公开(公告)号：US20040217057A1

公开(公告)日：2004-11-04

申请号：US10479608

申请日：2003-12-04

发明人： Paolo Rovatti

IPC分类号： C02F001/44

CPC分类号： B01F1/0022 ,  A61M1/1607 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  B01F1/0038 ,  B01F5/0413

摘要： A device for preparing dialysate for a dialysis machine is provided with a cartridge (9) containing salts (S), a first line (6) for supplying purified water to the cartridge (9) to form a saturated solution in the said cartridge (9), a second line (7) for supplying the said saturated solution from the cartridge (9) to the first line (6) and for mixing the saturated solution with the purified water and forming the dialysate, and a discharge line (18) for discharging the said saturated solution from the second line (7) and from the said cartridge (9) at the end of the dialysis treatment.

公开(公告)号：US20040188351A1

公开(公告)日：2004-09-30

申请号：US10477390

申请日：2004-05-13

发明人： Thomas Thiele ,  Rudiger Storm ,  Heike Matuschewski ,  Uwe Schedler

IPC分类号： C02F001/44

CPC分类号： B01D67/0093 ,  B01D2323/38 ,  C09D4/06 ,  C08F283/00

摘要： The invention concerns a method for reducing a tendency toward adsorption of molecules or biological cells from solutions or suspensions on a material surface placed in contact with the solution or suspension, as well as a use of the method, and a method for the production of a material with reduced tendency toward adsorption of molecules or biological cells from solutions or suspensions, which is suitable for conducting this method. It is provided that an organic or inorganic support material with a modified surface is used as the material, and that the surface is modified by in-situ polymerization of monomers which are selected as a function of a property of the molecule or the cell, onto the surface.

摘要翻译： 本发明涉及一种减少从与溶液或悬浮液接触放置的材料表面上的溶液或悬浮液中吸附分子或生物细胞的趋势的方法，以及该方法的使用和生产方法 从溶液或悬浮液吸附分子或生物细胞的倾向降低的材料，适用于进行该方法。 提供具有改性表面的有机或无机载体材料用作材料，并且通过基于分子或细胞的性质选择的单体的原位聚合将表面改性为 表面。

公开(公告)号：US20040124147A1

公开(公告)日：2004-07-01

申请号：US10660056

申请日：2003-09-11

发明人： William H. Fissell IV ,  H. David Humes ,  Shuvo Roy ,  Aaron Fleischman

IPC分类号： C02F001/44 ,  C02F001/48

CPC分类号： B01D67/0088 ,  A61M1/1678 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/3489 ,  A61M2205/3331 ,  A61M2205/50 ,  B01D57/02 ,  B01D61/18 ,  B01D61/28 ,  B01D61/425 ,  B01D67/0058 ,  B01D67/0072 ,  B01D67/0086 ,  B01D67/0093 ,  B01D71/027 ,  B01D2323/38 ,  B01D2325/028 ,  B01D2325/28 ,  C12N13/00 ,  G01N27/3271 ,  G01N2001/4016

摘要： The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.

摘要翻译： 本发明涉及超滤。 特别地，本发明提供了一种紧凑的超滤装置和用于产生超滤液的方法，两者都可用于各种应用，包括但不限于过滤血液，诊断应用和生物反应器。

公开(公告)号：US20040057949A1

公开(公告)日：2004-03-25

申请号：US10252228

申请日：2002-09-23

发明人： Potito U. DePaolis ,  Saleh Salehmoghaddam

IPC分类号： A61K039/395 ,  C02F001/44 ,  A61K031/715

CPC分类号： B01D61/243 ,  A61K31/715 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/022 ,  B01D61/04 ,  B01D2311/04 ,  B01D2311/12 ,  B01D2311/18

摘要： An improved method for hemodialysis employing reverse osmosis raises the pH of the blood to preserve the activity of the enzyme lysozyme to improve immune function and reduce the risk of infection in dialysis. In general, this method comprises: (1) removing arterial blood from a patient in need of hemodialysis; (2) increasing the pH of the arterial blood to a value of about 7.8 by adding a sufficient quantity of a 5% solution of sodium chloride buffered to a pH value of 7.9; (3) passing the arterial blood from step (b) through a dialyzer operating by reverse osmosis; (4) adding a pH-reducing agent selected from the group consisting of acetate buffer and dextran sulfate to reduce the pH of the blood to its normal value; (5) passing the blood from step (4) through a dialyzer operating by reverse osmosis to remove antigen; and (6) returning the blood to the patient.

摘要翻译： 使用反渗透的血液透析改进方法提高了血液的pH值，以保持酶溶菌酶的活性，从而改善免疫功能，降低透析感染的风险。 一般来说，该方法包括：（1）从需要血液透析的患者中除去动脉血; （2）通过加入足够量的缓冲至pH值为7.9的氯化钠的5％溶液将动脉血的pH值提高至约7.8; （3）将来自步骤（b）的动脉血通过反渗透操作的透析器; （4）添加选自乙酸盐缓冲液和硫酸葡聚糖的pH降低剂，将血液的pH值降低至正常值; （5）将来自步骤（4）的血液通过反渗透操作的透析器除去抗原; 和（6）将血液返回给患者。

公开(公告)号：US20040024342A1

公开(公告)日：2004-02-05

申请号：US10402912

申请日：2003-03-28

发明人： William Frederick Weitzel ,  H. David Humes ,  Emil Presley Paganini ,  Deborah Ann Buffington ,  Angela J. Funke

IPC分类号： A61M037/00 ,  C02F001/44

CPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3603 ,  A61M1/3621 ,  A61M1/3655 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368

摘要： A circuit for extracorporeal treatment of a body fluid, the circuit including in serial fluidic communication an inlet for receiving the body fluid from a patient, a first pump, a first treatment device for processing the body fluid, a second pump, an outlet for returning processed body fluid to the patient; and a shunt. The shunt is upstream from the first pump and downstream from the second pump.

摘要翻译： 一种用于体液体外处理的电路，所述电路包括串联流体连通，用于从患者接收体液的入口，第一泵，用于处理体液的第一处理装置，第二泵，用于返回的出口 加工体液给病人; 和分流。 分流器位于第一泵的上游并且在第二泵的下游。

公开(公告)号：US20040022784A1

公开(公告)日：2004-02-05

申请号：US09958272

申请日：2003-06-12

发明人： Kurt Nilsson

IPC分类号： A61K039/00 ,  C08B037/00 ,  C02F001/44

CPC分类号： B01J20/3219 ,  A61M1/3679 ,  A61M2202/0445 ,  A61M2202/206 ,  B01J20/3208 ,  B01J20/3212 ,  B01J20/3255 ,  B01J20/3274 ,  A61M2202/0057

摘要： Material characterized by that the material contains at least one biologically active saccharide which is covalently bound via at least one spacer to a cross-linked matrix and that the material is autoclaved.

摘要翻译： 材料的特征在于该材料含有至少一种通过至少一个间隔物与交联基质共价结合的生物活性糖，并且该材料被高压灭菌。

公开(公告)号：US20040011740A1

公开(公告)日：2004-01-22

申请号：US10606365

申请日：2003-06-26

发明人： Steven J. Bernard ,  John J. O'Mahony ,  Andrew V. Halpert ,  Mark Gelfand ,  Howard R. Levin

IPC分类号： C02F001/44

CPC分类号： B01D61/145 ,  A61M1/342 ,  A61M1/3431 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3613 ,  A61M1/3621 ,  B01D61/22

摘要： An extracorpeal blood circuit for removal of contrast from human blood using a filter and withdrawal filter pump and a by-pass pump. The withdrawal filter blood pump operates when a contrast bolus has been detected. Otherwise the bypass blood pump maintains physiological blood flow from the coronary sinus preventing the need for deflation and re-inflation of the balloon catheter. When contrast is detected blood the bypass blood pump is stopped to prevent contrast from leaking back into the patients circulatory system via the bypass pump and CS blood flow is maintained at its physiological blood flow resulting in the heart being oblivious to the transition by the prefilter blood pump.

摘要翻译： 使用过滤器和抽出式过滤器泵和旁通泵除去人血液对比度的傍晚血液回路。 当检测到对比剂时，抽出式过滤器血泵运行。 否则，旁路血液泵维持来自冠状窦的生理血流，防止气囊导管的放气和再充气的需要。 当检测到对比血液时，旁路血液泵停止，以防止对比通过旁路泵泄漏回患者循环系统，并且CS血流保持在其生理血流，导致心脏不被预过滤血液过渡 泵。

公开(公告)号：US20030111417A1

公开(公告)日：2003-06-19

申请号：US10307002

申请日：2002-11-30

发明人： Andrew Joseph Paszkowski

IPC分类号： C02F001/44

CPC分类号： B01D61/16 ,  B01D61/145 ,  B01D2311/04 ,  B82Y30/00 ,  C01B33/18 ,  C01B33/193 ,  C01P2002/02 ,  C01P2004/04 ,  C01P2004/32 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/80 ,  C09G1/02 ,  B01D2311/18

摘要： A system and method are disclosed for producing uniform size silica particles by the steps of providing preformed colloidal silica particles having a surface area, adding an alkali metal silicate and a cation exchange resin to produce a quantity of feed silica at a feed rate which is less than a nucleation rate, and increasing the feed rate as the feed silica is added wherein the feed rate is less than the nucleation rate.

摘要翻译： 公开了一种通过以下步骤生产均匀尺寸的二氧化硅颗粒的系统和方法：提供具有表面积的预制的胶体二氧化硅颗粒，加入碱金属硅酸盐和阳离子交换树脂，以较少的进料速率生产一定量的进料二氧化硅 比成核速率增加，并且当加入进料二氧化硅时增加进料速率，其中进料速率小于成核速率。

公开(公告)号：US20030031590A1

公开(公告)日：2003-02-13

申请号：US09925690

申请日：2001-08-10

发明人： Han Chul Park

IPC分类号： A61M001/36 ,  A61M037/00 ,  C02F001/44

CPC分类号： A61M1/3663 ,  A61M1/14 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M2205/103 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3365 ,  A61M2205/3379 ,  A61M2205/505 ,  F04B43/0081 ,  F04B43/1253 ,  F04B2205/09

摘要： An apparatus for measuring an amount of hemodialysis is disclosed. The apparatus comprises a rotation detecting unit for detecting the number of rotations of a dialysis blood pump, the pump being rotated to pump blood; a counting unit for counting the number of rotations of the dialysis blood pump by receiving a rotation detecting signal from the rotation detecting unit; and a display unit for displaying a value counted by the counting unit to determine the entire amount of hemodialysis based on the amount of hemodialysis per unit rotation of the dialysis blood pump.

摘要翻译： 公开了一种用于测量血液透析量的装置。 该装置包括：旋转检测单元，用于检测透析血液泵的旋转次数，泵旋转以泵送血液; 计数单元，用于通过从旋转检测单元接收旋转检测信号来计数透析血液泵的旋转数; 以及显示单元，用于显示由计数单元计数的值，以根据透析血液泵的每单位旋转的血液透析量确定全部血液透析量。

公开(公告)号：US20020121471A1

公开(公告)日：2002-09-05

申请号：US09980864

申请日：2002-04-12

发明人： Renato Pedrazzi

IPC分类号： C02F001/44

CPC分类号： A61M1/342 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M39/28 ,  A61M2230/30

摘要： A dialysis machine having an extracorporeal blood circuit having an arterial pipe and a venous pipe respectively connected to an inlet and an outlet of a blood compartment of a filter having a blood compartment and a dialysis liquid compartment separated by a semi-permeable membrane; means for determining a sequence of infusion of a liquid in the extracorporeal blood circuit, from at least one characteristic value (FF, TMPave, Kuf) correlated with the concentration of the blood (CE) and/or a filtration efficiency of the filter; and means for infusing the infusion solution in the arterial pipe and in the venous pipe in accordance with the determined infusion sequence.

摘要翻译： 一种具有体外血液循环的透析机，其具有动脉管和静脉管，所述静脉管分别连接到具有由半透膜隔开的血液室和透析液室的过滤器的血液室的入口和出口; 用于从与血液浓度（CE）相关的至少一个特征值（FF，TMPave，Kuf）和/或过滤器的过滤效率确定在体外血液回路中液体的输注顺序的装置; 以及用于根据确定的输注顺序将输注溶液注入动脉管和静脉管中的装置。