公开(公告)号：US11744700B2

公开(公告)日：2023-09-05

申请号：US16940198

申请日：2020-07-27

Applicant: Edwards Lifesciences Corporation

Inventor： Hanoch Cohen-Tzemach ,  Tamir S. Levi ,  Noam Nir ,  Bella Felsen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0017 ,  A61F2230/0026 ,  A61F2230/0069 ,  A61F2250/0069 ,  A61F2250/0098

Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.

公开(公告)号：US20230270541A1

公开(公告)日：2023-08-31

申请号：US18195288

申请日：2023-05-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Shahram Zamani ,  Michael Bukin ,  Ziv Yohanan ,  Noam Nir ,  Tyler Dale O'Dell ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075

Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.

公开(公告)号：US11717400B2

公开(公告)日：2023-08-08

申请号：US17114251

申请日：2020-12-07

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/844

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2/2439 ,  A61F2/2436 ,  A61F2/844 ,  A61F2/9517 ,  A61F2002/9511

Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.

公开(公告)号：US20230190462A1

公开(公告)日：2023-06-22

申请号：US17892654

申请日：2022-08-22

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Eran Goldberg ,  Michael Bukin

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2418

Abstract: An implantable prosthetic device can include a hybrid frame movable between a radially compressed configuration and a radially expanded configuration. The hybrid frame can include a mechanically-expandable first sub-frame comprising a plurality of struts pivotably coupled to one another, and a self-expanding second sub-frame coupled to the first sub-frame. When the hybrid frame is in the expanded configuration, the second sub-frame can be configured to resist radial compression of the frame.

公开(公告)号：US20230190459A1

公开(公告)日：2023-06-22

申请号：US18108259

申请日：2023-02-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Tamir S. Levi ,  Ziv Yohanan ,  Michael Bukin ,  Elena Sherman ,  Yana Mayatskaya

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2220/0075

Abstract: A prosthetic valve includes a radially expandable and compressible annular frame and a valvular structure. The frame includes a first strut and an adjacent second strut that overlap at a pivot joint. Radial expansion or compression of the frame causes the first strut to pivot relative to the second strut at the pivot joint. The valvular structure includes first and second leaflets attached to the first and second struts with a suture. The first and second struts define four strut segments connected by the pivot joint. The suture comprises three interconnected locking knots that are respectively attached to three of the four strut segments.

公开(公告)号：US20230172710A1

公开(公告)日：2023-06-08

申请号：US18096511

申请日：2023-01-12

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2210/0014

Abstract: The present invention is directed toward prosthetic heart valves that include an expandable frame provided with expansion and locking assemblies, which can be kept in a locked state by a twist formed along a portion of a wire of each expansion and locking assemblies. The present invention is further directed toward delivery assemblies that include actuation assemblies configured to actuate the expansion and locking assemblies, and to methods of utilizing the actuation assemblies and the expansion and locking assemblies.

公开(公告)号：US20230165678A1

公开(公告)日：2023-06-01

申请号：US18096728

申请日：2023-01-13

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0025 ,  A61F2250/0012

Abstract: The present invention relates to implantable prosthetic devices, such as prosthetic heart valves with mechanisms for adjusting the tension of leaflets mounted therein, and to methods, adjustment assemblies and delivery assemblies for, and including, such devices.

公开(公告)号：US20230065795A1

公开(公告)日：2023-03-02

申请号：US18054305

申请日：2022-11-10

Applicant: Edwards Lifesciences Corporation

Inventor： Shahram Zamani ,  Tyler Dale O'Dell ,  Tamir S. Levi ,  Michael Bukin ,  Noam Nir ,  Ziv Yohanan

IPC: A61F2/24

Abstract: A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including an annular frame and a plurality of leaflets is disclosed. As one example, the valve includes a plurality of commissures, each commissure including an attachment member including a protruding portion, a first commissure tab of a first leaflet of the plurality of leaflets arranged adjacent to a first side of the protruding portion and secured directly to the attachment member. Each commissure further includes a second commissure tab of a second leaflet of the plurality of leaflets arranged adjacent to an opposite, second side of the protruding portion and secured directly to the attachment member.

公开(公告)号：US11547544B2

公开(公告)日：2023-01-10

申请号：US17174784

申请日：2021-02-12

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Carmel Peleg ,  Tomer Saar ,  Alexander Barash ,  David Maimon

IPC: A61F2/24 ,  A61F2/00 ,  A61F2/95

Abstract: Disclosed herein is a storage container for an expandable prosthetic heart valve that crimps the valve upon opening the container and removal of the valve from the container. The container includes a housing sized to receive the heart valve in its expanded configuration and a crimping mechanism. The crimping mechanism is incorporated into the container and engages the heart valve so as to operably convert the heart valve from its expanded configuration to its smaller crimped configuration upon opening the container and removing the valve.

公开(公告)号：US20220323209A1

公开(公告)日：2022-10-13

申请号：US17851232

申请日：2022-06-28

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin ,  Elena Sherman

IPC: A61F2/24 ,  B29C65/62

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming each of a plurality of commissures with a plurality of leaflets by pairing a first commissure tab of a first leaflet with an adjacent, second commissure tab of a second leaflet, folding a support strip over an inner reinforcing element, positioning the folded support strip between the first and second commissure tabs, and attaching first and second outer reinforcing elements to the first and second commissure tabs, respectively, via stitching, the stitching extending over at least a portion of the first reinforcing element opposite a fold region of the support strip, and, for each commissure, securing end portions of the support strip to a respective support portion of a frame of the prosthetic heart valve.