摘要:
The invention provides a process for the preparation of a compound of general formula (I): wherein Im represents an imidazolyl group of the formula: and R1 represents a hydrogen atom or a group as herein defined including —CO2R5, —COR5, —CONR5R6 or —SO2R5 wherein R5 and R6, which may be the same or different, are as herein defined with the proviso that R5 does not represent a hydrogen atom when R1 represents a group —CO2R5 or —SO2R5; one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6alkyl, C3-7cycloaklyl, C3-6alkenyl, phenyl or phenyl C1-3alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6alkyl group; and n represents 2 or 3; which comprises reacting a compound of formula (II) or a protected derivative thereof, with a compound of formula (III): HOCH2-Im (III) or a salt thereof in the presence of an acid at an elevated temperature, followed where necessary by removal of any protecting groups.
摘要翻译:本发明提供了制备通式(I)化合物的方法:其中Im表示下式的咪唑基:R 1表示氢原子或本文定义的基团,包括-CO 2 R 5,-COR 5,-CONR 5 R 6或 -SO 2 R 5,其中R 5和R 6可以相同或不同,如本文所定义,条件是当R 1表示-CO 2 R 5或-SO 2 R 5基团时,R 5不表示氢原子; 由R 2,R 3和R 4表示的基团之一是氢原子或C 1-6烷基,C 3-7环烯基,C 3-6烯基,苯基或苯基C 1-3烷基,其它两个基团可以相同 或不同的,表示氢原子或C 1-6烷基; n表示2或3; 其包括在酸的存在下在升高的温度下使式(II)化合物或其保护的衍生物与式(III)的化合物或其盐反应,然后在需要时通过除去任何保护基团。
摘要:
A brush seal assembly for turbo-engines is provided for sealing off spaces on a circumferential gap which are differently acted upon by pressure, particularly between an engine stator and an engine rotor. A holding device for a bristle bundle is provided on the engine stator, from which holding device the bristle bundle is guided between circumferential webs in a sealing manner against the engine rotor and forms an axial gap in the circumferential direction with respect to one web facing the high-pressure side. In this case, at least on the side which faces the space of the higher pressure on the seal, the bristle bundle is to have devices for the shielding against a turbulent flow triggered by the engine rotor.
摘要:
Primary and secondary amines in biological fluids are selectively derivitized by reaction with esters of N-hydroxysuccinimide or N-hydroxysulfosuccinimide to form an N-acylated derivative. Those N-acylated derivatives may then be extracted into a polar organic phase and extracted. Non-electroactive amines may be made suitable for coulometric analysis by selecting the ester used so as to attach an electroactive group to the amine. For example, histamine may be reacted with the Bolton-Hunter reagent to form a suitable derivative in high yield.
摘要:
A composite board with a multilayer laminated facer is presented having a nonwoven, a first polymer layer, and a second polymer layer. The laminate may be printed on the nonwoven, on the upper surface of the first polymer layer or inverted printed on the backside of an applied film. A number of configurations for the polymer layers are disclosed. The laminate may include exposed fibers on the lower surface or the nonwoven may be saturated. A removable peel-ply may be included. By controlling the placement and thickness of the polymer layers it is possible to tailor additive in the polymers such as colorants, opacifiers, UV stabilizers, and fire retardants to improve quality and reduce costs. In an alternate embodiment of the present invention, a first polymer layer is applied to the topside of the nonwoven and the second polymer is laminated to the first polymer layer as a preformed film. The laminated facer is thermally or adhesively bonded to the composite board.
摘要:
The present invention provides a laminate material having a polyester film and a layer of polyester fibers cohesively bonded thereto. Generally, a metal layer deposited at least one surface of the laminate. The invention may also include a glass reinforced polymer layer formed on the laminated facer where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. The laminate may further include a second polymer layer having a thickness joined to the fiber layer and/or a layer of hot melt adhesive applied to the polyester fibers. Also presented is a composite material having a polyester film, a layer of polyester fibers bonded to the second polymer layer; a second polymer layer joined to the polyester film; and a glass reinforced polymer layer formed on the laminated facer, where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer.
摘要:
The present invention relates to a network based, third-party beneficiary donation system, and in particular to systems and methods that allow a merchant to provide a choice to participating consumer(s) in the form of donations to third party beneficiaries based on consumer purchases wherein the consumer chooses their third party beneficiary from a merchant curated list or customer self-generated list and independently determines the percentage amount of the donation or selects a pre-determined amount. In this manner, consumers are provided with an option to purchase products from the authorized merchant knowing that the product purchases may result in a specified donation to a customer selected third-party beneficiary or multiple customer selected third party beneficiaries on a per product or per order basis. Third party beneficiaries are generally intended to be charities or causes but are not required to have tax-exempt status.
摘要:
The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
摘要:
A medical device for example a wound dressing having antibacterial and optionally, antifungal properties, are provided together with methods for making the device. An exemplary dressing includes a layer of silver-containing fabric, (optionally) a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.
摘要:
A device for determining material properties includes a bottom panel extending from a first end to a second end of the device, for supporting a material to be tested. A closed loop flexible wall extends upwardly from the panel and is in operational engagement with a flexible wall idle means towards the first end of the device and a flexible wall driving means in spaced relation with the flexible wall idle means. The flexible wall driving means causes movement of the closed loop flexible wall along a predetermined closed loop path. The flexible wall driving means and the means of driving it are arranged at a position outside of a material containment area of the device.
摘要:
A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures.