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    Dual specificity antibodies and methods of making and using
    74.
    发明授权
    Dual specificity antibodies and methods of making and using 有权
    双重特异性抗体及其制备和使用方法

    公开(公告)号：US07491516B2

    公开(公告)日：2009-02-17

    申请号：US09894550

    申请日：2001-06-28

    Applicant: Albert Collinson ,  George Avgerinos ,  Richard Dixon ,  Tariq Ghayur ,  Zehra Kaymakcalan

    Inventor： Albert Collinson ,  George Avgerinos ,  Richard Dixon ,  Tariq Ghayur ,  Zehra Kaymakcalan

    IPC: C12P21/08 ,  C12P21/04 ,  C07K16/00 ,  A61K39/00 ,  A61K39/395

    CPC classification number: C07K16/245 ,  A61K47/6845 ,  A61K2039/505 ,  C07K14/545 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/10 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  G01N33/6869

    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1α and IL-1β ) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1α and/or IL-1β activity is detrimental.

    Abstract translation: 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1β具有双重特异性，并在体外和体内中和IL-1α和IL-1β活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如IL-1α和IL-1β），并且用于抑制抗原的活性，例如在患有疾病的人类受试者中 其中IL-1α和/或IL-1β活性是有害的。

    Substrates and inhibitors for cysteine protease ICH-1
    77.
    发明授权
    Substrates and inhibitors for cysteine protease ICH-1 失效
    半胱氨酸蛋白酶ICH-1的底物和抑制剂

    公开(公告)号：US06288037B1

    公开(公告)日：2001-09-11

    申请号：US08665643

    申请日：1996-06-18

    Applicant: Robert V. Talanian ,  Tariq Ghayur ,  John C. Hodges

    Inventor： Robert V. Talanian ,  Tariq Ghayur ,  John C. Hodges

    IPC: A61K3807

    CPC classification number: C07K5/101 ,  A61K38/00 ,  C07K14/81

    Abstract: Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.

    Abstract translation: 公开了半胱氨酸蛋白酶Ich-1的底物和抑制剂。 这些化合物是基于Ich-1的最佳最小底物设计的，包括可逆抑制剂，不可逆抑制剂，选择性可逆抑制剂，显色底物，荧光底物和放射性标记底物/抑制剂。 还提供了包含本发明化合物的药物组合物。 还公开了用于抑制Ich-1的蛋白水解活性的方法，用于检测Ich-1的存在的方法和使用本发明的化合物分离Ich-1的方法。

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