-
公开(公告)号：US20070048834A1
公开(公告)日：2007-03-01
申请号：US11552710
申请日：2006-10-25
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： C12P21/06 , C07H21/04 , C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
-
公开(公告)号：US20070048260A1
公开(公告)日：2007-03-01
申请号：US11551362
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
63.发明申请SOLUBLE ZCYTOR14, ANTI-ZCYTOR14 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开可溶性ZCYTOR14抗体ZIYTOR14抗体和结合合作伙伴及其使用方法公开(公告)号：US20070048257A1
公开(公告)日：2007-03-01
申请号：US11538579
申请日：2006-10-04
申请人： Scott Presnell , Steven Burkhead , Steven Levin , Rolf Kuestner , Zeren Gao , Stephen Jaspers , Janine Bilsborough
发明人： Scott Presnell , Steven Burkhead , Steven Levin , Rolf Kuestner , Zeren Gao , Stephen Jaspers , Janine Bilsborough
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7155 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17F，IL-17A或IL-17A和IL-17F两者多肽分子的活性。 IL-17A和IL-17F是参与炎症过程和人类疾病的细胞因子。 ZcytoR14是IL-17A和IL-17F的常见受体。 本发明包括可溶性ZcytoR14，抗ZcytoR14抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17F，IL-17A或IL-17A和IL-17F两者的方法。
-
公开(公告)号：US20070041974A1
公开(公告)日：2007-02-22
申请号：US11549868
申请日：2006-10-16
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K39/395 , C07K16/24 , C12P21/04
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
-
公开(公告)号：US20050003475A1
公开(公告)日：2005-01-06
申请号：US09745792
申请日：2000-12-22
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： A61K38/00 , C07K14/715 , A61K38/17 , C07H21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
-
公开(公告)号：US20080095775A1
公开(公告)日：2008-04-24
申请号：US11762738
申请日：2007-06-13
申请人： Katherine Lewis , Scott Presnell , James West , Robert Mabry , Brent Meengs , Steven Levin
发明人： Katherine Lewis , Scott Presnell , James West , Robert Mabry , Brent Meengs , Steven Levin
IPC分类号： A61K39/395 , A61P43/00 , C07K16/00 , C12N5/02
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译： 本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。
-
公开(公告)号：US20070256145A1
公开(公告)日：2007-11-01
申请号：US11557689
申请日：2006-11-08
申请人： Scott Presnell , David Taft , Kevin Foley
发明人： Scott Presnell , David Taft , Kevin Foley
CPC分类号： C07K14/495
摘要： Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
-
公开(公告)号：US20070141051A1
公开(公告)日：2007-06-21
申请号：US11552238
申请日：2006-10-24
申请人： Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人： Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
-
公开(公告)号：US20070135347A1
公开(公告)日：2007-06-14
申请号：US11670074
申请日：2007-02-01
申请人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
-
公开(公告)号：US20070122883A1
公开(公告)日：2007-05-31
申请号：US11670147
申请日：2007-02-01
申请人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C07K14/715 , C12P21/06 , C07H21/04
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
-
-
-
-
-
-
-
-
-
搜索结果
84 条记录 (耗时 0.05 秒)
