公开(公告)号：US11951153B2

公开(公告)日：2024-04-09

申请号：US17935177

申请日：2022-09-26

申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED

发明人： Sidney L. Weiss ,  Ashim K. Mitra ,  Eugene J. McNally

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/202 ,  A61K38/13 ,  A61K47/10 ,  A61K47/44 ,  A61P27/02

CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/202 ,  A61K47/10 ,  A61K47/44 ,  A61P27/02

摘要： Provided herein are formulations for topical ophthalmic formulations containing 0.087-0.093 wt % of cyclosporine, and methods of making and using such formulations. In some aspects and embodiments the formulations may include a polyoxyl lipid or fatty acid, and/or a polyalkoxylated alcohol and may include nanomicelles. Also included herein are methods of treating or preventing diseases or conditions, such as ocular diseases or conditions.

公开(公告)号：US20240100165A1

公开(公告)日：2024-03-28

申请号：US18548680

申请日：2022-02-24

申请人： Evonik Operations GmbH

发明人： Christian Moers ,  Fabian-Pascal Schmied ,  Manuel Seibel ,  Alexander Bernhardt

IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K9/107

CPC分类号： A61K47/32 ,  A61K9/0053 ,  A61K9/1075

摘要： A method of preparing a specific solid self-nanoemulsifying drug delivery system involves applying an obtained self-nanoemulsifying drug delivery system on a mixture. The mixture contains (ia) 60 to 90 parts by weight of at least one dimethylaminoethyl methacrylate-butyl methacrylate-methyl methacrylate copolymer; (iia) 10 to 40 parts by weight of at least one methacrylic acid-ethyl acrylate copolymer; and (iiia) optionally, at least one additive; where the sum of (a) and (iia) is 100 parts by weight. The solid self-nanoemulsifying drug delivery system obtained by the method of the present invention is useful as a medicament.

公开(公告)号：US11938218B2

公开(公告)日：2024-03-26

申请号：US17160588

申请日：2021-01-28

申请人： The Regents of the University of California

发明人： Angela P. Blum ,  Jacquelin K. Kammeyer ,  Nathan C. Gianneschi

IPC分类号： A61K9/107 ,  A61K9/14 ,  A61K47/42 ,  A61K47/58 ,  C07K14/00 ,  C08G61/08

CPC分类号： A61K9/1075 ,  A61K9/146 ,  A61K47/42 ,  A61K47/58 ,  C07K14/001 ,  C08G61/08 ,  C08G2261/126 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/148 ,  C08G2261/164 ,  C08G2261/1644 ,  C08G2261/1646 ,  C08G2261/3324 ,  C08G2261/334 ,  C08G2261/418 ,  C08G2261/80 ,  C08G2261/90 ,  C08G2261/94

摘要： Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.

公开(公告)号：US11938099B2

公开(公告)日：2024-03-26

申请号：US18459778

申请日：2023-09-01

申请人： Dermavant Sciences GmbH

发明人： John E. Kraus ,  James Lee

IPC分类号： A61K31/05 ,  A61K9/00 ,  A61K9/107 ,  A61P17/04 ,  A61P17/06

CPC分类号： A61K31/05 ,  A61K9/0014 ,  A61K9/107 ,  A61P17/04 ,  A61P17/06

摘要： Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.

公开(公告)号：US20240091190A1

公开(公告)日：2024-03-21

申请号：US17946067

申请日：2022-09-16

申请人： Elsia Kelly

发明人： Elsia Kelly

IPC分类号： A61K31/235 ,  A61K9/00 ,  A61K9/107 ,  A61K31/355 ,  A61K33/30 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

CPC分类号： A61K31/235 ,  A61K9/0014 ,  A61K9/107 ,  A61K31/355 ,  A61K33/30 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

摘要： A composition for external use that is used to heal and prevent wounds is described. The composition is used to prevent bedsores. The composition includes a thickening agent, an anti-fungal agent, an emulsifier, a glycerol, a skin protectant, a petroleum jelly, an oil, and at least one vitamin.

公开(公告)号：US11931459B2

公开(公告)日：2024-03-19

申请号：US17697261

申请日：2022-03-17

申请人： Pacira Pharmaceuticals, Inc.

发明人： Roy Winston

IPC分类号： A61K9/127 ,  A61K9/107 ,  A61K31/4375 ,  A61K31/66

CPC分类号： A61K9/1271 ,  A61K9/107 ,  A61K31/4375 ,  A61K31/66

摘要： In some embodiments provided herein is a method of treating pain, the method comprising administering to the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

公开(公告)号：US20240082349A1

公开(公告)日：2024-03-14

申请号：US18205700

申请日：2023-06-05

申请人： Sublimity Therapeutics Limited

发明人： Ivan Coulter ,  Vincenzo Aversa ,  Mónica Torres Rosa ,  Dáire O'Donnell ,  Wyatt Renaud of Calhane

IPC分类号： A61K38/13 ,  A61K9/00 ,  A61K9/107 ,  A61K9/16 ,  A61K9/50 ,  A61K45/06

CPC分类号： A61K38/13 ,  A61K9/0053 ,  A61K9/107 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/5047 ,  A61K9/5073 ,  A61K45/06

摘要： The present invention relates to a formulation comprising a pharmaceutically active ingredient and coating. The invention also related to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.

公开(公告)号：US20240075052A1

公开(公告)日：2024-03-07

申请号：US18476506

申请日：2023-09-28

申请人： Alnylam Pharmaceuticals, Inc.

发明人： Jared A. Gollob

IPC分类号： A61K31/7105 ,  A61K9/00 ,  A61K9/107 ,  A61K31/07 ,  A61K31/135 ,  A61K31/167 ,  A61K31/341 ,  A61K31/423 ,  A61K31/426 ,  A61K31/445 ,  A61K31/495 ,  A61K31/573 ,  A61K31/603 ,  A61P25/28 ,  C12N15/113

CPC分类号： A61K31/7105 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/07 ,  A61K31/135 ,  A61K31/167 ,  A61K31/341 ,  A61K31/423 ,  A61K31/426 ,  A61K31/445 ,  A61K31/495 ,  A61K31/573 ,  A61K31/603 ,  A61P25/28 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2320/31 ,  C12N2320/35

摘要： Disclosed herein are methods for treating hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) in a human patient in need thereof by administering an effective amount of a transthyretin (TTR)-inhibiting composition.

公开(公告)号：US20240058332A1

公开(公告)日：2024-02-22

申请号：US18454292

申请日：2023-08-23

申请人： CalciMedica, Inc.

发明人： Kenneth A. STAUDERMAN ,  Michael DUNN

IPC分类号： A61K31/497 ,  A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28 ,  A61K47/32

CPC分类号： A61K31/497 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/19 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28 ,  A61K47/32

摘要： Provided herein are pharmaceutical compositions, such as emulsions and nanosuspensions, comprising a CRAC channel inhibitor. Also provided herein are methods of treating pancreatitis, viral infections, stroke, traumatic brain injury, fibrosis, inflammation, and autoimmune diseases by administering such pharmaceutical compositions.

公开(公告)号：US20240058270A1

公开(公告)日：2024-02-22

申请号：US18239587

申请日：2023-08-29

申请人： Pacira Pharmaceuticals, Inc.

发明人： Roy Winston

IPC分类号： A61K9/127 ,  A61K9/107 ,  A61K31/4375 ,  A61K31/66

CPC分类号： A61K9/1271 ,  A61K9/107 ,  A61K31/4375 ,  A61K31/66

摘要： In some embodiments provided herein is a method of treating pain, the method comprising administering to the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.