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公开(公告)号：US10952918B2
公开(公告)日：2021-03-23
申请号：US15287859
申请日：2016-10-07
发明人： Charles Palmer
摘要： The present invention relates to devices and methods for assisting breathing in a subject. In one embodiment, the device of the present invention is a splint that can be used to apply negative distending pressure, i.e., outward pull, to one or both of the chest walls and/or the abdomen of a subject. In certain embodiments, the splint comprises an air bladder that can be attached to the skin of the subject's chest and/or abdomen. When the air bladder is inflated, negative distending pressure is applied to the subject's chest and/or abdomen, thereby assisting or promoting respiration. In another embodiment, the splint comprises a piezoelectric material that when activated can provide negative distending pressure to the subject's chest and/or abdomen. In another embodiment, the subject is a neonate. In another embodiment, the inflated air bladder can apply a compressive force on the chest to facilitate expiration, and the removal of secretions in the airways.
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72.发明申请公开(公告)号：US20210056691A1
公开(公告)日：2021-02-25
申请号：US16996342
申请日：2020-08-18
发明人： Alison Gernand , James Z. Wang , Jeffery Goldstein , William Parks , Yukun Chen , Zhuomin Zhang , Dolzodmaa Davaasuren , Chenyan Wu
摘要： Systems and methods for completing a morphological characterization of an image of a placenta and providing suggested pathological diagnoses are disclosed. A system includes programming instructions that, when executed, cause processing devices to execute commands according to the following logic modules: an Encoder module that receives the digital image of the placenta and outputs a pyramid of feature maps, a SegDecoder module that segments the pyramid of feature maps on a fetal side image and on a maternal side image, a Classification Subnet module that classifies the fetal side image and the maternal side image, and a convolutional IPDecoder module that localizes an umbilical cord insertion point of the placenta from the classified fetal side image and the classified maternal side image. The localized umbilical cord insertion point, segmentation maps for the classified fetal side and maternal side images are provided to an external device for determining the morphological characterization.
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73.发明申请公开(公告)号：US20210052614A1
公开(公告)日：2021-02-25
申请号：US17087962
申请日：2020-11-03
摘要： A method is disclosed for altering the redox equilibrium of a transmembrane receptor-like protein tyrosine phosphatase (RPTP), particularly a type IIa RPTP, by chemically modulating the activity through contact of such an enzyme with a diaryl boron compound that preferentially reacts with an RPTP in an oxidized state (CyS-OH). This redox modulation is most readily observed and put to use by assaying the inhibition of the phosphatase activity of the RPTP. Such an assay can be carried out on an enzyme in vitro or by contacting the enzyme in a living organism (in vivo). A useful diaryl boron compound corresponds in structure to Formula I in which Ar-1, Ar-2, R1, R2, R3 and R4 are defined within. A pharmaceutical composition containing a useful diaryl boron compound is also disclosed, as are particularly preferred diaryl boron compounds.
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公开(公告)号：US20210041379A1
公开(公告)日：2021-02-11
申请号：US16979682
申请日：2019-03-12
发明人： Tinglu Yang , Bradley Rogers , Jifeng Zhang , Paul S. Cremer
摘要： The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes- but is not limited to- liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.
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公开(公告)号：US10813922B2
公开(公告)日：2020-10-27
申请号：US16026934
申请日：2018-07-03
发明人： Gong Chen , Zheng Wu , Ziyuan Guo
IPC分类号： A61P25/28 , A61K31/455 , A61K45/06 , A61K31/445 , A61K31/454 , A61K31/551 , A61K51/04 , G01N33/94 , A61K9/00 , A61K31/5517 , A61K31/7088 , A61K51/10
摘要： This document relates to methods and materials for reducing memory loss. For example, methods and materials for using inhibitors of GAT-3 polypeptide activity to reduce memory loss in mammals suffering from Alzheimer's disease are provided.
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公开(公告)号：US10809240B2
公开(公告)日：2020-10-20
申请号：US16072756
申请日：2017-01-26
发明人： Sayed Amin Afzal
摘要： Systems and methods for non-invasively determining a water content, a solute content, and a thickness of plant tissue are disclosed. A system includes a sensing device having a first piece and a second piece, where the first piece and the second piece are coupled together to form a clip. The system further includes a capacitive tissue sensor including a capacitor. The capacitor includes a plurality of coplanar conductive plates. The first piece and the second piece are biased in a closed position to provide a gripping force around the plant tissue such that at least a portion of the plant tissue contacts the plurality of coplanar conductive plates.
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公开(公告)号：US10744133B2
公开(公告)日：2020-08-18
申请号：US16396829
申请日：2019-04-29
IPC分类号： A61K31/496 , C07D307/71
摘要： The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
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公开(公告)号：US10734531B2
公开(公告)日：2020-08-04
申请号：US15945207
申请日：2018-04-04
发明人： Saptarshi Das
摘要： A device and method for manufacturing a two-dimensional electrostrictive field effect transistor having a substrate, a source, a drain, and a channel disposed between the source and the drain. The channel is a two-dimensional layered material and a gate proximate the channel. The gate has a column of an electrostrictive or piezoelectric or ferroelectric material, wherein an electrical input to the gate produces an elongation of the column that applies a force or mechanical stress on the channel and reduces a bandgap of two-dimensional material such that the two-dimensional electrostrictive field effect transistor operates with a subthreshold slope that is less than 60 mV/decade.
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公开(公告)号：US10730789B2
公开(公告)日：2020-08-04
申请号：US15831930
申请日：2017-12-05
发明人： Tak-Sing Wong , Yu Huang , Birgitt Boschitsch , Nan Sun
摘要： A substrate with a switchable surface has been developed that can rapidly switch its surface character such as between two distinct liquid-repellent modes: (1) a superhydrophobic mode and (2) a slippery mode. Such surfaces have demonstrated adaptive liquid repellency and water harvesting capabilities.
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公开(公告)号：US10721999B2
公开(公告)日：2020-07-28
申请号：US15490417
申请日：2017-04-18
申请人： BIRD WITH FRY, CORP.
发明人： Karen Phyllis Norheim , Joshua Ernest Fouraker , Zachary James Stehouwer , Cara Michelle Fiala , Donald Richard Fay, III , Douglas B. Schumer , Sedat Peker , Vrushti Modi
摘要： A device and method to facilitate the opening and closing and closing of a ski boot. The devices includes a buckle attachment section, a ski pole cooperation section and a securing member. The buckle attachment section has a cavity which is dimensioned to receive a free end of the buckle therein to prevent unwanted movement of the buckle attachment section relative to the buckle. The ski pole cooperation section has a ski pole receiving opening. The ski pole receiving opening extends through the ski pole cooperation section and is dimensioned to receive an end of a ski pole therein. The securing member secures the device to the buckle of the ski boot. The device allows the buckles of the ski boot to be latched and unlatched with minimal twisting of the skier's body.
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