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公开(公告)号：US20180237455A1
公开(公告)日：2018-08-23
申请号：US15891163
申请日：2018-02-07
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D498/04 , C07D495/04 , C07D471/04 , C07D417/14 , C07D409/14 , C07D401/12 , C07B59/00 , C07D405/14 , C07D401/14 , C07D413/14
CPC classification number: C07D498/04 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US09878995B2
公开(公告)日：2018-01-30
申请号：US15429086
申请日：2017-02-09
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/14
CPC classification number: C07D498/04 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20170362201A1
公开(公告)日：2017-12-21
申请号：US15697755
申请日：2017-09-07
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/12 , C07D453/02 , C07D417/14 , C07D413/14 , C07D413/12 , C07D409/14 , C07D405/14 , C07F7/08 , C07D401/14
CPC classification number: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D453/02 , C07F7/0814
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US09815818B2
公开(公告)日：2017-11-14
申请号：US15199779
申请日：2016-06-30
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D453/02 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/08
CPC classification number: C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D453/02 , C07F7/0814
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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![Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections](/abs-image/US/2017/05/30/US09663528B2/abs.jpg.150x150.jpg)
公开(公告)号：US09663528B2
公开(公告)日：2017-05-30
申请号：US14815504
申请日：2015-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , James G. Taylor
IPC: A61K31/4985 , C07D241/38 , C07D487/14
CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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Patent Agency Ranking
公开(公告)号：US09655944B2
公开(公告)日：2017-05-23
申请号：US15185273
申请日：2016-06-17
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K38/21 , A61K38/06 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/08 , C07K5/083 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20170008905A1
公开(公告)日：2017-01-12
申请号：US15199534
申请日：2016-06-30
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D498/04 , C07B59/00 , C07D471/04 , C07D409/14 , C07D417/14 , C07D495/04 , C07D401/14 , C07D405/14
CPC classification number: C07D498/04 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US20150175655A1
公开(公告)日：2015-06-25
申请号：US14412331
申请日：2013-07-02
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
Abstract translation: 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US12240862B2
公开(公告)日：2025-03-04
申请号：US17558130
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Eda Y. Canales , Laurent P. Debien , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Stephane Perreault , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: A61P35/02 , C07D519/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US12121511B2
公开(公告)日：2024-10-22
申请号：US17159485
申请日：2021-01-27
Applicant: Gilead Sciences, Inc.
Inventor： Stephen E. Ammann , Gediminas J. Brizgys , James S. Cassidy , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Chao-I Hung , Kavoos Kolahdouzan , Daniel G. Shore , Suzanne M. Szewczyk , James G. Taylor , Rhiannon Thomas-Tran , Nathan E. Wright , Zheng-Yu Yang
IPC: A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/424 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D471/04 , C07D493/04 , C07D493/10 , C07D498/04
CPC classification number: A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/424 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D471/04 , C07D493/04 , C07D493/10 , C07D498/04
Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.
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