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公开(公告)号：US20100286674A1
公开(公告)日：2010-11-11
申请号：US12811888
申请日：2009-01-22
CPC分类号： G01B9/04 , A61B5/0059 , A61B5/0066 , A61B5/6852 , A61B18/20 , A61B90/20 , A61B2018/20351 , G01N21/4795 , G01N21/6458
摘要： Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.
摘要翻译： 本文提供了用于生物组织成像的装置，系统和方法。 还提供了用于生物组织的外科手术操作的装置，系统和方法。 还提供了用于生物组织的组合成像和外科手术操作的装置，系统和方法。
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公开(公告)号：US08894637B2
公开(公告)日：2014-11-25
申请号：US12811888
申请日：2009-01-22
CPC分类号： G01B9/04 , A61B5/0059 , A61B5/0066 , A61B5/6852 , A61B18/20 , A61B90/20 , A61B2018/20351 , G01N21/4795 , G01N21/6458
摘要： Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.
摘要翻译： 本文提供了用于生物组织成像的装置，系统和方法。 还提供了用于生物组织的外科手术操作的装置，系统和方法。 还提供了用于生物组织的组合成像和外科手术操作的装置，系统和方法。
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公开(公告)号：US09329308B2
公开(公告)日：2016-05-03
申请号：US13317768
申请日：2011-10-26
申请人： Olav Solgaard , Reinhold Dauskardt , Nina Vaidya
发明人： Olav Solgaard , Reinhold Dauskardt , Nina Vaidya
CPC分类号： G02B3/0087 , G02B19/00 , G02B19/0042 , G02B19/0047 , G02B19/0076 , G02B19/0085 , G02B19/009 , G02B19/0095
摘要： An Axially Graded Index LEns (AGILE) is provided. Such optical elements can provide optical concentration in excess of the free-space brightness theorem limit, because of the increased refractive index at the output of the concentrator compared to the input. Optical contact (i.e., no intervening low index material) between the AGILE and the absorbing element (or an optical source) can be employed to ensure no loss of brightness at the interface between the AGILE and the absorbing element (or source). Although solar cell concentration is a significant application of this technology, there are various other applications, such as increasing the efficiency of optical emission, and providing transmissive optical windows that include optically cloaked regions.
摘要翻译： 提供了轴向分级索引LEns（AGILE）。 由于与输入相比，聚光器的输出处的折射率增加，所以这种光学元件可以提供超过自由空间亮度定理极限的光学浓度。 可以使用AGILE和吸收元件（或光源）之间的光学接触（即，没有中间的低折射率材料），以确保AGILE和吸收元件（或源）之间的界面处的亮度不会损失。 尽管太阳能电池集中是该技术的重要应用，但是存在各种其他应用，例如提高光发射的效率，并且提供包括光学掩蔽区域的透射光学窗口。
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公开(公告)号：US08505544B2
公开(公告)日：2013-08-13
申请号：US11444286
申请日：2006-05-31
申请人： Xiaojing Zhang , Olav Solgaard
发明人： Xiaojing Zhang , Olav Solgaard
IPC分类号： A61M5/20
摘要： According to an example embodiment of the present invention, a vibration-actuated microsurgical system includes an optical force detection arrangement having an optical encoding device configured to modulate an intensity of light in response to a displacement of a portion of the microsurgical system. Light sensing circuitry is configured to detect a force applied to the microsurgical system (e.g., and thereby to a sample) based on the intensity of light sensed from the optical encoding device. This detected force is used in controlling the application of the microsurgical system.
摘要翻译： 根据本发明的示例性实施例，振动致动的显微外科系统包括具有光学编码装置的光学力检测装置，所述光学编码装置被配置为响应于显微外科系统的一部分的位移来调制光的强度。 光感测电路被配置为基于从光学编码装置感测的光的强度来检测施加到显微外科系统（例如并且由此到样本）的力。 该检测力用于控制显微外科系统的应用。
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5.发明申请公开(公告)号：US20130022307A1
公开(公告)日：2013-01-24
申请号：US13554995
申请日：2012-07-20
申请人： Onur Kilic , Michel J.F. Digonnet , Gordon S. Kino , Olav Solgaard , Shrestha Basu Mallick , Onur Can Akkaya
发明人： Onur Kilic , Michel J.F. Digonnet , Gordon S. Kino , Olav Solgaard , Shrestha Basu Mallick , Onur Can Akkaya
摘要： An optical structure includes an optical waveguide and at least one photonic crystal structure. The optical structure also includes a structural portion mechanically coupled to the optical waveguide and the at least one photonic crystal structure such that a region substantially bounded by the structural portion, the optical waveguide, and the at least one photonic crystal structure has a specified volume.
摘要翻译： 光学结构包括光波导和至少一个光子晶体结构。 光学结构还包括机械耦合到光波导和至少一个光子晶体结构的结构部分，使得基本上由结构部分，光波导和至少一个光子晶体结构限定的区域具有指定的体积。
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公开(公告)号：US20120186353A1
公开(公告)日：2012-07-26
申请号：US13356432
申请日：2012-01-23
IPC分类号： G01H9/00
摘要： An acoustic sensor includes at least one photonic crystal structure and an optical fiber in optical communication with the at least one photonic crystal structure. The at least one photonic crystal structure has at least one optical resonance with a resonance frequency and a resonance lineshape, wherein at least one of the resonance frequency and the resonance lineshape is responsive to acoustic waves incident upon the acoustic sensor. The acoustic sensor further includes an optical fiber in optical communication with the at least one photonic crystal structure. The optical fiber is configured to transmit light which impinges the at least one photonic crystal structure and to receive at least a portion of the light which impinges the at least one photonic crystal structure.
摘要翻译： 声学传感器包括至少一个光子晶体结构和与所述至少一个光子晶体结构光学通信的光纤。 至少一个光子晶体结构具有至少一个具有谐振频率和谐振线形的光学谐振，其中谐振频率和谐振线形形状中的至少一个对入射到声学传感器上的声波作出响应。 声学传感器还包括与至少一个光子晶体结构光学通信的光纤。 光纤被配置为透射照射至少一个光子晶体结构的光并且接收照射至少一个光子晶体结构的光的至少一部分。
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公开(公告)号：US20120002913A1
公开(公告)日：2012-01-05
申请号：US13256355
申请日：2010-03-24
IPC分类号： G02B6/122
CPC分类号： G01N21/7703 , B82Y20/00 , G01N21/39 , G01N21/7746 , G01N2021/7773 , G02B6/1225 , G02B6/136
摘要： This invention relates to an optical sensor element comprising a photonic crystal constituted by a membrane of a chosen transparent material, the membrane being provided with a number of defined openings in a chosen pattern, the pattern being adapted to provide resonance at a chosen wavelength or range of wavelengths, wherein said openings are provided with a reactive material acting as a receptor for a chosen type of molecules, e.g. proteins, the presence of which alters the resonance and/or scattering conditions in the sensor element thus altering the amount of light propagating out of the membrane plane.
摘要翻译： 本发明涉及一种光学传感器元件，其包括由所选择的透明材料的膜构成的光子晶体，所述膜以选定的图案设置有多个限定的开口，所述图案适于在选定的波长或范围内提供谐振 的波长，其中所述开口设置有用作所选类型分子的受体的反应性材料，例如 蛋白质，其存在改变传感器元件中的共振和/或散射条件，从而改变从膜平面传播的光的量。
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8.发明申请公开(公告)号：US20110041616A1
公开(公告)日：2011-02-24
申请号：US12874104
申请日：2010-09-01
IPC分类号： G01H9/00
摘要： An acoustic sensor includes at least one structure including at least one photonic crystal slab and an optical fiber optically coupled to the at least one photonic crystal slab, and having at least one optical resonance with a resonance frequency and a resonance lineshape. The acoustic sensor further includes a housing mechanically coupled to the at least one structure. At least one of the resonance frequency and the resonance lineshape is responsive to acoustic waves incident upon the housing.
摘要翻译： 声学传感器包括至少一个结构，其包括至少一个光子晶体板和光学耦合到所述至少一个光子晶体板的光纤，并且具有至少一个具有谐振频率和谐振线形的光学谐振。 声学传感器还包括机械地联接到所述至少一个结构的壳体。 谐振频率和谐振线形形状中的至少一个响应于入射到壳体上的声波。
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公开(公告)号：US20100309474A1
公开(公告)日：2010-12-09
申请号：US12770545
申请日：2010-04-29
IPC分类号： G01C19/72
CPC分类号： G01C19/56 , G01C19/5712 , G01C19/5776 , Y10T29/49609
摘要： A gyroscope and a method of detecting rotation are provided. The gyroscope includes a structure configured to be driven to move about a drive axis. The structure is further configured to move about a sense axis in response to a Coriolis force generated by rotation of the structure about a rotational axis while moving about the drive axis. The gyroscope further includes an optical sensor system configured to optically measure movement of the structure about the sense axis. In certain embodiments, the gyroscope is a microelectromechanical system (MEMS) gyroscope.
摘要翻译： 提供了陀螺仪和旋转检测方法。 陀螺仪包括构造成被驱动以围绕驱动轴线移动的结构。 该结构进一步构造成响应于围绕驱动轴线移动而围绕旋转轴线的旋转旋转产生的科里奥利力而围绕感测轴移动。 陀螺仪还包括光学传感器系统，其被配置为光学地测量围绕感测轴的结构的移动。 在某些实施例中，陀螺仪是微机电系统（MEMS）陀螺仪。
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10.发明申请Detection of macromolecular complexes on ultraflat surfaces with harmonic cantilevers 失效在具有谐波悬臂的超平坦表面上检测大分子复合物公开(公告)号：US20090227040A1
公开(公告)日：2009-09-10
申请号：US11977541
申请日：2007-10-24
CPC分类号： G01Q60/34 , C12Q1/6816 , G01Q60/42 , Y10T436/143333 , C12Q2565/607 , C12Q2565/501
摘要： Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA molecule attached to the surface with another DNA molecule. The complexed macromolecule is less flexible than an uncomplexed molecule. It will typically have more negative charge due to amino acids or DNA monomers. Both stiffness of the surface and the attractive capillary forces will change after binding and may be detected. The present methods and materials enable ultraflat surfaces for the macromolecule deposition, and may include the use of a gold-coated mica substrate and a self-assembling monolayer.
摘要翻译： 使用诸如用于原子力显微镜的谐波悬臂的方法和装置来检测由于大分子结合而导致的固体表面上的吸引力和排斥力的变化，例如附着在表面上的单链DNA分子的杂交 与另一个DNA分子。 络合的大分子比未复合的分子灵活性低。 由于氨基酸或DNA单体，它通常会具有更多的负电荷。 表面的刚度和吸引的毛细管力将在结合后改变并且可以被检测。 本发明的方法和材料可以实现用于高分子沉积的超平坦表面，并且可以包括使用镀金的云母基材和自组装单层。
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