公开(公告)号：US08285014B2

公开(公告)日：2012-10-09

申请号：US12061357

申请日：2008-04-02

申请人： Guenter Lauritsch ,  Thomas Redel ,  Michael Zellerhoff

发明人： Guenter Lauritsch ,  Thomas Redel ,  Michael Zellerhoff

IPC分类号： G06K9/00 ,  H05G1/64

CPC分类号： A61B6/504 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/507

摘要： A system and method of obtaining perfusion data for cerebral tissue is described. The system includes a C-arm X-ray device and a computing system configured to obtain sets of rotational projection X-ray data suitable for reconstructing 3D voxel data sets. A first data set is obtained of the patient, and then contrast material is injected into the vascular system to obtain a second 1 data set. A first voxel data set is subtracted from the second voxel data set, and the resultant data set is processed so as to segment the contrast-enhanced vasculature from the remaining data. The segmented voxels are subtracted from the resultant voxel data set, so as to yield a functional data set representing the difference between the attenuation of the tissues after administering contrast agent and the tissues prior to administering the contrast agent, without the contrast enhanced vasculature. The attenuation of the functional data set represents the perfusion or cerebral blood volume (CBV).

摘要翻译： 描述了获得脑组织灌注数据的系统和方法。 该系统包括C臂X射线装置和被配置为获得适于重建3D体元数据集的旋转投影X射线数据的组的计算系统。 获得患者的第一数据集，然后将造影材料注入血管系统以获得第二个1数据集。 从第二体素数据集中减去第一体素数据集，并且处理结果数据集，以便从剩余数据中分割对比度增强的脉管系统。 从所得到的体元数据集中减去分割体素，从而产生表示施用造影剂之前的组织的衰减与施用造影剂之前的组织之间的差异的功能数据集，而没有对比度增强的脉管系统。 功能数据集的衰减表示灌注或脑血容量（CBV）。

公开(公告)号：US20100329534A1

公开(公告)日：2010-12-30

申请号：US12825721

申请日：2010-06-29

申请人： Volker Biermann ,  Jan Boese ,  Georg Buchheim ,  Frank Dennerlein ,  Michael Fuhrmann ,  Holger Kunze ,  Alois Nöttling ,  Thomas Redel

发明人： Volker Biermann ,  Jan Boese ,  Georg Buchheim ,  Frank Dennerlein ,  Michael Fuhrmann ,  Holger Kunze ,  Alois Nöttling ,  Thomas Redel

IPC分类号： G06T7/00 ,  H05G1/02

CPC分类号： A61B6/466 ,  A61B6/027 ,  A61B6/4441

摘要： A method and an X-ray image acquisition system for the acquisition of X-ray images of a region of interest of an examination object from a multiplicity of angles of view for an 3-D image reconstruction are provided. The X-ray image acquisition system comprises an X-ray focus and an X-ray detector, which can be separately positioned and oriented relative to each other. The X-ray focus is moved along a combination of straight line segments and/or arc segments for the acquisition of X-ray images. The X-ray detector is oriented relative to the X-ray focus and moved in such a way that the region of interest is projected completely onto the X-ray detector upon each image acquisition.

摘要翻译： 提供了一种用于从3-D图像重构的多个视角获取检查对象的感兴趣区域的X射线图像的方法和X射线图像获取系统。 X射线图像采集系统包括X射线焦点和X射线检测器，其可以相对于彼此分开定位和取向。 X射线焦点沿着直线段和/或弧段的组合移动以获取X射线图像。 X射线检测器相对于X射线焦点定向并且以这样的方式移动，使得在每次图像采集时，感兴趣的区域完全投影到X射线检测器上。

公开(公告)号：US20100329526A1

公开(公告)日：2010-12-30

申请号：US12825369

申请日：2010-06-29

申请人： Marcus Pfister ,  Thomas Redel

发明人： Marcus Pfister ,  Thomas Redel

IPC分类号： G06K9/62

CPC分类号： A61B6/5235 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5217 ,  G06T7/254 ,  G06T2207/10121 ,  G06T2207/30101

摘要： A determination method for reinitialization of a temporal sequence of fluoroscopic images of an examination region of an examination object is provided. The examination region comprises a vascular system including arteries and/or veins. An acquisition time is assigned to each of the images representing a given distribution of a substance in the examination region at the acquisition time. A computer receives the temporal sequence of the images, determines an evaluation image corresponding spatially on a pixel-by-pixel basis to the images, and calculates a differential value between a pixel of the evaluation image at a time and a pixel at a preceding time during a time characteristic of the sequence. A reinitialization of the temporal sequence of the images is performed at a specific time and thereafter the determination method is started over and/or repeated. The specific time is determined as a function of at least one previously calculated differential value.

摘要翻译： 提供了一种用于重新初始化检查对象的检查区域的荧光透视图像的时间序列的确定方法。 检查区域包括包括动脉和/或静脉的血管系统。 在采集时间将采集时间分配给表示检查区域中物质的给定分布的每个图像。 计算机接收图像的时间序列，确定在图像上逐像素地对应的评估图像，并计算一次评估图像的像素与前一时刻的像素之间的差分值 在序列的时间特征。 在特定时间执行图像的时间序列的重新初始化，此后，确定方法开始和/或重复。 确定具体时间作为至少一个先前计算的微分值的函数。

公开(公告)号：US20100329523A1

公开(公告)日：2010-12-30

申请号：US12825785

申请日：2010-06-29

申请人： Martin Ostermeier ,  Marcus Pfister ,  Thomas Redel

发明人： Martin Ostermeier ,  Marcus Pfister ,  Thomas Redel

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B6/463 ,  A61B6/503 ,  A61B6/5235 ,  G06T11/001

摘要： A method for computing a color-coded analysis image of an examination area of an examination object from a temporal sequence of fluoroscopic images of the examination area comprising a vascular system containing arteries and/or veins is provided. An acquisition time instant has been assigned to each of the fluoroscopic images representing a given distribution of a material embolizing some of the vascular system. The fluoroscopic image spatially corresponds to an analysis image pixel by pixel. A computer receives the fluoroscopic images with a color attribute assigned to each pixel of the analysis image at an image point and a time instant. If a pixel differs from a pixel at a preceding time instant, the color attribute assumes a color attribute of the time instant and the difference. If a pixel corresponds to a background color of the analysis image, the color attribute assumes a background color.

摘要翻译： 提供了一种用于从包括含有动脉和/或静脉的血管系统的检查区域的荧光透视图像的时间序列计算检查对象的检查区域的颜色编码分析图像的方法。 已经将采集时刻分配给表示栓塞一些血管系统的材料的给定分布的每个透视图。 透视图像在空间上对应于逐像素的分析图像。 计算机接收在图像点和时刻分配给分析图像的每个像素的颜色属性的透视图像。 如果像素与前一时刻的像素不同，则颜色属性假定时刻的颜色属性和差异。 如果像素对应于分析图像的背景颜色，则颜色属性假定为背景颜色。

公开(公告)号：US20090287066A1

公开(公告)日：2009-11-19

申请号：US12122856

申请日：2008-05-19

申请人： Oliver Meissner ,  John Christopher Rauch ,  Thomas Redel ,  Michael Zellerhoff

发明人： Oliver Meissner ,  John Christopher Rauch ,  Thomas Redel ,  Michael Zellerhoff

IPC分类号： A61B5/00

CPC分类号： A61B6/481 ,  A61B6/4441 ,  A61B6/504

摘要： A workflow for a minimally invasive intervention, such as a treatment for a cancerous tumor, includes positioning a patient at a multi-functional imaging apparatus, obtaining pre-interventional images of the anatomy of the patient using a computed tomography or angiography imaging function, performing the minimally invasive intervention while the patient is positioned at the multi-functional imaging apparatus and while using a fluoroscopic imaging function, and performing a post-interventional imaging of the patient's anatomy while the patient is positioned at the multi-functional imaging apparatus using the computed tomography or angiographic imaging function. If the post-interventional imaging determines that additional intervention is in order, the additional intervention is performed while the patient is positioned at the imaging apparatus. Pre-intervention images and data sets from other sources may be combined with or used during the intervention. A treatment planning step may be included following the pre-interventional imaging and the intervention.

摘要翻译： 用于微创干预的工作流程，例如用于癌性肿瘤的治疗，包括将患者定位在多功能成像装置上，使用计算机断层摄影或血管造影成像功能获得患者的解剖结构的介入前图像，执行 当患者位于多功能成像设备并且同时使用荧光透视成像功能时进行微创干预，并且当患者使用计算出的多功能成像设备定位在多功能成像设备时对患者的解剖结构进行介入后成像 断层扫描或血管造影成像功能。 如果介入后成像确定额外干预是有序的，则在患者定位在成像装置的同时执行附加介入。 来自其他来源的预干预图像和数据集可以在干预期间组合或使用。 治疗计划步骤可以包括在介入前成像和干预之后。

公开(公告)号：US20080317323A1

公开(公告)日：2008-12-25

申请号：US12157356

申请日：2008-06-10

申请人： Klaus Kinnstaetter ,  Thomas Redel

发明人： Klaus Kinnstaetter ,  Thomas Redel

IPC分类号： G06K9/46

CPC分类号： G06T7/0012 ,  A61B6/507 ,  G06T2207/10121 ,  G06T2207/30104

摘要： A computer receives a temporal sequence of x-ray images of an examination region of an examination object. The examination region includes a blood vessel system and tissue supplied with blood. A detection time is assigned in each instance to the x-ray images. The x-ray images correspond locally with one another in terms of pixels and each display a distribution of a contrast agent in the examination region at the respective detection time. The computer determines the temporal course of the temporal derivation of the data values and/or of the average value of the data values of the pixels located in the evaluation region for at least one evaluation region which is standard for all x-ray images. It assigns a type to the evaluation region as a function hereof.

摘要翻译： 计算机接收检查对象的检查区域的X射线图像的时间序列。 检查区域包括供血的血管系统和组织。 在每种情况下将检测时间分配给x射线图像。 X射线图像在像素上彼此局部对应，并且在相应的检测时间显示检查区域中造影剂的分布。 计算机确定对于对于所有X射线图像是标准的至少一个评估区域，数据值的时间推导的时间导航和/或位于评估区域中的像素的数据值的平均值的时间过程。 它作为一个函数为评估区域分配一个类型。

公开(公告)号：US20080212857A1

公开(公告)日：2008-09-04

申请号：US11901674

申请日：2007-09-18

申请人： Marcus Pfister ,  Thomas Redel

发明人： Marcus Pfister ,  Thomas Redel

IPC分类号： G06K9/00

CPC分类号： A61B5/055 ,  A61B5/02007 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B90/36 ,  A61B2017/00778 ,  A61B2090/364 ,  A61B2090/376 ,  G06T5/50 ,  G06T7/136 ,  G06T7/30 ,  G06T2207/10072 ,  G06T2207/10116 ,  G06T2207/30101 ,  Y10S378/901

摘要： The invention relates to a method for post-processing a 3D image data set of a vessel structure of a human or animal body, in which a 2D DSA (Digital Subtraction Angiography) of the vessel structure is recorded and registered with the 3D image data set. The 2D DSA is compared with a corresponding projection image computed from the 3D data set and this is changed, e.g. by changing the segmentation parameters, to adapt it to the 2D DSA. This enables the outstanding local resolution of the 2D DSA to be used for improving the 3D image data set.

摘要翻译： 本发明涉及一种用于后处理人或动物体的血管结构的3D图像数据集的方法，其中记录血管结构的2D DSA（数字减影血管造影）并将其与3D图像数据集对齐 。 将2D DSA与从3D数据集计算的相应投影图像进行比较，并且将其改变，例如， 通过改变分割参数，使其适应2D DSA。 这使得2D DSA的出色局部分辨率可用于改进3D图像数据集。

公开(公告)号：US07408648B2

公开(公告)日：2008-08-05

申请号：US11429176

申请日：2006-05-05

申请人： Martin Kleen ,  Marcus Pfister ,  Thomas Redel

发明人： Martin Kleen ,  Marcus Pfister ,  Thomas Redel

IPC分类号： G01B9/02 ,  G01B11/02

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/02007

摘要： The invention relates to a method for tomographically displaying a cavity by optical coherence tomography (OCT) and to an OCT device, wherein the path length of a measuring light beam in the catheter can change as a result of a movement of the catheter and brings about a change in the display scale, wherein a possible change in the path length of the measuring light beam in the event of a movement of the catheter is electronically determined and automatically compensated.

摘要翻译： 本发明涉及一种用于通过光学相干断层摄影（OCT）和OCT装置层析显示腔的方法，其中导管中的测量光束的路径长度可以由于导管的运动而改变，并带来 显示尺度的变化，其中电子地确定导管移动时测量光束的路径长度的可能变化并自动补偿。

公开(公告)号：US20180061047A1

公开(公告)日：2018-03-01

申请号：US15687295

申请日：2017-08-25

申请人： Thomas Redel

发明人： Thomas Redel

IPC分类号： G06T7/00 ,  A61B5/021 ,  A61B5/026 ,  A61B5/02 ,  G06T7/60 ,  G06T7/11 ,  G06T11/00

CPC分类号： G06T7/0012 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/026 ,  A61B5/055 ,  A61B6/032 ,  A61B6/481 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5217 ,  A61B6/5235 ,  G06T7/11 ,  G06T7/60 ,  G06T11/003 ,  G06T11/008 ,  G06T2200/04 ,  G06T2200/08 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/30104 ,  G06T2211/404

摘要： A method for determining a clinical characteristic of a body vessel segment including providing, to a computing device, a three-dimensional reconstruction of a body vessel containing the body vessel segment. A segmented angiography recording of the body vessel segment is provided to the computing device. The computing device extracts at least one global feature of the body vessel from the three-dimensional reconstruction and extracts at least one local feature of the body vessel segment from the angiography recording. The clinical characteristic is determined for the body vessel segment as a function of the at least one extracted local feature and the at least one extracted global feature.

公开(公告)号：US20180055379A1

公开(公告)日：2018-03-01

申请号：US15684609

申请日：2017-08-23

申请人： Thomas Redel

发明人： Thomas Redel

IPC分类号： A61B5/026 ,  A61B6/03 ,  A61B6/00 ,  A61B8/08

摘要： A method for operating an x-ray device, (e.g., a fluoroscope), is described herein. The method includes: creating planning information for a therapeutic intervention into a body vessel segment based on a reconstruction of the body vessel segment; providing the planning information to a processing unit of the x-ray device; providing the reconstruction of the body vessel segment to the processing unit; creating a recording of the body vessel segment introduced into a recording region of the x-ray device; registering the reconstruction of the body vessel segment with the body vessel segment in the recording region of the x-ray device; displaying the recording of the body vessel segment on a display device of the x-ray device; and superimposing a graphical representation of the planning information on the recording displayed on the display device, in order to increase the efficiency of the therapeutic intervention into the body vessel segment.