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    Controlling pulses in optical microscopy
    712.
    发明授权
    Controlling pulses in optical microscopy 失效
    光学显微镜控制脉冲

    公开(公告)号：US07480045B2

    公开(公告)日：2009-01-20

    申请号：US11554713

    申请日：2006-10-31

    Applicant: Andy Kung ,  Tse-Luen Wee ,  Shu-Wei Huang

    Inventor： Andy Kung ,  Tse-Luen Wee ,  Shu-Wei Huang

    IPC: G01N21/63 ,  G01N21/64 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/656 ,  G02B21/16

    Abstract: A method for imaging a sample is described. The sample is characterized by a limit on incident optical energy absorbed over a given time period. The method includes providing at least one input optical wave that includes pulses that each have a full-width half-maximum time duration of more than 100 picoseconds and a pulse energy sufficiently large such that a sufficient number of consecutive pulses absorbed by the sample would exceed the limit. The method also includes directing the input optical wave to focus on a first portion of the sample; detecting energy from an output optical wave generated from a nonlinear optical interaction in the first portion of the sample with the input optical wave; and generating a representation of the first portion of the sample based on the detected energy from the output optical wave.

    Abstract translation: 描述了用于对样品进行成像的方法。 样品的特征在于在给定时间段内吸收的入射光能的限制。 该方法包括提供包括脉冲的至少一个输入光波，每个脉冲具有大于100皮秒的全宽度半最大持续时间和足够大的脉冲能量，使得由样本吸收的足够数量的连续脉冲将超过 极限。 该方法还包括引导输入光波聚焦在样品的第一部分上; 从具有输入光波的样品的第一部分中的非线性光学相互作用产生的输出光波中检测能量; 以及基于来自输出光波的检测能量生成样本的第一部分的表示。

    Risk assessment for adverse drug reactions
    713.
    发明授权
    Risk assessment for adverse drug reactions 有权
    不良药物反应的风险评估

    公开(公告)号：US07470513B2

    公开(公告)日：2008-12-30

    申请号：US10705245

    申请日：2003-11-10

    Applicant: Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Wen-Hung Chung ,  Jer-Yuarn Wu

    Inventor： Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Wen-Hung Chung ,  Jer-Yuarn Wu

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  G01N33/53

    CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/94

    Abstract: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.

    Abstract translation: 本发明提供了一种预测患者发展不良药物反应（特别是SJS或TEN）的风险的方法。 发现HLA-B等位基因HLA-B * 1502与由各种药物诱导的SJS / TEN相关。 与HLA-B * 1502的相关性对于卡马西平诱导的SJS / TEN是最显着的，其中所有测试的患者具有HLA-B * 1502等位基因。 另外HLA-B等位基因HLA-B * 5801与别嘌呤醇诱导的SJS / TEN特别相关。 特别是与第三等位基因HLA-B * 4601相关的皮肤反应较轻，如斑丘疹，多形性红斑，荨麻疹和固定药物爆发。 对于任何等位基因，位于特异性HLA-B单倍型的DRB1和HLA-A区之间的遗传标记（例如HLA标记，微卫星或单核苷酸多态性标记）也可用于测试。

    Substrate for surface-enhanced raman spectroscopy, sers sensors, and method for preparing same
    714.
    发明授权
    Substrate for surface-enhanced raman spectroscopy, sers sensors, and method for preparing same 有权
    用于表面增强拉曼光谱的基板，传感器及其制备方法

    公开(公告)号：US07453565B2

    公开(公告)日：2008-11-18

    申请号：US11423818

    申请日：2006-06-13

    Applicant: Yuh-Lin Wang ,  Huai-Hsien Wang ,  Chih-Yi Liu ,  Juen-Kai Wang

    Inventor： Yuh-Lin Wang ,  Huai-Hsien Wang ,  Chih-Yi Liu ,  Juen-Kai Wang

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/658

    Abstract: This invention relates to methods of preparing substrates that enhance the Raman signal of analytes in surface-enhanced Raman spectroscopy (SERS). The SERS-active substrate comprises an array of metal nanoparticles at least partially embedded in a template. The substrate's uniform and readily reproducible SERS-active properties with a wide range of analyte concentrations substantially enhance the power and utility of SERS. This invention also provides sensors, as well as Raman instruments, comprising the SERS-active substrates.

    Abstract translation: 本发明涉及在表面增强拉曼光谱（SERS）中制备增强分析物拉曼信号的底物的方法。 SERS活性基底包括至少部分地嵌入模板中的金属纳米颗粒阵列。 底物均匀且易于重现的具有广泛分析物浓度的SERS-活性特性显着增强了SERS的功效和效用。 本发明还提供了包括SERS活性基底的传感器以及拉曼仪器。

    Rice Glutelin Gene Promoters
    715.
    发明申请
    Rice Glutelin Gene Promoters 有权
    水稻谷蛋白基因启动子

    公开(公告)号：US20080250528A1

    公开(公告)日：2008-10-09

    申请号：US12053792

    申请日：2008-03-24

    Applicant: Su-may Yu ,  Chwan-yang Hong

    Inventor： Su-may Yu ,  Chwan-yang Hong

    IPC: C12N15/11 ,  C07H21/00 ,  C12N15/82 ,  C12N5/10 ,  A01H5/00

    CPC classification number: C12N15/8234 ,  C12N15/8257

    Abstract: A nucleic acid containing a glutelin gene promoter. Disclosed are transformed plant cells and transgenic plants containing a nucleic acid that includes the promoter operably linked to a sequence encoding heterologous protein. Also disclosed are methods of making the transformed plant cells and transgenic plants and methods for expressing a polypeptide.

    Abstract translation: 含有谷蛋白基因启动子的核酸。 公开了转化的植物细胞和含有核酸的转基因植物，所述核酸包括可操作地连接到编码异源蛋白质的序列的启动子。 还公开了制备转化的植物细胞和转基因植物的方法以及用于表达多肽的方法。

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