公开(公告)号：US20080255198A1

公开(公告)日：2008-10-16

申请号：US12138459

申请日：2008-06-13

申请人： Chang An Chu ,  Paul Gillespie ,  Jefferson Wright Tilley

发明人： Chang An Chu ,  Paul Gillespie ,  Jefferson Wright Tilley

IPC分类号： A61K31/4525 ,  C07C63/331 ,  A61K31/192 ,  C07D405/06 ,  C07D307/68 ,  A61K31/341

CPC分类号： C07D213/79 ,  C07C65/24 ,  C07D277/56 ,  C07D307/68 ,  C07D333/40 ,  C07D405/06

摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.

公开(公告)号：US20080031686A1

公开(公告)日：2008-02-07

申请号：US11893873

申请日：2007-08-16

申请人： Paul Gillespie ,  Charles Wood

发明人： Paul Gillespie ,  Charles Wood

IPC分类号： E04G17/00 ,  E04G11/36

CPC分类号： E04G11/38 ,  E04G11/48 ,  E04G11/486 ,  E04G17/18 ,  E04G25/066 ,  E04G2009/025 ,  Y10T403/59 ,  Y10T403/591

摘要： A system of interconnecting structural components for supporting and forming suspended concrete slabs that allow removal of form panels without disturbing the slab support posts (shores). Additional features of the system accommodate changes in suspended slab thickness, horizontal slab dimensions that are not multiples of the basic component dimensions, slab edge cantilevered form panels, attachment to walls and remote manipulation of form panels from the floor below using an erection staff. The primary system components are panels, support posts, telescopic beams, adjustable hanger connections, wall hangers, wall beams, raking shore assemblies and erection/stripping staffs. Form panels are directly supported by the shores without the use of an intermediate member (usually a beam) that is common practice in the concrete forming industry. The system reduces the number of required components that in turn reduces the capital cost to the user and improves his labor efficiency and quality of the concrete surface.

摘要翻译： 互连用于支撑和形成悬挂混凝土板的结构部件的系统，其允许在不干扰板支撑柱（海岸）的情况下移除模板。 该系统的附加功能适应悬挂板坯厚度的变化，水平板尺寸不是基本部件尺寸的倍数，板坯边缘悬臂板，墙壁附件和使用安装人员从下面的地板远程操作板形板。 主要系统组件是面板，支撑柱，伸缩梁，可调节的衣架连接，壁挂架，墙梁，耙岸组件和安装/拆卸人员。 在不使用在混凝土成形工业中常见的中间构件（通常为梁）的情况下，板形板直接由岸边支撑。 该系统减少了所需组件的数量，从而降低了用户的资本成本，提高了他的劳动效率和混凝土表面的质量。

公开(公告)号：US08642629B2

公开(公告)日：2014-02-04

申请号：US12614485

申请日：2009-11-09

申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Eric Mertz ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Eric Mertz ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

IPC分类号： A61K31/44 ,  C07D213/02

CPC分类号： C07D213/71 ,  C07C255/54 ,  C07C311/29 ,  C07C317/22 ,  C07C317/36 ,  C07C317/44 ,  C07C317/46 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07D211/38 ,  C07D295/26 ,  C07D491/10

摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中W，X，Y和R 1 -R 7在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。

公开(公告)号：US08420675B2

公开(公告)日：2013-04-16

申请号：US13342150

申请日：2012-01-02

申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

IPC分类号： A61K31/416 ,  A61K31/4439 ,  A61K31/4245 ,  C07D413/12 ,  C07D401/12 ,  C07D231/54

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D413/12

摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1—R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，W，X，R 1 -R 5和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

公开(公告)号：US08404859B2

公开(公告)日：2013-03-26

申请号：US13399106

申请日：2012-02-17

申请人： Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

发明人： Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

IPC分类号： A61K31/426 ,  A61K31/381 ,  C07D417/12 ,  C07D277/46 ,  C07D333/38

CPC分类号： C07D277/20 ,  C07D333/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。

公开(公告)号：US20120101131A1

公开(公告)日：2012-04-26

申请号：US13342150

申请日：2012-01-02

申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun ,  Zhenshan Zhang

IPC分类号： A61K31/416 ,  C07D413/12 ,  A61P11/06 ,  C07D401/12 ,  A61K31/4439 ,  C07D231/54 ,  A61K31/4245

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D413/12

摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，W，X，R 1 -R 5和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

公开(公告)号：US08124641B2

公开(公告)日：2012-02-28

申请号：US12497786

申请日：2009-07-06

申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

IPC分类号： A61K31/4439 ,  C07D401/12

CPC分类号： C07D231/56 ,  C07D401/12

摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，R 1 -R 3和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

公开(公告)号：US20100125058A1

公开(公告)日：2010-05-20

申请号：US12614485

申请日：2009-11-09

申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Eric Mertz ,  Sung-Sau So ,  Hong Ying Yun ,  Zhenshan Zhang

发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Eric Mertz ,  Sung-Sau So ,  Hong Ying Yun ,  Zhenshan Zhang

IPC分类号： A61K31/397 ,  A61K31/44 ,  C07D211/72 ,  A61K31/19 ,  C07C315/00 ,  C07D241/04 ,  A61K31/497 ,  C07D205/00

CPC分类号： C07D213/71 ,  C07C255/54 ,  C07C311/29 ,  C07C317/22 ,  C07C317/36 ,  C07C317/44 ,  C07C317/46 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07D211/38 ,  C07D295/26 ,  C07D491/10

摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中W，X，Y和R 1 -R 7在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。

公开(公告)号：US20070049632A1

公开(公告)日：2007-03-01

申请号：US11507080

申请日：2006-08-18

申请人： Bruce Banner ,  Joseph Bilotta ,  Nader Fotouhi ,  Paul Gillespie ,  Robert Goodnow ,  Matthew Hamilton ,  Nancy-Ellen Haynes ,  Agnieszka Kowalczyk ,  Alexander Mayweg ,  Michael Myers ,  Sherrie Pietranico-Cole ,  Nathan Scott ,  Kshitij Thakkar ,  Jefferson Tilley

发明人： Bruce Banner ,  Joseph Bilotta ,  Nader Fotouhi ,  Paul Gillespie ,  Robert Goodnow ,  Matthew Hamilton ,  Nancy-Ellen Haynes ,  Agnieszka Kowalczyk ,  Alexander Mayweg ,  Michael Myers ,  Sherrie Pietranico-Cole ,  Nathan Scott ,  Kshitij Thakkar ,  Jefferson Tilley

IPC分类号： A61K31/416 ,  C07D231/54

CPC分类号： C07D231/54

摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。

公开(公告)号：US07105670B2

公开(公告)日：2006-09-12

申请号：US10685267

申请日：2003-10-14

申请人： Qingjie Ding ,  Paul Gillespie ,  Kyungjin Kim ,  Warren William McComas ,  Agostino Perrotta

发明人： Qingjie Ding ,  Paul Gillespie ,  Kyungjin Kim ,  Warren William McComas ,  Agostino Perrotta

IPC分类号： C07D239/02 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00

CPC分类号： C07D295/185 ,  C07B2200/11 ,  C07C45/63 ,  C07C49/80 ,  C07C49/825 ,  C07C49/84 ,  C07C2601/08 ,  C07D277/40 ,  C07D277/42 ,  C07D295/073 ,  C07D295/135 ,  C07D295/205 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12

摘要： Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.

摘要翻译： 公开了作为Cdk4选择性抑制剂的新型二氨基噻唑。 这些化合物及其药学上可接受的盐和酯是可用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物以及可用于制备化合物的中间体。