公开(公告)号：US20100240893A1

公开(公告)日：2010-09-23

申请号：US12622411

申请日：2009-11-19

申请人： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

发明人： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

IPC分类号： C07D295/215

CPC分类号： C07D239/94

摘要： The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

摘要翻译： 本发明提供含氮杂环化合物及其药学上可接受的盐及其制备方法。 这些化合物对抑制这种激酶活性的激酶的磷酸化具有抑制活性。 本发明还提供了可用于该方法的中间体化合物，以及通过该方法生产的最终产物及其盐或前药。 本发明进一步提供了通过抑制激酶的磷酸化来抑制哺乳动物激酶和治疗疾病状态的方法，包括向有需要的患者施用有效量的本发明化合物。

公开(公告)号：US20100177078A1

公开(公告)日：2010-07-15

申请号：US12731842

申请日：2010-03-25

申请人： Robert J. Lowles ,  Marc C. Drader ,  James Robinson

发明人： Robert J. Lowles ,  Marc C. Drader ,  James Robinson

IPC分类号： G09G5/10 ,  H05B39/04

CPC分类号： H04M1/22 ,  G09G3/3406 ,  G09G2320/0626 ,  G09G2360/144 ,  H04M19/04 ,  H04M19/048 ,  H04M2250/12

摘要： A light emitter/sensor includes a lamp, a light sensor, a light guide, and a light controller. The light guide has a pair of opposite ends and is optically-coupled to the lamp and the light sensor at one of the ends. The light guide is configured to convey light emitted from the lamp to the other end of the light guide, and from that other end to the light sensor. The light controller is coupled to the lamp and the light sensor and is configured to flash the lamp and to determine the intensity of light at that other end of the light guide, via the light guide and the light sensor, during an interval between the flashes.

摘要翻译： 光发射器/传感器包括灯，光传感器，光导和光控制器。 光导具有一对相对的端部，并且在其一端处与灯和光传感器光学耦合。 光导被配置为将从灯发出的光传送到光导的另一端，并且从另一端传送到光传感器。 光控制器耦合到灯和光传感器，并被配置为在闪光之间的间隔期间经由光导和光传感器来闪烁灯并确定光导的另一端的光强度 。

公开(公告)号：US07714829B2

公开(公告)日：2010-05-11

申请号：US10957606

申请日：2004-10-05

申请人： Marc Drader ,  James Robinson ,  Jerry Mailloux ,  Robert Lowles

发明人： Marc Drader ,  James Robinson ,  Jerry Mailloux ,  Robert Lowles

IPC分类号： G09G3/36 ,  G09G5/00 ,  G09G5/10 ,  G06F3/038

CPC分类号： G09G3/3413 ,  G09G2320/0242 ,  G09G2320/043 ,  G09G2320/0666

摘要： A field sequential liquid crystal display maintains its white colour point through compensation values to at least one colour light emitting diode that illuminates the display. The compensation values may be impedances to control the current or pulsing of the current source according to a pulse width modulation technique. A degradation curve may be used to calculate extrapolate the theoretical forward voltage of the light emitting diode. Additional complexity arises from the need for calculating uptime for multiple light emitting diodes of different colours. Brightness levels may also be factored in.

摘要翻译： 场顺序液晶显示器将其白色色点通过补偿值保持到照亮显示器的至少一个彩色发光二极管。 补偿值可以是根据脉冲宽度调制技术来控制电流源的电流或脉冲的阻抗。 可以使用退化曲线来计算外推发光二极管的理论正向电压。 另外的复杂性是由于需要计算不同颜色的多个发光二极管的正常运行时间。 亮度水平也可能被考虑在内。

公开(公告)号：US20100018853A1

公开(公告)日：2010-01-28

申请号：US12531322

申请日：2008-03-18

申请人： James Robinson ,  Graham Ruecroft

发明人： James Robinson ,  Graham Ruecroft

IPC分类号： B01J19/10

CPC分类号： B01J19/10 ,  B01D9/0054 ,  B01D9/0081 ,  B01J2/02 ,  B01J2/18 ,  B01J19/18 ,  B01J2219/0011 ,  B01J2219/00114 ,  C07J31/006

摘要： A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.

摘要翻译： 一种在超声波照射的存在下制备活性物质的结晶颗粒的方法，该方法包括使第一流动中的溶剂中的溶质与抗溶剂在第二流动流中接触，引起其混合，其中流动 反溶剂：溶剂的速率比高于20:1，收集产生的结晶。

公开(公告)号：US20080096187A1

公开(公告)日：2008-04-24

申请号：US11578761

申请日：2005-04-08

申请人： George Shaw ,  James Robinson ,  Frederic Bibollet-Ruche ,  Julie Decker ,  Beatrice Hahn

发明人： George Shaw ,  James Robinson ,  Frederic Bibollet-Ruche ,  Julie Decker ,  Beatrice Hahn

IPC分类号： C07H21/04 ,  C07K16/00 ,  C12N5/00 ,  C12N7/00 ,  C12Q1/70

CPC分类号： G01N33/56988 ,  C07K16/1063 ,  C07K16/2812 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/76 ,  G01N2469/20

摘要： Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.

摘要翻译： 提供了使用来自不是HIV-1作为HIV-1表位的分子支架的慢病毒的包膜多肽或其功能变体的方法和组合物。 HIV-1表位可被HIV-1结合抗体，HIV-1中和抗体和/或CD4诱导的抗体识别。 因此，提供了用于检测感染HTV-1的受试者中的HIV-1结合抗体的方法。 还提供了确定HIV-1结合抗体的表位的方法; 测定HIV-1结合抗体的方法; 识别可溶性CD4模拟物的方法; 中和非HIV-1病毒的方法; 用于监测受试者中艾滋病病毒的诊断测定或监测受试者对HIV疫苗免疫接种的反应; 以及改变HIV-1衍生的CD4诱导抗体的中和电位的方法。 还提供了嵌合多肽，嵌合多核苷酸，试剂盒，细胞和病毒。

公开(公告)号：US20080087072A1

公开(公告)日：2008-04-17

申请号：US11925066

申请日：2007-10-26

申请人： Jonathan Asher ,  Anthony Walker ,  James Robinson

发明人： Jonathan Asher ,  Anthony Walker ,  James Robinson

IPC分类号： G01N30/00

CPC分类号： G01N30/88 ,  G01N2030/0095 ,  G01N2030/025 ,  G01N2030/8804 ,  G01N2030/8881 ,  Y10T137/86558 ,  Y10T137/87265 ,  Y10T137/87716 ,  Y10T137/87764 ,  Y10T137/87893

摘要： The present invention is directed to a field-mounted analyzer having a graphical user interface (GUI). The analyzer has a display screen visible from the exterior of the housing. A plurality of magnetically-actuatable switches are mounted behind the display screen. The GUI has a plurality of windows that may be displayed on the display screen. Navigation through the windows is accomplished by activating switches aligned with graphical navigation icons in the windows.

摘要翻译： 本发明涉及具有图形用户界面（GUI）的现场安装分析器。 分析仪具有从外壳的外部可见的显示屏。 多个可磁致动开关安装在显示屏幕后面。 GUI具有可以在显示屏幕上显示的多个窗口。 通过窗口导航是通过激活与窗口中的图形导航图标对齐的开关实现的。

公开(公告)号：US20070188438A1

公开(公告)日：2007-08-16

申请号：US11353014

申请日：2006-02-14

申请人： Bergen Fletcher ,  Robert Lowles ,  James Robinson

发明人： Bergen Fletcher ,  Robert Lowles ,  James Robinson

IPC分类号： G09G3/36

CPC分类号： G09G3/3406 ,  G09G2320/064 ,  G09G2330/021 ,  G09G2360/144 ,  G09G2360/16

摘要： The invention provides a system and method for calculating a backlight level for an image being displayed on an electronic device. The system comprises: a backlight adjustment module to calculate an intensity value of an image for display on the electronic device; a display for displaying the image; and a backlight system to provide a backlight for the display. The backlight system is responsive to control signals generated by the backlight adjustment module. In the system, the intensity value represents an average intensity of the image.

摘要翻译： 本发明提供了一种用于计算正在显示在电子设备上的图像的背光级的系统和方法。 该系统包括：背光调整模块，用于计算用于在电子设备上显示的图像的强度值; 用于显示图像的显示器; 以及为显示器提供背光的背光系统。 背光系统响应于由背光调节模块产生的控制信号。 在系统中，强度值表示图像的平均强度。

公开(公告)号：US20070091060A1

公开(公告)日：2007-04-26

申请号：US11585336

申请日：2006-10-24

申请人： Marc Drader ,  James Robinson ,  Robert Lowles

发明人： Marc Drader ,  James Robinson ,  Robert Lowles

IPC分类号： G09G3/36

CPC分类号： G09G3/34 ,  G06F3/04897 ,  G09G2330/022 ,  Y10S362/802

摘要： In a handheld computing device that includes a backlit display having a variable-intensity backlight, a method for controlling the intensity of light produced by the backlight involves the following steps. The computing device also includes user data input means, and data processing means coupled to the user data input means and the backlit display. The data processing means includes at least one software application that is configured to display information on the display. The method involves the steps of (1) setting the intensity to a first intensity level and activating one of the software applications; and (2) setting the intensity to a minimum intensity level, less than the first intensity level, after expiry of a predetermined elapsed time of non-activity from the user data input means. The predetermined elapsed time is based on the activated software application.

摘要翻译： 在包括具有可变强度背光的背光显示器的手持计算设备中，用于控制由背光产生的光的强度的方法包括以下步骤。 计算设备还包括用户数据输入装置和耦合到用户数据输入装置和背光显示器的数据处理装置。 数据处理装置包括被配置为在显示器上显示信息的至少一个软件应用程序。 该方法包括以下步骤：（1）将强度设置为第一强度水平并激活软件应用之一; 以及（2）在来自用户数据输入装置的非活动的预定经过时间期满之后，将强度设定为小于第一强度水平的最小强度水平。 预定的经过时间是基于激活的软件应用程序。

公开(公告)号：US20070089445A1

公开(公告)日：2007-04-26

申请号：US10553541

申请日：2004-04-07

申请人： James Robinson

发明人： James Robinson

IPC分类号： F25D23/12

CPC分类号： B01D5/0093 ,  B01D5/0036 ,  B01D53/002 ,  B01D53/265 ,  Y10S55/15 ,  Y10S165/207

摘要： A condenser and a containment vessel adapted to efficiently condense a gas out of a mixture of condensing and non-condensing gases. In condensers, the fraction of gas within a condenser made up of non-condensing gases can be significantly reduced by withdrawing gas from localised regions of relatively low temperature where the mass fraction of non-condensing gases will be relatively high. In containment vessels, pressures can be reduced by providing a large surface area of the liquid into which the condensing gas condenses in a relatively cool region of the containment vessel. Both these effects result from an appreciation of the manner in which non-condensing gases tend to accumulate in regions which are relatively cold.

摘要翻译： 冷凝器和容纳容器适于有效地将气体从冷凝和非冷凝气体的混合物中冷凝。 在冷凝器中，通过从非冷凝气体的质量分数相对较高的较低温度的局部区域抽出气体，可以显着地减少由非冷凝气体组成的冷凝器内的气体分数。 在容纳容器中，可以通过提供冷凝气体在容器的相对较冷的区域中冷凝的液体的大的表面积来减小压力。 这两种影响都是由于非冷凝气体倾向于积累在相对较冷的区域中的方式的理解。

公开(公告)号：US20070044611A1

公开(公告)日：2007-03-01

申请号：US11348566

申请日：2006-02-07

申请人： Frank Bondarowicz ,  Scott Rote ,  Scott Zeeb ,  Aaron Eiger ,  Philip Anthony ,  Todd Clem ,  Hardev Somal ,  James Fournier ,  Alan Varacins ,  James Robinson

发明人： Frank Bondarowicz ,  Scott Rote ,  Scott Zeeb ,  Aaron Eiger ,  Philip Anthony ,  Todd Clem ,  Hardev Somal ,  James Fournier ,  Alan Varacins ,  James Robinson

IPC分类号： B26D7/06

CPC分类号： B26D7/00 ,  B26D1/143 ,  B26D2210/02 ,  Y10T83/4556 ,  Y10T83/6515

摘要： A food slicer is provided having a support member including a base portion and an upstanding portion integrally formed with the base portion. The upstanding portion includes a rotating cutting blade secured thereto for slicing food product and at least one motor positioned within the upstanding portion for rotating the cutting blade. The base portion includes a food product table slidably secured thereto and is movable across the cutting blade for holding product while it is being sliced by the cutting blade. An adjustable gage plate also is provided for determining the thickness of a food product to be sliced by the cutting blade. First and second top surfaces are formed by a distal end of the upstanding portion of the support member. The base portion and the upstanding portion are formed as a single piece with a total continuous surface with no openings, seams, crevices or the like below the first and second top surfaces.

摘要翻译： 提供一种食品切片机，具有支撑部件，该支撑部件包括基部和与基部一体形成的直立部。 直立部分包括固定在其上用于切割食品的旋转切割刀片和位于直立部分内的用于旋转切割刀片的至少一个马达。 基部包括可滑动地固定在其上的食品台，并且当切割刀片被切片时可移动跨越切割刀片以保持产品。 还提供了一种用于确定由切割刀片切片的食品的厚度的可调量度板。 第一和第二顶表面由支撑构件的直立部分的远端形成。 基部和直立部分形成为具有在第一和第二顶表面下方没有开口，接缝，裂缝等的总连续表面的单件。