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公开(公告)号：US20120270875A1
公开(公告)日：2012-10-25
申请号：US13399117
申请日：2012-02-17
申请人： Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
发明人： Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
IPC分类号： A61K31/5377 , A61K31/506 , C07D413/14 , C07D409/14 , C07D239/42 , C07D409/12 , C07D401/12 , C07D417/14 , A61P11/06 , A61P11/00 , A61K31/505 , A61K31/497 , C07D403/12
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：US20120238569A1
公开(公告)日：2012-09-20
申请号：US13399106
申请日：2012-02-17
IPC分类号： A61K31/5377 , C07D417/12 , C07D417/14 , C07D409/12 , C07D409/14 , A61P11/06 , A61K31/427 , A61K31/381 , A61K31/416 , A61K31/506 , A61K31/497 , A61P11/00 , C07D277/56 , A61K31/426
CPC分类号： C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：US08404859B2
公开(公告)日：2013-03-26
申请号：US13399106
申请日：2012-02-17
IPC分类号： A61K31/426 , A61K31/381 , C07D417/12 , C07D277/46 , C07D333/38
CPC分类号： C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：US07622492B2
公开(公告)日：2009-11-24
申请号：US11507080
申请日：2006-08-18
申请人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
发明人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20100137250A1
公开(公告)日：2010-06-03
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/69 , C07C63/33 , A61K31/18 , C07D295/00 , A61K31/535 , C07C69/76 , C07D239/00 , C07D239/42
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。
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公开(公告)号：US08124629B2
公开(公告)日：2012-02-28
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/44 , A61K31/192 , C07D211/54 , C07C63/64
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。
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7.发明申请Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11B-羟基类固醇脱氢酶的抑制剂公开(公告)号：US20070225280A1
公开(公告)日：2007-09-27
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/541 , A61K31/496 , A61K31/454 , A61K31/4196 , A61K31/416 , C07D403/02 , C07D417/02
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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8.发明授权Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11＆amp; - 类固醇脱氢酶的抑制剂公开(公告)号：US07728029B2
公开(公告)日：2010-06-01
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/4155 , A61K31/415 , A61K31/454 , A61K31/5377 , C07D231/14 , C07D401/04 , C07D413/04 , C07D403/04
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US20070203210A1
公开(公告)日：2007-08-30
申请号：US11703306
申请日：2007-02-07
申请人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kang Le , Christophe Michoud
发明人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kang Le , Christophe Michoud
IPC分类号： A61K31/427 , C07D417/04
CPC分类号： C07D417/04
摘要： The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
摘要翻译： 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。
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公开(公告)号：US07504513B2
公开(公告)日：2009-03-17
申请号：US11703306
申请日：2007-02-07
申请人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kang Le , Christophe Michoud
发明人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kang Le , Christophe Michoud
IPC分类号： A61K31/427 , C07D417/04 , C07D417/14
CPC分类号： C07D417/04
摘要： The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
摘要翻译： 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。
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