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公开(公告)号：US20110177079A1
公开(公告)日：2011-07-21
申请号：US11662322
申请日：2005-09-08
申请人： Yao-Tseng Chen , Lloyd J. Old , Andrew J.G. Simpson , Victor C. Jongeneel , Matthew J. Scanlan , Cynthia H. Scanlan
发明人： Yao-Tseng Chen , Lloyd J. Old , Andrew J.G. Simpson , Victor C. Jongeneel , Matthew J. Scanlan , Cynthia H. Scanlan
IPC分类号： A61K39/395 , A61K39/00 , C07K14/435 , G01N33/574 , C12N15/12 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/505 , C07K14/4748 , G01N33/574
摘要： The invention relates to cancer-testis antigens and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof in methods and compositions for the diagnosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of novel cancer-testis (CT) antigens.
摘要翻译： 本发明涉及癌 - 睾丸抗原和编码它们的核酸分子。 本发明还涉及用于诊断和治疗诸如癌症的疾病的方法和组合物中核酸分子，多肽和其片段的用途。 更具体地，本发明涉及新型癌 - 睾丸（CT）抗原的发现。
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公开(公告)号：US20100322937A1
公开(公告)日：2010-12-23
申请号：US12657919
申请日：2010-01-29
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译： 本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。 本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明还涉及特异性针对受体肽的抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。
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公开(公告)号：US07589180B2
公开(公告)日：2009-09-15
申请号：US10145598
申请日：2002-05-13
申请人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/39541 , A61K45/06 , A61K2039/505 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/77 , A61K2300/00
摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.
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公开(公告)号：US20090220510A1
公开(公告)日：2009-09-03
申请号：US12317683
申请日：2008-12-23
申请人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gred Ritter , Achim Jungbluth , Elisabeth Stockert , V. Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gred Ritter , Achim Jungbluth , Elisabeth Stockert , V. Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12P21/00 , G01N33/574 , C12N1/21 , C12N1/19 , C12N5/06 , C12N5/04
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/39541 , A61K45/06 , A61K2039/505 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/77 , A61K2300/00
摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.
摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。
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公开(公告)号：US20090137782A1
公开(公告)日：2009-05-28
申请号：US10145598
申请日：2002-05-13
申请人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , V. Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , V. Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice
IPC分类号： C07K16/30
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/39541 , A61K45/06 , A61K2039/505 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/77 , A61K2300/00
摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.
摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。
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76.发明申请Isolated Ny-Eso-1 Peptides Which Bind To Hla Class II Molecules And Uses Thereof 审中-公开隔离的Ny-Eso-1肽，其绑定到Hla II类分子及其用途公开(公告)号：US20080139464A1
公开(公告)日：2008-06-12
申请号：US10556853
申请日：2004-05-27
申请人： Sacha Gnjatic , Djordje Atanackovic , Lloyd J. Old
发明人： Sacha Gnjatic , Djordje Atanackovic , Lloyd J. Old
CPC分类号： C07K14/4748
摘要： The invention relates to peptides which consist of amino acid sequences found in the NY-ESO-1 molecule, which bind to MHC-Class II molecules. These can be used alone, or in combination with other peptides.
摘要翻译： 本发明涉及由NY-ESO-1分子中发现的结合MHC-II类分子的氨基酸序列组成的肽。 这些可以单独使用，也可以与其他肽组合使用。
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公开(公告)号：US07335467B2
公开(公告)日：2008-02-26
申请号：US10146473
申请日：2002-05-15
申请人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
发明人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N1/00 , G01N33/48 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.
摘要翻译： 本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。 鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。
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78.发明授权Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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79.发明授权Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof 有权对应于NY-ESO-1的氨基酸序列的分离的肽，其结合MHC I类和II类分子，以及其用途公开(公告)号：US06723832B1
公开(公告)日：2004-04-20
申请号：US09165546
申请日：1998-10-02
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07K700
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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80.发明授权公开(公告)号：US06576756B2
公开(公告)日：2003-06-10
申请号：US09899651
申请日：2001-07-06
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
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