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    Two-dimensional mass spectrometry using ion micropacket detection
    62.
    发明授权
    Two-dimensional mass spectrometry using ion micropacket detection 有权

    公开(公告)号：US11804370B2

    公开(公告)日：2023-10-31

    申请号：US16972099

    申请日：2019-05-23

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Lucas Szalwinski

    IPC: H01J49/00

    CPC classification number: H01J49/004 ,  H01J49/0031 ,  H01J49/0081

    Abstract: The invention generally relates to two-dimensional mass spectrometry using ion micropacket detection. In certain aspects, the invention provides systems including a mass spectrometer having an ion trap and one or more detectors. The system includes a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to: apply one or more scan functions to the ion trap that excite a precursor ion and eject a product ion from the ion trap; and determine a secular frequency of the product ion by detecting micropackets of the product ion as the micropackets are ejected from the ion trap.

    Mass tag analysis for rare cells and cell free molecules
    67.
    发明授权
    Mass tag analysis for rare cells and cell free molecules 有权

    公开(公告)号：US11531024B2

    公开(公告)日：2022-12-20

    申请号：US15762597

    申请日：2016-09-24

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    REACTION MONITORING
    68.
    发明申请
    REACTION MONITORING 有权

    公开(公告)号：US20220199383A1

    公开(公告)日：2022-06-23

    申请号：US17691294

    申请日：2022-03-10

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Xin Yan ,  Christopher Pulliam ,  Ryan M. Bain ,  Tawnya Flick

    IPC: H01J49/00 ,  H01J49/16 ,  H01J49/04 ,  G01N33/68

    Abstract: The invention generally relates to systems and methods for on-line reaction monitoring. In certain embodiments, the invention provides systems that include a reaction vessel having an outlet, a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into reaction solution flowed from the reaction vessel, one or more ion generating devices that receive flow from the quantitation unit, and a mass spectrometer. In certain embodiments, the invention provides systems for multiple reaction monitoring that include a plurality of reaction vessels, a plurality of ion generating devices, a plurality of channels, each channel coupling a reaction vessel to an ion generating device, an actuator coupled to the plurality of ion generating devices to thereby allow movement of the plurality of ion generating devices, and a mass spectrometer

    LOGICAL OPERATIONS IN MASS SPECTROMETRY
    69.
    发明申请
    LOGICAL OPERATIONS IN MASS SPECTROMETRY 有权

    公开(公告)号：US20210375612A1

    公开(公告)日：2021-12-02

    申请号：US17401774

    申请日：2021-08-13

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Lucas Szalwinski

    IPC: H01J49/42

    Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

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