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    Methods of inhibiting vascular endothelial growth factor activity
    71.
    发明授权
    Methods of inhibiting vascular endothelial growth factor activity 有权
    抑制血管内皮生长因子活性的方法

    公开(公告)号：US09273113B2

    公开(公告)日：2016-03-01

    申请号：US13584241

    申请日：2012-08-13

    申请人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    发明人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62 ,  C07K16/28 ,  A61K38/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

    Inhibitors of vascular endothelial growth factor activity
    72.
    发明授权
    Inhibitors of vascular endothelial growth factor activity 有权
    抑制血管内皮生长因子活性

    公开(公告)号：US08273353B2

    公开(公告)日：2012-09-25

    申请号：US13096723

    申请日：2011-04-28

    申请人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    发明人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC分类号： A61K38/18 ,  C07K14/71

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

    METHODS FOR USING CHIMERIC VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR PROTEINS
    77.
    发明申请
    METHODS FOR USING CHIMERIC VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR PROTEINS 有权
    使用重型血管内皮生长因子受体蛋白的方法

    公开(公告)号：US20090010933A1

    公开(公告)日：2009-01-08

    申请号：US12104825

    申请日：2008-04-17

    申请人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    发明人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/00 ,  C12P21/00 ,  A61P9/00 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and anglogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质与VEGF结合并拮抗其内皮细胞增殖和萌生活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

    GLYCOPROTEIN COMPOSITIONS
    80.
    发明申请
    GLYCOPROTEIN COMPOSITIONS 审中-公开
    GLYCOPROTEIN组合物

    公开(公告)号：US20080095762A1

    公开(公告)日：2008-04-24

    申请号：US11625201

    申请日：2007-01-19

    申请人： Leonard Presta

    发明人： Leonard Presta

    IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/18 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/2896 ,  C07K16/32 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

    摘要： The present invention concerns compositions comprising a glycoprotein having an Fc region, wherein about 80-100% of the glycoprotein in the composition comprises a mature core carbohydrate structure which lacks fucose, attached to the Fc region of the glycoprotein. The preferred glycoprotein is an antibody or immunoadhesin.

    摘要翻译： 本发明涉及包含具有Fc区的糖蛋白的组合物，其中组合物中约80-100％的糖蛋白包含与糖蛋白的Fc区连接的缺少岩藻糖的成熟核心碳水化合物结构。 优选的糖蛋白是抗体或免疫粘附蛋白。