公开(公告)号：US20070055289A1

公开(公告)日：2007-03-08

申请号：US10636899

申请日：2003-08-06

申请人： Charles Scouten ,  James Unnerstall ,  John Thompson

发明人： Charles Scouten ,  James Unnerstall ,  John Thompson

IPC分类号： A61B19/00

CPC分类号： A61D3/00 ,  A61B90/11 ,  A61B90/14

摘要： A digital stereotaxic manipulator for animal research is provided with two enhancements. In one enhancement, rotary encoders are provided, to allow tilting of the manipulator, about vertical and/or horizontal axes, to be measured within a fraction of a degree. With assistance from software that applies sine and cosine values, orthogonal coordinates that are emitted by linear reader heads can be corrected to provide accurate orthogonal coordinates, even when an instrument has been rotated and/or tilted substantially. In a second enhancement, a “fine-drive” mechanism provides precise control over dorsal/ventral motion of an instrument. A radial gear is mounted on the main threaded shaft in the vertical arm assembly. A helical gear on a horizontal shaft is used to drive rotation of the radial gear and vertical shaft. If a 1:20 gearing ratio is provided by the helical and radial gears, this provides an operator with 20-times more precise control over vertical motion of an instrument. A detente is also provided, to enable the helical gear to pop out of position without damage, if an operator rotates the main vertical shaft before disengaging the fine-drive mechanism. A digital display device with touch-screen controls is also disclosed.

摘要翻译： 数字立体定位机器人为动物研究提供了两个增强。 在一个增强中，提供了旋转编码器，以允许操纵器绕垂直和/或水平轴倾斜，以在一定程度上测量。 在使用正弦和余弦值的软件的帮助下，即使当仪器已经旋转和/或大幅倾斜时，也可以校正由线性读取头发出的正交坐标以提供准确的正交坐标。 在第二个增强中，“精细驱动”机制可以精确控制仪器的背/腹侧运动。 径向齿轮安装在垂直臂组件中的主螺纹轴上。 水平轴上的斜齿轮用于驱动径向齿轮和垂直轴的旋转。 如果通过螺旋和径向齿轮提供1:20的传动比，这为操作者提供了对仪器的垂直运动进行20倍更精确的控制。 还提供一个止动件，以便在拆卸精细驱动机构之前操作者旋转主垂直轴使螺旋齿轮能够弹出位置而不损坏。 还公开了具有触摸屏控制的数字显示装置。

公开(公告)号：US20070003877A1

公开(公告)日：2007-01-04

申请号：US11173521

申请日：2005-07-02

申请人： David Punsalan ,  John Thompson

发明人： David Punsalan ,  John Thompson

IPC分类号： G03C5/00

CPC分类号： C30B5/00 ,  C23C8/02 ,  C23C26/00 ,  H01L21/02554 ,  H01L21/02565 ,  H01L21/02628

摘要： Inorganic semiconductive films are made by depositing a suitable precursor substance upon a substrate, irradiating the precursor substance with electromagnetic radiation to form a nascent film, and heating the nascent film at a predetermined temperature to form an inorganic semiconductive film.

摘要翻译： 无机半导体膜通过将合适的前体物质沉积在基材上，用电磁辐射照射前体物质以形成新生膜，并在预定温度下加热新生膜以形成无机半导体膜，从而制备无机半导体膜。

公开(公告)号：US20060294623A1

公开(公告)日：2006-12-28

申请号：US11207020

申请日：2005-08-19

申请人： John Thompson ,  Tzann-Wei Wang ,  Dongen Lu

发明人： John Thompson ,  Tzann-Wei Wang ,  Dongen Lu

IPC分类号： C12N15/82 ,  C07H21/04 ,  C07K14/415

CPC分类号： C07K14/415 ,  C12N9/0004 ,  C12N15/8261 ,  Y02A40/146

摘要： The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.

摘要翻译： 本发明涉及真核起始因子5A（“eIF-5A”）的独特同工型：衰老诱导的eIF-5A; 伤员诱导的eIF-5A; 和生长eIF-5A，以及编码这三个因子的多核苷酸。 本发明还涉及涉及调节这些因子的表达的方法。 本发明还涉及脱氧螺旋体合成酶（“DHS”），编码DHS的多核苷酸以及涉及调节DHS表达的方法。

公开(公告)号：US20060240457A1

公开(公告)日：2006-10-26

申请号：US11397327

申请日：2006-04-04

申请人： Yejun Tan ,  Hongyue Dai ,  Pek Lum ,  John Thompson ,  Joel Berger ,  Eric Muise ,  Richard Raubertas ,  Kenny Wong

发明人： Yejun Tan ,  Hongyue Dai ,  Pek Lum ,  John Thompson ,  Joel Berger ,  Eric Muise ,  Richard Raubertas ,  Kenny Wong

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/142 ,  C12Q2600/158

摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

摘要翻译： 在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。 另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。 提供了可用于本发明实践的基因群体。

公开(公告)号：US20060094677A1

公开(公告)日：2006-05-04

申请号：US11134445

申请日：2005-05-23

申请人： John Thompson ,  Bruce Galton ,  Catherine Taylor ,  Charles Dinarello ,  Leonid Reznikov ,  Adrienne Boone ,  Marianne Hopkins

发明人： John Thompson ,  Bruce Galton ,  Catherine Taylor ,  Charles Dinarello ,  Leonid Reznikov ,  Adrienne Boone ,  Marianne Hopkins

IPC分类号： A61K48/00 ,  C07H21/04 ,  C07H21/02 ,  C12N15/85

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/53

摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFKB by inhibiting expression of apoptosis-specific eIF-5A.

摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFκB的活化。

公开(公告)号：US20060031968A1

公开(公告)日：2006-02-09

申请号：US11206810

申请日：2005-08-19

申请人： John Thompson ,  Tzann-Wei Wang ,  Dongen Lu

发明人： John Thompson ,  Tzann-Wei Wang ,  Dongen Lu

IPC分类号： A01H5/00 ,  C07H21/04 ,  C12N9/10 ,  C12N5/04 ,  C12N15/82

CPC分类号： C12N15/8243 ,  C07K14/415 ,  C12N9/0004 ,  C12N15/8249 ,  C12N15/8261 ,  C12N15/8266 ,  C12N15/8271 ,  C12N15/8279 ,  Y02A40/146

摘要： Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced eIF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced eIF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

摘要翻译： 通过将编码衰老诱导的脱氧螺旋体合成酶的基因或基因片段，衰老诱导的eIF-5A或两者整合到反义方向的植物基因组中来实现对植物中程序性细胞死亡（包括衰老）的表达的调节。 鉴定编码衰老诱导的脱氧螺旋体合酶和衰老诱导的eIF-5A的植物基因，单独和组合的每个核苷酸序列用于修饰转基因植物中的衰老。

公开(公告)号：US20050150606A1

公开(公告)日：2005-07-14

申请号：US10756042

申请日：2004-01-13

申请人： Bret Marschand ,  John Thompson ,  Frank Peterson

发明人： Bret Marschand ,  John Thompson ,  Frank Peterson

IPC分类号： B44C7/00 ,  B65H35/00 ,  B65H37/00 ,  B65H37/02

CPC分类号： B65H37/007 ,  Y10T156/1348 ,  Y10T156/1365 ,  Y10T156/1795 ,  Y10T156/18

摘要： A transfer tape dispenser comprises a housing and a supply spool and a take up spool disposed within the housing. A carrier ribbon has a first end and a second end, with the first end connected to the supply spool, and the second end connected to the take-up spool. An applicator tip is partially disposed within the housing and includes a platform with a front edge, a rear edge, a first side edge, a second side edge, a top surface, a bottom surface. A first wall is adjacent to the first side edge and a second wall is adjacent to the second side edge. At least one protuberance extends from the applicator tip and is adapted to maintain outer edges of the transfer tape adjacent to the top surface of the platform.

摘要翻译： 转移胶带分配器包括壳体和供给卷轴以及设置在壳体内的卷取卷轴。 载体带具有第一端和第二端，其第一端连接到供给卷轴，第二端连接到卷取卷轴。 施加器尖端部分地设置在壳体内，并且包括具有前边缘，后边缘，第一侧边缘，第二侧边缘，顶表面，底表面的平台。 第一壁与第一侧边缘相邻，第二壁与第二侧边缘相邻。 至少一个突起从施用器尖端延伸并且适于保持转移带的外边缘与平台的顶表面相邻。

公开(公告)号：US20050056597A1

公开(公告)日：2005-03-17

申请号：US10664249

申请日：2003-09-16

申请人： William Fries ,  John Thompson ,  Benjamin Holko ,  Kenton Salisbury

发明人： William Fries ,  John Thompson ,  Benjamin Holko ,  Kenton Salisbury

IPC分类号： C02F1/30 ,  C02F1/32

CPC分类号： C02F1/30 ,  C02F1/325 ,  C02F2201/3223 ,  C02F2201/3228 ,  C02F2201/326 ,  C02F2201/328

摘要： A system for treating a fluid comprising a treatment chamber; a light source for emitting light, such that at least a portion of the light travels within the treatment chamber; and a treatment area within the treatment chamber; wherein a flow profile of the fluid in the treatment area matches the fluence profile of the light that travels within the treatment area. An apparatus for providing a substantially uniform light treatment of a flowing fluid by providing a light source or sources and establishing (or controlling) the flow such that the combination of light intensity and flow velocity provides substantially uniform treatment (i.e. the faster moving fluid streams are treated at higher intensity and the slower moving fluid streams are treated at lower intensity).

公开(公告)号：US20050029170A1

公开(公告)日：2005-02-10

申请号：US10939570

申请日：2004-09-13

申请人： Karl Urquhart ,  John Thompson ,  Joe Hoffman

发明人： Karl Urquhart ,  John Thompson ,  Joe Hoffman

IPC分类号： B01F15/04 ,  H01L21/306 ,  B01D17/12

CPC分类号： B01F15/00227 ,  B01F15/0408 ,  H01L21/02052 ,  H01L21/30604 ,  H01L21/30608 ,  Y10T137/0329 ,  Y10T137/034 ,  Y10T137/2509

摘要： Provided are a method and apparatus for continuously blending a chemical solution for use in semiconductor processing. The method involves the step of: mixing a first chemical stream with a second chemical stream in a controlled manner, to form a stream of a solution having a predetermined formulation. The apparatus allows one to practice the above method. The method and apparatus can accurately provide chemical solutions of desired concentration in a continuous manner. The invention has particular applicability in semiconductor device fabrication.

摘要翻译： 提供了用于连续混合用于半导体处理的化学溶液的方法和装置。 该方法包括以下步骤：以受控的方式将第一化学物流与第二化学物流混合，形成具有预定配方的溶液流。 该装置允许实施上述方法。 该方法和装置可以以连续的方式准确地提供所需浓度的化学溶液。 本发明在半导体器件制造中具有特别的适用性。

公开(公告)号：US06292031B1

公开(公告)日：2001-09-18

申请号：US09461324

申请日：1999-12-15

申请人： John Thompson ,  Raymond Filippi ,  Joakim Bängs

发明人： John Thompson ,  Raymond Filippi ,  Joakim Bängs

IPC分类号： H03K522

CPC分类号： H03F3/45479

摘要： There is disclosed a level shift circuit which has a differential input, for receiving input signals, and a differential output, for supplying output signals derived from the input signals. The level shift circuit further includes a control level setting input, and a feedback circuit for setting a common mode level of the output signals to a level set on the control level setting input. This allows the output common mode to be set accurately, independently of the input common mode.

摘要翻译： 公开了一种电平移位电路，其具有用于接收输入信号的差分输入和用于提供从输入信号导出的输出信号的差分输出。 电平移位电路还包括控制电平设置输入和用于将输出信号的共模电平设置为在控制电平设置输入上设置的电平的反馈电路。 这允许输出公共模式被精确地设置，独立于输入共模。