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604 条记录 (耗时 0.021 秒)

    OIL-IN-WATER EMULSION COSMETIC
    71.
    发明申请
    OIL-IN-WATER EMULSION COSMETIC 审中-公开

    公开(公告)号：US20200155440A1

    公开(公告)日：2020-05-21

    申请号：US16773142

    申请日：2020-01-27

    申请人： SHISEIDO COMPANY, LTD.

    发明人： MAYURI TASHIRO ,  YUKO NAGARE ,  TAKASHI MATSUI

    IPC分类号： A61K8/73 ,  A61K8/88 ,  A61K8/49 ,  A61K8/41 ,  A61K8/37 ,  A61K8/29 ,  A61K8/27 ,  A61K8/25 ,  A61K8/06 ,  A61Q17/04 ,  A61K8/81

    摘要： The present invention has the purpose of providing an oil-in-water emulsion cosmetic that contains a high quantity of an ultraviolet absorbing agent and an ultraviolet scattering agent in the oil phase and achieves a high SPF, while simultaneously having a Distinctive fresh feeling in use when applied to the skin. The present invention provides an oil-in-water emulsion cosmetic characterized by comprising (A) 0.05 to 1% by mass of a hydrophobically modified alkyl cellulose; (B) 5 to 40% by mass of an oil component; (C) 2.5 to 30% by mass of an ultraviolet scattering agent having a hydrophobic surface; and (D) a water phase thickener having low salinity tolerance; wherein the (C) ultraviolet scattering agent is dispersed in the oil phase.

    WATER-IN-OIL TYPE EMULSIFICATION COSMETIC
    72.
    发明申请
    WATER-IN-OIL TYPE EMULSIFICATION COSMETIC 审中-公开

    公开(公告)号：US20200038302A1

    公开(公告)日：2020-02-06

    申请号：US16607203

    申请日：2018-04-25

    申请人： SHISEIDO COMPANY, LTD.

    发明人： YUKIKO SATO ,  Tomoko IKED A

    IPC分类号： A61K8/29 ,  A61K8/02 ,  A61K8/06 ,  A61Q1/02 ,  A61K8/92

    摘要： The purpose of the present invention is to provide a water-in-oil emulsified solid cosmetic having a relatively high internal-aqueous-phase proportion (about 40% or higher), the cosmetic being a makeup which has an excellent concealing effect and gives a natural finish and which is stable and has satisfactory applicability. The present invention relates to a solid cosmetic in water-in-oil emulsified type characterized by comprising (A) at least one fatty acid glyceryl ester selected from the group consisting of glyceryl isostearate, poly(2-glyceryl) diisostearate, and glyceryl oleate, (B) an aqueous component, (C) an oily component, and (D) a powdery component, the oily component (C) comprising a solid oil (C1) and an oil-soluble film former (C2) and the powdery component (D) comprising titanium dioxide (D1) having a primary-particle diameter of 0.05-0.5 μm in an amount of 10 mass % or more relative to the whole cosmetic preparation and further containing a pearl pigment (D2).

    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE
    73.
    发明申请
    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开

    公开(公告)号：US20190339282A1

    公开(公告)日：2019-11-07

    申请号：US16511097

    申请日：2019-07-15

    申请人： Shiseido Company, Ltd.

    发明人： Kenji Hamase ,  Yurika MIYOSHI ,  Masashi MITA

    IPC分类号： G01N33/68

    摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

    BLOOD SAMPLE ANALYSIS METHOD AND SYSTEM, FOR DETERMINING DIABETES
    74.
    发明申请
    BLOOD SAMPLE ANALYSIS METHOD AND SYSTEM, FOR DETERMINING DIABETES 审中-公开

    公开(公告)号：US20190271708A1

    公开(公告)日：2019-09-05

    申请号：US16302235

    申请日：2017-05-17

    申请人： Osaka University ,  Shiseido Company, Ltd.

    发明人： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

    IPC分类号： G01N33/68

    摘要： The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.

    Marker for early diagnosis of kidney failure
    75.
    发明授权
    Marker for early diagnosis of kidney failure 有权

    公开(公告)号：US10393749B2

    公开(公告)日：2019-08-27

    申请号：US15103539

    申请日：2014-12-11

    申请人： Shiseido Company, Ltd.

    发明人： Kenji Hamase ,  Yurika Miyoshi ,  Masashi Mita

    IPC分类号： G01N33/68

    摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

    COSMETIC BRUSH CLEANER
    77.
    发明申请
    COSMETIC BRUSH CLEANER 审中-公开

    公开(公告)号：US20190218481A1

    公开(公告)日：2019-07-18

    申请号：US16319440

    申请日：2017-08-03

    申请人： SHISEIDO COMPANY, LTD.

    发明人： Ayano TOSHIDA ,  Akira MATSUO

    IPC分类号： C11D7/26 ,  C11D7/24

    CPC分类号： C11D7/261 ,  C11D7/24 ,  C11D7/242 ,  C11D7/26 ,  C11D11/0017 ,  C11D17/04 ,  C11D17/041

    摘要： [Problem] To provide a cosmetic brush cleaner excellent in quick dryability and capable of removing stains such as deposited cosmetics with ease in the following manner: impregnating tissue paper, towel, or the like with the cleaner to wipe off the cosmetics, sebum, and the like deposited on a cosmetic brush; or directly spraying the cleaner on a cosmetic brush, and wiping the brush with dry tissue paper or the like.[Solution] A cosmetic brush cleaner including: (A) a lower alcohol in an amount of 30 to 99 mass %; (B) a volatile oil in an amount of 1 to 70 mass %; and (C) water in an amount of 7 mass % or less (including 0 mass %).

    Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin
    78.
    发明授权
    Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin 有权

    公开(公告)号：US10344266B2

    公开(公告)日：2019-07-09

    申请号：US14788925

    申请日：2015-07-01

    申请人： Shiseido Company, Ltd.

    发明人： Shigeyoshi Fujiwara ,  Jiro Kishimoto ,  Tsutomu Soma

    IPC分类号： C12N5/00 ,  C12N5/071 ,  C12N5/0775

    摘要： The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.

    INDEX OF LOCAL SEVERITY OF ATOPIC DERMATITIS IN SKIN AND THERAPEUTIC EFFECT THEREON
    79.
    发明申请
    INDEX OF LOCAL SEVERITY OF ATOPIC DERMATITIS IN SKIN AND THERAPEUTIC EFFECT THEREON 审中-公开

    公开(公告)号：US20190145967A1

    公开(公告)日：2019-05-16

    申请号：US16096861

    申请日：2017-04-19

    申请人： Shiseido Company. Ltd.

    发明人： Chika TANAKA ,  Chieko MIZUMOTO ,  Tomoko ONODERA ,  Setsuya AIBA ,  Katsuko KIKUCHI ,  Kenshi YAMASAKI ,  Maki OZAWA

    IPC分类号： G01N33/543 ,  G06F17/18 ,  G16H50/30

    摘要： Provided is an objective and convenient index for judging full recovery from atopic dermatitis and severity thereof. The present invention provides a diagnosis assisting method for determining a treatment policy for an atopic dermatitis subject under the treatment, said method comprising: measuring the expression value of SCCA-1 in skin horny cells of the subject; i) when the SCCA-1 expression value is not statistically significantly higher than the level of those who do not suffer from atopic dermatitis, then determining that the continuation of the treatment for the disease becomes unnecessary thanks to the treatment; and, in the case where the continuation of the treatment is determined as still necessary, ii) ranking the severity of atopic dermatitis of the subject using the SCCA-1 expression value as an index and determining an adequate treatment method for atopic dermatitis to be given to the subject depending on the rank.