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    Polypeptide propoxyphene derivatives for immunoassay reagents
    61.
    发明授权
    Polypeptide propoxyphene derivatives for immunoassay reagents 失效
    用于免疫测定试剂的多肽丙氧芬衍生物

    公开(公告)号：US4025501A

    公开(公告)日：1977-05-24

    申请号：US560079

    申请日：1975-03-20

    申请人： Richard K. Leute

    发明人： Richard K. Leute

    IPC分类号： G01N33/531 ,  C07G7/00

    CPC分类号： G01N33/531 ,  Y10S435/961 ,  Y10S435/964 ,  Y10S436/823 ,  Y10S530/806 ,  Y10S530/807

    摘要： Novel compounds are provided which are derivatives of 1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol. The indicated alcohol is employed to prepare the monoester of a dibasic acid which is conjugated with an antigen for the production of antibodies which recognize both propoxyphene and its N-desmethyl metabolite in immunoassays.

    摘要翻译： 提供了1,2-二苯基-3-甲基-4-二甲基氨基-2-丁醇的衍生物的新型化合物。 使用所指示的醇制备与抗原缀合的二元酸的单酯，用于产生在免疫测定中识别丙氧芬及其N-去甲基代谢物的抗体。

    NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS
    67.
    发明申请
    NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS 失效
    用于测定TROPONIN I和T的新方法和TROPONIN I和T的复合物以及选择用于免疫球蛋白的抗体

    公开(公告)号：US20110143455A1

    公开(公告)日：2011-06-16

    申请号：US12986893

    申请日：2011-01-07

    申请人： Kenneth F. BUECHLER ,  Paul H. McPherson

    发明人： Kenneth F. BUECHLER ,  Paul H. McPherson

    IPC分类号： G01N33/566

    CPC分类号： G01N33/6887 ,  Y10S435/961 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/819

    摘要： Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma.Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex.Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassays.Also disclosed are antibodies which recognize, unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.

    摘要翻译： 用于检测和定量体液中肌钙蛋白I和肌钙蛋白T的测定系统和专用抗体作为心肌梗死的指标。 由于肌钙蛋白I和T存在于血液中的各种构象中，单体肌钙蛋白I与T和二元和三元复合物的比例以及存在于血液中的肌钙蛋白形式可能与代谢状态有关 心。 公开了一种确定全血，血清或血浆样品中肌钙蛋白形式或一组肌钙蛋白形式存在的系统。 公开了稳定的肌钙蛋白的组合物; 稳定的组合物可以包含肌钙蛋白I的稳定化组合物，其中肌钙蛋白I被氧化，肌钙蛋白I可以是未结合的，或者肌钙蛋白I可以在复合物中。 公开了一种用于从免疫测定中使用的表面改善肌钙蛋白I或T的恢复的方法。 还公开了识别未结合的肌钙蛋白形式，二元复合物中的肌钙蛋白的形式，肌钙蛋白I，T和C的三元复合物以及具有分子内氧化和还原的半胱氨酸的肌钙蛋白I的构象的抗体。

    NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS
    69.
    发明申请
    NOVEL METHODS FOR THE ASSAY OF TROPONIN I AND T AND COMPLEXES OF TROPONIN I AND T AND SELECTION OF ANTIBODIES FOR USE IN IMMUNOASSAYS 审中-公开
    用于测定TROPONIN I和T的新方法和TROPONIN I和T的复合物以及选择用于免疫球蛋白的抗体

    公开(公告)号：US20100167307A1

    公开(公告)日：2010-07-01

    申请号：US12554668

    申请日：2009-09-04

    申请人： Kenneth F. Buechler ,  Paul H. McPherson

    发明人： Kenneth F. Buechler ,  Paul H. McPherson

    IPC分类号： G01N33/53 ,  G01N33/566

    CPC分类号： G01N33/6887 ,  Y10S435/961 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/819

    摘要： Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma.Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex.Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassays.Also disclosed are antibodies which recognize, unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.

    摘要翻译： 用于检测和定量体液中肌钙蛋白I和肌钙蛋白T的测定系统和专用抗体作为心肌梗死的指标。 由于肌钙蛋白I和T存在于血液中的各种构象中，单体肌钙蛋白I与T和二元和三元复合物的比例以及存在于血液中的肌钙蛋白形式可能与代谢状态有关 心。 公开了一种确定全血，血清或血浆样品中肌钙蛋白形式或一组肌钙蛋白形式存在的系统。 公开了稳定的肌钙蛋白的组合物; 稳定的组合物可以包含肌钙蛋白I的稳定化组合物，其中肌钙蛋白I被氧化，肌钙蛋白I可以是未结合的，或者肌钙蛋白I可以在复合物中。 公开了一种用于从免疫测定中使用的表面改善肌钙蛋白I或T的恢复的方法。 还公开了识别未结合的肌钙蛋白形式，二元复合物中的肌钙蛋白的形式，肌钙蛋白I，T和C的三元复合物以及具有分子内氧化和还原的半胱氨酸的肌钙蛋白I的构象的抗体。

    Diagnosis and prevention of fetal heart disease
    70.
    发明授权
    Diagnosis and prevention of fetal heart disease 失效
    诊断和预防胎儿心脏病

    公开(公告)号：US07709210B2

    公开(公告)日：2010-05-04

    申请号：US11538527

    申请日：2006-10-04

    申请人： Pirooz Eghtesady

    发明人： Pirooz Eghtesady

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6887 ,  G01N33/6893 ,  G01N2800/32 ,  Y10S435/961 ,  Y10S435/975

    摘要： The present invention relates to a method for assessing the likelihood of the presence or formation of fetal heart disease (such as HLHS) in a fetus. In this methodology, the mother, either before or during pregnancy, is tested for the presence of anti-strep antibodies. If positive, the fetus is evaluated and monitored for the presence of fetal heart disease; the fetus can be treated, if appropriate. In addition, either prior to pregnancy or during the first trimester, the mother can be treated to prevent the formation of such antibodies or to neutralize their presence or effect fetal heart tissue.

    摘要翻译： 本发明涉及一种用于评估胎儿心脏病（如HLHS）的存在或形成的可能性的方法。 在这种方法中，母亲在怀孕之前或期间测试抗Strep抗体的存在。 如果阳性，胎儿被评估和监测胎儿心脏病的存在; 如果适当，胎儿可以治疗。 另外，在怀孕之前或在妊娠前三个月，可以治疗母亲以防止形成这种抗体或中和其存在或影响胎儿心脏组织。