Cyclic, cystein-free protein
    63.
    发明授权
    Cyclic, cystein-free protein 有权
    循环,半胱氨酸蛋白

    公开(公告)号:US08501679B2

    公开(公告)日:2013-08-06

    申请号:US12747723

    申请日:2008-12-12

    IPC分类号: A61K38/00

    CPC分类号: A61K38/191 C07K14/525

    摘要: A protein selected from the amino acid sequence of the region valine Val(91) to glycine Gly(121) of the mature human tumor necrosis factor, or a portion thereof, with the proviso that the protein comprises at least the amino acid sequence of the region lysine Lys(98) to glutamic acid Glu(116), with the cysteine Cys(101) being replaced by a glycine and an amide bond being formed between the amino group of the side chain of the lysine Lys(98) and the carboxyl group of the side chain of the glutamic acid Glu(116), which activates epithelial ion channels and improves the lung function and which can be used for the manufacture of medicaments for the treatment of diseases associated with the lung function, such as oedemas.

    摘要翻译: 选自成熟人肿瘤坏死因子的缬氨酸Val(91)至甘氨酸Gly(121)的氨基酸序列的蛋白质或其部分,条件是蛋白质至少包含氨基酸序列 区域赖氨酸Lys(98)至谷氨酸Glu(116),半胱氨酸Cys(101)被赖氨酸Lys(98)侧链的氨基与羧基之间形成的甘氨酸和酰胺键所取代 谷氨酸Glu(116)的侧链基团,其激活上皮离子通道并改善肺功能,并且其可用于制备用于治疗与肺功能相关的疾病如药物的药物。

    Metering device
    64.
    发明授权
    Metering device 有权
    计量装置

    公开(公告)号:US08038119B2

    公开(公告)日:2011-10-18

    申请号:US10595159

    申请日:2004-09-10

    IPC分类号: F16K31/12

    摘要: A metering device has an actuating unit within a housing in which an actuator is inserted and a hydraulic compensating element. The hydraulic compensating element is connected to the actuator and can be filled with a fluid when subjected to pressure. A first end of the actuator is provided with a first end cap. The metering device further has a stop that is disposed on the housing in the form of a seat, faces the first end cap, and defines a stopping position for the first end cap. The stop maintains a maximum distance between a sealing element and the end cap, the distance being smaller than the actuator traveling distance such that the actuator stroke beyond the end cap is sufficient for opening the valve. The first end cap hits the stop when moving in the direction of the hydraulic compensating element such that the movement is blocked.

    摘要翻译: 计量装置具有在其中插入致动器的壳体内的致动单元和液压补偿元件。 液压补偿元件连接到致动器,并且当受到压力时可以填充流体。 致动器的第一端设置有第一端盖。 计量装置还具有以座椅形式设置在壳体上的止挡件,面向第一端盖并且限定第一端盖的停止位置。 止动件保持密封元件和端盖之间的最大距离,该距离小于致动器行进距离,使得超过端盖的致动器行程足以打开阀。 当沿液压补偿元件的方向移动时,第一端盖撞击止动件,使得该运动被阻挡。

    Staged modular hydrocarbon reformer with internal temperature management
    65.
    发明申请
    Staged modular hydrocarbon reformer with internal temperature management 审中-公开
    具有内部温度管理的分段模块化烃重整器

    公开(公告)号:US20070227070A1

    公开(公告)日:2007-10-04

    申请号:US11395672

    申请日:2006-03-31

    IPC分类号: B01J8/00

    摘要: A CPOx hydrocarbon reformer comprising a plurality of sequential reforming stages for generating reformate. The first stage comprises adjacent active and inactive flow channels. Only a portion of the surface is provided with catalyst. The active channels have low catalytic activity such that about one-quarter of the reactants passing through the first stage is catalyzed. Reactants flowing through the inactive channels cool the active channels, preventing bed erosion. The fast exothermic combustion reaction near the front edge of the catalyst produces largely water and carbon dioxide but little hydrogen. Endothermic reactions in the following stages produce hydrogen and carbon monoxide while consuming water, carbon dioxide, and the remaining hydrocarbon fuel and oxygen using steam- and dry-reforming. Preferably, the intermediate stage reacts about one-half of the fuel. The last stage is fully coated to react the remainder of the fuel, and catalyst activity is increased.

    摘要翻译: 一种CPOx烃重整器,包括用于产生重整产物的多个连续重整级。 第一级包括相邻的主动和不活动的流动通道。 只有一部分表面设有催化剂。 活性通道具有低催化活性,使得通过第一阶段的约四分之一的反应物被催化。 流过非活动通道的反应物冷却活性通道,防止床层侵蚀。 催化剂前缘附近的快速放热燃烧反应主要产生水和二氧化碳,但几乎没有氢气。 以下阶段的吸热反应产生氢气和一氧化碳,同时使用蒸汽和干式重整方式消耗水,二氧化碳和剩余的烃燃料和氧气。 优选地,中间阶段反应大约一半的燃料。 最后一个阶段被完全涂覆以反应剩余的燃料,催化剂活性增加。

    Avoidance of poisoning during anesthesia
    66.
    发明授权
    Avoidance of poisoning during anesthesia 有权
    麻醉期间避免中毒

    公开(公告)号:US07002678B1

    公开(公告)日:2006-02-21

    申请号:US10069892

    申请日:1999-08-28

    申请人: Bernhard Fischer

    发明人: Bernhard Fischer

    IPC分类号: G01J3/44

    摘要: For avoiding poisoning effects during anesthesia, the quantitative amount of an anesthetic agent degradation product, preferably carbon monoxide CO and/or trifluoromethane CHF3, in an anesthetic gas mixture is determined. When the determined quantitative amount of the anesthetic agent degradation product in the anesthetic gas mixture exceeds a given threshold, an alarm is provided. This is preferably accomplished by measuring a Raman spectrum of the gas mixture, and determining the quantitative amount of the anesthetic agent degradation product in the gas mixture by comparing the measured Raman spectrum with a reference spectrum of the anesthetic agent degradation product.

    摘要翻译: 为了避免麻醉期间的中毒作用,测定麻醉剂气体混合物中麻醉剂降解产物,优选一氧化碳CO和/或三氟甲烷CHF 3 3的定量。 当麻醉剂混合物中麻醉剂降解产物的确定量超过给定阈值时,提供警报。 这优选通过测量气体混合物的拉曼光谱,并通过将测量的拉曼光谱与麻醉剂降解产物的参考光谱进行比较来确定气体混合物中麻醉剂降解产物的定量。

    Ultra low Nox emissions combustions system for gas turbine engines
    67.
    发明申请
    Ultra low Nox emissions combustions system for gas turbine engines 有权
    用于燃气轮机的超低NOx排放燃烧系统

    公开(公告)号:US20050103023A1

    公开(公告)日:2005-05-19

    申请号:US10620295

    申请日:2003-07-16

    申请人: Bernhard Fischer

    发明人: Bernhard Fischer

    IPC分类号: F23C13/02 F23R3/36 F23R3/40

    摘要: A combustion system for a gas turbine engine includes a Catalyst (CAT) combustion sub-system for generating combustion products under a lean premixed fuel/air condition in the presence of a Catalyst and a Dry-Low-Emissions (DLE) combustion sub-system, for generating combustion products under a lean premixed fuel/air condition. Gaseous and liquid fuels are used for the DLE combustion sub-system while only gaseous fuel is used for the CAT combustion system. The engine operates at start-up and under low load conditions with the DLE combustion system and switches over the combustion process to the CAT combustion sub-system under high load conditions. Thus the combustion system according to the invention combines the advantages of DLE and CAT combustion processes so that the gas turbine engine operates over an entire operating range thereof at high engine efficiency while minimizing omissions of nitrogen oxides and carbon monoxide from the engine.

    摘要翻译: 用于燃气涡轮发动机的燃烧系统包括催化剂(CAT)燃烧子系统,用于在催化剂和干 - 低排放(DLE)燃烧子系统的存在下,在贫燃混合燃料/空气条件下产生燃烧产物 用于在贫燃混合燃料/空气条件下产生燃烧产物。 气体和液体燃料用于DLE燃烧子系统,而只有气体燃料用于CAT燃烧系统。 发动机在启动和低负载条件下使用DLE燃烧系统运行,并在高负载条件下将燃烧过程切换到CAT燃烧子系统。 因此,根据本发明的燃烧系统结合了DLE和CAT燃烧过程的优点,使得燃气涡轮发动机在高发动机效率下在其整个工作范围内运行,同时最小化来自发动机的氮氧化物和一氧化碳的遗漏。

    Injection valve
    68.
    发明申请
    Injection valve 失效
    注射阀

    公开(公告)号:US20050092854A1

    公开(公告)日:2005-05-05

    申请号:US11010587

    申请日:2004-12-13

    IPC分类号: F02M61/18 F02M59/00 F02M61/08

    CPC分类号: F02M61/18 F02M61/08

    摘要: The injector tip of an injection valve which injects directly into the combustion chamber protrudes therein, thereby incurring the risk that combustion residues can become deposited on the injector tip. When the injection valve is in a closed state, the possible attachments of combustion residues along a separation line (10) are eliminated by means of a special configuration of the surface at the separation line (10) between the valve body and a valve plate. The surface is represented in a smooth, step-less, edge-less and curved manner.

    摘要翻译: 直接喷射到燃烧室中的喷射阀的喷射器尖端在其中突出,从而引起燃烧残余物可能沉积在喷射器尖端上的风险。 当注射阀处于关闭状态时,通过在阀体和阀板之间的分离管线(10)处的表面的特殊构造来消除沿着分离管线(10)的燃烧残余物的可能附着。 表面以平滑,无级,无边缘和弯曲的方式表示。

    Injection valve
    69.
    发明申请
    Injection valve 失效
    注射阀

    公开(公告)号:US20050017096A1

    公开(公告)日:2005-01-27

    申请号:US10924007

    申请日:2004-08-23

    摘要: An injection valve for injecting fuel comprises a valve housing (1) inside of which a drive unit (15) controls the movement of a valve needle (5) that is pretensioned by a spring (11). The injection valve also comprises a main chamber (27), which is provided inside the valve housing, is filled with fuel and accommodates the valve needle (5), and comprises a hydraulic bearing for the drive unit (15). The hydraulic bearing has a hydraulic chamber (29) that is connected to the main chamber (27), whereby fuel serves as the operating substance of the hydraulic bearing.

    摘要翻译: 用于喷射燃料的喷射阀包括阀壳体(1),驱动单元(15)在其内部控制由弹簧(11)预张紧的阀针(5)的运动。 注射阀还包括设置在阀壳体内部的主室(27),其被填充燃料并容纳阀针(5),并且包括用于驱动单元(15)的液压轴承。 液压轴承具有连接到主室(27)的液压室(29),由此燃料用作液压轴承的操作物质。