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    COMPOSITION OF A FIRST NON-LABELED MONOCLONAL ANTIBODY BINDING TO A TUMOR ANTIGEN AND A NON-CROSS REACTIVE SECOND MONOCLONAL ANTIBODY LABELED WITH A NIR FLUORESCENCE LABEL
    64.
    发明申请
    COMPOSITION OF A FIRST NON-LABELED MONOCLONAL ANTIBODY BINDING TO A TUMOR ANTIGEN AND A NON-CROSS REACTIVE SECOND MONOCLONAL ANTIBODY LABELED WITH A NIR FLUORESCENCE LABEL 有权
    第一个非标记的单克隆抗体与肿瘤抗原结合的组合物和标记有近红色荧光标记的非交叉反应性第二单克隆抗体

    公开(公告)号：US20130323180A1

    公开(公告)日：2013-12-05

    申请号：US13961167

    申请日：2013-08-07

    申请人： Hoffmann-La Roche Inc.

    发明人： Max Hasmann ,  Helmut Lenz ,  Werner Scheuer

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0058 ,  A61K39/39558 ,  A61K49/0032

    摘要： This invention relates to a composition of a non-labeled monoclonal antibody binding to a tumor antigen and a second monoclonal antibody labeled with a NIR fluorescence label, binding to the same tumor antigen, wherein the first and second antibody exhibit no cross reactivity. The composition can be used for the treatment of patients suffering of solid tumors which are associated with an overexpression of such a tumor antigen. The invention further relates to a the co-administration of said first and second antibody as wells as to a method of acquiring a NIR fluorescence images of such tumors or the patients suffering from such tumors during the treatment of said patient with such composition.

    摘要翻译： 本发明涉及结合肿瘤抗原的非标记单克隆抗体的组合物和用NIR荧光标记标记的第二单克隆抗体，其结合相同的肿瘤抗原，其中第一抗体和第二抗体不表现出交叉反应性。 该组合物可用于治疗与这种肿瘤抗原的过表达相关的实体瘤患者。 本发明还涉及所述第一和第二抗体的共同给药，以获得在用所述组合物治疗所述患者期间获得这种肿瘤或患有此类肿瘤的患者的NIR荧光图像的方法。

    POLYMERIC CARRIERS FOR IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION
    67.
    发明申请
    POLYMERIC CARRIERS FOR IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION 有权
    用于免疫组织化学和原位杂交的聚合物载体

    公开(公告)号：US20130273565A1

    公开(公告)日：2013-10-17

    申请号：US13905918

    申请日：2013-05-30

    申请人： Ventana Medical Systems, Inc.

    发明人： Jerry W. Kosmeder, II ,  Casey A. Kernag ,  Donald Johnson ,  Christopher Bieniarz

    IPC分类号： G01N33/58

    CPC分类号： G01N33/581 ,  A61K47/6883 ,  A61K49/0058 ,  A61K49/0067 ,  C07K17/08 ,  G01N33/532 ,  G01N33/54353 ,  G01N33/544 ,  G01N33/545 ,  G01N33/56983 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/587 ,  G01N33/588

    摘要： Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels, particularly haptens. The remaining reactive functional groups may be conjugated directly to a specific binding molecule, such as to the oxidized carbohydrate of the Fc region of the antibody. Disclosed conjugates display large signal amplification as compared to those based on molecules derivatized with single haptens, and are useful for assay methods, particularly multiplexed assays.

    摘要翻译： 本发明的某些公开的实施方案涉及到具有多个与多个感兴趣的分子反应的反应性官能团的离散的，较短的聚合物的合成，衍生化，免疫球蛋白的缀合和信号扩增。 反应性官能团，例如酰肼，可用各种可检测的标记，特别是半抗原衍生化。 剩余的反应性官能团可以直接与特异性结合分子结合，例如与抗体Fc区的氧化碳水化合物结合。 与基于用单个半抗原衍生的分子相比，所公开的缀合物显示出大的信号扩增，并且可用于测定方法，特别是多重测定。