公开(公告)号：US20130134077A1

公开(公告)日：2013-05-30

申请号：US13697132

申请日：2011-05-11

Applicant: Sebastian Wieskotten ,  Tobias Groeber ,  Paul Chamney

Inventor： Sebastian Wieskotten ,  Tobias Groeber ,  Paul Chamney

IPC: G01N27/00

CPC classification number: G01N27/00 ,  A61M1/3626 ,  A61M1/3669 ,  A61M2205/3317 ,  G01N33/48735

Abstract: Method and device according to the method for determining intracellular and/or extracellular, in particular macromolecular fractions of fluids, preferably of body fluids of living organisms, with the steps: coupling-in a measurement signal through an electrically non-conductive wall into the fluid to be measured; coupling-out an electrical measurement value that is thereby generated in the fluid to be measured; detecting the coupled-out electrical measurement value at a plurality of different frequencies of the electrical measurement signal; determining the intracellular and/or extracellular, in particular macromolecular fractions of the fluid to be measured by means of evaluation of the detected electrical measurement value at a plurality of frequencies of the measurement signal.

Abstract translation: 根据用于确定细胞内和/或细胞外，特别是流体，优选活体的体液的大分子部分的方法的方法和装置，其步骤为：将测量信号通过非导电壁耦合到流体 待测 耦合出由此在被测流体中产生的电测量值; 检测所述电测量信号的多个不同频率处的耦合输出电测量值; 通过在测量信号的多个频率处的检测到的电测量值的评估来确定待测量的流体的细胞内和/或细胞外，特别是大分子级分。

公开(公告)号：US20130096480A1

公开(公告)日：2013-04-18

申请号：US13709870

申请日：2012-12-10

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A.

Inventor： James Han ,  Thomas P. Hartranft ,  Thomas D Kelly ,  Angel Lasso

IPC: A61M1/36 ,  A61M1/30

CPC classification number: A61M1/3669 ,  A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  Y10S439/909

Abstract: An extracorporeal blood system includes: an extracorporeal blood machine; an arterial line extending from the extracorporeal blood machine; a venous line extending from the extracorporeal blood machine; and an access disconnection circuit for detecting a disconnection of at least one of the arterial or venous lines from a patient, the access disconnection circuit including (i) a signal generation source having first and second signal generation source electrical lines each in electrical communication with blood traveling through one of the arterial or venous lines, (ii) a conductive pathway electrically communicating blood traveling through the arterial line with blood traveling through the venous line, and (iii) a signal processing unit positioned and arranged to process a signal generated by the source to detect the disconnection of the at least one of the arterial and venous lines.

Abstract translation: 体外血液系统包括：体外血液机器; 从体外血液机器延伸的动脉线; 从体外血液机器延伸的静脉线; 以及用于检测来自患者的动脉或静脉线中的至少一个的断开的接入断开电路，所述接入断开电路包括（i）具有与血液电连通的第一和第二信号发生源电线的信号发生源 穿过动脉或静脉线之一，（ii）将通过动脉线行进的血液与穿过静脉线的血液电连通的导电路径，以及（iii）信号处理单元，其被定位和布置成处理由 源，以检测动脉和静脉线中的至少一个的断开。

公开(公告)号：US07927010B2

公开(公告)日：2011-04-19

申请号：US11780685

申请日：2007-07-20

Applicant: Karl G. Schick ,  David Uhen

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N25/58 ,  G01N27/00

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor. The sensors are calibrated using 0.100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器设计用于将传感器特定信息（如校准和生产信息）存储在传感器上的非易失性存储器芯片中。 传感器在25摄氏度下使用0.100摩尔氯化钾（KCl）溶液进行校准。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。

公开(公告)号：US07530962B2

公开(公告)日：2009-05-12

申请号：US11422891

申请日：2006-06-08

Applicant: Edward Allan Ross ,  Rosalind J. Sadleir

Inventor： Edward Allan Ross ,  Rosalind J. Sadleir

IPC: A61M37/00 ,  C02F1/00 ,  G01F1/86

CPC classification number: A61M1/3621 ,  A61M1/3656 ,  A61M1/3669 ,  A61M2205/13

Abstract: The present invention describes a system, apparatus, and method for detection of disconnection of a device from a patient, such as dislodgment of a device during medical treatments or therapies, using a patient's electrical voltages.

Abstract translation: 本发明描述了一种系统，装置和方法，用于使用患者的电压来检测装置与患者之间的断开，例如医疗处理或治疗期间装置的脱离。

公开(公告)号：US20070255527A1

公开(公告)日：2007-11-01

申请号：US11741162

申请日：2007-04-27

Applicant: Karl Schick ,  David Uhen

Inventor： Karl Schick ,  David Uhen

IPC: G01R35/00 ,  G01R13/04 ,  G06F17/18 ,  G01R27/08

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor on in a barcode printed on the sensor The sensors are calibrated using 0100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器设计用于将传感器特定的信息（例如校准和生产信息）存储在印刷在传感器上的条形码上的传感器上的非易失性存储器芯片中。传感器使用0100摩尔氯化钾（KCl）溶液进行校准 25摄氏度。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。

公开(公告)号：US20070126794A1

公开(公告)日：2007-06-07

申请号：US11294296

申请日：2005-12-05

Applicant: Karl Schick ,  David Uhen

Inventor： Karl Schick ,  David Uhen

IPC: B41J2/135

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor. The sensors are calibrated using 0.100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器设计用于将传感器特定信息（如校准和生产信息）存储在传感器上的非易失性存储器芯片中。 传感器在25摄氏度下使用0.100摩尔氯化钾（KCl）溶液进行校准。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。

公开(公告)号：US20060081517A1

公开(公告)日：2006-04-20

申请号：US11246385

申请日：2005-10-07

Applicant: Masahiro Toyoda ,  Yasushi Takakuwa

Inventor： Masahiro Toyoda ,  Yasushi Takakuwa

IPC: B01D61/32

CPC classification number: A61M1/367 ,  A61M1/3656 ,  A61M1/3669 ,  A61M2205/13

Abstract: A hemodialysis device includes a hemodialysis device main body including an arterial blood circuit, venous blood circuit, blood pump, dialyzer, dialysate inlet and outlet lines, voltage adding means, electric potential measuring means, and monitoring means monitoring the needle when it is detached from the patient based on an electric potential measured by the electric potential measuring means. One electrode of the voltage adding means is attached between an arterial blood needle in the arterial blood circuit and the pump, and another electrode is attached to the dialysate outlet line. The hemodialysis device allows the precise detection of a needle that is detached from a patient taking a blood hemodialysis treatment by monitoring a voltage difference at a predetermined position while providing voltage to the blood flowing in the blood circuit. The device also allows the suppression of an increase in production cost for a disposable blood circuit.

Abstract translation: 血液透析装置包括：血液透析装置主体，包括动脉血液回路，静脉血液回路，血液泵，透析器，透析液入口和出口管线，加压装置，电位测量装置，以及监测装置， 所述患者基于由所述电位测量装置测量的电位。 电压添加装置的一个电极安装在动脉血液回路中的动脉血针与泵之间，另一个电极连接到透析液出口管线上。 血液透析装置允许通过在向血液回路中流动的血液提供电压的同时监视预定位置处的电压差来精确检测与进行血液透析治疗的患者分离的针。 该装置还允许抑制一次性血液回路的生产成本的增加。

公开(公告)号：US20030130607A1

公开(公告)日：2003-07-10

申请号：US10343856

申请日：2003-02-05

Inventor： Annalisa Delnevo ,  Carlo Alberto Lodi

IPC: A61M037/00

CPC classification number: A61M1/367 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3669 ,  A61M5/16831 ,  A61M2039/1005 ,  A61M2205/12

Abstract: A blood circuit (1) for a dialysis machine is made form plastic material and is provided with a metallic plate (30), which is applied to an external face of the blood circuit (1) and is connectable to a voltage generator (34) in such a way as to form a capacitor, in which the plate (30) and the blood act as the capacitor plates and the plastic material acts as the dielectric.

Abstract translation: 用于透析机的血液回路（1）由塑料制成，并设置有金属板（30），其被施加到血液回路（1）的外表面并且可连接到电压发生器（34）， 以形成电容器的方式，其中板（30）和血液用作电容器板，并且塑料材料用作电介质。

公开(公告)号：US06452371B1

公开(公告)日：2002-09-17

申请号：US09563107

申请日：2000-05-02

Applicant: James M Brugger

Inventor： James M Brugger

IPC: G01N2700

CPC classification number: A61M1/16 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3659 ,  A61M1/3661 ,  A61M1/3669 ,  G01F1/7046 ,  G01F1/708 ,  G01F1/7088

Abstract: A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the altered conductivity fluid to pass a conductivity measuring location. The measured conductivity is integrated over the time it takes to pass the conductivity measuring location. The integral is interpreted to determine the flow rate.

Abstract translation: 在管中流动的流体的流速通过注射大量盐水改变流体的电导率而定量地确定。 在改变的导电流体通过电导率测量位置的时间内测量改变的导电性的导电性。 测量的电导率在通过电导率测量位置所需的时间内积分。 积分被解释为确定流量。

公开(公告)号：US20020009385A1

公开(公告)日：2002-01-24

申请号：US09337109

申请日：1999-06-21

Inventor： NIKOLAI M. KRIVITSKI ,  VICTOR V. KISLUKHIN

IPC: A61M001/14 ,  A61M037/00 ,  B01D035/00 ,  C02F001/44

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/702 ,  A61M2205/707

Abstract: A method and apparatus for monitoring and measuring the filter blood volume by dilution techniques in real time, wherein the filter may be in use or off line during the measurements. The system includes a method and apparatus for measuring or monitoring the volume of a blood side of a filter by employing one of a bolus in the blood side upstream of the filter; a change of the filtration rate in the filter; and a bolus on the dialysate side, wherein the filter blood volume is calculated from the obtained data.

Abstract translation: 一种用于通过实时稀释技术来监测和测量过滤血液体积的方法和装置，其中在测量期间可以使用或离线过滤器。 该系统包括用于通过使用在过滤器上游的血液侧中的推注中的一种来测量或监测过滤器的血液侧的体积的方法和装置; 过滤器中过滤速率的变化; 并且在透析液侧进行推注，其中根据获得的数据计算出过滤血液体积。