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公开(公告)号:US20240026452A1
公开(公告)日:2024-01-25
申请号:US18206133
申请日:2023-06-06
发明人: Salvador Soriano , Michael Castello
IPC分类号: C12Q1/6883 , G01N33/50 , G01N33/68 , A61B5/00
CPC分类号: C12Q1/6883 , G01N33/5023 , G01N33/6896 , A61B5/00 , C12Q2600/118 , C12Q2600/136 , G01N2800/2821 , G01N2800/50 , G01N2800/52 , C12Q2600/158 , G01N2500/10
摘要: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.
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公开(公告)号:US11680273B2
公开(公告)日:2023-06-20
申请号:US14217070
申请日:2014-03-17
发明人: Alan P. Escher
IPC分类号: C12N15/85 , A61K48/00 , C12N15/11 , C12N15/117
CPC分类号: C12N15/85 , C12N2800/107 , C12N2830/46
摘要: Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss.
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公开(公告)号:US20230165749A1
公开(公告)日:2023-06-01
申请号:US17997303
申请日:2021-04-27
发明人: Erin Hoch , Janel Duggins
CPC分类号: A61H23/006 , A41B13/06 , A61F7/03 , A61N5/0625 , A61H23/02 , A41B2400/32 , A61N2005/0659 , A61N2005/0645 , A61H2201/1647 , A61H2205/081 , A61H2205/086 , A61H2201/0107 , A61H2201/0207 , A61H2201/0214 , A61H2201/0278 , A61H2201/0221 , A61H2205/083 , A61H2205/12 , A61H2201/10 , A61H2201/165
摘要: Described herein are devices and methods used for providing comfort to an infant, and in particular, to devices and methods for introducing a therapy protocol to an infant in, for example, a neonatal intensive care unit.
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公开(公告)号:US11464712B2
公开(公告)日:2022-10-11
申请号:US16430634
申请日:2019-06-04
发明人: Erin Hoch , Eric C. Gosink
IPC分类号: A61J9/00 , A61J15/00 , A61M39/00 , A61J11/00 , A61J7/00 , A61J9/08 , A61J11/04 , A61J9/06 , B65D1/02 , A61M3/02
摘要: The disclosure includes embodiments of an apparatus, a device, and methods to transform an infant feeding bottle into an infant gavage feeding apparatus. According to an embodiment, an infant gavage feeding apparatus can include an infant feeding bottle, a gavage milk delivery component, a retaining ring, and a cord component. In another embodiment, an infant milk dual-delivery device to transform an infant feeding bottle to an alternate nipple feeding and gavage feeding apparatus includes a gavage milk delivery component, a retaining ring, and a nipple receiving component. The gavage milk delivery component and the nipple receiving component can be positioned in a branched or a stacked configuration. The device can include a flow closure component and a controller to transition the milk flow for a gavage feeding and nipple feeding. The device can include a funnel to allow milk in the nipple to flow back into the infant feeding bottle.
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公开(公告)号:US20220071748A1
公开(公告)日:2022-03-10
申请号:US17016181
申请日:2020-09-09
发明人: Abraham MONTALVO , Jessica KIM , Joseph CARUSO , Seth MYHRE , Roberto SAVIGNANO
摘要: An evacuation dam apparatus including a frame having a top frame member, a bottom frame member, and two side frame members. A working area formed by the frame, a plurality of ports adjacent the working area, an outlet fluidly coupled with the plurality of ports. A fluid flow from at least a portion of the plurality of ports to the outlet forms a fluid flow path across the working area and at least a portion of the fluid flow path is formed within the frame.
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公开(公告)号:US11080554B2
公开(公告)日:2021-08-03
申请号:US16466681
申请日:2017-12-19
发明人: Montry Suprono , Robert Walter
摘要: Embodiments provide techniques, including systems and methods, for processing imaging data to identify an installed component. Embodiments include a component identification system that is configured to receive imaging data including an installed component, extract features of the installed component from the imaging data, and search a data store of components for matching reference components that match those features. A relevance score may be determined for each of the reference components based on a similarity between the image and a plurality of reference images in a component model of each of the plurality of reference components. At least one matching reference component may be identified by comparing each relevance score to a threshold relevance score and matching component information may be provided to an end-user for each matching reference component.
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公开(公告)号:US20210137763A1
公开(公告)日:2021-05-13
申请号:US15733752
申请日:2019-04-23
发明人: Mark BUSSELL
摘要: The disclosure is related to a system and method for operating a traction device to detect blood flow patterns in a subject for managing neuropathy related conditions through intraneural facilitation (INF). According to an embodiment, the INF system and method rely on the traction device for positioning the subject in one or more positions, and a processing device for processing intervening signals obtained by a probe positioned on the subject. The signals received from the probe may be used to determine a two dimensional (2D) plane blood flow pattern. Detected changes in the measured blood flow may be used to determine if further traction device positions are required to ensure that the intervening signals demonstrate normal blood flow patterns with improvements to the neuropathy condition. The 2D flow pattern may calculate at least one of Volume Flow (VF) and Pulsatility Index (PI) for each set of signals received.
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公开(公告)号:US20210093310A1
公开(公告)日:2021-04-01
申请号:US16949981
申请日:2020-11-23
发明人: Dalton Duane Baldwin
IPC分类号: A61B17/00 , A61B17/32 , A61B17/29 , A61M1/00 , A61B17/08 , A61B17/34 , A61B17/128 , A61B90/00
摘要: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.
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公开(公告)号:US10577669B2
公开(公告)日:2020-03-03
申请号:US15550501
申请日:2016-02-11
摘要: Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.
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公开(公告)号:US10207028B2
公开(公告)日:2019-02-19
申请号:US14500907
申请日:2014-09-29
IPC分类号: A61K39/395 , A61L24/00 , A61P35/00 , C07H21/00 , A61L27/44 , A61L27/50 , A61L27/54 , A61L27/56
摘要: Compositions having a drug-loaded microparticle and bone cement and methods of making such compositions are disclosed. Also disclosed are methods of employing such compositions for the treatment of injected joint spaces and bone disease.
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