Abstract:
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
Abstract:
The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.
Abstract:
A rabbit skin containing biologically active substances is obtained by the process including vaccinating rabbit skin tissues with vaccinia virus, feeding a rabbit vaccinated with vaccinia virus, killing the rabbit when its skin tissues are sufficiently inflamed, and skinning the rabbit. The rabbit skin of the present invention can be used for preparing drugs and health foods.
Abstract:
A time-based and event-based interrupt frequency mitigation scheme is provided. A holdoff event counter is programmed to count a holdoff event count corresponding to a number of interrupts. A holdoff timer is programmed to time a holdoff interval representing the time period to elapse before the generation of an interrupt request to the host system can occur. When a data transfer request associated with the transfer of data from or to the host system is serviced and results in the occurrence of an interrupt event, the holdoff event counter is modified by one. If either the holdoff event counter or the holdoff timer has expired and the interrupt is enabled, an interrupt request to the host system is generated. In response to such interrupt request generation, the interrupt is processed and both the holdoff event counter and the holdoff timer retriggered.
Abstract:
In a network node having a host system coupled to a network by an adapter, VC-specific congestion is detected and reported to the host system. The host memory includes rx slots or buffers, each corresponding to one of one or more supported slot types. Per-VC slots consumed counters are maintained to count slot consumption for each active VC. Free buffer FIFOs are maintained for each of the one or more slot types, which have a predetermined congestion threshold associated therewith. Entries in each free buffer FIFO correspond to an rx slot posted by the host system. When a new rx slot or buffer in host memory is to be allocated to an incoming cell received on a given VC, the slots consumed counter is compared to the predetermined congestion threshold. If they are equal, the VC is at threshold level and the incoming cell is discarded and a report is sent to the host system. If the slots consumed counter is below threshold, a new rx slot is allocated for the reception of the data and the slots consumed counter is incremented. If the VC is credit-based flow control enabled and the slots consumed counter is below threshold, a credit is returned. If the VC is credit-based flow control enabled and the slots consumed counter is greater than or equal to the threshold, the credit return is deferred until the counter falls below threshold.
Abstract:
A status report frequency mitigation mechanism for mitigating the frequency of status report generation for raw cells during transmit operations in a network node is presented. The status report frequency mitigation mechanism operates to adjust the frequency with which status reports for raw cells are generated by manipulating the End-of-Packet (EOP) bit in transmit slot descriptors associated with transmit slots containing raw cell data.