公开(公告)号：US5744120A

公开(公告)日：1998-04-28

申请号：US415908

申请日：1995-04-03

申请人： David Scott Edwards ,  Shuang Liu

发明人： David Scott Edwards ,  Shuang Liu

IPC分类号： A61K51/00 ,  A61K51/04 ,  A61K51/08 ,  A61M36/00 ,  C07B59/00 ,  C07F5/00 ,  C07F13/00 ,  C07K7/56 ,  C07K14/75 ,  A61M36/14

CPC分类号： C07K14/75 ,  A61K51/0476 ,  A61K51/0497 ,  A61K51/082 ,  A61K51/088 ,  C07B59/004 ,  C07B59/008 ,  C07K7/56 ,  A61K2123/00

摘要： This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated technetium-99m labeled hydrazino or diazino modified biologically active molecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. This invention also provides methods for using the radiopharmaceuticals and kits comprising radiopharmaceutical precursors. The radiopharmaceuticals of this invention have the structure: �(Q).sub.d' L.sub.n --C.sub.h' !.sub.x --M.sub.t (A.sub.L1).sub.y (A.sub.L2).sub.z ; wherein the variables are as defined herein.

公开(公告)号：US09271978B2

公开(公告)日：2016-03-01

申请号：US14134793

申请日：2013-12-19

申请人： Shuang Liu ,  Bryan Cordell Duffy ,  John Frederick Quinn ,  May Xiaowu Jiang ,  Ruifang Wang ,  Gregory Scott Martin ,  He Zhao ,  Bruce Francis Molino ,  Peter Ronald Young

发明人： Shuang Liu ,  Bryan Cordell Duffy ,  John Frederick Quinn ,  May Xiaowu Jiang ,  Ruifang Wang ,  Gregory Scott Martin ,  He Zhao ,  Bruce Francis Molino ,  Peter Ronald Young

IPC分类号： A61K31/501 ,  C07D413/04 ,  C07D401/12 ,  A61K31/4439 ,  C07D417/04 ,  C07D413/14 ,  A61K31/496 ,  C07D237/04 ,  A61K31/50 ,  A61K45/06

CPC分类号： A61K31/5377 ,  A61K31/4375 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07D213/64 ,  C07D213/74 ,  C07D237/04 ,  C07D237/14 ,  C07D237/22 ,  C07D237/32 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  Y02A50/467

摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

摘要翻译： 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。

公开(公告)号：US20150344442A1

公开(公告)日：2015-12-03

申请号：US14729959

申请日：2015-06-03

申请人： David John Fairfax ,  Bryan Cordell Duffy ,  Gregory Scott Martin ,  John Frederick Quinn ,  Shuang Liu ,  Gregory Steven Wagner ,  Peter Ronald Young

发明人： David John Fairfax ,  Bryan Cordell Duffy ,  Gregory Scott Martin ,  John Frederick Quinn ,  Shuang Liu ,  Gregory Steven Wagner ,  Peter Ronald Young

IPC分类号： C07D239/91 ,  C07D401/14 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/517 ,  C07D401/04

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D265/32 ,  C07D401/04 ,  C07D401/14 ,  Y02A50/467 ,  A61K2300/00

摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

摘要翻译： 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。

公开(公告)号：US20140179648A1

公开(公告)日：2014-06-26

申请号：US14134793

申请日：2013-12-19

申请人： Shuang Liu ,  Bryan Cordell Duffy ,  John Frederick Quinn ,  May Xiaowu Jiang ,  Ruifang Wang ,  Gregory Scott Martin ,  He Zhao ,  Bruce Francis Molino ,  Peter Ronald Young

发明人： Shuang Liu ,  Bryan Cordell Duffy ,  John Frederick Quinn ,  May Xiaowu Jiang ,  Ruifang Wang ,  Gregory Scott Martin ,  He Zhao ,  Bruce Francis Molino ,  Peter Ronald Young

IPC分类号： A61K31/501 ,  C07D401/12 ,  A61K31/4439 ,  A61K45/06 ,  C07D413/14 ,  A61K31/496 ,  C07D237/04 ,  A61K31/50 ,  C07D413/04 ,  C07D417/04

CPC分类号： A61K31/5377 ,  A61K31/4375 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07D213/64 ,  C07D213/74 ,  C07D237/04 ,  C07D237/14 ,  C07D237/22 ,  C07D237/32 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  Y02A50/467

摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

摘要翻译： 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。

公开(公告)号：US08445494B2

公开(公告)日：2013-05-21

申请号：US12995771

申请日：2009-06-04

申请人： Jun Qiu ,  Qi Gao ,  Shuang Liu ,  Matthew Isherwood

发明人： Jun Qiu ,  Qi Gao ,  Shuang Liu ,  Matthew Isherwood

IPC分类号： A61K31/501 ,  C07D401/04 ,  A61P25/24

CPC分类号： C07F5/04 ,  C07C215/20 ,  C07C217/58 ,  C07C223/02 ,  C07D217/04 ,  C07D237/20 ,  C07D401/04 ,  C07D413/10 ,  C07F5/022 ,  C07F5/025

摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.

公开(公告)号：US20110160220A1

公开(公告)日：2011-06-30

申请号：US12995771

申请日：2009-06-04

申请人： Jun Qiu ,  Qi Gao ,  Shuang Liu ,  Min Hu ,  Yuh-Lin Allen Yang ,  Matthew Isherwood ,  Rasidul Amin

发明人： Jun Qiu ,  Qi Gao ,  Shuang Liu ,  Min Hu ,  Yuh-Lin Allen Yang ,  Matthew Isherwood ,  Rasidul Amin

IPC分类号： A61K31/501 ,  C07D401/02 ,  A61P25/24 ,  A61P25/22 ,  A61P29/00 ,  A61P3/04

CPC分类号： C07F5/04 ,  C07C215/20 ,  C07C217/58 ,  C07C223/02 ,  C07D217/04 ,  C07D237/20 ,  C07D401/04 ,  C07D413/10 ,  C07F5/022 ,  C07F5/025

摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.

摘要翻译： 本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。 本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。

公开(公告)号：US07317104B2

公开(公告)日：2008-01-08

申请号：US10864857

申请日：2004-06-09

申请人： Shuang Liu

发明人： Shuang Liu

IPC分类号： C07D211/72

CPC分类号： C07F13/005 ,  C07F9/58

摘要： Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as radiopharmaceuticals for the diagnosis of cardiovascular disorders, infectious diseases and cancer are also disclosed. Chelants as bifunctional chelators (BFCs) for the radiolabeling of target-specific biomolecules, such as proteins, peptides, peptidomimetics, non-peptide receptor ligands, enzyme inhibitors, and enzyme substrates are disclosed. Methods of using macrocyclic metal complexes containing the chelant-biomolecule conjugates as target-specific diagnostic radiopharmaceuticals that selectively localize at sites of disease and allow an image to be obtained of the loci using gamma scintigraphy are disclosed. Methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders, such as thromboembolic disease or atherosclerosis, infectious disease and cancer are further disclosed.

公开(公告)号：US20070021408A1

公开(公告)日：2007-01-25

申请号：US11487884

申请日：2006-07-17

申请人： Bruce Molino ,  Shuang Liu ,  Aruna Sambandam ,  Peter Guzzo ,  Min Hu ,  Congxiang Zha ,  Kassoum Nacro ,  David Manning ,  Matthew Isherwood ,  Kristen Fleming ,  Wenge Cui ,  Richard Olson

发明人： Bruce Molino ,  Shuang Liu ,  Aruna Sambandam ,  Peter Guzzo ,  Min Hu ,  Congxiang Zha ,  Kassoum Nacro ,  David Manning ,  Matthew Isherwood ,  Kristen Fleming ,  Wenge Cui ,  Richard Olson

IPC分类号： A61K31/55 ,  C07D487/02 ,  C07D403/02

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.

摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。

公开(公告)号：US20050201933A1

公开(公告)日：2005-09-15

申请号：US11124537

申请日：2005-05-06

申请人： Shuang Liu

发明人： Shuang Liu

IPC分类号： A61K51/04 ,  A61K51/08 ,  C07F9/6584 ,  C07F9/6587 ,  A61K51/00 ,  C07F5/00

CPC分类号： C07F9/6587 ,  A61K51/04 ,  A61K51/0482 ,  C07F9/6584

摘要： This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and radiotherapy. This invention relates especially to the use of metal chelates of the macrocyclic chelants as metallopharmaceuticals in Magnetic Resonance Imaging (MRI) and radiopharmaceuticals. This invention also relates to macrocyclic chelants as bifunctional chelating agents (BFC's) for the labeling of biologically active targeting molecules such as proteins, peptides, peptidomimetics, and non-peptide receptor ligands, with metal ions and radioisotopes.

摘要翻译： 本发明涉及由一个或两个含杂原子的桥组成的大环螯合剂，含有它们的组合物及其在医药中的用途，特别是在诊断成像和放射治疗中。 本发明特别涉及大环螯合物的金属螯合物作为磁共振成像（MRI）和放射性药物中的金属药物。 本发明还涉及用金属离子和放射性同位素标记生物活性靶向分子如蛋白质，肽，肽模拟物和非肽受体配体的双功能螯合剂（BFC's）的大环螯合剂。

公开(公告)号：US06916460B2

公开(公告)日：2005-07-12

申请号：US10663090

申请日：2003-09-15

申请人： Shuang Liu

发明人： Shuang Liu

IPC分类号： A61K51/04 ,  A61K51/08 ,  C07F9/6584 ,  C07F9/6587 ,  A61B49/00

CPC分类号： C07F9/6587 ,  A61K51/04 ,  A61K51/0482 ,  C07F9/6584

摘要： This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and radiotherapy. This invention relates especially to the use of metal chelates of the macrocyclic chelants as metallopharmaceuticals in Magnetic Resonance Imaging (MRI) and radiopharmaceuticals. This invention also relates to macrocyclic chelants as bifunctional chelating agents (BFC's) for the labeling of biologically active targeting molecules such as proteins, peptides, peptidomimetics, and non-peptide receptor ligands, with metal ions and radioisotopes.