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129 条记录 (耗时 0.054 秒)

    Therapeutic agents useful for treating pain
    71.
    发明申请
    Therapeutic agents useful for treating pain 有权
    用于治疗疼痛的治疗剂

    公开(公告)号：US20060235055A1

    公开(公告)日：2006-10-19

    申请号：US11317832

    申请日：2005-12-22

    申请人： Donald Kyle ,  Qun Sun ,  Xiaoming Zhou

    发明人： Donald Kyle ,  Qun Sun ,  Xiaoming Zhou

    IPC分类号： A61K31/4439 ,  C07D403/02

    CPC分类号： C07D401/04 ,  C07D401/12

    摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.

    摘要翻译： 本发明提供式（I）化合物：其中R 1，Q，A和R 2 2在本文中公开）或其药学上可接受的盐（“吡啶” - 炔基化合物“）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能 亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

    Therapeutic agents useful for treating pain
    72.
    发明申请
    Therapeutic agents useful for treating pain 有权
    用于治疗疼痛的治疗剂

    公开(公告)号：US20060235022A1

    公开(公告)日：2006-10-19

    申请号：US11386058

    申请日：2006-03-20

    申请人： Qun Sun

    发明人： Qun Sun

    IPC分类号： A61K31/506 ,  A61K31/497 ,  A61K31/501 ,  A61K31/4439 ,  A61K31/433 ,  C07D417/02 ,  C07D403/02 ,  C07D413/02

    CPC分类号： C07D417/12 ,  C07D213/56

    摘要： The present invention discloses compounds of formula: where Ar1, Ar2, X, R1, R2, R3, m, and n are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Phenylene Compound”); compositions comprising an effective amount of a Phenylene Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Phenylene Compound.

    摘要翻译： 本发明公开了下式的化合物：其中Ar 1，Ar 2，X，R 1，R 2， R 3，m和n如本文所公开或其药学上可接受的盐（“苯撑化合物”）; 包含有效量的苯亚甲基化合物的组合物; 以及用于治疗或预防动物中的疼痛和其他病症的方法，其包括向有需要的动物施用有效量的苯撑化合物。

    1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety
    73.
    发明申请
    1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety 有权
    可用于治疗疼痛，抑郁和焦虑的1,2,5-噻二唑-3-基 - 哌嗪治疗剂

    公开(公告)号：US20060074090A1

    公开(公告)日：2006-04-06

    申请号：US11246498

    申请日：2005-10-07

    申请人： Donald Kyle ,  Qun Sun

    发明人： Donald Kyle ,  Qun Sun

    IPC分类号： A61K31/496

    CPC分类号： C07D285/10

    摘要： A compound of formula: (wherein X, R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical compositions comprising a Thiadiazolylpiperazine Compound, and methods for treating or preventing, e.g., pain, depression and anxiety, in a patient comprising administering to a patient in need thereof an effective amount of a Thiadiazolylpiperazine Compound are disclosed.

    摘要翻译： 下式化合物：其中X，R 1，R 3，R 4和R 5均为 本文公开的）或其药学上可接受的盐（“噻二唑基哌嗪化合物”），包含噻二唑基哌嗪化合物的药物组合物，以及用于治疗或预防例如疼痛，抑郁和焦虑的方法，包括向有需要的患者施用 公开了有效量的噻二唑基哌嗪化合物。

    Process for the preparation of spherically shaped microcomposites
    76.
    发明授权
    Process for the preparation of spherically shaped microcomposites 失效
    制备球形微复合材料的方法

    公开(公告)号：US06262326B1

    公开(公告)日：2001-07-17

    申请号：US09588528

    申请日：2000-06-06

    申请人： Mark Andrew Harmer ,  Qun Sun

    发明人： Mark Andrew Harmer ,  Qun Sun

    IPC分类号： C07C523

    CPC分类号： B01J31/10 ,  B01J35/08 ,  B01J35/10 ,  B01J2231/12 ,  B01J2231/341 ,  B01J2231/52 ,  C07C5/2273 ,  C07C2531/08

    摘要： A process for the preparation of at least one spherically shaped porous microcomposite is provided which microcomposite comprises a perfluorinated ion-exchange polymer containing pendant sulfonic and/or carboxylic acid groups entrapped within and highly dispersed throughout a network of inorganic oxide, wherein the weight percentage of the perfluorinated ion-exchange polymer in the microcomposite is from about 0.1 to about 90 percent, and wherein the size of the pores in the microcomposite is about 0.5 nm to about 75 nm; said process comprising the steps of: (a) combining a water-miscible inorganic oxide network precursor system, a water-miscible liquid composition comprising a perfluorinated ion-exchange polymer containing pendant sulfonic and/or carboxylic acid groups, and an organic liquid to form a two phase liquid system; (b) agitating the two phase liquid system sufficiently to sustain a dispersion of the water-miscible phase in the shape of spheres in the organic phase; (c) allowing the inorganic oxide network precursor system to form a network of inorganic oxide to yield at least one spherically shaped porous microcomposite having the above-described properties; and (d) recovering the at least one spherically shaped porous microcomposite.

    摘要翻译： 提供了制备至少一种球形多孔微复合材料的方法，该微复合材料包含全部含有离子交换聚合物的全氟化离子交换聚合物，所述全氟化离子交换聚合物包含在无机氧化物网络内并且高度分散在无机氧化物网络中的侧链磺酸和/或羧酸基团，其中重量百分数 微复合材料中的全氟化离子交换聚合物为约0.1至约90％，并且其中微复合材料中的孔的尺寸为约0.5nm至约75nm; 所述方法包括以下步骤：（a）将水混溶性无机氧化物网络前体体系，包含含有侧链磺酸和/或羧酸基团的全氟化离子交换聚合物的水混溶性液体组合物和有机液体混合以形成 两相液体系统; （b）充分搅拌两相液体系统以维持有机相中球混合物的水混溶相分散; （c）使无机氧化物网络前体体系形成无机氧化物网络，得到至少一种具有上述性质的球形多孔微复合材料; 和（d）回收至少一个球形多孔微复合物。

    Fluorine-modified perfluorinated ion-exchange microcomposite catalysts
    77.
    发明授权
    Fluorine-modified perfluorinated ion-exchange microcomposite catalysts 失效
    氟改性全氟化离子交换微复合催化剂

    公开(公告)号：US06248930B1

    公开(公告)日：2001-06-19

    申请号：US09380417

    申请日：1999-09-01

    申请人： Mark Andrew Harmer ,  Qun Sun

    发明人： Mark Andrew Harmer ,  Qun Sun

    IPC分类号： C07C266

    CPC分类号： B01J21/08 ,  B01J31/10 ,  B01J31/26 ,  B01J37/26 ,  B01J2231/323

    摘要： This invention concerns fluorine-modified perfluorinated ion-exchange microcomposites, comprising a perfluorinated ion-exchange polymer containing pendant sulphonic acid groups and/or carboxylic acid groups, entrapped within and highly dispersed throughout a network of inorganic oxide, said network having a plurality of fluoride groups bonded thereto; processes for their preparation and their use as catalysts in chemical processes such as alkylation of aromatic compounds.

    摘要翻译： 本发明涉及氟改性的全氟化离子交换微复合材料，其包含含有侧链磺酸基团和/或羧酸基团的全氟化离子交换聚合物，其被包埋在并且高度分散在无机氧化物的网络中，所述网络具有多个氟化物 结合的基团 其制备方法及其在化学方法中的用作催化剂，例如芳族化合物的烷基化。

    Terbenzimidazoles useful as antifungal agents
    79.
    发明授权
    Terbenzimidazoles useful as antifungal agents 失效
    泰苯咪唑可用作抗真菌剂

    公开(公告)号：US5770617A

    公开(公告)日：1998-06-23

    申请号：US786629

    申请日：1997-01-21

    申请人： Edmond J. LaVoie ,  Leroy Fong Liu ,  Qun Sun

    发明人： Edmond J. LaVoie ,  Leroy Fong Liu ,  Qun Sun

    IPC分类号： A61K31/4184 ,  A61K31/4439 ,  A61P31/10 ,  A61P35/00 ,  A61P43/00 ,  C07D235/18 ,  C07D401/14 ,  A61K31/415

    CPC分类号： C07D401/14 ,  C07D235/18

    摘要： The present invention provides a method of treatment of fungal infection with an antifungal topoisomerase I inhibitor of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl, a (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C.sub.1 -C.sub.4)alkyl or benzyl; or benzo; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; and each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了一种使用下式的抗真菌拓扑异构酶I抑制剂治疗真菌感染的方法：其中Ar是（C 6 -C 12）芳基，包含1-3个N的（5-至12-元）杂芳基， S或非过氧化物O，其中N是未取代的或被H，（C 1 -C 4）烷基或苄基取代; 或苯并; X是H，CN，CHO，OH，乙酰基，CF 3，O（C 1 -C 4）烷基，NO 2，NH 2，卤素或卤代（C 1 -C 4） 每个Y各自为H，（C 1 -C 4）烷基或芳烷基; Y'是H或（C 1 -C 4）烷基; n为0或1; 并且每个Z独立地为H，（C 1 -C 4）烷基，卤素或卤素（C 1 -C 4）烷基; 或其药学上可接受的盐。

    Abiraterone derivative and formulations thereof
    80.
    发明授权
    Abiraterone derivative and formulations thereof 有权

    公开(公告)号：US10717762B2

    公开(公告)日：2020-07-21

    申请号：US16341206

    申请日：2017-10-11

    申请人： Zhuhai Beihai Biotech Co., Ltd. ,  Qun Sun

    发明人： Qun Sun

    IPC分类号： C07J43/00 ,  A61K47/64 ,  A61K9/08

    摘要： This document relates to an abiraterone derivative, 2-(((3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-2-oxoacetic acid (ABOA). This document also relates to compositions comprising a non-covalently bound complex comprising ABOA and human serum albumin, wherein the ABOA and the human serum albumin in the composition have a ratio of weight from about 1:1 to about 1:2000. This document also relates to compositions comprising ABOA and human serum albumin, wherein the ABOA and the human serum albumin in the composition have a ratio of weight from about 1:1 to about 1:2000. This document also relates to compositions consisting essentially of ABOA and human serum albumin, wherein the ABOA and the human serum albumin in the composition have a ratio of weight from about 1:1 to about 1:2000.