中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1257 records (took 0.026 seconds)

    Mutant-type lipases and applications thereof
    733.
    发明授权
    Mutant-type lipases and applications thereof 失效

    公开(公告)号：US07049122B2

    公开(公告)日：2006-05-23

    申请号：US10233443

    申请日：2002-09-04

    Applicant: Rey-Chang Chang ,  Shu-Jen Chou ,  Jei-Fu Shaw

    Inventor： Rey-Chang Chang ,  Shu-Jen Chou ,  Jei-Fu Shaw

    IPC: C12N9/20

    CPC classification number: C12N9/18 ,  C12N9/20 ,  C12Y301/01003

    Abstract: The present invention provides mutant-type lipases which demonstrate superior lipolytic and esterific activities. The mutant-type lipases are characterized by an amino acid alteration at the residue immediately followed either the serine residue or the histidine residue or both residues of the Ser-His-Asp catalytic triad. The Ser-His-Asp catalytic triad is known to be the three residues, although occur far apart in the amino acid sequence of a lipase, that contribute to the hydrolytic activity in the active site of the lipase. The amino acid residue that follows the serine residue of the Ser-His-Asp catalytic triad is alanine. The amino acid residue that follows the histidine residue of the Ser-His-Asp catalytic triad is isoleucine. The wild-type lipase is preferably originated from Staphylococcus, particularly Staphylococcus epidermindis. The present invention also relates to a method for preparing the mutant-type lipases by site-directed mutagenesis using PCR and a method for utilizing the mutant-type lipase to catalyze synthesis of flavor esters to be used in food industry.

    CD7 as biomarker and therapeutic target for psoriasis
    734.
    发明申请
    CD7 as biomarker and therapeutic target for psoriasis 审中-公开
    CD7作为银屑病的生物标志物和治疗靶标

    公开(公告)号：US20050277587A1

    公开(公告)日：2005-12-15

    申请号：US10866530

    申请日：2004-06-10

    Applicant: Yuan-Tsong Chen ,  Jer-Yuarn Wu ,  Whu-Liang Hwu ,  Cathy Fann ,  Chi-Fan Yang

    Inventor： Yuan-Tsong Chen ,  Jer-Yuarn Wu ,  Whu-Liang Hwu ,  Cathy Fann ,  Chi-Fan Yang

    IPC: A61K38/17 ,  C07H21/04 ,  C07K14/705 ,  C07K14/74 ,  C12Q1/68

    CPC classification number: C12Q1/6883 ,  C07K14/70596 ,  C12Q2600/156

    Abstract: We present information obtained from the occurrence of psoriasis and its related disease pityriasis rubra pilaris (PRP) in a large, five-generation kindred. Using a genome-wide scan and single nucleotide polymorphism (SNP) fine mapping, the psoriasis/PRP locus was mapped to chromosome 17q terminus, a region close to but distinct from the 17q PSOR2 locus. Moreover, we sequenced the candidate genes in this region, and identified CD7 as the susceptibility gene in this family. Compositions and methods of use are provided for the prediction, diagnosis, disease monitoring and therapeutic development of psoriasis and pityriasis rubra pilaris (PRP).

    Abstract translation: 我们提供从大型五代亲属中发现的牛皮癣及其相关疾病糠疹糠疹（PRP）发生的信息。 使用全基因组扫描和单核苷酸多态性（SNP）精细定位，牛皮癣/ PRP基因座被映射到染色体17q末端，这是接近但不同于17q PSOR2基因座的区域。 此外，我们对该区域的候选基因进行了测序，并将CD7鉴定为该家族的易感基因。 提供了组合和使用方法，用于预测，诊断，疾病监测和牛皮癣和糠疹糠疹（PRP）的治疗发展。

    Quadruplex stabilizer
    736.
    发明申请
    Quadruplex stabilizer 审中-公开
    四重稳定剂

    公开(公告)号：US20050249669A1

    公开(公告)日：2005-11-10

    申请号：US11131905

    申请日：2005-05-17

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang

    IPC: A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K49/00 ,  C07D401/14 ,  C07D403/14 ,  C12Q1/00

    CPC classification number: C07D401/14 ,  C07D403/14 ,  G01N1/30 ,  G01N33/5091 ,  G01N2800/7028

    Abstract: This invention relates to a method for detecting cancer cells in a subject. The method includes contacting a plurality of cells in a sample obtained from the subject with carbazole compounds of the following formula: and calculating the percentage of the cells that emit florescence upon irradiation with an excitation light, in which, if the percentage is above a pre-set value, the subject is determined to contain cancer cells. In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R1—R6, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, NH2, C1l-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, or halogen; R7 is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl; and each of m and n, independently, is 1, 2, or 3.

    Abstract translation: 本发明涉及一种用于检测受试者中癌细胞的方法。 该方法包括使得自受试者获得的样品中的多个细胞与下式的咔唑化合物接触：计算在用激发光照射时发出荧光的细胞的百分比，其中如果百分比高于预先 确定值，确定受试者含有癌细胞。 在上式中，环A和B各自独立地为含有至少一个氮原子的杂芳基; X和Y各自独立地是CH或N; R 1 -R 6中的每一个独立地是H，C 1 -C 8烷基，C 1 -C 6烷基， C 2 -C 8亚烷基，C 2 -C 8炔基，C 3 - C 8环烷基，C 3 -C 8杂环烷基，芳基，杂芳基，OH，C 1 -C 3烷基， C 1 -C 6烷氧基，芳氧基，杂芳氧基，NH 2，C 1 -C 6烷基氨基，C 1〜 C 1 -C 12二烷基氨基，芳基氨基，二芳基氨基或卤素; R 7是H，C 1 -C 8烷基，C 2 -C 8烷基，C 2 -C 8烷基， 亚烷基，C 2 -C 8炔基，C 3 -C 8环烷基，C 1 -C 3烷基， 杂环烷基，芳基，杂芳基; m和n各自独立地为1,2或3。

    Carbohydrate encapsulated nanoparticles
    737.
    发明申请
    Carbohydrate encapsulated nanoparticles 失效
    碳水化合物包封的纳米颗粒

    公开(公告)号：US20050130240A1

    公开(公告)日：2005-06-16

    申请号：US10782076

    申请日：2004-02-19

    Applicant: Chun-Cheng Lin ,  Chia-Chu Chen ,  Yi-Chun Wu

    Inventor： Chun-Cheng Lin ,  Chia-Chu Chen ,  Yi-Chun Wu

    IPC: A61K47/48 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/554 ,  G01N33/569 ,  G01N33/58

    CPC classification number: G01N33/587 ,  B82Y5/00 ,  G01N33/56916

    Abstract: The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in biologically important carbohydrate molecules, such as sugars, sugar derivatives, P-blood group antigens and analogues thereof. The present invention also provides methods of employing these carbohydrate encapsulated nanoparticles in diagnostic and therapeutic applications.

    Abstract translation: 本发明提供碳水化合物包封的纳米颗粒。 特别地，本发明提供了包封在生物重要的碳水化合物分子中的金属纳米颗粒（例如金纳米颗粒），例如糖，糖衍生物，P-血型抗原及其类似物。 本发明还提供了在诊断和治疗应用中使用这些碳水化合物包封的纳米颗粒的方法。

Patent Agency Ranking