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    Molecular Scaffolds for HIV-1 Epitopes
    1.
    发明申请
    Molecular Scaffolds for HIV-1 Epitopes 失效
    HIV-1表位的分子支架

    公开(公告)号：US20080096187A1

    公开(公告)日：2008-04-24

    申请号：US11578761

    申请日：2005-04-08

    申请人： George Shaw ,  James Robinson ,  Frederic Bibollet-Ruche ,  Julie Decker ,  Beatrice Hahn

    发明人： George Shaw ,  James Robinson ,  Frederic Bibollet-Ruche ,  Julie Decker ,  Beatrice Hahn

    IPC分类号： C07H21/04 ,  C07K16/00 ,  C12N5/00 ,  C12N7/00 ,  C12Q1/70

    CPC分类号： G01N33/56988 ,  C07K16/1063 ,  C07K16/2812 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/76 ,  G01N2469/20

    摘要： Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.

    摘要翻译： 提供了使用来自不是HIV-1作为HIV-1表位的分子支架的慢病毒的包膜多肽或其功能变体的方法和组合物。 HIV-1表位可被HIV-1结合抗体，HIV-1中和抗体和/或CD4诱导的抗体识别。 因此，提供了用于检测感染HTV-1的受试者中的HIV-1结合抗体的方法。 还提供了确定HIV-1结合抗体的表位的方法; 测定HIV-1结合抗体的方法; 识别可溶性CD4模拟物的方法; 中和非HIV-1病毒的方法; 用于监测受试者中艾滋病病毒的诊断测定或监测受试者对HIV疫苗免疫接种的反应; 以及改变HIV-1衍生的CD4诱导抗体的中和电位的方法。 还提供了嵌合多肽，嵌合多核苷酸，试剂盒，细胞和病毒。

    Secure data transfer on a handheld communications device
    2.
    发明授权
    Secure data transfer on a handheld communications device 有权
    在手持通信设备上安全的数据传输

    公开(公告)号：US08798265B2

    公开(公告)日：2014-08-05

    申请号：US13566315

    申请日：2012-08-03

    申请人： Marc Drader ,  James Robinson ,  Michael Purdy

    发明人： Marc Drader ,  James Robinson ,  Michael Purdy

    IPC分类号： H04L9/00 ,  H04L9/08

    CPC分类号： H04L9/0861 ,  G09C5/00 ,  G09G2360/145 ,  H04L9/0819 ,  H04L9/0863 ,  H04L9/0894 ,  H04L9/32 ,  H04L63/068 ,  H04L63/0853 ,  H04L2209/805 ,  H04L2463/061

    摘要： A handheld communications device and method for transmitting an encryption key are provided. The method comprises: generating an encryption key via the data processor, the encryption key comprising a bit sequence; and varying an output of the display device over a period of time to transmit the encryption key from the handheld communications device by varying at least one of a sequence at least one of colour rendered on the display device or a sequence of brightness levels output by the display device.

    摘要翻译： 提供了一种用于发送加密密钥的手持通信设备和方法。 该方法包括：经由数据处理器生成加密密钥，加密密钥包括比特序列; 以及在一段时间内改变显示设备的输出，以通过改变显示设备上呈现的颜色中的至少一个或由显示设备输出的亮度级别中的至少一个的序列中的至少一个来从手持通信设备发送加密密钥 显示设备。

    Method for maintaining the white colour point in a field-sequential LCD over time
    4.
    发明授权
    Method for maintaining the white colour point in a field-sequential LCD over time 有权
    随时间保持场顺序LCD中的白色色点的方法

    公开(公告)号：US08421827B2

    公开(公告)日：2013-04-16

    申请号：US12718626

    申请日：2010-03-05

    申请人： Marc Drader ,  James Robinson ,  Jerry Mailloux ,  Robert Lowles

    发明人： Marc Drader ,  James Robinson ,  Jerry Mailloux ,  Robert Lowles

    IPC分类号： G09G5/10

    CPC分类号： G09G3/3413 ,  G09G2320/0242 ,  G09G2320/043 ,  G09G2320/0666

    摘要： A field sequential liquid crystal display maintains its white color point through compensation values to at least one color light emitting diode that illuminates the display. The compensation values may be impedances to control the current or pulsing of the current source according to a pulse width modulation technique. A degradation curve may be used to calculate extrapolate the theoretical forward voltage of the light emitting diode. Additional complexity arises from the need for calculating uptime for multiple light emitting diodes of different colors. Brightness levels may also be factored in. Additional processing of a display element may be provided when a grey scale image is being generated.

    摘要翻译： 场顺序液晶显示器将其白色色点通过补偿值保持到照亮显示器的至少一个彩色发光二极管。 补偿值可以是根据脉冲宽度调制技术来控制电流源的电流或脉冲的阻抗。 可以使用退化曲线来计算外推发光二极管的理论正向电压。 另外的复杂性是由于需要计算不同颜色的多个发光二极管的正常运行时间。 也可以考虑亮度水平。当生成灰度图像时，可以提供显示元件的附加处理。

    ROUNDED AIR DAM FOR MAXIMUM AERODYNAMICS AND COOLING PERFORMANCE
    5.
    发明申请
    ROUNDED AIR DAM FOR MAXIMUM AERODYNAMICS AND COOLING PERFORMANCE 有权
    圆形空气达到最大的空气动力学和冷却性能

    公开(公告)号：US20130069389A1

    公开(公告)日：2013-03-21

    申请号：US13239074

    申请日：2011-09-21

    申请人： Christopher D. Meeks ,  Michael W. Maurer ,  Jason A. Widmer ,  James Robinson ,  Sukwon Kim ,  Kyle Stephen Mihok ,  Jeremy Paul Lucas

    发明人： Christopher D. Meeks ,  Michael W. Maurer ,  Jason A. Widmer ,  James Robinson ,  Sukwon Kim ,  Kyle Stephen Mihok ,  Jeremy Paul Lucas

    IPC分类号： B62D35/00

    CPC分类号： B62D35/005

    摘要： A modified air dam includes an integral spring-like, corrugate-shaped portion for absorbing impact forces imposed on the air dam. A lower portion of the air dam is generally planar and angled slightly from a vertical plane toward the front of the vehicle. The air dam also includes a rounded portion to provide a horizontal offset between upper and lower portions of the air dam and to direct airflow toward a bottom portion of the radiator. The air dam may also be curved side-to-side or employ an inverted, generally U-shaped portion as a first force absorbing region and a spaced rib that serves as a second force absorbing region. The generally U-shaped portion also advantageously extends over a fastener and mounting region of the air dam.

    摘要翻译： 改进的空气坝包括用于吸收施加在空气坝上的冲击力的一体的弹簧状波纹状部分。 空气坝的下部通常是平面的，并且从垂直平面向车辆前方稍微倾斜。 空气坝还包括圆形部分，以在空气坝的上部和下部之间提供水平偏移并且将气流引向散热器的底部。 空气坝也可以是侧面或侧面弯曲的，或者采用倒置的大致U形部分作为第一吸力区域和用作第二吸力区域的隔开的肋。 大致U形部分还有利地在空气坝的紧固件和安装区域上延伸。

    System and method for adjusting an intensity value and a backlight level for a display of an electronic device
    7.
    发明授权
    System and method for adjusting an intensity value and a backlight level for a display of an electronic device 有权
    用于调整电子设备的显示器的强度值和背光级的系统和方法

    公开(公告)号：US08194028B2

    公开(公告)日：2012-06-05

    申请号：US12039905

    申请日：2008-02-29

    申请人： Bergen Albert Fletcher ,  James Robinson ,  Conrad Aleksander Kreek ,  David Mak-Fan ,  Andrew Dewi Williams ,  Michael Purdy

    发明人： Bergen Albert Fletcher ,  James Robinson ,  Conrad Aleksander Kreek ,  David Mak-Fan ,  Andrew Dewi Williams ,  Michael Purdy

    IPC分类号： G09G3/36

    CPC分类号： G09G3/3406 ,  G09G2320/062 ,  G09G2360/144

    摘要： The disclosure relates to a system and method for determining pixel intensity values (luma values) for an image being displayed on a display of an electronic device, then adjusting the pixel intensity and the backlight level for the image that is output to a liquid crystal display (LCD). The system comprises: a display for displaying an image to be displayed on the device; an image adjustment module to identify the pixel intensity values of the image, to determine new pixel intensity values for the image based in part on the original pixel intensity values, to provide the (adjusted) image at the new pixel intensity values to the display and to determine a backlight level for the image at the new pixel intensity values. The system further comprises a backlight system to provide a backlight for the adjusted image at the adjusted backlight level.

    摘要翻译： 本公开涉及一种用于确定显示在电子设备的显示器上的图像的像素强度值（亮度值）的系统和方法，然后调整输出到液晶显示器的图像的像素强度和背光级 （LCD）。 该系统包括：用于显示要在设备上显示的图像的显示器; 图像调整模块，用于识别图像的像素强度值，以部分地基于原始像素强度值来确定图像的新像素强度值，以将新的像素强度值的（调整的）图像提供给显示和 以确定新像素强度值下的图像的背光级。 该系统还包括一个背光系统，用于为调整后的照明级别的调整图像提供背光源。

    Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof
    8.
    再颁专利
    Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof 失效
    含氮杂环化合物及其制备含氮杂环化合物的方法及其中间体

    公开(公告)号：USRE43098E1

    公开(公告)日：2012-01-10

    申请号：US11866275

    申请日：2007-10-02

    申请人： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough ,  Carroll Scarborough, legal representative

    发明人： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

    IPC分类号： A61K31/495 ,  C07D487/00 ,  C07D487/04 ,  C07D239/94

    摘要： The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

    摘要翻译： 本发明提供了含氮杂环化合物及其药学上可接受的盐及其制备方法。 这些化合物对抑制这种激酶活性的激酶的磷酸化具有抑制活性。 本发明还提供了可用于该方法的中间体化合物，以及通过该方法生产的最终产物及其盐或前药。 本发明进一步提供了通过抑制激酶的磷酸化来抑制哺乳动物激酶和治疗疾病状态的方法，包括向有需要的患者施用有效量的本发明化合物。

    Backlight control for a handheld computing device
    9.
    发明授权
    Backlight control for a handheld computing device 有权
    手持式计算设备的背光控制

    公开(公告)号：US08063869B2

    公开(公告)日：2011-11-22

    申请号：US11585336

    申请日：2006-10-24

    申请人： Marc A. Drader ,  James Robinson ,  Robert J. Lowles

    发明人： Marc A. Drader ,  James Robinson ,  Robert J. Lowles

    IPC分类号： G09G3/36

    CPC分类号： G09G3/34 ,  G06F3/04897 ,  G09G2330/022 ,  Y10S362/802

    摘要： In a handheld computing device that includes a backlit display having a variable-intensity backlight, a method for controlling the intensity of light produced by the backlight involves the following steps. The computing device also includes user data input means, and data processing means coupled to the user data input means and the backlit display. The data processing means includes at least one software application that is configured to display information on the display. The method involves the steps of (1) setting the intensity to a first intensity level and activating one of the software applications; and (2) setting the intensity to a minimum intensity level, less than the first intensity level, after expiry of a predetermined elapsed time of non-activity from the user data input means. The predetermined elapsed time is based on the activated software application.

    摘要翻译： 在包括具有可变强度背光的背光显示器的手持计算设备中，用于控制由背光产生的光的强度的方法包括以下步骤。 计算设备还包括用户数据输入装置和耦合到用户数据输入装置和背光显示器的数据处理装置。 数据处理装置包括被配置为在显示器上显示信息的至少一个软件应用程序。 该方法包括以下步骤：（1）将强度设置为第一强度水平并激活软件应用之一; 以及（2）在来自用户数据输入装置的非活动的预定经过时间期满之后，将强度设定为小于第一强度水平的最小强度水平。 预定的经过时间是基于激活的软件应用程序。