optical medium using an approach that facilitates the mitigation of interference. According to an example embodiment, a filtering-type approach is used with an optical signal conveyed in an optical fiber, such as a multimode fiber (MMF) or a multimode waveguide. Adaptive spatial domain signal processing, responsive to a feedback signal indicative of data conveyed in the multimode waveguide, is used to mitigate interference in optical signals conveyed in the multimode waveguide.

摘要翻译： 光信号通过使用有助于减轻干扰的方法在光学介质中传播。 根据示例实施例，滤波型方法与诸如多模光纤（MMF）或多模波导之类的光纤中传送的光信号一起使用。 响应于指示在多模波导中传送的数据的反馈信号的自适应空间域信号处理被用于减轻在多模波导中传送的光信号中的干扰。

公开(公告)号：US07412127B2

公开(公告)日：2008-08-12

申请号：US11464781

申请日：2006-08-15

申请人： Wonjoo Suh ,  Mehmet Fatih Yanik ,  Olav Solgaard ,  Shanhui Fan

发明人： Wonjoo Suh ,  Mehmet Fatih Yanik ,  Olav Solgaard ,  Shanhui Fan

IPC分类号： G02B6/26 ,  G02B6/24

CPC分类号： B82Y20/00 ,  G02B6/1225

摘要： We introduce a mechanically tunable photonic crystal structure consisting of coupled photonic crystal slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that the transmission and reflection coefficients for light normally incident upon such structures can be highly sensitive to nano-scale variations in the spacing between the slabs. Moreover, by specifically configuring the photonic crystal structures, the high sensitivity can be preserved in spite of significant fabrication-related disorders. We expect such a structure to play important roles in micro-mechanically tunable optical sensors and filters.

摘要翻译： 我们引入了由耦合光子晶体板组成的机械可调光子晶体结构。 使用分析理论和第一原理有限差分时域仿真，我们证明了通常在这种结构上入射的光的透射和反射系数可以对板之间的间距的纳米尺度变化高度敏感。 此外，通过具体配置光子晶体结构，可以保持高灵敏度，尽管有显着的制造相关障碍。 我们预计这种结构在微机械可调光学传感器和滤波器中起重要作用。

公开(公告)号：US07286292B2

公开(公告)日：2007-10-23

申请号：US10541317

申请日：2003-12-22

申请人： H{dot over (a)}kon Sagberg ,  Ib-Rune Johansen ,  Odd Løvhaugen ,  Olav Solgaard ,  Matthieu Lacolle

发明人： H{dot over (a)}kon Sagberg ,  Ib-Rune Johansen ,  Odd Løvhaugen ,  Olav Solgaard ,  Matthieu Lacolle

IPC分类号： G02B5/18

CPC分类号： G02B5/1828

摘要： This invention relates to a configurable diffractive optical element comprising an array of diffractive sub-elements having a reflective surface, wherein each sub-element has a controllable position with a chosen range, and in which a number of sub-elements are provided with a reflective grating with a number of predetermined spectral characteristics.

摘要翻译： 本发明涉及一种可配置衍射光学元件，其包括具有反射表面的衍射子元件的阵列，其中每个子元件具有可选择的范围的可控位置，并且其中多个子元件设置有反射 光栅具有多个预定的光谱特性。

公开(公告)号：US07142364B2

公开(公告)日：2006-11-28

申请号：US10936837

申请日：2004-09-08

申请人： Wonjoo Suh ,  Olav Solgaard ,  Shanhui Fan

发明人： Wonjoo Suh ,  Olav Solgaard ,  Shanhui Fan

IPC分类号： G02B1/10

CPC分类号： B82Y20/00 ,  G02B6/1225

摘要： We theoretically introduce a new type of optical all-pass filter based on guided resonance in coupled photonic crystal slabs. The filter exhibits near-complete transmission for both on- and off-resonant frequencies and yet generates large resonant group delay. We further show that such a filter can be mechanically switched into a flat-top band rejection filter. We also show that a single photonic crystal slab can also function either as optical all-pass transmission or flattop reflection filter for normally incident light. Both filter functions are synthesized by designing the spectral properties of guided resonance in the slab. The structure is extremely compact along the vertical direction.

摘要翻译： 我们理论上引入了一种基于耦合光子晶体板中的引导谐振的新型光学全通滤波器。 滤波器对于开启和关闭谐振频率都表现出近乎完整的传输，并且产生大的谐振群延迟。 我们进一步表明，这种滤波器可以机械地切换成平顶带阻滤波器。 我们还表明，单个光子晶体板也可以作为普通入射光的光学全透镜或平面反射滤光片。 通过设计板坯中引导共振的光谱特性来合成滤波器功能。 该结构沿垂直方向非常紧凑。

公开(公告)号：US20060261032A1

公开(公告)日：2006-11-23

申请号：US11130904

申请日：2005-05-17

申请人： Uma Krishnamoorthy ,  Daesung Lee ,  Olav Solgaard ,  Kyoungsik Yu

发明人： Uma Krishnamoorthy ,  Daesung Lee ,  Olav Solgaard ,  Kyoungsik Yu

IPC分类号： C23F1/00 ,  B44C1/22

CPC分类号： G02B26/0833

摘要： A method for fabricating an optical device and micromechanical device, wherein both devices are monolithically-integrated with a substrate. The optical surfaces and micromechanical devices are each formed in an etch step that is well-suited for forming that device. In addition, the embodiments of the present invention enable the optical surface and micromechanical device to be fabricated irrespective of severe topography on the surface of the substrate.

摘要翻译： 一种用于制造光学器件和微机械器件的方法，其中两个器件与衬底单片集成。 光学表面和微机械装置各自以适合于形成该装置的蚀刻步骤形成。 此外，本发明的实施例使得能够制造光学表面和微机械装置，而与基板表面上的严重形貌无关。