公开(公告)号：US12084728B2

公开(公告)日：2024-09-10

申请号：US17286699

申请日：2019-10-14

申请人： DANISCO US INC ,  ARCHER DANIELS MIDLAND COMPANY

发明人： Kristin Y. Nose Crotty ,  Bradley R. Kelemen ,  Colin Fritz ,  Erin Rockafellow ,  Jacob Summerlott

IPC分类号： C12P19/02 ,  C12P19/14 ,  C13K1/02 ,  C13K1/06

CPC分类号： C13K1/02 ,  C12P19/02 ,  C12P19/14 ,  C13K1/06

摘要： Described are compositions and methods relating to the measurement of glucose derivable from the cellulosic components of a feedstock. The compositions and methods are particularly useful for ensuring that biofuel producers comply with the Renewable Fuel Standard while maximizing the value of the biofuel they produce.

公开(公告)号：US12084686B2

公开(公告)日：2024-09-10

申请号：US17051528

申请日：2019-04-30

申请人： Amgen Inc.

发明人： Christopher Kenyon Crowell ,  Jian Wu ,  Neil Kitchen ,  Alison Jean Gillespie ,  Simina Crina Petrovan ,  Michael Charles Brandenstein

IPC分类号： C12P21/00 ,  C07K16/00 ,  C07K16/28 ,  C12N1/38 ,  C12N5/071 ,  C12N5/16

CPC分类号： C12N5/0682 ,  C07K16/2875 ,  C07K2317/14 ,  C07K2317/92 ,  C12N2500/34

摘要： This invention relates to recombinantly-expressed denosumab molecules and methods for modulating glycan profiles of denosumab molecules.

公开(公告)号：US12084681B2

公开(公告)日：2024-09-10

申请号：US16575518

申请日：2019-09-19

申请人： KLING BIOTHERAPEUTICS B.V.

发明人： Paula Maria Wilhelmina Van Helden ,  Mark Jeroen Kwakkenbos ,  Hergen Spits ,  Tim Beaumont

IPC分类号： C12N5/0781 ,  A61K38/00 ,  C07K16/00 ,  C07K16/10 ,  C12N15/06 ,  C12N15/86 ,  C12P21/00

CPC分类号： C12N5/0635 ,  C07K16/00 ,  C07K16/1018 ,  C12N15/86 ,  C12P21/005 ,  C07K2317/14 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2740/13045 ,  C12N2810/6054

摘要： The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.

公开(公告)号：US12084665B2

公开(公告)日：2024-09-10

申请号：US17276306

申请日：2019-09-23

申请人： SK INNOVATION CO., LTD.

发明人： Jae Yeon Park ,  Tae Young Lee ,  Ki Sung Lee

IPC分类号： C12N1/16 ,  C12N9/04 ,  C12N9/88 ,  C12N15/81 ,  C12P7/56

CPC分类号： C12N15/81 ,  C12N1/165 ,  C12N9/0006 ,  C12N9/88 ,  C12P7/56 ,  C12Y101/01027 ,  C12Y401/01001

摘要： The present invention relates to: acid-resistant yeast to which lactic acid productivity is imparted, and in which the conversion of pyruvate into acetaldehyde is inhibited and, consequently, the ethanol production pathway is inhibited; and a method for producing lactic acid by using same.

公开(公告)号：US20240295570A1

公开(公告)日：2024-09-05

申请号：US18594431

申请日：2024-03-04

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Gopal Thinakaran

IPC分类号： G01N33/68 ,  C12P21/02

CPC分类号： G01N33/6896 ,  C12P21/02

摘要： Provided herein are isolated BIN1 SH3 domain proteins and methods for their use to identify candidate Alzheimer's disease therapeutics.

公开(公告)号：US20240294964A1

公开(公告)日：2024-09-05

申请号：US18439838

申请日：2024-02-13

申请人： IKARIA INC.

发明人： Stephen DiMagno

IPC分类号： C12P21/02 ,  C07B59/00 ,  C07C233/51 ,  C07C327/42 ,  C07C327/44 ,  C07K14/54 ,  C07K14/545 ,  C12N9/00

CPC分类号： C12P21/02 ,  C07B59/001 ,  C07B59/008 ,  C07C233/51 ,  C07C327/42 ,  C07C327/44 ,  C07K14/54 ,  C07K14/545 ,  C12N9/93 ,  C12Y601/01026 ,  C07B2200/05

摘要： Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.

公开(公告)号：US20240294962A1

公开(公告)日：2024-09-05

申请号：US18532609

申请日：2023-12-07

申请人： The Scripps Research Institute

发明人： Floyd E. ROMESBERG ,  Vivian T. DIEN ,  Aaron W. FELDMAN ,  Rebekah J. KARADEEMA ,  Lingjun LI ,  Michael P. LEDBETTER ,  Anne Xiaozhou ZHOU

IPC分类号： C12P19/34 ,  C07H19/24 ,  C07H21/04

CPC分类号： C12P19/34 ,  C07H19/24 ,  C07H21/04

摘要： Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

公开(公告)号：US20240294951A1

公开(公告)日：2024-09-05

申请号：US18590712

申请日：2024-02-28

申请人： DANISCO US INC.

发明人： Paulus Petrus DE WAAL ,  Jozef Petrus Johannes SCHMITZ ,  Hans Marinus Charles Johannes DE BRUIJN

IPC分类号： C12P7/06 ,  C12N9/02 ,  C12N9/04 ,  C12N9/12 ,  C12N9/88

CPC分类号： C12P7/06 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1205 ,  C12N9/88 ,  C12Y101/01002 ,  C12Y101/01006 ,  C12Y102/0101 ,  C12Y207/01029 ,  C12Y401/02009

摘要： The invention relates to a recombinant cell, preferably a yeast cell comprising one or more genes coding for an enzyme having glycerol dehydrogenase activity, one or more genes coding dihydroxyacetone kinase (E.C. 2.7.1.28 and/or E.C. 2.7.1.29); one or more genes coding for an enzyme in an acetyl-CoA-production pathway and one or more genes coding for an enzyme having at least NAD+ dependent acetylating acetaldehyde dehydrogenase activity (EC 1.2.1.10 or EC 1.1.1.2), and optionally one or more genes coding for a glycerol transporter. This cell can be used for the production of ethanol and advantageously produces little or no glycerol.

公开(公告)号：US20240294949A1

公开(公告)日：2024-09-05

申请号：US18594264

申请日：2024-03-04

申请人： Lystek International Corp.

发明人： Michael BESWICK ,  Ajay SINGH ,  Hanna BENNETT

IPC分类号： C12P5/02

CPC分类号： C12P5/023

摘要： A method of processing an animal manure that includes biosolids to provide an output animal manure digestate and an output biogas. The method includes heating the animal manure to a predetermined hydrolysis temperature for a preselected hydrolysis time period. In addition, a pH of the animal manure is caused to be a target hydrolysis pH. The biosolids are subjected to shearing, to produce a hydrolyzed animal manure digestate. After the hydrolysis time period, the hydrolyzed animal manure digestate is subjected to anaerobic digestion at a predetermined anaerobic digestion temperature for a preselected anaerobic digestion time period, to produce the output animal manure digestate and the output biogas.

公开(公告)号：US20240294886A1

公开(公告)日：2024-09-05

申请号：US18652554

申请日：2024-05-01

申请人： Agilent Technologies, Inc.

发明人： Michelle Cayouette ,  Jeffrey Fox ,  Connie Hansen ,  Holly Hogrefe ,  Weidong Wu

IPC分类号： C12N9/12 ,  C12P19/34 ,  C12Q1/6869

CPC分类号： C12N9/1252 ,  C12P19/34 ,  C12Q1/6869 ,  C12Y207/07007

摘要： Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′—OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.