公开(公告)号：US10470691B2

公开(公告)日：2019-11-12

申请号：US15370357

申请日：2016-12-06

Applicant: DexCom, Inc.

Inventor： Daiting Rong ,  Sebastian Böhm ,  Matthew D. Wightlin

IPC: G01N33/483 ,  G01N33/50 ,  A61B5/145 ,  A61B5/1486

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

公开(公告)号：US20190261902A1

公开(公告)日：2019-08-29

申请号：US16405887

申请日：2019-05-07

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N33/49 ,  A61B5/145 ,  G01D18/00 ,  G01N27/327 ,  G01N27/02 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1473

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US10238324B2

公开(公告)日：2019-03-26

申请号：US14717967

申请日：2015-05-20

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Rack-Gomer ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/01 ,  A61B5/11 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  A61M5/172 ,  G06F19/00

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US10238322B2

公开(公告)日：2019-03-26

申请号：US14717643

申请日：2015-05-20

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Rack-Gomer ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/01 ,  A61B5/11 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  A61M5/172 ,  G06F19/00

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US09844328B2

公开(公告)日：2017-12-19

申请号：US14962972

申请日：2015-12-08

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Jennifer Blackwell ,  Sebastian Böhm

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B17/34 ,  A61B5/1486 ,  A61B17/00

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6848 ,  A61B17/3468 ,  A61B2017/00004

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US20160095542A1

公开(公告)日：2016-04-07

申请号：US14968643

申请日：2015-12-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Böhm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/145 ,  A61B5/00

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

Abstract translation: 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体可以在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护 传感器体的膜。

公开(公告)号：US20160073941A1

公开(公告)日：2016-03-17

申请号：US14956210

申请日：2015-12-01

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49 ,  H05K999/00 ,  H05K999/99

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.