公开(公告)号：US10826124B2

公开(公告)日：2020-11-03

申请号：US16388216

申请日：2017-07-18

申请人： Contemporary Amperex Technology Co., Limited

发明人： Tiancheng Yi ,  Chunhua Hu ,  Yao Jiang ,  Lu Miao ,  Chengdu Liang

IPC分类号： H01M10/0525 ,  H01M10/0567 ,  C07D239/04 ,  C07D241/04 ,  C07D251/04 ,  C07D317/34 ,  C07D327/04 ,  H01G11/06 ,  H01G11/64 ,  H01M6/16

摘要： An electrolyte and an electrochemical device, which relates to the field of energy storage materials. The electrolyte includes an additive A, an additive B and an additive C, the additive A selected from a group consisting of multi-cyano six-membered N-heterocyclic compounds represented by Formula I-1, Formula I-2 or Formula I-3, and combinations thereof, the additive B is at least one sulfonate compound, and the additive C is at least one halogenated cyclic carbonate compound. The electrochemical device includes the above electrolyte. The electrolyte of the present disclosure can effectively passivate the surface activity of the positive electrode material, inhibit the oxidation of the electrolyte, and effectively reduce gas production of a battery, meanwhile the electrolyte can be also adsorbed catalytically active of the graphite surface to form a more stable SEI film, thereby effectively reducing side reactions

公开(公告)号：US20200317658A1

公开(公告)日：2020-10-08

申请号：US16753439

申请日：2018-10-05

申请人： FORMA Therapeutics, Inc.

发明人： Justin Caravella ,  Bingsong Han ,  Cuixian Liu ,  Stephanos Ioannidis ,  Alexandre Joseph Buckmelter ,  David James Richard ,  Matthew W. Martin ,  Steven Mischke ,  Scot Mente

IPC分类号： C07D417/12 ,  C07D417/04 ,  C07D277/56 ,  C07D231/40 ,  C07D277/46 ,  C07C261/04 ,  C07D241/04 ,  C07D265/30

摘要： The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments.

公开(公告)号：US20200291010A1

公开(公告)日：2020-09-17

申请号：US16874961

申请日：2020-05-15

申请人： LEO PHARMA A/S

发明人： Alan Stuart JESSIMAN ,  Patrick Stephen JOHNSON ,  Kristoffer MAANSSON ,  Morten Dahl SØRENSEN

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D241/04

摘要： The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

公开(公告)号：US20200270217A1

公开(公告)日：2020-08-27

申请号：US16812625

申请日：2020-03-09

申请人： KABUSHIKI KAISHA TOSHIBA

发明人： Mitsuko ISHIHARA ,  Eiichi Akahoshi ,  Katsuyuki Naito ,  Emi Nozaki ,  Saeko Saruwatari

IPC分类号： C07D243/08 ,  C07C229/30 ,  C07D233/02 ,  C07D241/04 ,  C07D211/14 ,  A61K9/127

摘要： The present embodiment provides a compound represented by the formula (1): Q-CHR2  (1) (Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.

公开(公告)号：US10738039B2

公开(公告)日：2020-08-11

申请号：US15559574

申请日：2015-04-28

申请人： Dow Global Technologies LLC ,  Rohm and Haas Electronic Materials LLC

发明人： Lingli Duan ,  Chen Chen ,  Shaoguang Feng ,  Zukhra I. Niazimbetova ,  Maria Anna Rzeznik

IPC分类号： C07D413/12 ,  C25D3/38 ,  C07D241/04 ,  C07D265/33 ,  C07D413/06 ,  C07D413/10 ,  C25D3/30

摘要： Reaction products of diamines with the reaction products of monoamines and bisanhydrides are included as additives in metal electroplating baths. The metal electroplating baths have good throwing power and deposit metal layers having substantially planar surfaces. The metal plating baths may be used to deposit metal on substrates with surface features such as through-holes and vias.

公开(公告)号：US20200231564A9

公开(公告)日：2020-07-23

申请号：US16286700

申请日：2019-02-27

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  C07D405/14 ,  C07D403/12 ,  C07D451/02 ,  A61K31/445 ,  C07D241/04 ,  C07D211/22 ,  C07D401/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20200095205A1

公开(公告)日：2020-03-26

申请号：US16577901

申请日：2019-09-20

申请人： Arvinas, Inc.

发明人： Andrew P. CREW ,  Keith R. HORNBERGER ,  Lawrence B. SNYDER ,  Kurt ZIMMERMANN ,  Jing WANG ,  Michael BERLIN ,  Craig M. CREWS ,  Hanqing DONG

IPC分类号： C07D233/42 ,  A61K31/166 ,  C07D211/76 ,  C07D241/04 ,  C07D231/12 ,  C07D213/72 ,  C07D205/04 ,  C07D237/08 ,  C07D239/24 ,  C07D221/20 ,  A61K31/277 ,  A61K47/10 ,  A61K31/02 ,  A61K31/497 ,  C07D209/48 ,  C07D401/14 ,  A61K45/06

摘要： The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

公开(公告)号：US10577357B2

公开(公告)日：2020-03-03

申请号：US16334285

申请日：2017-09-19

申请人： The Texas A&M University System

发明人： Kevin Burgess

IPC分类号： C07D241/04 ,  C07D241/12 ,  C07D403/06 ,  C07D405/14 ,  A61P3/06 ,  C07D233/02 ,  C07D403/14

摘要： Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.

公开(公告)号：US10577335B2

公开(公告)日：2020-03-03

申请号：US15770289

申请日：2016-11-28

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Sean M. Smith ,  Michael J. Bulinski ,  Michael G. Costello ,  William M. Lamanna

IPC分类号： C07D265/30 ,  C07C43/17 ,  C07C211/24 ,  C07D207/10 ,  C07D241/04 ,  C09K5/10 ,  H01M10/0563

摘要： Described herein is an unsaturated fluorinated compound of formula (I) where X is O or N; Y is F or H; Z is F or CF3; and A is F or CF3 wherein when X is O, then n is 1, Y is H, Z is F, A is F, and Rf is a linear or branched perfluorinated alkyl group comprising 1 to 10 carbon atoms and optionally comprising at least one catenated O or N; and when X is N, then n is 2 and each Rf group are (i) independently selected from a linear or branched perfluorinated alkyl group comprising 1 to 8 carbon atoms and optionally comprising at least one catenated O or N; or (ii) bonded together to form a ring structure comprising 4 to 8 carbon atoms and optionally comprising at least one catenated O or N with the proviso that when Z is CF3 then A is F and when A is CF3 then Z is F and methods of making and using the same.

公开(公告)号：US10577331B2

公开(公告)日：2020-03-03

申请号：US15953817

申请日：2018-04-16

申请人： MannKind Corporation

发明人： John J. Freeman ,  Otto Phanstiel ,  William Elliot Bay ,  Kelly Sullivan Kraft

IPC分类号： C07D241/08 ,  C07D241/04 ,  C07D241/10

摘要： A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.