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61.
公开(公告)号:US20240149350A1
公开(公告)日:2024-05-09
申请号:US18548639
申请日:2022-04-15
发明人: Cemal Cem TASAN , Jiyun KANG
CPC分类号: B22F10/64 , B33Y10/00 , B33Y30/00 , B33Y40/20 , C21D10/005
摘要: Systems, devices, and methods for improved manufacturing of parts are disclosed. One or more devices realize in situ laser shock peening for selective laser melting process to allow for microstructural control of a manufactured part, both locally and globally. The device can include a platform, an energy source (e.g., a laser), an applier to provide one or more opaque materials to form an opaque overlay, and one or more transparent materials that is/are disposed above the deposited opaque material to form a transparent overlay. The platform can include at least a first conduit used with generating a shock wave as part of the peening process and a second conduit to receive a vacuum device for residue collection from the peening process. The platform can be configured to translate relative to the sample on which the peening process is performed such that printing, peening and vacuuming can be performed substantially simultaneously.
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公开(公告)号:US11977074B2
公开(公告)日:2024-05-07
申请号:US16691788
申请日:2019-11-22
IPC分类号: G01N31/00 , G01N33/53 , G01N33/543 , G01N33/573
CPC分类号: G01N33/573 , G01N33/54306 , G01N2333/974 , G01N2800/226
摘要: The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.
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公开(公告)号:US20240144904A1
公开(公告)日:2024-05-02
申请号:US18342339
申请日:2023-06-27
发明人: Evelyn N. Wang , Gang Chen , Xuanhe Zhao , Elise M. Strobach , Bikramjit S. Bhatia , Lin Zhao , Sungwoo Yang , Lee A. Weinstein , Thomas A. Cooper , Shaoting Lin
IPC分类号: G10K11/168 , B32B7/027 , B32B7/12 , B32B9/04 , E06B9/24
CPC分类号: G10K11/168 , B32B7/027 , B32B7/12 , B32B9/045 , E06B9/24 , B32B2255/10 , B32B2255/20 , B32B2305/026 , B32B2307/102 , B32B2307/304 , B32B2307/412 , B32B2307/54 , B32B2307/546 , B32B2307/72 , E06B2009/2417
摘要: Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of 94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.
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公开(公告)号:US20240141324A1
公开(公告)日:2024-05-02
申请号:US18310039
申请日:2023-05-01
发明人: Ron Weiss , Breanna E. DiAndreth , Noreen Wauford
CPC分类号: C12N15/1024 , C12N15/111 , C12N15/86 , C12N2310/12
摘要: The present disclosure, at least in part, provides RNA cleavage based engineered bi-stable toggle switch utilizing the Programmable Endonucleolytic Scission-Induced Stability Tuning (PERSIST) platform. Also provided herein, are vectors encoding the engineered bi-stable toggle switch, and uses thereof.
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65.
公开(公告)号:US20240141309A1
公开(公告)日:2024-05-02
申请号:US18220808
申请日:2023-07-11
CPC分类号: C12N9/22 , C12N15/11 , C12N15/85 , C12N2310/20 , C12N2800/80
摘要: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5′-NG-3′ or 5′-NNG-3′ and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.
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公开(公告)号:US11970542B2
公开(公告)日:2024-04-30
申请号:US16762410
申请日:2018-11-08
发明人: Damian J. Green , Yukang Lin , Oliver W. Press , Alice Tzeng , Karl Dane Wittrup
IPC分类号: A61K39/395 , A61K31/203 , A61K45/06 , A61K51/04 , A61P35/00 , C07K16/28 , C07K16/44 , A61K39/00
CPC分类号: C07K16/2896 , A61K31/203 , A61K39/3955 , A61K45/06 , A61K51/0482 , A61P35/00 , C07K16/2878 , C07K16/44 , A61K2039/505 , C07K2317/31 , C07K2317/622
摘要: The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7, and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.
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公开(公告)号:US20240135224A1
公开(公告)日:2024-04-25
申请号:US18193730
申请日:2023-03-31
发明人: Guoqing WANG , Yixiang LUI , Jennifer SCHLOSS , Scott ALSID , Danielle A. BRAJE , Paola CAPPELLARO
摘要: Quantum sensors provide excellent performance combining high sensitivity with spatial resolution. Unfortunately, they can only detect signal fields at frequencies in a few accessible ranges, typically low frequencies up to the experimentally achievable control field amplitudes and a narrow window around their resonance frequencies. Fortunately, arbitrary-frequency signals can be detected by using the sensor qubit as a quantum frequency mixer, enabling a variety of sensing applications. The technique leverages nonlinear effects in periodically driven (Floquet) quantum systems to achieve quantum frequency mixing of the signal and an applied AC bias field. The frequency-mixed field can be detected using Rabi and CPMG sensing techniques with the bias field. Frequency mixing can distinguish vectorial components of an oscillating signal field, thus enabling arbitrary-frequency vector magnetometry. Using this protocol with nitrogen-vacancy centers in diamond to sense a 150 MHz signal field demonstrates the versatility of the quantum mixer sensing technique.
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公开(公告)号:US20240132400A1
公开(公告)日:2024-04-25
申请号:US18395376
申请日:2023-12-22
发明人: Yet-Ming Chiang , Leah Ellis , Andres Badel
CPC分类号: C04B2/08 , B01J19/0033 , B01J2219/00029 , B01J2219/00033 , C04B2290/20
摘要: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.
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公开(公告)号:US20240132381A1
公开(公告)日:2024-04-25
申请号:US18277562
申请日:2022-02-17
发明人: Trevor Alan Hatton , Kripa K. Varanasi , John Lake , Seoni Kim
CPC分类号: C02F1/469 , B01D19/0031 , B01D19/0084 , C02F1/20 , C02F1/66 , C02F2103/08
摘要: Electrochemical removal of chemical products in seawater, or other aqueous environments, resulting from increased atmospheric carbon dioxide levels is described.
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70.
公开(公告)号:US20240124987A1
公开(公告)日:2024-04-18
申请号:US18395422
申请日:2023-12-22
发明人: Yet-Ming Chiang , Leah Ellis , Andres Badel , Isaac W. Metcalf
摘要: Chemical reaction devices involving acid and/or base, and related systems and methods, are generally described.
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