公开(公告)号：US20120008184A1

公开(公告)日：2012-01-12

申请号：US13257546

申请日：2010-02-04

Applicant: Shinichiro Hara ,  Naoki Kaneko ,  Hiroshi Takagi

Inventor： Shinichiro Hara ,  Naoki Kaneko ,  Hiroshi Takagi

IPC: G02B26/12 ,  G02B5/08

CPC classification number: G02B26/126 ,  B29C45/1704 ,  B29C45/7613 ,  B29C45/762 ,  B29C2945/76167 ,  B29C2945/76257 ,  B29C2945/76381 ,  B29C2945/76411 ,  B29C2945/76454 ,  B29C2945/76474 ,  B29C2945/76488 ,  B29C2945/76585 ,  B29C2945/76943 ,  B29D11/00596 ,  B29L2011/0058 ,  B41J2/471 ,  G02B27/0031

Abstract: Provided are a resinous reflecting optical element that achieves high mirror surface precision by mitigating the warping effects associated with contraction during resin hardening and suppressing the distortion of a mirror surface that results from resistance to mold release, and a scanning optical device that uses said reflecting optical element. The reflecting optical element is characterized by having a long, tabular substrate (3), a mirror surface section (2) positioned on one surface of the substrate (3), and a hollow portion (4) positioned within the interior of the substrate (3), and is also characterized in that, as a result of configuring so that the hollow portion (4) is longer than the mirror surface section (2), warping and sink marks which form due to contraction during resin hardening are mitigated across the entire mirror surface section (2), and in that the entire mirror surface section (2) protrudes above the surface of the substrate (3), thereby suppressing the increase in resistance to mold release that occurs when a metallic mold is gripped by the molding during resin contraction, and preventing distortion of the mirror surface section (2) that is caused by resistance to mold release.

Abstract translation: 提供一种树脂反射光学元件，其通过减轻与树脂硬化期间的收缩相关的翘曲效应并抑制由于抵抗脱模导致的反射镜表面的变形而实现高镜面精度;以及扫描光学装置，其使用所述反射光学 元件。 反射光学元件的特征在于具有长的平板状基板（3），位于基板（3）的一个表面上的镜面部分（2）和位于基板内部的中空部分（4） 3），其特征还在于，通过构造使得中空部分（4）比镜面部分（2）长，由于在树脂硬化期间由于收缩而形成的翘曲和凹痕被缓和 整个镜面部分（2），并且整个镜面部分（2）突出在基底（3）的表面上方，从而抑制当通过模制夹持金属模具时发生的抗脱模性的增加 在树脂收缩期间，并且防止由于抵抗脱模而引起的镜面部分（2）的变形。

公开(公告)号：US20110055031A1

公开(公告)日：2011-03-03

申请号：US12873571

申请日：2010-09-01

Applicant: Hiroshi Takagi

Inventor： Hiroshi Takagi

IPC: G06Q30/00

CPC classification number: G06Q20/20 ,  G06Q30/06

Abstract: According to one embodiment, a registration terminal includes: a connecting unit connected to a settlement terminal, the settlement terminal being configured to store sales data indicating transaction content of a transaction for purchase of a commodity transmitted from the outside and execute processing concerning settlement of the transaction on the basis of the stored sales data; a generating unit configured to generate, every time the transaction is performed, sales data indicating content of the transaction; a registering unit configured to transmit the sales data generated by the generating unit to the settlement terminal; a readout requesting unit configured to request the settlement terminal to read out the sales data stored in the settlement terminal; and a changing unit configured to change the transaction content of the sales data read out from the settlement terminal and transmit the sales data after the change to the settlement terminal as sales data for update.

Abstract translation: 根据一个实施例，登记终端包括：连接到结算终端的连接单元，结算终端被配置为存储指示用于购买从外部发送的商品的交易的交易内容的销售数据，并且执行涉及到的结算的处理 在存储的销售数据的基础上进行交易; 生成单元，被配置为在每次执行交易时生成指示交易内容的销售数据; 注册单元，被配置为将生成单元生成的销售数据发送给结算终端; 读出请求单元，被配置为请求结算终端读出存储在结算终端中的销售数据; 以及改变单元，被配置为改变从结算终端读出的销售数据的交易内容，并将更改之后的销售数据作为销售数据发送到结算终端作为更新。

公开(公告)号：US07892784B2

公开(公告)日：2011-02-22

申请号：US11710612

申请日：2007-02-26

Applicant: Hiroshi Takagi ,  Yoshimitsu Hamano

Inventor： Hiroshi Takagi ,  Yoshimitsu Hamano

IPC: C12P1/00 ,  C12P17/00 ,  C12P17/16 ,  C12P15/00

CPC classification number: C12N9/86 ,  C12P19/28

Abstract: An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.

Abstract translation: 提供能够降低链霉素相对于真核细胞的抗生素活性（即毒性）而不牺牲相对于原核细胞的抗生素活性的酶以及相对于真核细胞毒性降低的链球菌素衍生物，同时保持抗生素活性 原核细胞及其制造方法。 通过打开链霉素的内酰胺环，具有根据本发明的SEQ ID NO：2,4,6,8,10,12,14或16的氨基酸序列的蛋白质可以降低链球菌D的抗生素活性，相对于 真核细胞，而不牺牲相对于原核细胞的抗生素活性。

公开(公告)号：US20100093045A1

公开(公告)日：2010-04-15

申请号：US12635404

申请日：2009-12-10

Applicant: Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

Inventor： Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

IPC: C12P13/12

CPC classification number: C12P13/12

Abstract: L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of L-cysteine in the medium, and collecting L-cysteine from the medium.

Abstract translation: 通过培养具有L-半胱氨酸生产能力的埃希氏菌属细菌并含有编码O-乙酰丝氨酸巯基酶B或MalY调节蛋白的基因来产生L-半胱氨酸，所述基因被修饰以使得半胱氨酸脱硫酸酶活性被降低或消除。 将细菌培养在培养基中以产生并引起培养基中L-半胱氨酸的积累，并从培养基中收集L-半胱氨酸。

公开(公告)号：US20080076163A1

公开(公告)日：2008-03-27

申请号：US11070084

申请日：2005-03-03

Applicant: Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

Inventor： Hiroshi Takagi ,  Shigeru Nakamori ,  Masaru Wada ,  Hirotada Mori

IPC: C12P13/12 ,  C12N1/21

CPC classification number: C12P13/12

Abstract: L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of L-cysteine in the medium, and collecting L-cysteine from the medium.

Abstract translation: 通过培养具有L-半胱氨酸生产能力的埃希氏菌属细菌并含有编码O-乙酰丝氨酸巯基酶B或MalY调节蛋白的基因来产生L-半胱氨酸，所述基因被修饰以使得半胱氨酸脱硫酸酶活性被降低或消除。 将细菌培养在培养基中以产生并引起培养基中L-半胱氨酸的积累，并从培养基中收集L-半胱氨酸。

公开(公告)号：US07332259B2

公开(公告)日：2008-02-19

申请号：US11102311

申请日：2005-04-08

Applicant: Hiroshi Takagi

Inventor： Hiroshi Takagi

IPC: G03F7/00

CPC classification number: B41N3/038 ,  B41C1/1008 ,  B41C1/1016 ,  B41C1/1025 ,  B41C2201/02 ,  B41C2201/12 ,  B41C2201/14 ,  B41C2210/04 ,  B41C2210/06 ,  B41C2210/22 ,  B41C2210/24

Abstract: Disclosed is a process for manufacturing an aluminum support for a light sensitive planographic printing plate material, the process comprising the steps of surface-roughening an aluminum plate, anodizing the surface-roughened aluminum plate, surface treating the anodized aluminum plate with an aqueous polyvinyl phosphonic acid solution, and drying the resulting plate at from 150 to 230° C. to obtain the aluminum support.

Abstract translation: 公开了一种用于制造光敏平版印刷版材料的铝支架的方法，该方法包括以下步骤：对铝板进行表面粗糙化，阳极氧化表面粗糙化的铝板，用阳离子化铝板表面处理聚乙烯基膦酸盐 酸溶液，并将所得板在150-230℃下干燥，得到铝载体。

公开(公告)号：US07329726B2

公开(公告)日：2008-02-12

申请号：US11010800

申请日：2004-12-13

Applicant: Shigeru Nakamori ,  Hiroshi Takagi ,  Masakazu Takahashi ,  Kazuhisa Tsujimoto ,  Hideyuki Yamada

Inventor： Shigeru Nakamori ,  Hiroshi Takagi ,  Masakazu Takahashi ,  Kazuhisa Tsujimoto ,  Hideyuki Yamada

IPC: C07K7/06 ,  A61K38/08 ,  C12N5/02

CPC classification number: C07K14/43586 ,  C12N5/0018 ,  C12N5/0601 ,  C12N2501/998 ,  C12N2501/999

Abstract: A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having cell death-preventing activity and/or cell growth-promoting activity; and (c) a peptide which has an amino acid sequence having at least 80% homology with the peptide consisting of the amino acid sequence described in (a) above and has cell death-preventing activity and/or cell growth-promoting activity. The peptide has cell death-preventing activity and/or cell growth-promoting activity, is highly safe, and can be produced without difficulty. The peptide is useful as a culture supplement or as an effective component for a cell culture medium.

Abstract translation: 根据本发明的肽选自：（a）具有由SEQ ID NO：1表示的氨基酸序列的肽; （b）具有上述（a）中所述的氨基酸序列的修饰氨基酸序列的肽，其中一个或多个氨基酸残基被缺失，取代，插入或添加并具有细胞死亡预防活性和/或 细胞生长促进活性; 和（c）具有与由上述（a）中所述的氨基酸序列组成的肽具有至少80％同源性的氨基酸序列并具有细胞死亡预防活性和/或细胞生长促进活性的肽。 肽具有细胞死亡预防活性和/或细胞生长促进活性，是高度安全的，可以毫无困难地制备。 该肽可用作培养物补充物或作为细胞培养基的有效成分。

公开(公告)号：US20060037506A1

公开(公告)日：2006-02-23

申请号：US11187398

申请日：2005-07-22

Applicant: Hiroshi Takagi

Inventor： Hiroshi Takagi

IPC: B41N1/00

CPC classification number: B41C1/1008 ,  B41C1/1016 ,  B41C2201/02 ,  B41C2201/12 ,  B41C2201/14 ,  B41C2210/02 ,  B41C2210/04 ,  B41C2210/22 ,  B41C2210/24 ,  B41N1/083 ,  B41N3/034

Abstract: An object of the invention is to provide a planographic printing plate material exhibiting excellent dot reproduction and printing durability and a support for the planographic printing plate material. Disclosed is a support for a planographic printing plate material having a surface roughened via electrolytic surface-roughening treatment and anodization treatment conducted to one surface of an aluminum plate, wherein a) average surface roughness (Ra) of the roughened surface is 0.30-0.55 μm, and b) the roughened surface possesses a surface profile in which a ratio of Xa/Xb is 0.40-0.70, where Xa is the width expanding to the shallow region side and Xb is the width expanding to the deep region side at the position reaching peak depth in amplitude frequency.

Abstract translation: 本发明的目的是提供一种平版印刷版材料，其具有优异的点再现性和印刷耐久性，并且对平版印刷版材料的支持。 公开了通过经由电解表面粗糙化处理进行表面粗糙化并对铝板的一个表面进行阳极氧化处理的平版印刷版材的支撑体，其中，a）粗糙面的平均表面粗糙度（Ra）为0.30〜0.55μm ，b）粗糙表面具有Xa / Xb的比例为0.40-0.70的表面轮廓，其中Xa是向浅区域侧扩展的宽度，Xb是在到达的位置处扩展到深区域侧的宽度 振幅频率峰值深度。

公开(公告)号：US20050233250A1

公开(公告)日：2005-10-20

申请号：US11102311

申请日：2005-04-08

Applicant: Hiroshi Takagi

Inventor： Hiroshi Takagi

IPC: G03F7/09 ,  B41C1/10 ,  B41N1/08 ,  B41N3/03 ,  G03F7/00

CPC classification number: B41N3/038 ,  B41C1/1008 ,  B41C1/1016 ,  B41C1/1025 ,  B41C2201/02 ,  B41C2201/12 ,  B41C2201/14 ,  B41C2210/04 ,  B41C2210/06 ,  B41C2210/22 ,  B41C2210/24

Abstract: Disclosed is a process for manufacturing an aluminum support for a light sensitive planographic printing plate material, the process comprising the steps of surface-roughening an aluminum plate, anodizing the surface-roughened aluminum plate, surface treating the anodized aluminum plate with an aqueous polyvinyl phosphonic acid solution, and drying the resulting plate at from 150 to 230 ° C. to obtain the aluminum support.

Abstract translation: 公开了一种用于制造光敏平版印刷版材料的铝支架的方法，该方法包括以下步骤：对铝板进行表面粗糙化，阳极氧化表面粗糙化的铝板，用阳离子化铝板表面处理聚乙烯基膦酸盐 酸溶液，并将所得板在150-230℃下干燥，得到铝载体。

公开(公告)号：US20050221453A1

公开(公告)日：2005-10-06

申请号：US10957828

申请日：2004-10-05

Applicant: Hiroshi Takagi ,  Shigeru Nakamori ,  Akihito Yamaguchi ,  Kunihiko Nishino

Inventor： Hiroshi Takagi ,  Shigeru Nakamori ,  Akihito Yamaguchi ,  Kunihiko Nishino

IPC: C12N15/09 ,  C12N1/21 ,  C12P13/06 ,  C12P13/12

CPC classification number: C12P13/12 ,  C12P13/06

Abstract: L-Cysteine is produced by culturing a microorganism having an ability to produce L-cysteine and modified so that expression of emrAB, emrKY, yojIH, acrEF, bcr, or cusA gene should be enhanced in a medium to produce and accumulate L-cysteine in the medium and collecting the L-cysteine from the medium. Genes coding for novel L-cysteine-excreting proteins are identified, and utilized for breeding of L-cysteine-producing microorganism to provide a novel method of producing L-cysteine.

Abstract translation: L-半胱氨酸通过培养具有产生L-半胱氨酸的能力的微生物并进行修饰以使得在培养基中增强emrAB，emrKY，yojIH，acrEF，bcr或cusA基因的表达以产生和积累L-半胱氨酸来产生L-半胱氨酸 培养基并从培养基中收集L-半胱氨酸。 鉴定出编码新型L-半胱氨酸分泌蛋白的基因，用于生产L-半胱氨酸的微生物的育种，以提供L-半胱氨酸的新方法。