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    2-AMINOOXAZOLINES AS TAAR1 LIGANDS
    61.
    发明申请
    2-AMINOOXAZOLINES AS TAAR1 LIGANDS 审中-公开
    2-AMINOOXAZOLINES as TAAR1 LIGANDS

    公开(公告)号：US20100120864A1

    公开(公告)日：2010-05-13

    申请号：US12639076

    申请日：2009-12-16

    申请人： Guido Galley ,  Katrin Groebke Zbinden ,  Roger Norcross ,  Henri Stalder

    发明人： Guido Galley ,  Katrin Groebke Zbinden ,  Roger Norcross ,  Henri Stalder

    IPC分类号： A61K31/4439 ,  A61K31/421 ,  C07D263/08 ,  C07D413/02 ,  A61P25/00 ,  A61P3/00 ,  A61P9/00

    CPC分类号： C07D263/28 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07F7/0812

    摘要： The invention relates to compounds of formula I wherein X, Y, R1, R2, and n are as defined herein or to a pharmaceutically suitable acid addition salt thereof. The invention also relates to pharmaceutical compositions containing such compounds and methods for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases include depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

    摘要翻译： 本发明涉及其中X，Y，R 1，R 2和n如本文所定义或其药学上合适的酸加成盐的式I化合物。 本发明还涉及含有这些化合物的药物组合物和用于治疗与微量胺相关受体的生物功能相关的疾病的方法，所述疾病包括抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍，应激相关疾病， 精神病，精神分裂症，神经系统疾病，帕金森病，神经变性疾病，阿尔茨海默病，癫痫，偏头痛，药物滥用和代谢紊乱，进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍， 体温稳态，睡眠障碍和昼夜节律，以及心血管疾病。

    Antimycobacterial compounds
    65.
    发明授权
    Antimycobacterial compounds 失效
    抗分解细菌化合物

    公开(公告)号：US07691889B2

    公开(公告)日：2010-04-06

    申请号：US11082947

    申请日：2005-03-18

    申请人： Sudershan Kumar Arora ,  Vijaykumar Jagdishwar Patil ,  Prathap Sreedharan Nair ,  Prasad Purushottam Dixit ,  Shankar Ajay ,  Rakesh Kumar Sinha

    发明人： Sudershan Kumar Arora ,  Vijaykumar Jagdishwar Patil ,  Prathap Sreedharan Nair ,  Prasad Purushottam Dixit ,  Shankar Ajay ,  Rakesh Kumar Sinha

    IPC分类号： A61K31/422 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/454 ,  A61K31/496 ,  C07D263/20 ,  C07D413/02 ,  C07D417/02

    CPC分类号： C07D263/20 ,  C07D413/10 ,  C07D413/14

    摘要： Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts act as antibacterial agents. Also mentioned is a method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial conditions such as Mycobacterium tuberculosis, drug resistant Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai., including administering an antimycobacterially effective amount of the compound and/or pharmaceutically acceptable salts. There is also mentioned a process for the manufacture of the compound or its pharmaceutically acceptable salts.

    摘要翻译： 属于恶唑烷酮类的新型化合物具有强效的抗分支杆菌特性，特别适用于治疗结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶然遗传和关西等酸性快速生物。 该化合物及其药学上可接受的盐作为抗菌剂。 还提及了抑制分枝杆菌细胞生长的方法以及治疗结核分枝杆菌，耐药性结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶然和关西的分枝杆菌病症的方法，包括施用抗菌分泌杆菌 化合物和/或其药学上可接受的盐的量。 还提及了制备化合物或其药学上可接受的盐的方法。

    Method For Producing Bisbenzoxazoles
    66.
    发明申请
    Method For Producing Bisbenzoxazoles 有权
    双苯并恶唑生产方法

    公开(公告)号：US20100076040A1

    公开(公告)日：2010-03-25

    申请号：US12444630

    申请日：2007-10-05

    申请人： Mathias KRULL

    发明人： Mathias KRULL

    IPC分类号： C07D413/02 ,  A61K31/421

    CPC分类号： C07D263/62 ,  C07D263/64 ,  C07D413/06 ,  C07D413/10

    摘要： The invention relates to a method for producing bisbenzoxazoles that are interconnected by means of a system of conjugated double bonds, according to which o-aminophenols are reacted with dicarboxylic acids, the carboxyl groups of which are interconnected via a double bond or a system of conjugated double bonds, to form an ammonium salt, said ammonium salt being converted in the presence of dehydrogenating catalysts and solvents with a low dielectric loss into benzoxazol by means of microwave radiation.

    摘要翻译： 本发明涉及一种通过共轭双键体系相互连接的双苯并恶唑的方法，根据该方法，邻氨基苯酚与二羧酸反应，二羧酸通过双键或共轭体系互连 双键形成铵盐，所述铵盐在脱氢催化剂和低介电损耗的溶剂存在下通过微波辐射转化成苯并恶唑。